Productivity for free: Residence time gradients during loading increase dynamic binding capacity and productivity

Protein-protein interactions and reduced excluded volume increase dynamic binding capacity of dual salt systems in hydrophobic interaction chromatography

(2021) Leo A. Jakob et al.   JOURNAL OF CHROMATOGRAPHY A

In silico process characterization for biopharmaceutical development following the quality by design concept

(2021) David Saleh et al.   BIOTECHNOLOGY PROGRESS

Mechanistic modeling of continuous capture step purification of biosimilar monoclonal antibody therapeutic

(2021) Prashant Deulgaonkar et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Toward in silico CMC: An industrial collaborative approach to model‐based process development

(2020) David Roush et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimization of Single‐Column Batch and Multicolumn Continuous Protein A Chromatography and Performance Comparison Based on Mechanistic Model

(2020) Jing Guo et al.   Biotechnology Journal

Cross‐scale quality assessment of a mechanistic cation exchange chromatography model

(2020) David Saleh et al.   BIOTECHNOLOGY PROGRESS

Separation of monoclonal antibody monomer-dimer mixtures by gradient elution with ceramic hydroxyapatite

(2020) Yiran Wang et al.   JOURNAL OF CHROMATOGRAPHY A

Linear flow‐velocity gradient chromatography—An efficient method for increasing the process efficiency of batch and continuous capture chromatography of proteins

(2020) Chyi‐Shin Chen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Mechanistic modeling of ligand density variations on anion exchange chromatography

(2020) Gabriela Sanchez‐Reyes et al.   JOURNAL OF SEPARATION SCIENCE

Prediction of the Quantity and Purity of an Antibody Capture Process in Real Time

(2019) Nicole Walch et al.   Biotechnology Journal

Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process development

(2019) Bernhard Sissolak et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Modeling and simulation of anion exchange chromatography for purification of proteins in complex mixtures

(2019) Leandro J. Benedini et al.   JOURNAL OF CHROMATOGRAPHY A

Reduced nonlinear unknown inputs observer using mean value theorem and patternsearch algorithm

(2019) Ramzi Ben Messaoud   AUTOMATICA

Adjoint optimization for the general rate model of liquid chromatography

(2019) Sebastian Osterroth et al.   COMPUTERS & CHEMICAL ENGINEERING

Global optimization of batch and steady-state recycling chromatography based on the equilibrium model

(2019) Jana Dienstbier et al.   COMPUTERS & CHEMICAL ENGINEERING

Evaluation of recent Protein A stationary phase innovations for capture of biotherapeutics

(2018) Timothy M. Pabst et al.   JOURNAL OF CHROMATOGRAPHY A

Design of two-column batch-to-batch recirculation to enhance performance in ion-exchange chromatography

(2018) Oliver Persson et al.   JOURNAL OF CHROMATOGRAPHY A

Model assisted comparison of Protein A resins and multi-column chromatography for capture processes

(2018) Daniel Baur et al.   JOURNAL OF BIOTECHNOLOGY

Systematic interpolation method predicts protein chromatographic elution with salt gradients, pH gradients and combined salt/pH gradients

(2017) Arch Creasy et al.   Biotechnology Journal

Separation science is the key to successful biopharmaceuticals

(2011) Georges Guiochon et al.   JOURNAL OF CHROMATOGRAPHY A