Review
Sport Sciences
Heidi Kressel, Antonios Matsakas
Summary: Vitamin D supplementation may have a subtle beneficial effect on muscle strength and mass, especially when co-administered with other supplements. However, there is limited clinical evidence on the correlation between vitamin D dosage and changes in muscle strength or mass. Future studies are needed to clarify the net effect of vitamin D on sarcopenia.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Review
Nutrition & Dietetics
Miguel Agoncillo, Josephine Yu, Jenny E. Gunton
Summary: Vitamin D is strongly associated with skeletal muscle regeneration and function, with studies showing its role in regulating muscle cell growth and gene expression. Animal experiments and human studies support the benefits of vitamin D in muscle function and recovery, particularly in the elderly and post-operative patients. However, its role may be less significant in muscle/ligament tear repair.
Review
Nutrition & Dietetics
Karina Romeu Montenegro, Milene Amarante Pufal, Philip Newsholme
Summary: Vitamin D has positive effects on muscle development at the cell and animal levels, but its impact on muscle in the ageing population is inconclusive according to human studies. Well-designed trials and standardized measurements are needed for accurate comparison across different experimental models.
Article
Nutrition & Dietetics
Luciano Mendoza-Garces, Maria Consuelo Velazquez-Alva, Maria Fernanda Cabrer-Rosales, Isabel Arrieta-Cruz, Roger Gutierrez-Juarez, Maria Esther Irigoyen-Camacho
Summary: The study revealed a high prevalence of low plasma 25(OH)D concentrations among Mexican community-dwelling older women, and Vitamin D deficiency was associated with low handgrip strength, being at risk of malnutrition/malnourished, and diagnosed with type 2 diabetes mellitus.
Review
Physiology
Christine M. Latham, Camille R. Brightwell, Alexander R. Keeble, Brooke D. Munson, Nicholas T. Thomas, Alyaa M. Zagzoog, Christopher S. Fry, Jean L. Fry
Summary: Vitamin D plays a crucial role in muscle regeneration and maintenance, protecting muscle structure and mitochondrial function, and promoting the activity of muscle stem cells.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Joshua P. Sutherland, Ang Zhou, Elina Hypponen
Summary: This study used genetic methods to explore the causal relationship between vitamin D and skeletal muscle-related traits, as well as to investigate the potential pathophysiology of probable sarcopenia and sarcopenic obesity. The results suggested a causal relationship between vitamin D and skeletal muscle health, but a weaker association with the risk of sarcopenic obesity.
Article
Nutrition & Dietetics
Jan Mieszkowski, Paulina Brzezinska, Blazej Stankiewicz, Andrzej Kochanowicz, Bartlomiej Niespodzinski, Joanna Reczkowicz, Tomasz Waldzinski, Bartlomiej Kacprzak, Natalia Siuba-Jarosz, Miroslav Petr, Jedrzej Antosiewicz
Summary: This study analyzed the impact of vitamin D supplementation on tryptophan metabolism in runners after an ultramarathon. The results showed that vitamin D supplementation can attenuate the increase in KPM levels and the decrease in tryptophan, tyrosine, and phenylalanine levels induced by exercise, indicating a regulatory role of vitamin D in exercise-induced metabolic changes.
Review
Biochemistry & Molecular Biology
Jung Yoon Jang, Donghwan Kim, Nam Deuk Kim
Summary: Sarcopenia, the loss of muscle strength and mass in older individuals, is a major concern globally due to its impact on fall risk, disability, and mortality. Despite its clinical importance, sarcopenia is often under-recognized and poorly managed in routine clinical practice, primarily due to the lack of diagnostic testing and uniform criteria. While some countries have assigned disease codes for sarcopenia, there are currently no approved pharmacological treatments, with interventions primarily focusing on physical therapy and protein intake.
Article
Cell Biology
Yongxin Wu, Yaoxuan Wu, Yunfei Yang, Jing Yu, Jianghao Wu, Zhiyin Liao, Ai Guo, Yue Sun, Yuxing Zhao, Jinliang Chen, Qian Xiao
Summary: The study suggests that LOXL2 inhibitor can alleviate aging-related sarcopenia by inhibiting fibroblast senescence, fibrosis, and oxidative stress in skeletal muscle, potentially through the TGF-β1/p38 MAPK pathway.
Article
Cell Biology
Shelby E. Bollen, Joseph J. Bass, Satoshi Fujita, Daniel Wilkinson, Martin Hewison, Philip J. Atherton
Summary: Muscle atrophy and sarcopenia can impact an individual's health, and vitamin D deficiency may worsen this effect. The mechanisms linking vitamin D and sarcopenia are not fully understood, but research has shown the importance of vitamin D in skeletal muscle functioning.
CELLULAR SIGNALLING
(2022)
Article
Endocrinology & Metabolism
Stephen P. Ashcroft, Gareth Fletcher, Ashleigh M. Philp, Carl Jenkinson, Shatarupa Das, Philip M. Hansbro, Philip J. Atherton, Andrew Philp
Summary: The study found that diet-induced vitamin D deficiency reduced skeletal muscle mitochondrial respiration in C57BL/6J mice, indicating a potential role of vitamin D in regulating muscle fatigue and performance deficits.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
B. J. Shim, M. H. Lee, J. Y. Lim, H. S. Gong
Summary: The study found that vitamin D supplementation can significantly increase muscle VDR expression and CSA cross-sectional area in patients with a distal radius fracture, especially in those who are vitamin D deficient.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Geriatrics & Gerontology
Charles Phillipe de Lucena Alves, Samuel Brito de Almeida, Danielle Pessoa Lima, Pedro Braga Neto, Ana Lucia Miranda, Todd Manini, Lara Vlietstra, Debra L. Waters, Renata Moraes Bielemann, Rosaly Correa-de-Araujo, Ana Paula Fayh, Eduardo Caldas Costa
Summary: This scoping review aimed to map out definitions and assessment methods of muscle quality in older adults. A total of 96 articles were included, revealing a substantial heterogeneity of definitions and assessment methods across functional and morphological domains. Standardizing the definition of muscle quality may help utilize it as a potential marker of skeletal muscle health in older adults.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Natany G. Reis, Ana P. Assis, Natalia Lautherbach, Dawit A. Goncalves, Wilian A. Silveira, Henrique J. N. Morgan, Rafael R. Valentim, Lucas F. Almeida, Lilian C. Heck, Neusa M. Zanon, Tatiana E. Koike, Audrei R. Santos, Elen H. Miyabara, Isis C. Kettelhut, Luiz C. Navegantes
Summary: This study found that maternal vitamin D deficiency selectively affects the development of type-II muscle fibers in male offspring rats, leading to muscle atrophy. However, compensatory increase in vitamin D content in adult age may increase fiber size and fatigue resistance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Public, Environmental & Occupational Health
Junmin Mi, Litao Zhang, Wei Sun, Zhen Wang, Pengbo Yang, Jiachen Zhang, Yani Zhang
Summary: This study identifies the research hotspots of resistance training (RT) intervention in aging and predicts the research frontiers and development trends using bibliometric analysis. The research results can provide references for further exploration and government policies.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Matti Lauren Gild, Mico Chan, Jay Gajera, Brett Lurie, Ziba Gandomkar, Roderick J. Clifton-Bligh
Summary: The use of TI-RADS scoring along with two deep learning models can assist in distinguishing benign and malignant nodules. The study established high-risk (TI-RADS 4,5) and low-risk (TI-RADS 2,3) radiological categories, providing new strategies for preoperative diagnosis of thyroid nodules.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leonit Kiriaev, Peter J. Houweling, Kathryn N. North, Stewart Head
Summary: In this study, researchers found a correlation between the common null polymorphism (R577X) in the ACTN3 gene and the development of dystrophin-deficient muscular dystrophy. Using a mouse model, they discovered that the absence of ACTN3 gene results in reduced branching complexity of muscle fibers and decreased susceptibility to eccentric contraction damage. They also found that the increased oxidative metabolism of fast-twitch glycolytic fibers is associated with this protective mechanism.
HUMAN MOLECULAR GENETICS
(2022)
Article
Endocrinology & Metabolism
Dahlia F. Davidoff, Diana E. Benn, Michael Field, Ashley Crook, Bruce G. Robinson, Katherine Tucker, Richard De Abreu Lourenco, John R. Burgess, Roderick J. Clifton-Bligh
Summary: Tumors detected through surveillance in carriers of SDHB pathogenic variants (PVs) were smaller, had a reduced risk of metastatic disease, and lower mortality rate compared to probands.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Chemistry, Analytical
Taryn Chalmers, Blake Anthony Hickey, Phillip Newton, Chin-Teng Lin, David Sibbritt, Craig S. McLachlan, Roderick Clifton-Bligh, John Morley, Sara Lal
Summary: This study aimed to investigate whether changes in heart rate variability can predict the quality of response to acute stress, and whether baseline stress levels can affect the changes in heart rate variability. Although no ubiquitous patterns were found, novel changes were identified between resting and stress states.
Article
Behavioral Sciences
Taryn Chalmers, Shamona Eaves, Ty Lees, Chin-Teng Lin, Phillip J. Newton, Roderick Clifton-Bligh, Craig S. McLachlan, Sylvia M. Gustin, Sara Lal
Summary: This study explores the relationship between neurocognitive parameters and heart rate variability (HRV) in nurses during acute stress situations. The findings show differences in cognitive performance and HRV parameters between nurses and non-nurses, highlighting the potential use of HRV markers in relation to cognitive performance and autonomic dysfunction.
BRAIN AND BEHAVIOR
(2022)
Letter
Genetics & Heredity
Victoria L. Wyckelsma, Tomas Venckunas, Peter J. Houweling, Maja Schlittler, Volker M. Lauschke, Chrystal F. Tiong, Harrison D. Wood, Henrikas Paulauskas, Nerijus Eimantas, Daniel C. Andersson, Kathryn N. North, Marius Brazaitis, Hakan Westerblad
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Chantal A. Coles, Ian Woodcock, Daniel G. Pellicci, Peter J. Houweling
Summary: The lack of dystrophin in Duchenne muscular dystrophy results in muscle fragility, inflammation, and subsequent fibrosis. Understanding the involvement of the immune system, especially T cells, in the disease progression is crucial for developing better treatments. This review focuses on the importance of T cells in DMD and suggests targeting T cells as a potential therapeutic approach.
Article
Endocrinology & Metabolism
Ayanthi Wijewardene, Jeremy Hoang, Aung Min Maw, Matti Gild, Lyndal Tacon, Paul Roach, Geoffrey Schembri, David Chan, Roderick Clifton-Bligh
Summary: In this study, a new scoring system (I-PET) combining whole body scan (WBS) and FDG findings was proposed to identify patients who are refractory to radioactive iodine in thyroid cancer. The results showed that patients with I-PET [3B] were more likely to receive multikinase inhibitor therapy and had a higher mortality rate.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Sue Lynn Lau, Rebecca A. Stokes, Beverly Ng, Kim Cheng, Roderick Clifton-Bligh, Jenny E. Gunton
Summary: The expression of VDR has been found in various cell types involved in metabolism, including the beta-cells of the pancreatic islets. The study investigates the effects of VDR-null (VDRKO) on organs involved in energy metabolism and glucose homeostasis. While VDRKO mice showed reduced bone density, subcutaneous fat mass, and muscle weights, there was no significant effect on glucose tolerance, especially in the setting of decreased fat mass.
Article
Cell & Tissue Engineering
Joshua S. Clayton, Isabella Suleski, Christina Vo, Robert Smith, Carolin K. Scriba, Safaa Saker, Thierry Larmonier, Edoardo Malfatti, Norma B. Romero, Peter J. Houweling, Kristen J. Nowak, Gianina Ravenscroft, Nigel G. Laing, Rhonda L. Taylor
Summary: Variants in the ACTA1 gene are a common cause of nemaline myopathy, and induced pluripotent stem cell lines may contribute to the research on treatment methods for this disease.
STEM CELL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Roderick J. Clifton-Bligh
Summary: Diagnosis of pheochromocytoma or paraganglioma (PPGL) during pregnancy has historically led to high rates of maternal and fetal morbidity and mortality. Recent evidence suggests that early recognition of PPGL and appropriate medical management can improve outcomes. The need for antepartum surgery and the mode of delivery in PPGL cases are still controversial. It is important to offer genetic counseling and testing to women with PPGL in pregnancy, as they are often associated with heritable syndromes.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Editorial Material
Oncology
Karel Pacak, Roderick Clifton-Bligh
Summary: Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors that produce catecholamines. Recent advances in their management, localization, treatment, and surveillance have significantly improved outcomes for patients with PPGLs or carriers of pathogenic genetic variants linked to these tumors. Molecular stratification, revised definitions, specific clinical features, plasma biomarkers, imaging techniques, treatment guidelines, and international consensus play important roles in enhancing understanding and future interventions for PPGLs.
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Dahlia F. Davidoff, Eugenie S. Lim, Diana E. Benn, Yuvanaa Subramaniam, Eleanor Dorman, John R. Burgess, Scott A. Akker, Roderick J. Clifton-Bligh
Summary: Phaeochromocytoma and paraganglioma are highly heritable tumours, often caused by mutations in Krebs's cycle genes such as succinate dehydrogenase (SDH). This study found evidence of transmission ratio distortion (TRD) in the transmission of SDHB and SDHD pathogenic variants, suggesting a departure from Mendelian inheritance. The reasons for TRD and its implications for reproductive counseling and further research were discussed.
ENDOCRINE-RELATED CANCER
(2023)
Review
Oncology
Susan Richter, Timothy J. Garrett, Nicole Bechmann, Roderick J. Clifton-Bligh, Hans K. Ghayee
Summary: Metabolites play a crucial role in maintaining life and can be quantified to improve the diagnosis and treatment of pheochromocytoma/paraganglioma (PPGL). PPGLs have unique features that provide biomarkers and clues for targeted treatments. Genetic aberrations in PPGL alter cellular pathways and can be exploited diagnostically. Personalized diagnostics and treatment are within reach with the availability of omics technologies.
ENDOCRINE-RELATED CANCER
(2023)
Article
Physiology
Asma Redwan, Leonit Kiriaev, Sindy Kueh, John W. Morley, Peter Houweling, Ben D. Perry, Stewart I. Head
Summary: This study tested the hypothesis that adding the antioxidant NAC to the drinking water of mdx mice could treat the inflammatory phase and reduce pathological muscle fiber branching and splitting. The results showed that NAC treatment significantly reduced muscle mass and abnormal fiber branching and splitting in mdx EDL muscles.
FRONTIERS IN PHYSIOLOGY
(2023)