Regulatory T cells: A review of manufacturing and clinical utility

Administration of CD4+CD25highCD127−FoxP3+ Regulatory T Cells for Relapsing-Remitting Multiple Sclerosis: A Phase 1 Study

(2021) Kamil Chwojnicki et al.   BIODRUGS

First-in-human phase 1 trial of induced regulatory T cells for graft-versus-host disease prophylaxis in HLA-matched siblings

(2021) Margaret L. MacMillan et al.   Blood Advances

The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes

(2021) Shen Dong et al.   JCI Insight

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

(2020) Birgit Sawitzki et al.   LANCET

Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial

(2020) Andy Roemhild et al.   BMJ-British Medical Journal

Building a CAR-Treg: Going from the basic to the luxury model

(2020) Isaac Rosado-Sánchez et al.   CELLULAR IMMUNOLOGY

Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes

(2019) Michel Tenspolde et al.   JOURNAL OF AUTOIMMUNITY

Next-generation regulatory T cell therapy

(2019) Leonardo M. R. Ferreira et al.   NATURE REVIEWS DRUG DISCOVERY

Applicability, Safety And Biological Activity Of Regulatory T Cell Therapy In Liver Transplantation

(2019) Alberto Sánchez‐Fueyo et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol

(2019) Katherine N. MacDonald et al.   CYTOTHERAPY

Immune regulatory cell infusion for graft-versus-host disease prevention and therapy

(2018) Bruce R. Blazar et al.   BLOOD

Regulatory T cells in autoimmune disease

(2018) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

Autoimmune Polyendocrine Syndromes

(2018) Eystein S. Husebye et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

(2018) James M. Mathew et al.   Scientific Reports

Treg cells—the next frontier of cell therapy

(2018) Jeffrey A. Bluestone et al.   SCIENCE

Third party, umbilical cord blood derived regulatory T-cells for prevention of graft versus host disease in allogeneic hematopoietic stem cell transplantation: feasibility, safety and immune reconstitution

(2018) Joshua N. Kellner et al.   Oncotarget

Cell Therapy in Kidney Transplantation: Focus on Regulatory T Cells

(2017) Nicholas A. Zwang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antigen-specific regulatory T cells: are police CARs the answer?

(2017) Nicholas A.J. Dawson et al.   Translational Research

A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation

(2016) Satoru Todo et al.   HEPATOLOGY

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes

(2016) Natalia Marek-Trzonkowska et al.   Journal of Translational Medicine

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation

(2016) Niloufar Safinia et al.   Oncotarget

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells

(2015) I. E. Dijke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

(2015) C. G. Brunstein et al.   BLOOD

Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease

(2015) Anke Theil et al.   CYTOTHERAPY

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Isolation and expansion of human natural T regulatory cells for cellular therapy

(2010) Rajendra Pahwa et al.   JOURNAL OF IMMUNOLOGICAL METHODS

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Amelioration of Colitis by Genetically Engineered Murine Regulatory T Cells Redirected by Antigen-Specific Chimeric Receptor

(2009) Eran Elinav et al.   GASTROENTEROLOGY

Human T Regulatory Cell Therapy: Take a Billion or So and Call Me in the Morning

(2009) James L. Riley et al.   IMMUNITY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology