Review
Oncology
Saevar Ingthorsson, Gunnhildur Asta Traustadottir, Thorarinn Gudjonsson
Summary: This review discusses the structure, function, and dynamics of the breast gland, as well as how changes in breast cell function can lead to different types of cancer. The development of the breast gland is closely related to the menstrual cycle, and stem cells and progenitor cells play important roles in the proliferation, differentiation, and involution cycles of the breast. Breast cancer originates from stem cells and progenitor cells, and both stem cells and cancer cells exhibit cellular plasticity. Additionally, the stromal environment plays a vital role in cancer initiation and progression.
Review
Oncology
Yu-Yang Liao, Wen-Ming Cao
Summary: Chromosomal instability (CIN) is an important marker of cancer, closely related to tumorigenesis, disease progression, treatment efficacy, and patient prognosis. Its clinical significance remains unclear due to limitations in current detection methods. However, studies have shown that CIN is present in 89% of invasive breast cancer cases, indicating its potential for breast cancer diagnosis and treatment. This review provides insights into the types of CIN, detection methods, and its impact on breast cancer development, treatment, and prognosis, aiming to serve as a reference for researchers and clinicians.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Raul Munoz Velasco, Ana Garcia Garcia, Paula Jimenez Sanchez, Inmaculada Montanuy Sellart, Victor Javier Sanchez-Arevalo Lobo
Summary: Pancreatic ductal adenocarcinoma is a challenging disease with low survival rate due to its chemoresistance and tumor microenvironment. New therapies targeting the tumor microenvironment should be developed for effective treatment.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Masashi Soga, Kevin J. Gaston
Summary: Interest in the interactions between individuals and nature has grown rapidly, spanning multiple academic disciplines. To create a rich cross-disciplinary understanding of these interactions, synthesizing concepts and theories from diverse disciplines within a unified conceptual framework is crucial for future research and scientific advancement.
NATURE SUSTAINABILITY
(2022)
Review
Immunology
F. Thiam, S. Al Yazeedi, K. Feng, S. Phogat, E. Demirsoy, J. Brussow, F. A. Abokor, E. T. Osei
Summary: Asthma is a chronic lung disease characterized by airway inflammation and fibrosis. Fibroblasts, traditionally seen as structural cells, have been found to play an active role in lung inflammatory and fibrotic processes in asthma. Recent studies using 2D and 3D in vitro co-culture models have revealed complex interactions between lung fibroblasts and immune cells, shedding light on their contributions to chronic inflammation and fibrotic mechanisms in asthma pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Applied
Stephen Gitonga Giteru, M. Azam Ali, Indrawati Oey
Summary: Interest in using zein as an ingredient in food and bio-based materials has been increasing in the last decade. Understanding the interaction mechanisms of zein with other compounds is crucial for improving the structure-function relationship and expanding its applications in various industries. By exploring the assembly mechanisms and aggregation behavior of zein in composite macromolecular systems, specialized biomaterials can be developed for food, agricultural, biomedical, and cosmetic applications.
FOOD HYDROCOLLOIDS
(2021)
Review
Microbiology
Giulia Daly, Veronica Ghini, Alessandra Adessi, Marco Fondi, Alison Buchan, Carlo Viti
Summary: The complex relationship between microalgae and bacteria is best understood through integrated approaches that focus on metabolites. Metabolomic studies have allowed for a comprehensive understanding of these interactions, while mathematical models enhance interpretation of experimental data and generate testable hypotheses.
FEMS MICROBIOLOGY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Robert E. Hynds, Kristopher K. Frese, David R. Pearce, Eva Gronroos, Caroline Dive, Charles Swanton
Summary: NSCLC is the leading cause of cancer-related deaths worldwide, and although progress is being made in early detection and the development of targeted therapies and immunotherapies, the survival rate for advanced patients remains low. Effective cancer research relies on pre-clinical models that accurately reflect disease progression and patient responses to therapy.
Article
Economics
Dinithi N. Jayasekara
Summary: Recent studies have found that agricultural legacies can influence cultural formation and individual preferences for modern technology. Societies historically cultivating low labor-intensive crops tend to have more favorable attitudes towards technology, while societies growing labor-intensive crops lean towards collectivist norms and show lower affinity for technology.
ECONOMIC MODELLING
(2021)
Review
Pharmacology & Pharmacy
Ren Xu, Xiaotao Zhou, Shike Wang, Christine Trinkle
Summary: Tumor development and progression rely on signals from the tumor microenvironment, and recent advances in 3D culture and patient-derived tumor organoid models provide valuable tools for studying cancer development, treatment, and drug response.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Oncology
Jia Ning Nicolette Yau, Giulia Adriani
Summary: Colorectal cancer (CRC) remains a major cause of death globally. Recent developments in 3D cell culture have allowed for better modeling of the tumor microenvironment, leading to more accurate predictions of tumor progression and drug response. Incorporating different cell types such as cancer-associated fibroblasts, endothelial cells, immune cells, and gut bacteria in 3D CRC spheroid models has improved their relevance and potential for identifying new therapeutic targets. This mini review discusses the advances in mimicking tumor heterogeneity in these models and highlights the impact of diverse cell populations on chemoresistance and tumor progression.
FRONTIERS IN ONCOLOGY
(2023)
Article
Ecology
G. Adam Meyer, Shawn J. Leroux
Summary: The study found that ungulate parturition material can impact soil processes and the nitrogen content of plant tissues, and this effect is mediated by plant-fungal associations. This research is important for understanding the microscale mechanisms of animal-ecosystem interactions and predicting the effects of ungulates on nutrient availability.
JOURNAL OF ANIMAL ECOLOGY
(2023)
Article
Chemistry, Physical
Kaikai Liu, Chengbo Tian, Yuming Liang, Yujie Luo, Liqiang Xie, Zhanhua Wei
Summary: This article comprehensively reviews the application of fullerene materials in regulating carrier transport, passivating defects, and enhancing device stability in perovskite solar cells (PSCs). The influence of fullerene-related chemical interactions, including fullerene-perovskite, fullerene-inorganic electron transport layer (IETL), and fullerene-fullerene, on device performance is well discussed. The article also outlines future perspectives for the design and application of fullerene materials to improve PSCs performance and commercialization.
Article
Oncology
Maria L. Lotsberg, Gro V. Rosland, Austin J. Rayford, Sissel E. Dyrstad, Camilla T. Ekanger, Ning Lu, Kirstine Frantz, Linda E. B. Stuhr, Henrik J. Ditzel, Jean Paul Thiery, Lars A. Akslen, James B. Lorens, Agnete S. T. Engelsen
Summary: The lack of adequate preclinical models hinders cancer drug development, and the heterotypic multicellular spheroids offer a promising solution. This study extensively characterizes the spheroids and demonstrates their applicability in evaluating the impact of cancer cell phenotype in drug screening experiments. High-dimensional and spatially resolved imaging mass cytometry analysis provides detailed insights into the heterogeneity of cancer-stroma interactions and epithelial phenotypic plasticity, which are crucial factors in therapy resistance in non-small cell lung cancer (NSCLC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Cassandra L. Roberge, Rebecca T. Miceli, Lillian R. Murphy, David M. Kingsley, Richard A. Gross, David T. Corr
Summary: Sophorolipids, derived from nonpathogenic yeasts, have potential efficacy in anticancer applications. They can be synthesized cost-effectively, making them promising alternatives to traditional chemotherapeutics. This study screened two sophorolipids and a clinically-used chemotherapeutic on breast cancer models in various dimensions. The findings demonstrate the importance of 3D tumor models in assessing drug response and suggest that one of the sophorolipids could be comparable in toxicity to the chemotherapeutic control.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Prashant Rajbhandari, Mary Szatkowski Ozers, Natalia M. Solodin, Christopher L. Warren, Elaine T. Alarid
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Engineering, Biomedical
Mary C. Regier, Lindsey J. Maccoux, Emma M. Weinberger, Keil J. Regehr, Scott M. Berry, David J. Beebe, Elaine T. Alarid
BIOMEDICAL MICRODEVICES
(2016)
Review
Pharmacology & Pharmacy
Molly M. Morgan, Brian P. Johnson, Megan K. Livingston, Linda A. Schuler, Elaine T. Alarid, Kyung E. Sung, David J. Beebe
PHARMACOLOGY & THERAPEUTICS
(2016)
Article
Biochemistry & Molecular Biology
Kyle T. Helzer, Mary Szatkowski Ozers, Mark B. Meyer, Nancy A. Benkusky, Natalia Solodin, Rebecca M. Reese, Christopher L. Warren, Wesley Pike, Elaine T. Alarid
MOLECULAR AND CELLULAR BIOLOGY
(2019)
Review
Oncology
David K. Lung, Rebecca M. Reese, Elaine T. Alarid
Article
Endocrinology & Metabolism
David K. Lung, Jay W. Warrick, Peiman Hematti, Natalie S. Callander, Christina J. Mark, Shigeki Miyamoto, Elaine T. Alarid
Review
Endocrinology & Metabolism
Rebecca M. Reese, Melissa M. Harrison, Elaine T. Alarid
Article
Endocrinology & Metabolism
Fatou Jallow, Jennifer L. Brockman, Kyle T. Helzer, Debra E. Rugowski, Vincent Goffin, Elaine T. Alarid, Linda A. Schuler
JOURNAL OF THE ENDOCRINE SOCIETY
(2018)