Article
Environmental Sciences
Yuehua Li, Baohong Jiang, Lijun Zeng, Yuanbin Tang, Xiaowen Qi, Zhixing Wan, Wenjie Feng, Liming Xie, Rongfang He, Hongbo Zhu, Yimou Wu
Summary: Obesity is strongly associated with adverse prognosis in TNBC. Adipose-secreted exo-circCRIM1 promotes TNBC progression by inhibiting miR-503-5p and activating the OGA/FBP1 signaling pathway.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cell Biology
Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang, Jinjian Yang
Summary: The study revealed that exosomes released by bladder cancer cells can promote the immunosuppressive polarization of macrophages, facilitating tumor growth. This process is mediated by down-regulation of PTEN and activation of AKT/STAT3/6 signaling. Inhibiting the generation or secretion of exosomes can suppress the immunosuppressive transformation of macrophages, thereby inhibiting tumor growth.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Hiu Yee Kwan, Minting Chen, Keyang Xu, Baisen Chen
Summary: This article critically reviews the impact of obesity on the exosomal cargo contents and the biogenesis of adipocyte-derived exosomes. It also discusses the differences in exosomal contents in different adipose depots, as well as the impact of obesity on exosomes derived from stromal vascular fraction components. The review also touches upon the development and potential application of exosome-based therapy for obesity and its comorbidities.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Mikin R. Patel, Alissa M. Weaver
Summary: Small extracellular vesicles (EVs) secreted from primary astrocytes enhance spine and synapse formation in primary cortical neurons through fibulin-2-mediated activation of TGF-beta signaling. Understanding the role of astrocytes in brain development may help elucidate the mechanisms underlying synapse formation.
Article
Medicine, General & Internal
Minsung Kim, Il Tae Son, Gyoung Tae Noh, So-Youn Woo, Ryung-Ah Lee, Bo Young Oh
Summary: This study investigated the role of colon cancer-cell-derived exosomes in colon cancer. The results showed that exosome treatment significantly increased cancer cell proliferation, altered cell adhesion molecule expression, enhanced cell motility, and had an impact on the gene regulation of cancer-associated fibroblasts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckmann, Kerstin Menck
Summary: EVs can transfer oncogenic Wnt receptors ROR1/2 to the surface of ROR-negative cancer cells, inducing an aggressive phenotype that supports tumor progression. This transfer was observed both in vitro and in vivo, and ROR-positive EVs were also found to be significantly elevated in the plasma of breast cancer patients.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Wenqi Fan, Haipeng Pang, Xiajie Shi, Jiaqi Li, Yimeng Wang, Shuoming Luo, Jian Lin, Haibo Yu, Yang Xiao, Xia Li, Gan Huang, Zhiguo Xie, Zhiguang Zhou
Summary: This study identified the plasma-derived exosomal mRNA expression profiles of T1DM for the first time, suggesting that the identified DEMs may play a role in the pathogenesis of T1DM and have the potential to serve as biomarkers and therapeutic targets for T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Chantell Payton, Lisa Y. Pang, Mark Gray, David J. Argyle
Summary: This study finds that exosomes secreted by radioresistant (RR) cells can increase cell viability, colony formation, and drug resistance in recipient cells, suggesting that exosomes may be potential mediators of radiation resistance in breast cancer therapy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Knud Josefsen, Lars Krogvold, Ivan C. Gerling, Flemming Pociot, Knut Dahl-Jorgensen, Karsten Buschard
Summary: This study suggests that dormant beta cells in type 1 diabetes (T1D) exhibit secretion defects, fetal dedifferentiation, and desynchronization. Combining with previous evidence, it is proposed to treat individuals with ongoing T1D development prophylactically with type 2 diabetes (T2D) medicine and anti-inflammatory compounds to reactivate dormant beta cells and prevent autoimmune destruction. Further investigation into T2D mechanisms during T1D development is needed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Zhang, Xiaoxiao Zheng, Yisong Yu, Li Zheng, Jiahua Lan, Ying Wu, Hao Liu, An Zhao, Hang Huang, Wei Chen
Summary: Tumor-derived exosomes facilitate tumor development by inducing macrophage polarization via transferring lncARSR, suggesting that RCC-derived exosomes, lncARSR, and STAT3 are potential therapeutic targets for the treatment of RCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Wanglong Gou, Liang Yue, Xin-yi Tang, Yan-yan Wu, Xue Cai, Menglei Shuai, Zelei Miao, Yuanqing Fu, Hao Chen, Zengliang Jiang, Jiali Wang, Yunyi Tian, Congmei Xiao, Nan Xiang, Zhen Wu, Yu-ming Chen, Tiannan Guo, Ju-Sheng Zheng
Summary: This study identified proteomic biomarkers for incident T2D among Chinese populations and found seven proteins associated with T2D. The research also indicated a potential synergistic interaction between dietary factors such as red meat intake and these biomarkers in exaggerating the risk of T2D.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Seng Kar Yap, Kian Leong Tan, Nor Yasmin Abd Rahaman, Nur Fazila Saulol Hamid, Der Jiun Ooi, Yin Sim Tor, Qi Hao Daniel Looi, Li Kar Stella Tan, Chee Wun How, Jhi Biau Foo
Summary: The study demonstrates that low-dose hUC-MSCs-sEVs treatment has positive effects on human skeletal muscle cells and type 2 diabetes mellitus rats, improving glucose tolerance and protecting against organ damage. hUC-MSCs-sEVs could be a potential therapy for diabetes mellitus.
Article
Oncology
Haimeng Yin, Xiaoxia Qiu, Ying Shan, Bo You, Lixiao Xie, Panpan Zhang, Jianmei Zhao, Yiwen You
Summary: In a hypoxic tumor microenvironment, resident adipocytes play a crucial role in cancer cell growth and invasion. Through exosomes, hypoxic adipocytes transfer low expression of miR-433-3p to nasopharyngeal carcinoma (NPC) cells. This low expression of miR-433-3p promotes proliferation, migration, and lipid accumulation in NPC cells by targeting SCD1.
Article
Biotechnology & Applied Microbiology
Lei Yan, Jinhu Chen, Weihua Fang
Summary: This study found that exosomes derived from CaOx-treated macrophages promote apoptosis of HK-2 cells by promoting autophagy. This suggests that macrophage-derived exosomes play a vital role in CaOx-induced human proximal tubular cell damage.
Article
Endocrinology & Metabolism
Fangcen Liu, Jielei He, Boxun Liu, Pengzi Zhang, Hongdong Wang, Xitai Sun, Xuehui Chu, Wenxian Guan, Wenhuan Feng, Yan Bi, Dalong Zhu
Summary: This study investigated the relationships between morphological changes in visceral adipose tissue and type 2 diabetes mellitus (T2DM) as well as impaired insulin sensitivity. The findings suggest that adipocyte hypertrophy is closely associated with T2DM and impaired systemic insulin sensitivity, while fibrosis deposition is negatively correlated with T2DM.
Article
Multidisciplinary Sciences
Dahai Wang, Nabil Rabhi, Shaw-Fang Yet, Stephen R. Farmer, Matthew D. Layne
Summary: This study identified ACLP as a mediator of adventitial cellular differentiation and potentially pathological vessel remodeling.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer
Summary: Roscovitine effectively prevents prolonged diet-induced metabolic disruption and restores mitochondrial activity in both brown adipose tissue and epididymal white adipose tissue. Additionally, it suppresses inflammation and extracellular matrix proteins in eWAT, while enhancing lipid metabolism, TCA cycle, fatty acid beta oxidation, and creatine biosynthesis pathways.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Pavan Bachireddy, Elham Azizi, Cassandra Burdziak, Vinhkhang N. Nguyen, Christina S. Ennis, Katie Maurer, Cameron Y. Park, Zi-Ning Choo, Shuqiang Li, Satyen H. Gohil, Neil G. Ruthen, Zhongqi Ge, Derin B. Keskin, Nicoletta Cieri, Kenneth J. Livak, Haesook T. Kim, Donna S. Neuberg, Robert J. Soiffer, Jerome Ritz, Edwin P. Alyea, Dana Pe'er, Catherine J. Wu
Summary: Research suggests that responsive tumors in leukemia treatment are characterized by enrichment of late-differentiated T cells, while resistance is defined by heterogeneous T cell dysfunction. Interestingly, early differentiated T cells in responders primarily originate from pre-existing and novel clonotypes recruited to the leukemic microenvironment.
Article
Cell Biology
Carlos Alberto Oliveira Biagi Jr, Sarah Santiloni Cury, Cleidson Padua Alves, Nabil Rabhi, Wilson Araujo Silva Jr, Stephen R. Farmer, Robson Francisco Carvalho, Miguel Luiz Batista Jr
Summary: Adipose tissue has different subtypes of adipocytes, including thermogenic adipocytes, identified through a deep analysis of publicly available single-nuclei RNAseq data. This study provides insights into adipocyte plasticity and transcriptional profiles under thermogenic challenges, serving as a useful resource for further investigations on adipocyte mechanisms.
Article
Cell Biology
Florine Bornaque, Clement Philippe Delannoy, Emilie Courty, Nabil Rabhi, Charlene Carney, Laure Rolland, Maeva Moreno, Xavier Gromada, Cyril Bourouh, Pauline Petit, Emmanuelle Durand, Francois Pattou, Julie Kerr-Conte, Philippe Froguel, Amelie Bonnefond, Frederik Oger, Jean-Sebastien Annicotte
Summary: This study found that environmental variations, such as glucose concentration, can control m(6)A methylation in pancreatic beta cells, modulating gene expression and pancreatic beta-cell functions. These findings provide new insights into the causes and mechanisms of type 2 diabetes.
Meeting Abstract
Oncology
Naser Jafari, Manohar Kolla, Isabella Pompa, Tova Meshulam, Miguel Batista, Gerald V. Denis
Article
Oncology
Sophia C. Kamran, Isabella R. Pompa, Andrzej Niemierko, Samantha L. Dawes, Sandra S. Zaky, Curtiland Deville Jr
Summary: This study aimed to investigate the diversity of task force members who develop evidence-based clinical practice guidelines for the American Society for Radiation Oncology (ASTRO). The results showed that the majority of task force members were male, and there was a lack of representation in terms of gender, race/ethnicity, and geographic distribution. It emphasizes the need for more intentional efforts to improve the diversity of task force members.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Kiranj Chaudagar, Hanna M. Hieromnimon, Rimpi Khurana, Brian Labadie, Taghreed Hirz, Shenglin Mei, Raisa Hasan, Jordan Shafran, Anne Kelley, Eva Apostolov, Ghamdan Al-Eryani, Kate Harvey, Srikrishnan Rameshbabu, Mayme Loyd, Kaela Bynoe, Catherine Drovetsky, Ani Solanki, Erica Markiewicz, Marta Zamora, Xiaobin Fan, Stephan Schuer, Alex Swarbrick, David B. Sykes, Akash Patnaik
Summary: This study aimed to elucidate the resistance mechanism to androgen deprivation therapy (ADT) and PI3K/AKT axis blockade in PTEN/p53-deficient metastatic castrate-resistant prostate cancer (mCRPC), and to develop rational combination strategies. The results showed that the combination of ADT and PI3Ki significantly enhanced anticancer responses by stimulating immune cell activation and reducing immune suppression of tumor-associated macrophages.
CLINICAL CANCER RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Naser Jafari, Manohar Kolla, Tova Meshulam, Jordan Shafran, Yuhan Qiu, Allison Casey, Carla Mazzeo, Nabil Rabhi, Stephen Farmer, Gerald Denis
