Article
Chemistry, Multidisciplinary
Ya-Chuan Liang, Qing Cao, Kai-Kai Liu, Xue-Yuan Peng, Lai-Zhi Sui, Shuang-Peng Wang, Shi-Yu Song, Xue-Ying Wu, Wen-Bo Zhao, Yuan Deng, Qing Lou, Lin Dong, Chong-Xin Shan
Summary: Water-soluble red afterglow imaging agents based on ecofriendly nanomaterials have been developed, utilizing CNDs and RhB to create a CNDs-RhB@silica nanocomposite, achieving efficient energy transfer and the best red afterglow performance.
Article
Biophysics
Zhiying Feng, Junchen Wang, Xin Chen, Jie Liu, Ying Zhu, Xiaoming Yang
Summary: Carbon dots (CDs) with room-temperature phosphorescence (RTP) doped with N, P elements were successfully synthesized using metformin as the carbon source through a simple microwave method. The RTP emission of CDs appeared when the solution was fixed on filter paper, with hydrogen bonds between CDs and the paper restricting molecular rotations and motions. Fluorescence and phosphorescence of the CDs were enhanced by L-tryptophan, leading to an innovative dual-channel detection of L-trp.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Ru Liang, Lijun Huo, Ao Yu, Jinjing Wang, Chunman Jia, Jianwei Li
Summary: Researchers reported a microwave approach to prepare room temperature phosphorescent carbon dots (CDs) in a short time. The formation of carbon and boron bonds through microwave irradiation resulted in long afterglow properties. The materials showed significant phosphorescence under UV light and had a long phosphorescence lifetime. The glass state of the material contributed to the stabilization of its characteristics.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Physical
Shuai Liu, Dongxia Li, Dongdong Shi, Guoxian Zhang, Xuyan Luo, Qiang Xu, Liang Zhao, Junping Guo, Guiqin Yan
Summary: A new quantitative detection system for thyroxine and carbamazepine was constructed using quantum dots and room-temperature phosphorescence. This method has advantages such as anti-interference, nontoxicity, high sensitivity, simplicity, and low cost, making it suitable for the quantitative detection of thyroxine and carbamazepine in human serum samples.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Xinqi Yang, Shiyin Wang, Ke Sun, Haichao Liu, Ming Ma, Shi-Tong Zhang, Bing Yang
Summary: In recent years, there has been significant interest in pure organic room-temperature phosphorescence (RTP) with highly efficient and long-persistent afterglow. This study investigates the RTP properties and mechanisms of a highly symmetric bird-like structure tetraphenylene (TeP) and its three symmetrical halogenated derivatives (TeP-F, TeP-Cl, and TeP-Br) through theoretical and experimental approaches. The results show that the rigid and highly twisted conformation of TeP restricts non-radiative processes and enhances electron-exchange, contributing to the RTP radiation process. Among the derivatives, TeP-F exhibits the longest phosphorescent lifetime and afterglow duration, making it a promising non-heavy-atom RTP material.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Kikuya Hayashi, Kei Fukasawa, Takashi Yamashita, Shuzo Hirata
Summary: In this study, we report a rational design of triplet sensitizers to achieve high-efficiency red afterglow emission at room temperature. By synthesizing sensitizer and acceptor molecules with different conjugated substituents, we found that the long conjugated substituent greatly enhanced the phosphorescence resonance energy transfer (PRET) from the sensitizer to the acceptor, resulting in improved yield of red afterglow emission at room temperature.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Analytical
Lin Chen, Shaoban Zhao, Yan Wang, Shiping Yu, Yongzhen Yang, Xuguang Liu
Summary: This study developed a heteroatom doping strategy to synthesize long-lived matrix-free phosphorescent B, N, P co-doped CDs (B, N, P-CDs) with cross-linked structure and rich hydrogen bonding network. By coating the surfaces of B, N, P-CDs with silica, the complex of B, N, P co-doped CDs and silica (B, N, P-CDs@SiO2) showed excellent RTP properties in aqueous solution and good biocompatibility, making it a potential phosphorescent bioimaging probe.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Rongji Zhu, Peiling Dai, Jun Yang, Jie Zhou, Jin Zhang, Kenneth Yin Zhang, Yonghua Li, Shujuan Liu, Kenneth Kam-Wing Lo, Qiang Zhao
Summary: In this study, dual-emissive iridium(III) complexes were developed to exhibit phosphorescence responses to copper(II) ions at a distinct wavelength from oxygen quenching. These complexes demonstrated colorimetric phosphorescence response in aqueous solutions under different copper(II) and oxygen conditions. In cellular imaging, the intensity and lifetime of green phosphorescence can be modulated by variation in oxygen concentration without affecting the response of red phosphorescence towards intracellular copper(II) ions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Analytical
Yudong Zhou, Song Lu, Jiahuan Zhi, Ruihong Jiang, Jiahao Chen, Hanbing Zhong, Huifang Shi, Xing Ma, Zhongfu An
Summary: This study demonstrates the preparation of ultralong organic phosphorescent nanoparticles (PDBCz@PVP) with excellent phosphorescence properties, which show promise for biological imaging applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Mozhgan Samandarsangari, Daria O. Kozina, Victor V. Sokolov, Anastasia D. Komarova, Marina V. Shirmanova, Ilya S. Kritchenkov, Sergey P. Tunik
Summary: In this study, new phosphorescent iridium complexes were synthesized with water-soluble and biocompatible properties. The major photophysical characteristics were determined by two cyclometallating ligands based on 2-pyridine-benzothiophene. The use of various diimine ligands influenced the quantum yield of phosphorescence and the sensitivity to oxygen. The complexes demonstrated low toxicity and good water solubility.
Review
Chemistry, Multidisciplinary
Yuanyuan Fan, Qianqian Li, Zhen Li
Summary: This review presents the recent progress of in vitro and in vivo afterglow bioimaging using organic RTP materials. The strategies of molecular design and controlling methods of molecular packing are summarized, with emphasis on high intensity, ultralong lifetimes and red-shifted wavelengths of phosphorescence emission.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Chemistry, Analytical
Mozhgan Samandarsangari, Ilya S. Kritchenkov, Daria O. Kozina, Anastasia D. Komarova, Marina V. Shirmanova, Sergey P. Tunik
Summary: The design, synthesis, and investigation of new molecular oxygen probes for bioimaging, based on phosphorescent transition metal complexes, have been studied. Three new iridium complexes with different ligands have been synthesized and characterized. These complexes exhibited phosphorescence and showed potential for use in bioimaging experiments. Furthermore, they were found to be internalized into cancer cells and localized in mitochondria and lysosomes.
Article
Chemistry, Multidisciplinary
Liangwei Ma, Siyu Sun, Bingbing Ding, Xiang Ma, He Tian
Summary: A series of high intersystem crossing yield phosphors based on single-benzene structure were obtained in this study, showing efficient phosphorescence emission after being embedded into a polyvinyl alcohol matrix. Photo-switchable phosphorescence emission can be achieved by doping these molecules into a PMMA matrix.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Physical
Shaoban Zhao, Lin Chen, Yongzhen Yang, Xuguang Liu
Summary: Phosphorescence imaging technology plays an important role in cell and organism monitoring, and phosphorescent probes provide a key material basis for its development. This review introduces the luminescence mechanism of phosphorescence and its principle for biological imaging, summarizes the synthesis, performance, and application of organic and inorganic phosphorescent probes, and prospects their development.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Materials Science, Multidisciplinary
Yaguang Wang, Qikun Sun, Lingtai Yue, Jie Ma, Shou Yuan, Danfeng Liu, Haichang Zhang, Shanfeng Xue, Wenjun Yang
Summary: This study successfully synthesized organic crystals with ultralong room-temperature white light emission, which exhibits non-discoloring white afterglow with high photoluminescence efficiency. The crystal can be excited at wide wavelengths and shows unique luminescent properties.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Pengli Gao, Zhigang Xie, Min Zheng
Summary: This review introduces carbon dots as a new type of carbon-based fluorescent nanomaterials with great potential in sensing. The preparation methods and strategies to modulate the photoluminescence properties of carbon dots from different starting materials are described. The optical properties and photoluminescence mechanisms of carbon dots are outlined. The research progress of carbon dots in sensing environmental pollutants, bioactive substances, bacteria, and viruses via different mechanisms is summarized. Additionally, the future development trends and prospects for carbon dots-based nanosensors are envisioned.
CHINESE CHEMICAL LETTERS
(2022)
Article
Oncology
Qiaoxia Shi, Chengjian Mou, Zhigang Xie, Min Zheng
Summary: Efficient and safe antimicrobials are urgently needed to combat drug-resistant bacteria. Antimicrobial photodynamic therapy (aPDT) shows promise in reducing antibiotic resistance and minimizing systemic side effects. In this study, six BODIPY derivatives were synthesized and their photophysical behaviors were characterized. The results indicate that BDP3, with 2,6-diiodo and 8-phenyl substitution, is the most effective photosensitizer (PS) candidate for aPDT, as it generates the highest levels of reactive oxygen species (ROS) and rapidly kills Staphylococcus aureus (S. aureus) under illumination. BDP3 also demonstrates excellent biofilm inhibition ability against S. aureus, disrupting the bacterial cell membrane structure and leading to bacterial lysis and death through ROS generation.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Chengjian Mou, Xinyuan Wang, Jiahui Teng, Zhigang Xie, Min Zheng
Summary: This study discovered anionic carbon dots with antimicrobial activity and applied them in disease therapy and tissue engineering. By constructing a self-healing hydrogel through conjugation with e-polylysine, these carbon dots can significantly accelerate wound healing and possess broad spectrum antibacterial activity.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Hongxin Liu, Zhigang Xie, Min Zheng
Summary: Chiral nanovaccines have potential applications in cancer immunotherapy by carrying antigens and inducing immune responses, showing inhibitory effects on melanoma growth.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Tianyu Gao, Hongxin Liu, Zhigang Xie, Min Zheng
Summary: Designing nanovectors inspired by nature is an effective approach to enhance the efficacy and bioavailability of chemotherapeutic agents while reducing toxicity. In this study, hydrophobic camptothecin was modified with different chain lengths of fatty acids to synthesize nanovectors that can readily complex with human serum albumin. The results demonstrated that CPT18C-HSA exhibited the highest cell killing capacity and remarkable antitumor efficiency with reduced physiological toxicity, indicating its great potential for efficient drug delivery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Libo Gao, Zhigang Xie, Min Zheng
Summary: Quantitatively probing and visualizing pH variation in living cells and organisms in real time is crucial but challenging. In this study, green fluorescent carbon dots with high fluorescence quantum yield, unique photostability, and high selectivity were synthesized as pH-activatable probes for continuous pH detection in various biological systems. These carbon dots are believed to be among the best pH probes for comprehensive biomedical applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Materials Science, Biomaterials
Kunmei Liu, Hongxin Liu, Chaonan Li, Zhigang Xie, Min Zheng
Summary: This study developed a multifunctional photothermal agent that combines diagnostic and therapeutic functions, with features such as redshifted absorption/emission, high photothermal conversion efficiency, and tumor accumulation. Experimental results demonstrated excellent diagnostic and therapeutic performance of this photothermal agent.
BIOMATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Chengjian Mou, Xinyuan Wang, Yanchao Liu, Zhigang Xie, Min Zheng
Summary: Developing highly effective antibacterial films for wound healing is a challenge. Homogeneous and flexible CDs-PVA composite films were constructed by doping CDs into PVA. PVA(5) and PVA(8) showed excellent antibacterial performance against both Gram-negative and Gram-positive bacteria, and could be easily processed into band-aid type dressings for wound healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Applied
Yanchao Liu, Min Zheng
Summary: Designing packaging materials with antibacterial properties is crucial for food safety and extending shelf life. Three BODIPY derivatives were synthesized and tested for their photophysical properties and antibacterial capacities. One derivative showed excellent antibacterial activity and was used in packaging strawberries, effectively inhibiting spoilage and extending shelf life.
Article
Biochemistry & Molecular Biology
Qiaoxia Shi, Xinyuan Wang, Hongxin Liu, Zhigang Xie, Min Zheng
Summary: Antimicrobial photodynamic therapy (aPDT) is a promising approach to eliminate bacteria without causing resistance. Recently, carrier-free nanoparticles (NPs) formed via self-assembly of BODIPYs have attracted attention. BNP2, a synthesized carrier-free NP, exhibited excellent anti-Staphylococcus aureus ability and promoted wound healing in vivo.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hongxin Liu, Zhigang Xie, Min Zheng
Summary: Cancer immunotherapy is a popular area of research, and carbon dots have shown potential as nanovectors to enhance its efficacy.
Article
Engineering, Environmental
Zixuan Li, Qing Pei, Yonghui Zheng, Zhigang Xie, Min Zheng
Summary: This study successfully synthesized fluorescent carbon dots (CDs) with excellent biosafety, stability, dispersibility, and photodynamic activity. The CDs emitted long-lasting near-infrared (NIR) fluorescence, enabling high penetration and long-term in vivo luminescent imaging of deep tissues. Moreover, the CDs generated abundant reactive oxygen species, effectively inhibiting tumor growth. This work demonstrates the enormous potential of CDs as multifunctional nanoplatforms for biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Xinyuan Wang, Min Zheng
Summary: Antibacterial photodynamic therapy is a promising approach for antimicrobial treatment, as it can effectively kill bacteria without causing drug resistance. The use of boron dipyrromethene (BDP) scaffolds as photosensitizers has shown high efficiency in this therapy. The designed BDP nanobactericides (BCu NPs) successfully destroyed bacteria by inducing surface depression and content leakage under green light irradiation. In addition, the in vivo experiments demonstrated the effectiveness of BCu NPs in killing bacteria and accelerating skin wound healing. This study provides a facile method for assembling hydrophobic dyes into nanoparticles through conjugation.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Biomaterials
Chengjian Mou, Xinyuan Wang, Yanchao Liu, Zhigang Xie, Min Zheng
Summary: In this study, a nano photosensitizer p-BDP was developed by assembling fluoroborondipyrrole (BODIPY) with cationic and anionic carbon dots (CDs), showing stronger photoinactivation activity against Staphylococcus aureus and lower MIC. Additionally, p-BDP could serve as an efficacious wound dressing to accelerate the healing of S. aureus infections.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
