Review
Medicine, Research & Experimental
Yongfeng Chen, Zhengxi Chen, Yin Tang, Qian Xiao
Summary: Noncanonical Wnt signaling plays a crucial role in various cancers, regulating both biological behavior of cancer cells and tumor progression. Recent studies have found that noncanonical Wnt is involved in key processes such as cancer cell invasion, metastasis, metabolism, and inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Editorial Material
Oncology
Elena Magrini, Cecilia Garlanda
Summary: Complement activation plays a role in tumor progression, and C1s and C4d are proposed as new prognostic markers for clear cell renal cell carcinoma. The mechanism of action of C1s involves canonical and intracellular functions, and the results offer new molecular targets to prevent tumor escape from immune surveillance, thus leading to tumor progression.
CANCER IMMUNOLOGY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Jinxin Tang, Jieyu He, Chengyao Feng, Chao Tu
Summary: MiRNAs are non-coding RNA molecules that play important roles in cancer. Recent studies have shown that exosomal miRNAs play crucial roles in tumor initiation and progression, and have potential diagnostic and therapeutic functions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Jian Chen, Chunsheng Han
Summary: This mini review highlights the important roles of microRNAs (miRNAs) in mammalian spermatogenesis, emphasizing the challenges in studying their functions and the progress in using genetic methods. The authors suggest that with the advancement of traditional methods and new technologies, studies on miRNAs in spermatogenesis can be conducted more effectively.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Rachel D. Kelly, Gursimran Parmar, Laila Bayat, Matthew E. R. Maitland, Gilles A. Lajoie, David R. Edgell, Caroline Schild-Poulter
Summary: The Ku70/80 heterodimer is involved in non-homologous end-joining DNA repair as well as other cellular functions. The underlying cause of Ku essentiality in human cells is not fully explored. In this study, conditional Ku70 knockout cells were used to investigate Ku70 function. The loss of cell viability upon Ku depletion is not linked to DNA repair or telomere maintenance, and dysregulations of various cellular pathways were observed.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Daqian Xu, Fei Shao, Xueli Bian, Ying Meng, Tingbo Liang, Zhimin Lu
Summary: Key pathological signaling pathways regulate metabolic enzymes, giving them nonmetabolic functions. These aberrantly regulated metabolic enzymes play critical roles in governing cellular activities, promoting disease progression.
Review
Neurosciences
Carla Taveggia, M. Laura Feltri
Summary: Schwann cells play a crucial role in the peripheral nervous system, supporting and myelinating axons for fast and accurate communication. They exhibit remarkable plasticity and the ability to modulate pathology. In addition to their canonical functions, Schwann cells and related glia also have exciting noncanonical functions, including organizing the PNS, regulating synaptic activity and pain, modulating immunity, providing a pool of stem cells for different organs, and influencing cancer.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Article
Biology
Susheel N. Chaurasia, Mohammad Ekhlak, Geeta Kushwaha, Vipin Singh, Ram L. Mallick, Debabrata Dash
Summary: The study demonstrates the expression of Notch1, its ligand DLL-4, and their respective transcripts in human platelets. Thrombin upregulates synthesis and surface translocation of Notch1 and DLL-4. DLL-4 cleaves Notch receptor to instigate neighboring platelets to switch to an 'activated' phenotype.
Article
Oncology
Xin Zhou, Cheng Liu, Yin Yin, Cheng Zhang, Xuan Zou, Tiansong Xia, Xiangnan Geng, Ping Liu, Wenfang Cheng, Wei Zhu
Summary: The study analyzed 3831 cancer samples and 248 umbilical cord blood samples, identifying circulating miRNAs related to both cancer and embryos. These oncofetal miRNAs showed consistent expression patterns in various cancers and umbilical cord blood, suggesting their potential for cancer detection.
Article
Biochemistry & Molecular Biology
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Summary: This passage focuses on the noncanonical function of EZH2 in the development of multiple myeloma (MM), and proposes a novel therapeutic strategy, pharmacological degradation of EZH2, for treating EZH2-dependent MM.
Article
Pathology
Talha Anwar, Maria E. Gonzalez, Celina G. Kleer
Summary: EZH2, the catalytic subunit of PRC2, plays a critical role in determining cell identity by depositing trimethyl marks on histone H3. In addition to its well-defined role in transcriptional repression, EZH2 also exerts some histonemethyltransferaseeindependent functions, which are important for breast cancer progression.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Se-Ra Park, Seong-Kwan Kim, Soo-Rim Kim, Doojin Kim, Kun-Woo Kim, In-Sun Hong, Hwa-Yong Lee
Summary: Chronic stress negatively impacts female fertility, possibly through the reduction of uterine receptivity by glucocorticoids. These hormones may directly damage endometrial stem cells, affecting endometrial reconstruction and leading to infertility. Additionally, cortisol suppresses beneficial functions of human endometrial stem cells through its receptor, contributing to the decline in fertility.
CELL DEATH & DISEASE
(2021)
Review
Cell Biology
Alexis D. Rickman, Addison Hilyard, Bradlee L. Heckmann
Summary: Neuroinflammation and neurodegeneration play important roles in the development and progression of neurodegenerative diseases. The non-canonical autophagy pathway known as LC3-associated endocytosis (LANDO) has been found to regulate neuroinflammation. Impairment of LANDO in AD models exacerbates disease severity and leads to neurodegeneration and memory impairment.
NEURAL REGENERATION RESEARCH
(2022)
Review
Biology
Jian Li, Yangyang Li, Rongyuan Wang, Jiangyan Fu, Xinxing Zhou, Yujie Fang, Youping Wang, Yaju Liu
Summary: This article summarizes the research progress on using the miRNA-mRNA regulatory network to respond to climate change challenges in rapeseed and discusses the functional role of miRNAs in rapeseed as well as strategies for miRNA manipulation in plants. The article states that constructing the miRNA regulatory network can promote the development of climate change-tolerant rapeseed.
Review
Multidisciplinary Sciences
Souvik Ghosh, Viney Kumar, Haimanti Mukherjee, Debrupa Lahiri, Partha Roy
Summary: Neurodegenerative diseases and brain cancer are both associated with dysregulation of miRNAs, which play important roles in both pathological conditions. Experimental evidence shows that nutraceuticals can regulate miRNA expression, making them crucial for the treatment of neurodegenerative diseases and brain cancer.
Article
Surgery
Mihnea P. Dragomir, Stefan Tudor, Monica Lacatus, Oana Stanciulea, Bogdan Trandafir, Adriana Diaconu, Daniel Coriu, Anca Colita, Gabriela Droc, Raluca Purnichescu-Purtan, George Calin, Catalin Vasilescu
Summary: The study found that after splenectomy, the releasing capacity of TNF-alpha in whole blood significantly decreased, while the capacities of IL-6 and IL-10 did not show significant changes. The impact of total splenectomy (TS) and subtotal/partial splenectomy (S/PS) on cytokine releasing capacities differed, with open surgery leading to a decrease in TNF-alpha releasing capacity and minimally invasive surgery significantly increasing it.
ACTA CHIRURGICA BELGICA
(2022)
Article
Medicine, Research & Experimental
Yongfeng Li, Daobao Chen, Haojun Xuan, Mihnea P. Dragomir, George A. Calin, Xuli Meng, Meng Chen, Hongchuan Jin
Summary: This study aimed to develop nomogram models for predicting overall survival and cancer-specific survival of patients with metaplastic breast carcinoma (MBC). The study collected data from 1973 to 2015 and used Cox analyses and calibration plots to evaluate model performance. The results showed that the nomogram models had good accuracy in predicting patient survival.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Oncology
Zhaohui Liang, Kongjia Luo, Yuting Wang, Qiuli Zeng, Xiuzhen Ling, Sifen Wang, Mihnea P. Dragomir, Qiaoqiao Li, Hong Yang, Mian Xi, Baoqing Chen
Summary: This study investigated the correlations between clinical factors and dose-volume histogram (DVH) parameters with postoperative cardiopulmonary complications in locally advanced esophageal squamous cell carcinoma (ESCC) patients. A nomogram model was constructed to predict the risk of these complications. The results showed that male sex, post-RT forced expiratory volume in 1 s (FEV1), mean lung dose (MLD), and pre-RT monocyte were significant predictors of postoperative pulmonary complications. Additionally, the paclitaxel and cisplatin (TP) concurrent chemotherapy regimen was an independent predictor of cardiac complications.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Zhaohui Liang, Mihnea P. Dragomir, Mian Xi, Baoqing Chen
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Zhaohui Liang, Kongjia Luo, Yuting Wang, Qiuli Zeng, Xiuzhen Ling, Sifen Wang, Mihnea P. Dragomir, Qiaoqiao Li, Hong Yang, Mian Xi, Baoqing Chen
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Florian N. N. Loch, Carsten Kamphues, Katharina Beyer, Christian Schineis, Wael Rayya, Johannes C. C. Lauscher, David Horst, Mihnea P. P. Dragomir, Simon Schallenberg
Summary: Immune checkpoint therapy has shown promise in treating solid tumors, but its role in pancreatic ductal adenocarcinoma is limited. This study aimed to create a profile of immune checkpoint expression and its prognostic relevance in PDAC. The presence of VISTA and PD-L1 significantly correlated with shorter overall survival, suggesting they may be potential targets for ICT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Rares Drula, Barbara Pardini, Xiao Fu, Mireia Cruz De los Santos, Ancuta Jurj, Lan Pang, Sherien M. El-Daly, Linda Fabris, Erik Knutsen, Mihnea P. Dragomir, Recep Bayraktar, Yongfeng Li, Meng Chen, Filippo Del Vecchio, Lea Berland, Jessica Dae, Daniel Fan, Masayoshi Shimizu, Anh M. Tran, Mercedes Barzi, Carlotta Pioppini, Angelica M. Gutierrez, Cristina Ivan, Salyna Meas, Carolyn S. Hall, Suresh K. Alahari, Ioana Berindan-Neagoe, Muller Fabbri, Anthony Lucci, Banu Arun, Simone Anfossi, George A. Calin
Summary: The causes and consequences of abnormal biogenesis of extracellular vesicles (EVs) in breast cancers (BCs), especially estrogen receptor-positive (ER+) BCs, have been investigated. It was found that physiological doses of estrogen can promote EV secretion from ER+ BC cells by inhibiting miR-149-5p, which affects the regulatory activity of SP1 on the EV biogenesis factor nSMase2. In addition, the downregulation of miR-149-5p promotes the expression of hnRNPA1, responsible for loading let-7's miRNAs into EVs. This estrogen-driven mechanism leads to the elimination of tumor suppressor miRNAs in EVs, affecting tumor-associated macrophages in the microenvironment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pathology
Svenja Kolb, Inga Hoffmann, Nanna Monje, Mihnea P. Dragomir, Paul Jank, Philip Bischoff, Carlotta Keunecke, Jonathan Pohl, Catarina Alisa Kunze, Sofya Marchenko, Wolfgang D. Schmitt, Hagen Kulbe, Christine Sers, Jalid Sehouli, Elena Ioana Braicu, Carsten Denkert, Silvia Darb-Esfahani, David Horst, Bruno V. Sinn, Eliane T. Taube
Summary: This study highlights the significant prognostic role of the LRP1B protein in tubo-ovarian high-grade serous carcinoma, showing that its high expression is associated with prolonged overall survival and progression-free survival in patients.
Article
Medicine, General & Internal
Mihnea P. Dragomir, Teodor G. Calina, Eilis Perez, Simon Schallenberg, Meng Chen, Thomas Albrecht, Ines Koch, Peggy Wolkenstein, Benjamin Goeppert, Stephanie Roessler, George A. Calin, Christine Sers, David Horst, Florian Rossner, David Capper
Summary: This study developed a classifier that can differentiate between iCCAs, intrahepatic metastases of a PAAD, and normal bile duct tissue with high accuracy, which can improve the diagnosis of pancreato-biliary cancers of the liver.
Article
Medicine, Research & Experimental
Mihnea P. Dragomir, Enrique Fuentes-Mattei, Melanie Winkle, Keishi Okubo, Recep Bayraktar, Erik Knutsen, Aiham Qdaisat, Meng Chen, Yongfeng Li, Masayoshi Shimizu, Lan Pang, Kevin Liu, Xiuping Liu, Simone Anfossi, Huanyu Zhang, Ines Koch, Anh M. Tran, Swati Mohapatra, Anh Ton, Mecit Kaplan, Matthew W. Anderson, Spencer J. Rothfuss, Robert Silasi, Ravi S. Keshari, Manuela Ferracin, Cristina Ivan, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Constantin Georgescu, Pinaki P. Banerjee, Rafet Basar, Ziyi Li, David Horst, Catalin Vasilescu, Maria Teresa S. Bertilaccio, Katayoun Rezvani, Florea Lupu, Sai-Ching Yeung, George A. Calin
Summary: miR-93-5p plays a critical role in sepsis pathogenesis and inhibiting it can prolong the survival of mice with sepsis induced by abdominal infection.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Ase Emblem, Erik Knutsen, Tor Erik Jorgensen, Hilde Fure, Steinar Daae Johansen, Ole-Lars Brekke, Tom Eirik Mollnes, Bard Ove Karlsen
Summary: Understanding the expression of long non-coding RNAs containing Alu elements in inflammation is crucial for predicting the development of severe diseases. By using a computational approach, we identified 48 immune genes with Alu insertion as potential candidates for further study, and one of these candidates located within the C5aR1 gene holds promise as a target for RNA therapeutics.
Meeting Abstract
Biochemistry & Molecular Biology
Ase Emblem, Arne Martin Slatsve, Erik Knutsen, Robin Mjelle, Corinna Lau, Anne Landsem, Per Nilsson, Ole-Lars Brekke, Tom Eirik Mollnes, Bard Karlsen
MOLECULAR IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
BaoQing Chen, Mihnea P. Dragomir, Chen Yang, Qiaoqiao Li, David Horst, George A. Calin
Summary: Non-coding RNAs (ncRNAs), especially microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play a crucial role in regulating resistance to different cancer therapies by rewiring essential signaling pathways. ncRNAs have the potential to serve as biomarkers for predicting and detecting resistance to treatment, and targeting ncRNAs may be a strategy to overcome cancer treatment resistance.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
