Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer

Identification of synergistic drug combinations using breast cancer patient-derived xenografts

(2020) Tia H. Turner et al.   Scientific Reports

G2M Cell Cycle Pathway Score as a Prognostic Biomarker of Metastasis in Estrogen Receptor (ER)-Positive Breast Cancer

(2020) Masanori Oshi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer

(2020) Maria Gagliardi et al.   Scientific Reports

Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer

(2020) Reid T. Powell et al.   Scientific Reports

A metastasis map of human cancer cell lines

(2020) Xin Jin et al.   NATURE

A Phase II Trial of Selinexor (KPT‐330) for Metastatic Triple‐Negative Breast Cancer

(2019) Michael Shafique et al.   ONCOLOGIST

Exportin 1 inhibition induces nerve growth factor receptor expression to inhibit the NF-kB pathway in preclinical models of pediatric high-grade glioma

(2019) John A. DeSisto et al.   MOLECULAR CANCER THERAPEUTICS

High-Speed Live-Cell Interferometry: A New Method for Quantifying Tumor Drug Resistance and Heterogeneity

(2018) Dian Huang et al.   ANALYTICAL CHEMISTRY

Characterizing the efficacy of cancer therapeutics in patient-derived xenograft models of metastatic breast cancer

(2018) Tia H. Turner et al.   BREAST CANCER RESEARCH AND TREATMENT

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts

(2017) Kuan-lin Huang et al.   Nature Communications

MultiQC: summarize analysis results for multiple tools and samples in a single report

(2016) Philip Ewels et al.   BIOINFORMATICS

Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone

(2016) Irfana Muqbil et al.   CANCER LETTERS

Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer

(2016) Vikram B. Wali et al.   CANCER RESEARCH

A phase Ib dose-escalation study of the MEK inhibitor trametinib in combination with the PI3K/mTOR inhibitor GSK2126458 in patients with advanced solid tumors

(2016) J. E. Grilley-Olson et al.   INVESTIGATIONAL NEW DRUGS

Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids

(2016) Kathrin Halfter et al.   Journal of Translational Medicine

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

(2016) Trinayan Kashyap et al.   Oncotarget

An overview of triple-negative breast cancer

(2015) Pankaj Kumar et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies

(2015) P. Munster et al.   CLINICAL CANCER RESEARCH

Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10-Dependent Apoptosis by Carfilzomib and Selinexor

(2015) S. Rosebeck et al.   MOLECULAR CANCER THERAPEUTICS

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

PAM50 proliferation score as a predictor of weekly paclitaxel benefit in breast cancer

(2013) Miguel Martín et al.   BREAST CANCER RESEARCH AND TREATMENT

Molecular Characterization of Basal-Like and Non-Basal-Like Triple-Negative Breast Cancer

(2013) A. Prat et al.   ONCOLOGIST

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

(2013) Shunqiang Li et al.   Cell Reports

Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse

(2011) J. Chuck Harrell et al.   BREAST CANCER RESEARCH AND TREATMENT

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

(2011) Yoko S DeRose et al.   NATURE MEDICINE

Predictive factors for the effectiveness of neoadjuvant chemotherapy and prognosis in triple-negative breast cancer patients

(2010) Hiroko Masuda et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Treatment outcomes and clinicopathologic characteristics of triple-negative breast cancer patients who received platinum-containing chemotherapy

(2008) Ji Eun Uhm et al.   INTERNATIONAL JOURNAL OF CANCER