Article
Veterinary Sciences
Chun-Yu Liu, Ming Jin, Hao Guo, Hong-Zhe Zhao, Li-Na Hou, Yang Yang, Yong-Jun Wen, Feng-Xue Wang
Summary: Bovine herpesvirus type I (BoHV-1) is a highly pathogenic virus that causes respiratory diseases in cattle, resulting in significant economic losses to the cattle industry worldwide. Researchers successfully knocked out the gE gene of BoHV-1 using the CRISPR/Cas9 system and observed interesting phenomena. This study provides a foundation for future research on BoHV-1 and vaccine development.
VETERINARY SCIENCES
(2022)
Article
Genetics & Heredity
Stephanie O'Donoghue, Bernadette Earley, Dayle Johnston, Matthew S. McCabe, Jae Woo Kim, Jeremy F. Taylor, Catherine Duffy, Ken Lemon, Michael McMenamy, S. Louise Cosby, Derek W. Morris, Sinead M. Waters
Summary: This study aimed to investigate the whole-blood transcriptome of dairy calves experimentally challenged with BoHV-1 and compare the gene expression results with data from a similar challenge study with BRSV. The results showed that BoHV-1 infection caused differential expression of 488 genes, involving several key pathways and gene ontology terms related to virus defense and inflammatory response.
FRONTIERS IN GENETICS
(2023)
Article
Microbiology
Chang Liu, Jiayu Lin, Hao Yang, Ningxi Li, Linke Tang, Donna Neumann, Xiuyan Ding, Liqian Zhu
Summary: This study demonstrates that TonEBP (NFAT5) is a potential host factor that restricts bovine herpesvirus 1 (BoHV-1) infection; virus infection controls NFAT5 signaling transduction by altering NFAT5 localization and downstream target expression. Furthermore, the presence of NFAT5 in mitochondria suggests its potential involvement in regulating mitochondrial functions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biotechnology & Applied Microbiology
Adepeju E. Onasanya, Charles El-Hage, Andres Diaz-Mendez, Paola K. Vaz, Alistair R. Legione, Glenn F. Browning, Joanne M. Devlin, Carol A. Hartley
Summary: This study analyzed the genome diversity and recombination mechanism of EHV2 virus. The results showed a high degree of genetic diversity and extensive recombination networks in EHV2 genomes. Recombination may be an important mechanism for EHV2 genome variation and evolution.
Article
Virology
Daiying Li, MingWang Long, Tingting Li, Yun Shu, Xiyun Shan, Juan Zhang, Dehong Ma, Shuying Long, Xiaodan Wang, Fan Jia, Yue Pan, Junying Chen, Pinghua Liu, Qiangming Sun
Summary: This study conducted a molecular epidemiological analysis of DENV-1 virus infection in Xishuangbanna in 2019, revealing the presence of different epidemic strains and suggesting the co-epidemic of local and cross-border strains.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Stefano Petrini, Alessandra Martucciello, Francesco Grandoni, Giovanna De Matteis, Giovanna Cappelli, Monica Giammarioli, Eleonora Scoccia, Carlo Grassi, Cecilia Righi, Giovanna Fusco, Giorgio Galiero, Michela Pela, Gian Mario De Mia, Esterina De Carlo
Summary: This study evaluated the safety and efficacy of a commercial inactivated gE-deleted marker vaccine in water buffaloes for the first time, demonstrating that the vaccine provides a good protection against BoHV-1 in water buffaloes.
Article
Virology
Yue Lei, Zhichao Zhuang, Yang Liu, Zhaolin Tan, Xin Gao, Xiaoyan Li, Dongjing Yang
Summary: Human adenovirus species C (HAdV-C) was isolated from sewage water and hospitalized children in Tianjin, China. Genomic and bioinformatics analyses showed three types of HAdV-C and revealed seven recombination patterns transmitted in Tianjin. The study highlights the importance of sewage and virological monitoring for HAdV-C in China.
Article
Virology
Islam Nour, Sonsiray Alvarez-Narvaez, Telvin L. Harrell, Steven J. Conrad, Sujit K. Mohanty
Summary: This study sequenced and analyzed the genomes of avian reovirus isolates from field strains in North Carolina, USA. The results showed significant divergence between the field strains and reference strains, and identified unique amino acid substitution events. These findings are important for updating vaccination regimes.
Article
Biochemical Research Methods
Chen Cao, Matthew Greenberg, Quan Long
Summary: WgLink is a tool that can reconstruct whole viral genomes with high accuracy, consuming significantly less memory and fewer CPU hours compared to existing methods.
Article
Virology
Ruiming Hu, Leyi Wang, Qingyun Liu, Lin Hua, Xi Huang, Yue Zhang, Jie Fan, Hongjian Chen, Wenbo Song, Wan Liang, Nengshui Ding, Zuohua Li, Zhen Ding, Xibiao Tang, Zhong Peng, Bin Wu
Summary: The genomes of novel PRV variants isolated in China from 2012 to 2017 show high relatedness and genetic similarity to classic China strains. Recombination events play a significant role in viral evolution, while most genes are under evolutionary constraint. Positive selection affects 19 amino acid residue sites in 15 genes, leading to the identification of 37 unique mutations distinguishing the novel variants from classic strains.
Article
Multidisciplinary Sciences
Chun Zhang, Nicholas A. Johnson, Nathan Hall, Xingshan Tian, Qin Yu, Eric L. Patterson
Summary: This study investigates the mechanism of glyphosate resistance in goosegrass, finding that resistance is associated with copy number variation (CNV) of the EPSPS gene, with the variation being driven by sub-telomeric-repeat sequences. This discovery further highlights the importance of subtelomeres in generating genetic variation and provides a unique example of herbicide resistance evolution.
NATURE COMMUNICATIONS
(2023)
Article
Virology
Qian Yang, Dongmei Yan, Yang Song, Shuangli Zhu, Yun He, Zhenzhi Han, Dongyan Wang, Tianjiao Ji, Yong Zhang, Wenbo Xu
Summary: This study systematically examined the genetic characteristics of coxsackievirus B3 (CVB3) based on its whole genome. The results showed a high level of genetic diversity and recombination forms among CVB3 isolates. Different clusters of CVB3 were associated with different disease types. Continuous surveillance of CVB3 is important for understanding its genetic diversity and evolution.
Article
Biotechnology & Applied Microbiology
Nehemie Nzoyikorera, Idrissa Diawara, Pablo Fresia, Fakhreddine Maaloum, Khalid Katfy, Kaotar Nayme, Mossaab Maaloum, Jennifer Cornick, Chrispin Chaguza, Mohammed Timinouni, Houria Belabess, Khalid Zerouali, Naima Elmdaghri
Summary: Whole genome sequencing provides detailed analysis of the virulent serotype 1 in Casablanca, Morocco. Results show that the phylogeography of S. pneumoniae serotype 1 is structured by country. Despite the small sample size from Morocco, the genetic cohesion of the Moroccan invasive isolates is evident.
Review
Immunology
Cecilia Righi, Giulia Franzoni, Francesco Feliziani, Clinton Jones, Stefano Petrini
Summary: Bovine Alphaherpesvirus 1 (BoHV-1) is a significant respiratory pathogen in cattle worldwide, causing bovine respiratory disease. Immunosuppression initially occurs after infection but is followed by the development of innate and adaptive immune responses. Vaccines targeting both humoral and cell-mediated immunity have been developed. This review summarizes the current understanding of cell-mediated immune responses against BoHV-1 infection and vaccination.
Article
Virology
Fouad S. El-mayet, Clinton Jones
Summary: Bovine alphaherpesvirus 1 (BoHV-1) infections in cows cause respiratory tract disorders and weaken immune responses, leading to bacterial pneumonia. After the initial infection, the virus enters a latent state in sensory neurons and cells in the pharyngeal tonsil. Stress can reactivate the virus from latency, and the cellular transcription factor Sp1 plays a role in enhancing viral replication and reactivation. The antibiotic mithramycin A has the potential to inhibit Sp1 function and reduce viral replication. The interaction between the glucocorticoid receptor and Sp1 stimulates viral gene expression and replication in response to stress.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mateus S. Dalcin, Bruna L. Dias, Luis O. Viteri Jumbo, Ana C. S. S. Oliveira, Sabrina H. C. Araujo, Wellington S. Moura, Dalmarcia S. C. Mourao, Talita P. S. Ferreira, Fabricio S. Campos, Alex Sander R. Cangussu, Marcos V. G. Alves, Bruno S. Andrade, Javier G. Mantilla-Afanador, Raimundo W. A. Aguiar, Eugenio E. Oliveira, Gil R. Santos
Summary: This study extracted and evaluated the composition of Morinda citrifolia essential oil and tested its activity against Stagonosporopsis cucurbitacearum. Molecular docking analyses predicted stable interactions between the major oil constituents and the fungal enzyme. The essential oil showed potential as a preventive measure against the fungus, but at higher concentrations, it had phytotoxic effects on the treated plants.
Article
Virology
Ueric Jose Borges de Souza, Raissa Nunes dos Santos, Marta Giovanetti, Luiz Carlos Junior Alcantara, Jucimaria Dantas Galvao, Franciano Dias Pereira Cardoso, Feliph Cassio Sobrinho Brito, Ana Claudia Franco, Paulo Michel Roehe, Bergmann Morais Ribeiro, Fernando Rosado Spilki, Fabricio Souza Campos
Summary: This study investigates the genomic epidemiology of the CHIKV virus in Tocantins state, Brazil, and finds that the virus belongs to the ECSA lineage and is closely related to outbreaks in Northeast and Southeast Brazil. The study identifies several frequent non-synonymous mutations in the virus genome, indicating local transmission in the state. The findings highlight the importance of continued genomic surveillance for predicting new infections and improving public health services.
Article
Microbiology
Filipe Vieira Santos de Abreu, Kamila Lorene Soares Rocha, Ramon Silva-Oliveira, Mariana Viana Macedo, Thamires Gabriele Macedo Silva, Maria Eduarda Goncalves-Dos-Santos, Cirilo Henrique de Oliveira, Sandy Micaele Aquino-Teixeira, Vinicius de Oliveira Ottone, Alex Junio Jardim da Silva, Ronaldo Medeiros Dos Santos, Aline Tatila-Ferreira, Marco Antonio Barreto de Almeida, Edmilson Dos Santos, Jader da Cruz Cardoso, Aline Alves Scarpellini Campos, George Rego Albuquerque, Anaia da Paixao Seva, Bergmann Morais Ribeiro, Danilo Simonini Teixeira, Fabricio Souza Campos, Ana Claudia Franco, Paulo Michel Roehe, Giliane de Souza Trindade, Danilo Bretas de Oliveira
Summary: Evidence of Orthopoxvirus (OPXV) infection has been detected for the first time in neotropical free-living primates in southeast Brazil, indicating their previous exposure to the virus. This finding is significant for understanding the transmission and infection risks of OPXV in primates.
Article
Microbiology
Lina Violet-Lozano, Vanessa Haach, Camila Mosca Barboza, Juliana dos Santos, Bianca Ferreira Gomes, Tatiane de Cassia Pardo de Souza, Pedro Carnieli Junior, Clarice Weis Arns, Helena Beatriz de Carvalho Ruthner Batista, Paulo Michel Roehe, Ana Claudia Franco
Summary: This study aimed to evaluate the presence of influenza A virus and coronavirus in non-hematophagous bats in Brazil. However, all samples analyzed were negative, suggesting that virus circulation in bats in the wild often occurs at low viral loads.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Microbiology
Camila Mengue Scheffer, Ana Paula Muterle Varela, Thais Fumaco Teixeira, Candice Schmidt, Samuel Paulo Cibulski, Helton Fernandes dos Santos, Phelipe Magalhaes Duarte, Fabricio Souza Campos, Ana Claudia Franco, Paulo Michel Roehe
Summary: Water buffaloes have been introduced as a source of animal protein, but little is known about infectious diseases of them. This study investigated the neutralizing antibodies to alphaherpesviruses in bubaline sera, and found that 46.9% of the samples neutralized at least one of the viruses tested.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Virology
Alessandra P. P. Lamarca, Ueric Jose Borges de Souza, Filipe Romero Rebello Moreira, Luiz G. P. de Almeida, Mariane Talon de Menezes, Adrieli Barboza de Souza, Alessandro Clayton de Souza Ferreira, Alexandra L. Gerber, Aline B. de Lima, Ana Paula de C. Guimaraes, Andrea Cony Cavalcanti, Aryel B. Paz e Silva, Bruna Israel Lima, Cirley Lobato, Cristiane Gomes Da Silva, Cristiane P. T. B. Mendonca, Daniel Costa Queiroz, Danielle Alves Gomes Zauli, Diego Menezes, Fabio Sossai Possebon, Franciano Dias Pereira Cardoso, Frederico Scott Varella Malta, Isabela Braga-Paz, Joice do Prado Silva, Jorge Gomes Goulart Ferreira, Jucimaria Dantas Galvao, Leandro Magalhaes de Souza, Leonardo Ferreira, Lia Goncalves Possuelo, Liliane Tavares de Faria Cavalcante, Luige B. Alvim, Luiz Fellype Alves de Souza, Luiza C. G. de Araujo E Santos, Rillery Calixto Dias, Rutilene Barbosa Souza, Thais Regina y Castro, Andreia Rosane de Moura Valim, Fabricio Souza Campos, Joao Pessoa Araujo Jr, Priscila de Arruda Trindade, Renato S. S. Aguiar, Robson Michael Delai, Ana Tereza R. de Vasconcelos
Summary: Brazil currently ranks second in absolute deaths by COVID-19, even though most of its population has completed the vaccination protocol. With the introduction of Omicron in late 2021, the number of COVID-19 cases soared once again in the country. We investigated the entry and spread of lineages BA.1 and BA.2 in Brazil through sequencing and analyzing new SARS-CoV-2 genomes, and found that Omicron has been mostly imported through the state of Sao Paulo, which in turn dispersed the lineages to other states and regions of Brazil. This knowledge can be used to implement more efficient non-pharmaceutical interventions against the introduction of new SARS-CoV variants focused on surveillance of airports and ground transportation.
Article
Virology
Cirilo H. de Oliveira, Miguel S. Andrade, Fabricio S. Campos, Jader da C. Cardoso, Maria Eduarda Goncalves-dos-Santos, Ramon Silva Oliveira, Sandy Micaele Aquino-Teixeira, Aline A. S. Campos, Marco A. B. Almeida, Danilo Simonini-Teixeira, Anaia da P. Seva, Andrea Oliveira Dias Temponi, Fernando Maria Magalhaes, Agna Soares da Silva Menezes, Bartolomeu Teixeira Lopes, Hermes P. Almeida, Ana Lucia Pedroso, Giovani Pontel Goncalves, Danielle Costa Capistrano Chaves, Givaldo Gomes de Menezes, Sofia Bernal-Valle, Nicolas F. D. Mueller, Luis Janssen, Edmilson dos Santos, Maria A. Mares-Guia, George R. Albuquerque, Alessandro P. M. Romano, Ana C. Franco, Bergmann M. Ribeiro, Paulo M. Roehe, Ricardo Lourenco-de-Oliveira, Filipe Vieira Santos de Abreu
Summary: In a survey conducted in the Cerrado areas of Minas Gerais, Brazil, it was found that mosquitoes of the Sabethes genus, particularly Sabethes chloropterus, were the primary vectors involved in maintaining the yellow fever virus (YFV) in semi-arid environments. The high number of YFV RNA copies and relative abundance in Sa. chloropterus indicate its importance as a vector, while Sa. albiprivus, despite being naturally infected with YFV, had fewer viral RNA copies and a lower infection rate.
Article
Veterinary Sciences
Camila Mengue Scheffer, Sylio Alfredo Petzhold, Ana Paula Muterle Varela, Willian Pinto Paim, Phelipe Magalhaes Duarte, Marcia Regina Loiko, Cristine Cerva, Candice Schmidt, Adrieli Wendlant, Samuel Paulo Cibulski, Diane Alves de Lima, Caroline Tochetto, Anne Caroline Ramos dos Santos, Juliana Ines Herpich, Thais Fumaco Teixeira, Helton Fernandes dos Santos, Fabricio Souza Campos, Ana Claudia Franco, Paulo Michel Roehe
Summary: A highly sensitive and specific multi-antigen ELISA method has been developed for detecting antibodies to Bovine alphaherpesviruses type 1, type 5, and bubaline herpesvirus type 1. The sensitivity and specificity of this method are comparable to serum neutralization tests.
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Rocio Lucia Tau, Carola Ferreccio, Natalia Bachir, Fatima Torales, Sonia Alejandra Romera, Silvina Soledad Maidana
Summary: This study analyzed interspecific recombination events between different equine alphaherpesvirus species and identified 14 recombination events involving important gene ORF64. The results suggest that infected cell protein 4 (ICP4) is a hotspot for recombination in equine alphaherpesviruses.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2023)
Editorial Material
Virology
Maite Freitas Silva Vaslin, Luciana de Barros Arruda, Fabricio Souza Campos
Article
Virology
Ueric Jose Borges de Souza, Ygor da Silva Miranda Macedo, Raissa Nunes dos Santos, Franciano Dias Pereira Cardoso, Jucimaria Dantas Galvao, Evgeni Evgeniev Gabev, Ana Claudia Franco, Paulo Michel Roehe, Fernando Rosado Spilki, Fabricio Souza Campos
Summary: The state of Tocantins in Brazil has experienced a significant number of cases of arboviral disease, particularly Dengue virus. Full genome sequencing of viral genomes recovered from patients revealed the circulation of different genotypes of Dengue virus in the state. Younger age groups were mostly affected, and there were no significant differences in gender distribution. This study highlights the importance of major population centers in Brazil in virus dispersion.
Article
Multidisciplinary Sciences
Marta Giovanetti, Francesco Pinotti, Camila Zanluca, Vagner Fonseca, Taishi Nakase, Andrea C. Koishi, Marcel Tscha, Guilherme Soares, Gisiane Gruber Dorl, Antonio Ernesto M. L. Marques, Renato Sousa, Talita Emile Ribeiro Adelino, Joilson Xavier, Carla de Oliveira, Sandro Patroca, Natalia Rocha Guimaraes, Hegger Fritsch, Maria Angelica Mares-Guia, Flavia Levy, Pedro Henrique Passos, Vinicius Leme da Silva, Luiz Augusto Pereira, Ana Flavia Mendonca, Isabel Luana de Macedo, Davi Emanuel Ribeiro de Sousa, Gabriela Rodrigues de Toledo Costa, Marcio Botelho de Castro, Miguel de Souza Andrade, Filipe Vieira Santos de Abreu, Fabricio Souza Campos, Felipe Campos de Melo Iani, Maira Alves Pereira, Karina Ribeiro Leite Jardim Cavalcante, Andre Ricardo Ribas de Freitas, Carlos Frederico Campelo de Albuquerque, Eduardo Marques Macario, Marlei Pickler Debiasi dos Anjos, Rosane Campanher Ramos, Aline Alves Scarpellini Campos, Adriano Pinter, Marcia Chame, Livia Abdalla, Irina Nastassja Riediger, Servio Pontes Ribeiro, Ana I. Bento, Tulio de Oliveira, Carla Freitas, Noely Fabiana Oliveira de Moura, Allison Fabri, Cintia Damasceno dos Santos Rodrigues, Carolina Cardoso Dos Santos, Marco Antonio Barreto de Almeida, Edmilson dos Santos, Jader Cardoso, Douglas Adriano Augusto, Eduardo Krempser, Luis Filipe Mucci, Renata Rispoli Gatti, Sabrina Fernandes Cardoso, Joao Augusto Brancher Fuck, Maria Goretti David Lopes, Ivana Lucia Belmonte, Gabriela Mayoral Pedroso da Silva, Maiane Regina Ferreira Soares, Marilia de Melo Santos de Castilhos, Joseana Cardoso Silva, Alceu Bisetto Junior, Emanuelle Gemin Pouzato, Laurina Setsuko Tanabe, Daniele Akemi Arita, Ricardo Matsuo, Josiane dos Santos Raymundo, Paula Cristina Linder Silva, Ana Santana Araujo Ferreira Silva, Sandra Samila, Glauco Carvalho, Rodrigo Stabeli, Wildo Navegantes, Luciano Andrade Moreira, Alvaro Gil A. Ferreira, Guilherme Garcia Pinheiro, Bruno Tardelli Diniz Nunes, Daniele Barbosa de Almeida Medeiros, Ana Cecilia Ribeiro Cruz, Rivaldo Venancio da Cunha, Wes Van Voorhis, Ana Maria Bispo de Filippis, Maria Almiron, Edward C. Holmes, Daniel Garkauskas Ramos, Alessandro Romano, Jose Lourenco, Luiz Carlos Junior Alcantara, Claudia Nunes Duarte dos Santos
Summary: This study reconstructed the transmission history of yellow fever virus (YFV) in Brazil using phylogenetic and epidemiological models. The results showed the circulation of three distinct lineages and provided evidence of a known spatial corridor for virus transmission. The study highlights the importance of combining genomics with eco-epidemiology for infectious disease surveillance and control.
Article
Virology
Mohamed S. H. Hassan, Ahmed Ali, Motamed Elsayed Mahmoud, Danah Altakrouni, Shahnas M. Najimudeen, Mohamed Faizal Abdul-Careem
Summary: This study compared the efficacy of different vaccination programs against Canadian DMV/1639 IBV and found that the autogenous inactivated DMV/1639 vaccine was more effective in reducing viral loads and boosting virus neutralization titers. Both vaccination programs provided significant protection against pathological effects.
Article
Virology
Wanda Christ, Jonas Klingstrom, Janne Tynell
Summary: The integrated stress response (ISR) is activated in response to SARS-CoV-2 infection, triggering translational arrest and inhibiting stress granule formation. However, the stress-responsive transcription factors ATF4 and CHOP are not induced. Different SARS-CoV-2 variants show variant-specific differences in ISR activation, suggesting potential impacts on pathogenesis and treatment strategies.
Article
Virology
Xiao Han, Hankun Xu, Yifan Weng, Rong Chen, Jidong Xu, Tong Cao, Renjie Sun, Ying Shan, Fang He, Weihuan Fang, Xiaoliang Li
Summary: Classical swine fever virus (CSFV) can inhibit the host innate immunity by decreasing the level of high mobility group box 1 (HMGB1), and CSFV Npro can evade host antiviral immune response through upregulating HMGB1 acetylation.
Article
Virology
Sunjian Lyu, Fulei Xiong, Tianpeng Qi, Weifeng Shen, Qi Guo, Mingming Han, Li Liu, Weishao Bu, Julin Yuan, Bao Lou
Summary: This study identified and characterized a novel temperate A. hydrophila phage, P05B, which has strong lytic ability and stability across different temperatures and pH values.
Article
Virology
Siyuan Liu, Wei Chen, Raphael Nyaruaba, Shunlong Wang, Cihan Yang, Qun Wu, Ying Liu, Puyu Liu, Fei Wang, Jingling Wang, Zhiming Yuan, Dingwei Sun, Han Xia
Summary: Specific, sensitive, and reliable RT-qPCR assays for the detection of OYAV and EBIV have been successfully developed in this study. These assays hold great promise for their potential application in clinical and field samples in the future.
Article
Virology
Rui Wang, Qiang Sun, Jinbo Xiao, Congcong Wang, Xiaoliang Li, Jichen Li, Yang Song, Huanhuan Lu, Ying Liu, Shuangli Zhu, Zhijun Liu, Yong Zhang
Summary: Coxsackievirus A6 (CVA6) has emerged as an important agent causing hand, foot, and mouth disease (HFMD). Mutations in residue 64 of the virus have been found to increase resistance to ribavirin and decrease sensitivity to guanidine hydrochloride. This mutation also leads to increased replication fidelity and reduced pathogenicity. These findings provide a foundation for the development of a safe and effective live attenuated CVA6 vaccine.
Article
Virology
Yao Xiong, Keran Ma, Xiao Zou, Yantao Liang, Kaiyang Zheng, Tiancong Wang, Hong Zhang, Yue Dong, Ziyue Wang, Yundan Liu, Hongbing Shao, Andrew Mcminn, Min Wang
Summary: This study isolated a novel virus, vB_VviC_ZQ26, infecting Vibrio cyclitrophicus from coastal waters near Qingdao, China. It was found that vB_VviC_ZQ26 belongs to a new vibriophage-specific family, Coheviridae, and is mainly found in temperate and tropical epipelagic zones.
Article
Virology
Xing Li, Zhiping Ye, Ewan P. Plant
Summary: By analyzing clinical and cultured samples using the same bioinformatic pipeline, it was found that 5' copyback DVGs are prevalent in human clinical samples but not in cultured samples. Furthermore, there are differences in DVG production and composition between in vivo and in vitro infections.
Article
Virology
Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Suvrotoa Mitra, Animesh Gope, Mamta Chawla-Sarkar
Summary: Rotavirus is a major cause of viral gastroenteritis in infants and continues to be a severe issue in underdeveloped nations. Recent research has shown that a long non-coding RNA called SLC7A11-AS1 is upregulated during rotavirus infection and plays a role in facilitating the virus's propagation by regulating intracellular glutathione and lipid peroxidation.
Article
Virology
Eiichi Hondo, Tetsufumi Katta, Ayato Sato, Naoya Kadofusa, Tomoki Ishibashi, Hiroshi Shimoda, Hirokazu Katoh, Atsuo Iida
Summary: Bat-borne emerging viruses, such as the Ebola virus and Nipah virus, pose a significant threat to public health. In this study, we identified micafungin as a potential antiviral drug against Pteropine orthoreovirus (PRV) and found that it inhibits viral release in human cells through activating the endoplasmic reticulum stress response pathway. This research provides valuable insights into the development of effective treatments for future virus pandemics.
Article
Virology
M. Joubert, N. van den Berg, J. Theron, V. Swart
Summary: This study investigated the host gene expression in asymptomatic avocado nursery trees infected with Avocado sunblotch viroid (ASBVd) using RNA sequencing. The results showed that 631 genes were differentially expressed during infection, with 63% upregulated. ASBVd infection significantly affected plant defence responses, phytohormone networks, gene expression pathways, secondary metabolism, cellular transport, as well as protein modification and degradation. This study provides insights into the molecular interactions underlying avsunviroid-host interactions.
Article
Virology
Wanling Zhang, Haiyan Yang, Zhengyun Liu, Shengyu Wang, Tianyang Chen, Hong Song, Yunbin Xu, Fajin Li, Guo Luo, Huan Wang
Summary: EV71 infection leads to changes in mitochondrial morphology and dynamics in human neuroblastoma cells, resulting in mitochondrial dysfunction that may contribute to nervous system dysfunction.
Article
Virology
Mikhail Oliveira Leastro, Elliot Watanabe Kitajima, Vicente Pallas, Jesus Angel Sanchez- Navarro
Summary: This study reports the construction and validation of an infectious cDNA clone of Citrus leprosis virus C (CiLV-C) based on an agroinfection system. Agro-injected Nicotiana benthamiana plants showed localized lesions similar to the natural infection process. The virus recovered from the infected plant tissue could be mechanically transmitted between plants. The CiLV-C reverse genetic system provides a powerful molecular tool for unraveling the peculiarities of the citrus leprosis pathosystem.
Article
Virology
Manel Essaidi-Laziosi, Francisco J. Perez-Rodriguez, Catia Alvarez, Pascale Sattonnet-Roche, Giulia Torriani, Meriem Bekliz, Kenneth Adea, Matthias Lenk, Tasnim Suliman, Wolfgang Preiser, Marcel A. Mueller, Christian Drosten, Laurent Kaiser, Isabella Eckerle
Summary: This study found that the Omicron variant has different replication characteristics compared to other variants of concern, being able to efficiently produce infectious virus in nasal cells but not lung cells. In addition, the Delta and Omicron variants showed increased infection efficiency in A549 cells. These findings suggest that the variants of concern have better adaptation to humans but do not have an extended host range.
Article
Virology
Martin Faye, Modeste Name Faye, Babacar Ndiaye, Moussa Moise Diagne, Safietou Sankhe, Ndeye Marieme Top, Amadou Diallo, Cheikh Loucoubar, Ndongo Dia, Amadou Alpha Sall, Ousmane Faye
Summary: Genomic surveillance in Senegal since March 2020 has detected the emergence of Omicron BA.4 and BA.5 sublineages in June 2022. Next-generation sequencing and phylogeny analysis of isolates from a cluster of cases in Northern Senegal in July 2022 revealed that the BA.4 cases originated from a XAS recombinant, marking the first reported sequence of this variant from Senegal. Continuous genomic surveillance of positive SARS-CoV-2 samples is crucial.