Evaluating microglial phenotypes using single-cell technologies

Recent single-cell technologies have enabled researchers to simultaneously assess the transcriptomes and other modalities of thousands of cells within their spatial context. Here, we have summarized available single-cell methods for dissociated tissues and tissue slides with respect to the specifics of microglial biology. We have focused on next-generation-based technologies. We review the potential of these single-cell sequencing methods and newer multiomics approaches to extend the understanding of microglia function beyond the status quo.

Automated summary

Recent advancements in single-cell technologies have allowed researchers to assess the transcriptomes and other characteristics of individual cells in their spatial context. In this article, we summarize the available single-cell methods for dissociated tissues and tissue slides, specifically focusing on microglial biology. We explore the potential of next-generation-based single-cell sequencing methods and newer multiomics approaches in advancing our understanding of microglia function.