Article
Gastroenterology & Hepatology
Penglei Jiang, Hongyu Jia, Xinyue Qian, Tian Tang, Yingli Han, Zhaoru Zhang, Lingli Jiang, Zebin Yu, Lin Zheng, Guodong Yu, Huan Cai, Shanyan Zhang, Xiaoli Zhang, Jueqing Gu, Chanyuan Ye, Lisha Yang, Yingfeng Lu, Heng Liu, Xiaoqing Lu, Ciliang Jin, Yue Ren, Miaomiao Lu, Lingling Xu, Jiong Yu, Xi Jin, Yida Yang, Pengxu Qian
Summary: This study used single-cell RNA sequencing to investigate the transcriptomic landscape of peripheral immune cells in CHB patients before and after PegIFN-alpha therapy. The study identified specific cell subsets associated with CHB and found that PegIFN-alpha treatment could decrease hyperactivated monocytes, increase long-lived naive/memory T cells, and enhance effector T cell cytotoxicity. Furthermore, the treatment altered the transcriptional profiles of immune cells and enhanced innate antiviral response.
Article
Immunology
Priyanka Talukdar, Beth F. Junecko, Daniel S. Lane, Pauline Maiello, Joshua T. Mattila
Summary: IFN-λ is expressed in granulomas and may influence myeloid cell function and immunity in tuberculosis. The expression of IFN-λ varies in different granuloma microenvironments, primarily expressed by macrophages and neutrophils, with differences in subcellular localization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Davit Baliashvili, Henry M. Blumberg, David Benkeser, Russell R. Kempker, Shaun Shadaker, Francisco Averhoff, Lia Gvinjilia, Natalia Adamashvili, Matthew Magee, George Kamkamidze, Mamuka Zakalashvili, Tengiz Tsertsvadze, Lali Sharvadze, Mamuka Chincharauli, Nestan Tukvadze, Neel R. Gandhi
Summary: In this large-scale cohort study, it was found that both treated and untreated hepatitis C are associated with active tuberculosis. People with hepatitis C should be considered for TB-preventive measures, such as treatment for latent TB infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Veterinary Sciences
Laura Hunter, Ines Ruedas-Torres, Irene Agullo-Ros, Emma Rayner, Francisco J. Salguero
Summary: Research on human tuberculosis is limited due to the availability of human tissues, making animal models crucial for understanding the disease's progression and evaluating new therapies. This review examines the pulmonary pathology induced by tuberculosis bacteria in different animal models and compares them to human pulmonary tuberculosis. Although the models share some histopathological features with human tuberculosis, further research is needed to establish the most appropriate model and standard characterization of pulmonary lesions.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Bernhard Schlevogt, Klaus H. W. Boeker, Stefan Mauss, Hartwig Klinker, Renate Heyne, Ralph Link, Karl-Georg Simon, Christoph Sarrazin, Yvonne Serfert, Michael P. Manns, Heiner Wedemeyer
Summary: The study indicates that patients receiving interferon-free antiviral treatment for chronic hepatitis C experience significant weight gain during long-term follow-up, with non-obese patients being more vulnerable to weight gain. A body mass index (BMI) < 30 was the only consistent predictor for weight gain, suggesting that non-obese individuals are more likely to gain weight after DAA treatment.
Article
Biotechnology & Applied Microbiology
Terufumi Kubo, Yoshihiko Hirohashi, Tomohide Tsukahara, Takayuki Kanaseki, Kenji Murata, Tadashi Hasegawa, Toshihiko Torigoe
Summary: This letter reports the strong expression of PD-L1 in various diseases and discusses the exacerbation of tuberculosis after anti-PD-1 antibody-based cancer immunotherapy.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Laura Hunter, Suzie Hingley-Wilson, Graham R. Stewart, Sally A. Sharpe, Francisco Javier Salguero
Summary: Non-human primate models of Tuberculosis (TB) are commonly used in experimental TB research to mimic the progression of human TB. This study examined the early cellular interactions in pulmonary granulomas and found that cynomolgus macaques had more CD68+ cells and CD20+ B cells compared to rhesus macaques. The findings provide valuable insights for future research on TB vaccines and therapeutics.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Lisa Sandmann, Heiner Wedemeyer
Summary: Interferon-alfa has been the main treatment for hepatitis D virus (HDV) infection, but only a portion of patients benefit from it. Successful interferon treatment is associated with improved long-term clinical outcomes. Although alternative treatments are being developed, pegylated interferon-alfa still plays an important role. There is a need for better biomarkers to select patients who are likely to benefit from interferon-based treatments.
LIVER INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Phumelele Yvonne Siphepho, Yi-Ting Liu, Ciniso Sylvester Shabangu, Jee-Fu Huang, Chung-Feng Huang, Ming-Lun Yeh, Ming-Lung Yu, Shu-Chi Wang
Summary: Metabolic derangement, particularly steatosis, is common in HCV-infected patients and may independently affect treatment outcomes. Genotype 3 HCV-infected patients have higher prevalence and severity of steatosis compared to other genotypes.
Article
Veterinary Sciences
Mitchell V. Palmer, Tyler C. Thacker, Carly Kanipe, Paola M. Boggiatto
Summary: The study found that bacterial burdens within individual granulomas examined 30 days after infection were greater and more heterogenous compared to those examined 90 to 270 days after infection. Granuloma stage had modest positive and negative correlations with TNF-alpha and IL-10, respectively. However, heterogeneity and mean expression of IFN-gamma, IL-10 and TNF-alpha did not differ significantly over time.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Medicine, General & Internal
Dominique Valeyre, Michel Brauner, Jean-Francois Bernaudin, Etienne Carbonnelle, Boris Duchemann, Cecile Rotenberg, Ingrid Berger, Antoine Martin, Hilario Nunes, Jean-Marc Naccache, Florence Jeny
Summary: Diagnosing pulmonary sarcoidosis is challenging due to the absence of specific diagnostic criteria and its ability to mimic many other conditions. This review aims to help non-experts establish tailored differential diagnosis strategies. Granulomatous diseases like infections, chronic beryllium disease, hypersensitivity pneumonitis, and drug-induced granulomatosis must be ruled out. Epidemiological factors, clinical history, physical examination, and chest computed tomography guide further investigations. Differentiating sarcoidosis from lymphoproliferative disorders can be difficult. Continuous gathering of information may be necessary for a definite diagnosis. Chronic beryllium disease and drug-induced granulomatosis closely resemble sarcoidosis.
FRONTIERS IN MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Michal Brzdek, Dorota Zarebska-Michaluk, Federica Invernizzi, Marta Cilla, Krystyna Dobrowolska, Robert Flisiak
Summary: Chronic infection with hepatitis C virus (HCV) is a major health problem affecting 58 million people worldwide. Treatment with direct-acting antivirals has significantly improved, offering hope for the elimination of HCV as a public threat by 2030. Patients treated with antiviral therapies are now younger, healthier, and have less advanced liver disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, Research & Experimental
Yaoju Tan, Yunhong Tan, Junlian Li, Pengnan Hu, Ping Guan, Haobin Kuang, Qide Liang, Yanyan Yu, Zhongnan Chen, Quan Wang, Zhenping Yang, DiLiNaZi AiKeReMu, Yu Pang, Jianxiong Liu
Summary: The study developed a new immunological method using IFN-gamma and IL-2 combinations to differentiate active TB from other pulmonary diseases, showing potential for accurate diagnosis. The sensitivity of series combination test was higher, while the specificity of parallel combination of IFN-gamma /IL-2 was increased. The diagnostic accuracy of series combination correlated with disease severity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Medicine, General & Internal
Xiaoyan Gai, Brian Allwood, Yongchang Sun
Summary: The burden of chronic airway diseases, including chronic obstructive pulmonary disease (COPD), continues to increase, especially in low- and middle-income countries. Post-tuberculosis lung disease (PTLD), characterized by chronic lung changes after the cure of pulmonary tuberculosis (TB), may be associated with the pathogenesis of COPD. However, data on PTLD's prevalence, clinical manifestations, computed tomography features, lung function impairment patterns, and influencing factors are limited. More research is needed to elucidate the pathogenesis of PTLD.
CHINESE MEDICAL JOURNAL
(2023)
Review
Public, Environmental & Occupational Health
Jinyu Liu, Min Guo, Lei Ke, Ruxu You
Summary: The economic evaluation of elbasvir/grazoprevir (EBR/GZR) for chronic hepatitis C (CHC) shows that EBR/GZR may be cost-effective or dominant compared with pegylated interferon and ribavirin (PegIFN/RBV) and other direct antiviral agents (SOF/VEL, 3D, DCV/ASV, LDF/SOF) or non-therapy. However, in certain scenarios, EBR/GZR is not a cost-effective option for CHC patients compared to glecaprevir/pibrentasvir (GLE/PIB).
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fa-Chih Shen, Tadashi Ogasawara, Koichi Shinotsuka, Kohta Miyahara, Kazushige Isono, Noriyasu Mochiduki, Kouhei Matsumura, Katsumitsu Shimada, Takanaga Ochiai, Yasuaki Kakinoki, Hiromasa Hasegawa
Article
Pathology
Shunichi Baba, Takumi Akashi, Kou Kayamori, Tomoyuki Ohuchi, Ikuko Ogawa, Nobuhisa Kubota, Keisuke Nakano, Hitoshi Nagatsuka, Hiromasa Hasegawa, Kenichi Matsuzaka, Shohei Tomii, Keisuke Uchida, Noriko Katsuta, Takahiro Sekiya, Noboru Ando, Keiko Miura, Hironori Ishibashi, Yousuke Ariizumi, Takahiro Asakage, Yasuyuki Michi, Hiroyuki Harada, Kei Sakamoto, Yoshinobu Eishi, Kenichi Okubo, Tohru Ikeda
Summary: En1 has diagnostic utility in salivary gland neoplasms, with consistent expression in AdCCs, frequent expression in PACs, but rare expression in other salivary gland neoplasms. It may serve as a possible diagnostic marker for AdCC and PAC in the histopathology of salivary gland neoplasms.
PATHOLOGY INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rita Rani Roy, Katsumitsu Shimada, Satoshi Murakami, Hiromasa Hasegawa
Summary: This study investigated the differences in distribution and expression of cornified envelope related proteins and genes between keratinized and non-keratinized oral epithelia. The research revealed significant differences in localization patterns and mRNA levels of transglutaminases between the two types of epithelia, indicating their role in cornified envelope formation. The results suggest that transglutaminases and their substrates, along with TG1 mRNA levels, play a crucial role in regulating cornified envelope formation in keratinized oral epithelium.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sho Miyamoto, Hiromasa Hasegawa, Tomoko Tamaki, Akira Matayoshi, Takahiro Goto, Jumpei Shirakawa, Shimpei Goto, Toshiyuki Nakasone, Naoki Wada, Hiroyuki Nakamura
Summary: Dentinogenic ghost cell tumor (DGCT) is a rare odontogenic tumor characterized by islands of epithelial cells and ghost cells. It can be classified as intraosseous or extraosseous, with the peripheral type being even rarer. We present a case of peripheral DGCT in a 61-year-old woman, which was successfully treated with surgery and showed no recurrence after one year.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Sayaka Yoshiba, Hiromasa Hasegawa, Tetsuo Nemoto, Yuzo Abe, Takashi Moriya, Tatsuo Shirota
Summary: This case report describes a rare case of extraskeletal Ewing sarcoma occurring in the maxillary gingiva concurrent with non-small cell lung cancer. The tumor exhibited unusual features, including lack of continuity with the maxilla and positive immunohistochemical staining for CD99 and ERG. The patient died from respiratory failure due to rapid lung cancer deterioration postoperatively.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2023)
Article
Geriatrics & Gerontology
Shunsuke Nakamura, Masashi Uehara, Shota Kobayashi, Hiromasa Hasegawa, Atsushi Tanaka, Jun Takahashi
Summary: This case report presents a rare case of primary composite hemangioendothelioma (CHE) in the cervical spine with kaposiform hemangioendothelioma (KHE)-like components in an elderly woman. The patient underwent posterior decompression and fusion surgery of the cervical spine followed by radiotherapy, resulting in a good outcome.
Article
Materials Science, Multidisciplinary
Keigo Nakamura, Noriko Horasawa, Toshiyuki Okuse, Ryutaro Uchikawa, Katsumitsu Shimada, Akihiro Kuroiwa, Satoshi Murakami, Hiromasa Hasegawa, Atsushi Kameyama
Summary: The aim of this study was to evaluate the physico-mechanical properties of a new cavity base material containing mineral trioxide aggregate, LA-T1, for indirect restoration. LA-T1 showed similar depth of cure and microshear bond strength as Cavios (CAV) but lower compressive strength than Bulk Base Hard (BBH). The results suggest that LA-T1 can be clinically applied as its properties are comparable to CAV.
Article
Dentistry, Oral Surgery & Medicine
Rita R. R. Roy, Takanaga Ochiai, Katsumitsu Shimada, Hiromasa Hasegawa
Summary: This study aimed to clarify the characteristics of cornified envelope formation in odontogenic keratocysts. The distribution of cornified envelope-related proteins differed significantly between odontogenic keratocysts and dentigerous cysts. The upregulation of cornified envelope-related genes in odontogenic epithelium suggests that it could be an important pathognomonic event during odontogenic keratocyst development.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Medicine, General & Internal
Rita R. Roy, Katsumitsu Shimada, Hiromasa Hasegawa
Summary: Glomeruloid hemangioma is a rare variant of hemangioma that is usually associated with POEMS syndrome. This case report presents a non-POEMS related glomeruloid hemangioma characterized by abnormal proliferation of endothelial and pericytic cells.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Katsumitsu Shimada, Maya Shimizu, Yuki Ohtani, Rita R. Roy, Satoshi Murakami, Takanaga Ochiai, Hiromasa Hasegawa
Summary: This study delved into the hypothesis that normal salivary gland tissue expresses both protein and mRNA of mammaglobin (MGB). The results showed that MGB-positive cells were distributed variably, with higher MGB-PR in acinar cells than ductal cells. Additionally, MGB expression in salivary gland neoplasms represents the nature of original cells.
JOURNAL OF ORAL SCIENCE
(2021)
Article
Engineering, Biomedical
Shunichiro Matsuokau, Hiromasa Hasegawa, Sachie Koike, Tsutomu Koyama, Tetsu Takeda, Kentaro Miura, Takashi Eguchi, Kazutoshi Hamanaka, Munehisa Kito, Jun Takahashi, Toshiro Fukushima, Tomonobu Koizumi, Kimihiro Shimizu, Takeshi Uehara
Summary: This study retrospectively analyzed five cases of UPS-ST-MGCs, identifying one case of malignant giant cell tumor subtype with aggressive clinicopathological features, and four cases consistent with conventional undifferentiated pleomorphic sarcoma of soft tissue features.
JOURNAL OF HARD TISSUE BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Asako Nogami, Satoru Saito, Hiromasa Hasegawa, Masato Yoneda, Kenichi Harada, Hirotoshi Fujikawa
Summary: LELCC is a rare intrahepatic tumor with no specific physical findings, often diagnosed incidentally in large size. We report a case of early stage LELCC successfully treated with radiofrequency ablation, suggesting it as a potential treatment for small-sized early stage LELCC.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Otorhinolaryngology
Kohta Miyahara, Tadashi Ogasawara, Hiromasa Hasegawa, Kohichi Shinotsuka, Katsumitsu Shimada, Takanaga Ochiai, Fa-Chih Shen, Yasuaki Kakinoki
Summary: The study reveals that the mucoid component of both oral and pharyngeal deposits comprises MUC7 salivary mucin, indicating that these deposits originate from the oral cavity and emphasizing the importance of oral care in relation to oral and pharyngeal conditions.
Article
Engineering, Biomedical
Hirokuni Ko, Hiromasa Hasegawa, Takanaga Ochiai, Katsumitsu Shimada, Rita Rani Roy, Sohichi Aizawa, Haruki Yamada
JOURNAL OF HARD TISSUE BIOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Anna Saito, Akira Taguchi, Hiromasa Hasegawa, Hideaki Kagami
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY
(2018)
