Ligustrazine activate the PPAR-γ pathway and play a protective role in vascular calcification

A HPLC-DAD-MS/MS Method for Simultaneous Determination of Six Active Ingredients of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in Rat Plasma and its Application to Pharmacokinetic Studies

(2021) Jianyang Pan et al.   CURRENT DRUG METABOLISM

Arterial Stiffness in Hypertension and Function of Large Arteries

(2020) Yi Zhang et al.   AMERICAN JOURNAL OF HYPERTENSION

Tetramethylpyrazine, a Promising Drug for Treatment of Pulmonary Hypertension

(2020) Yuqin Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Arterial Stiffness

(2020) Yabing Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Natural and engineered chemokine (C-X-C motif) receptor 4 agonists prevent acute respiratory distress syndrome after lung ischemia–reperfusion injury and hemorrhage

(2020) Favin S. Babu et al.   Scientific Reports

The protective effects of liguzinediol on congestive heart failure induced by myocardial infarction and its relative mechanism

(2020) Qi Chen et al.   Chinese Medicine

Association of Cardiovascular Disease Risk Factor Burden With Progression of Coronary Atherosclerosis Assessed by Serial Coronary Computed Tomographic Angiography

(2020) Donghee Han et al.   JAMA Network Open

AntagomiR‐29b inhibits vascular and valvular calcification and improves heart function in rats

(2020) Ming Fang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Roles of klotho and stem cells in mediating vascular calcification (Review)

(2020) Liangzhu Yu et al.   Experimental and Therapeutic Medicine

Ligustrazine inhibits the proliferation and migration of ovarian cancer cells via regulating miR-211

(2020) Hairong Zhang et al.   BIOSCIENCE REPORTS

The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction

(2020) Dean G. Campelj et al.   Cancers

Combination of Danshen and ligustrazine has dual anti-inflammatory effect on macrophages and endothelial cells

(2020) Tingting Ye et al.   JOURNAL OF ETHNOPHARMACOLOGY

Tetramethylpyrazine guards against cisplatin-induced nephrotoxicity in rats through inhibiting HMGB1/TLR4/NF-κB and activating Nrf2 and PPAR-γ signaling pathways

(2019) Haidy E. Michel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ligustrazine Protects Homocysteine-Induced Apoptosis in Human Umbilical Vein Endothelial Cells by Modulating Mitochondrial Dysfunction

(2019) Xuesong Fan et al.   Journal of Cardiovascular Translational Research

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

(2018) Andrew L Durham et al.   CARDIOVASCULAR RESEARCH

Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis

(2018) Wen-Qi Ma et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPARγ-NF-κB signaling pathway in rat vascular smooth muscle cells

(2018) Li Xu et al.   LIFE SCIENCES

Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients

(2017) O. Ulutas et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway

(2017) Cuiting Qiu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effect of pioglitazone on the calcification of rat vascular smooth muscle cells through the downregulation of the Wnt/β-catenin signaling pathway

(2017) Min Gao et al.   Molecular Medicine Reports

Effect of ligustrazine on preventing contrast-induced nephropathy in patients with unstable angina

(2017) Ziliang Ye et al.   Oncotarget

Osteopontin regulates macrophage activation and osteoclast formation in hypertensive patients with vascular calcification

(2017) Qian Ge et al.   Scientific Reports

Targeted Delivery of Carbaprostacyclin to Ischemic Hindlimbs Enhances Adaptive Remodeling of the Microvascular Network

(2013) Xiaobing Liu et al.   HYPERTENSION

Genetic Pathways of Vascular Calcification

(2012) Marion A. Hofmann Bowman et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Vascular calcification estimated by aortic calcification area index is a significant predictive parameter of cardiovascular mortality in hemodialysis patients

(2011) Masaki Ohya et al.   Clinical and Experimental Nephrology

Microarray analysis of senescent vascular smooth muscle cells: A link to atherosclerosis and vascular calcification

(2009) Dominick G.A. Burton et al.   EXPERIMENTAL GERONTOLOGY