Blood glucose control in the ICU: don’t throw out the baby with the bathwater!

Tight glycemic control in acutely ill patients: low evidence of benefit, high evidence of harm!

(2016) Paul E. Marik   INTENSIVE CARE MEDICINE

Increasing glucose load while maintaining normoglycemia does not evoke neuronal damage in prolonged critically ill rabbits

(2013) Romain Sonneville et al.   CLINICAL NUTRITION

Role of Disease and Macronutrient Dose in the Randomized Controlled EPaNIC Trial

(2012) Michael P. Casaer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

LOGIC-Insulin Algorithm-Guided Versus Nurse-Directed Blood Glucose Control During Critical Illness: The LOGIC-1 single-center, randomized, controlled clinical trial

(2012) T. Van Herpe et al.   DIABETES CARE

Early Parenteral Nutrition Evokes a Phenotype of Autophagy Deficiency in Liver and Skeletal Muscle of Critically Ill Rabbits

(2012) Sarah Derde et al.   ENDOCRINOLOGY

Neurocognitive Development of Children 4 Years After Critical Illness and Treatment With Tight Glucose Control

(2012) Dieter Mesotten et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Impact of Hyperglycemia on Neuropathological Alterations during Critical Illness

(2012) Romain Sonneville et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Circulating Levels of the Shed Scavenger Receptor sCD163 and Association with Outcome of Critically Ill Patients

(2012) Catherine Ingels et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Early versus Late Parenteral Nutrition in Critically Ill Adults

(2011) Michael P. Casaer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tight Glycemic Control Protects the Myocardium and Reduces Inflammation in Neonatal Heart Surgery

(2010) Dirk Vlasselaers et al.   ANNALS OF THORACIC SURGERY

Increasing intravenous glucose load in the presence of normoglycemia: Effect on outcome and metabolism in critically ill rabbits

(2010) Sarah Derde et al.   CRITICAL CARE MEDICINE

Blood Glucose Control in the Intensive Care Unit: Benefits and Risks

(2010) Jan Gunst et al.   SEMINARS IN DIALYSIS

Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness

(2009) Ilse Vanhorebeek et al.   CRITICAL CARE MEDICINE

The Effect of Strict Blood Glucose Control on Biliary Sludge and Cholestasis in Critically Ill Patients

(2009) Dieter Mesotten et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hyperglycemic kidney damage in an animal model of prolonged critical illness

(2009) Ilse Vanhorebeek et al.   KIDNEY INTERNATIONAL

Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study

(2009) Dirk Vlasselaers et al.   LANCET

Intensive versus Conventional Glucose Control in Critically Ill Patients

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Modulation of regional nitric oxide metabolism: Blood glucose control or insulin?

(2008) Björn Ellger et al.   INTENSIVE CARE MEDICINE

Tight Blood Glucose Control Is Renoprotective in Critically Ill Patients

(2008) M. Schetz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY