Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 351, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.130832
Keywords
Langmuir adsorption; Graphene oxide; Selectable sensitivity; Dynamic detection range
Funding
- National Natural Science Foun-dation of China [62075071]
- National Science Fund for Excellent Young Scholars [61922033]
Ask authors/readers for more resources
In this study, a Langmuir adsorption model was proposed to explain the sensing mechanism of a biosensor based on Ex-TFG functionalized with graphene oxide (GO). The experiment results showed that the GO coating enhanced the surface biological activity of Ex-TFG, making it sensitive to Hb biomolecule solutions. The bio-sensitivity and detection range of the sensors could be easily adjusted by controlling the amount of bio-functionalized materials.
Biosensors play a significant role in biomedical, clinical and disease diagnosis areas. Here, we proposed Langmuir adsorption model to explain sensing mechanism of biosensor based on excessively tilted fiber grating (Ex-TFG) functionalized with graphene oxide (GO). Due to GO containing plenty of six-membered rings and oxygen containing groups, the biomolecules can be easily adsorbed through 7C-7C interaction and hydrogen bond. The whole interaction process obeys the Langmuir adsorption model in which there always an equilibrium during detecting process, inducing the sensor with adjustable bio-sensitivity and detection range. Three biosensors based on Ex-TFG coated with three different amount of GO were investigated for hemoglobin (Hb) detection experiment, showing pronounced bio-interaction induced resonance shifts. The experiment results indicate that GO coating could enhance the surface biological activity of Ex-TFG, making the Ex-TFG sensitive to the Hb biomolecule solutions. The three GO coated Ex-TFG sensors have the bio-sensitivity of 3.83 nm/(mg/ml), 4.33 nm/(mg/ml), and 8.21 nm/(mg/ml), and the detection range of 0.8 mg/ml, 0.6 mg/ml and 0.4 mg/ml, respectively, which are in good agreement with the prediction from the Langmuir adsorption model. By controlling the amount of the bio-functionalized materials, the bio-sensitivity and detection range of the Ex-TFG based biosensors can be easily adjusted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available