Article
Biochemical Research Methods
Brenda Lyn A. Gavina, V. Aurelio A. de los Reyes, Mette Olufsen, Suzanne Lenhart, Johnny Ottesen
Summary: Anovulation can be achieved by using exogenous hormones, but high doses are associated with adverse effects. This study utilizes optimal control theory on a modified menstrual cycle model to determine the minimum total exogenous estrogen/progesterone dose, and timing of administration to induce anovulation. Results show significant reduction in dosage with combination therapy and the most effective timing for estrogen contraception is the mid follicular phase.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Engineering, Environmental
Gongduan Fan, Yujian Li, Banghao Du, Lei Yao, Chenjian Cai, Hao Li, Shoubin Chen, Jianyong Zou, Zhanglin Hong, Kai-Qin Xu
Summary: As an emerging advanced oxidation technology, UV/PAA shows great potential in removing pharmaceuticals and personal care products (PPCPs) in wastewater treatment. The study investigated the degradation effects and PAA activation mechanisms by UV irradiation on ibuprofen, and found that the UV/PAA process exhibited excellent degradation efficiency and a synergistic effect between UV and PAA. The study also identified the reactive oxygen species involved in the degradation and analyzed the intermediates produced during the process.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Food Science & Technology
Shanrui Li, Xiaolong Wang, Lian Li, Jun Liu, Yunhan Ding, Tong Zhao, Yuantao Zhang
Summary: In this study, the authors used Reactive Molecular Dynamics (RMD) simulation to investigate the detoxification pathways of the mycotoxin DON induced by reactive oxygen species (ROS). It was found that ROS can modify toxicologically important functional groups of DON through various reactions, reducing its toxicity and providing theoretical understanding for plasma degradation of mycotoxins in the future.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Immunology
Donald N. Ngwa, Sanjay K. Singh, Alok Agrawal
Summary: The study aimed to compare the protective capacity of E-CRP with clarithromycin. In a mouse model of pneumococcal infection, both E-CRP and clarithromycin provided minimal but equal protection when used alone. However, the combination of E-CRP and clarithromycin drastically reduced bacteremia and increased survival of mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Materials Science, Ceramics
Lingappa Rangaraj, Vijay Kashimatt, Pooja, Bheemapa Suresha
Summary: The study investigates the production of Ti2AlCx ceramics using different processing conditions and raw material ratios, analyzing their properties through methods such as density and phase analysis. The results indicate that high-quality Ti2AlCx ceramics can be produced under specific conditions.
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
(2022)
Article
Engineering, Industrial
Ting Li, Shuguang He, Xiujie Zhao
Summary: This study investigates the design of warranty policies for products with random failure thresholds, proposing three types of warranty policies and comparing them through model comparison to determine different expected profits. The research findings suggest that parameters of degradation models and random failure thresholds can impact the resulting profit levels.
RELIABILITY ENGINEERING & SYSTEM SAFETY
(2022)
Article
Chemistry, Multidisciplinary
Huixian Xu, Yanjun Li, Qin Li, Dandan Yang, Ting Li, Saimeng Jin, Liandi Zhou, Qihui Zhang, James H. Clark
Summary: In this study, a simple, green, and environmentally friendly strategy using biochar loaded with self-emulsifying orange peel essential oil (BC/SE-OPEO) was proposed to efficiently adsorb and degrade the aromatic amine p-phenylenediamine (PPD). The results showed that the PPD removal efficiency of 50 mg BC/SE-OPEO reached 98% after 110 min at 40 °C. Mechanistic investigations revealed that reactive oxygen species (ROS) played a vital role in the degradation of PPD, which was eventually degraded to carbon dioxide and water.
Review
Biochemistry & Molecular Biology
Alessio Biagioni, Sara Peri, Giampaolo Versienti, Claudia Fiorillo, Matteo Becatti, Lucia Magnelli, Laura Papucci
Summary: Blood vessels are crucial for cancer cells to survive and spread in the body, and the formation of abnormal vessel networks is closely related to patients' prognosis. It is urgent to find new pharmaceutical solutions to control and normalize the formation of these networks.
Article
Computer Science, Artificial Intelligence
Yasir Muhammad, Muhammad Asif Zahoor Raja, Muhammad Altaf, Farman Ullah, Naveed Ishtiaq Chaudhary, Chi-Min Shu
Summary: This paper presents a new computing paradigm based on fractional order comprehensive learning particle swarm optimization for solving the reactive power dispatch problems in power systems. The method is tested and verified to be stable, effective, and reliable.
APPLIED SOFT COMPUTING
(2022)
Article
Energy & Fuels
Timur Sayfutdinov, Petr Vorobev
Summary: The paper proposes a comprehensive battery storage modeling approach and applies it to realistic scenarios of peak-shaving, demonstrating the importance of considering the developed models. The study finds that larger battery capacity becomes economically feasible when the battery is used more extensively. Additionally, adapting the operation strategy during the battery's lifetime reduces degradation and extends its lifespan, resulting in potential cost savings of up to 12.1% in the battery storage system project.
Article
Green & Sustainable Science & Technology
Hao Li, Qing Xiao, Ting Peng
Summary: Due to income constraints and consumer preference for new products, consumers' switching purchases between new and remanufactured products cause a cannibalization effect in the market. This study examines the pricing problem of new and remanufactured products in a competitive market environment. The research analyzes the impact of consumer learning costs, initial consumers, and product differences on sellers' pricing decisions, and provides insights for sellers to choose appropriate pricing strategies.
Article
Construction & Building Technology
Jiarui Liu, Jeung-Hwan Doh, Dominic E. L. Ong, Sen Wang, Yuxin Yang, Hong Lich Dinh, Goangseup Zi
Summary: This study provides a universal index to quantify and evaluate the reactivity of fly ash, which is important for further utilization. The alkali leaching tests and dissolution efficiency analysis showed significant correlations with the mechanical properties of fly ash-based geopolymer.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Engineering, Environmental
Youn-Jun Lee, Chang-Gu Lee, Seong-Jik Park, Joon-Kwan Moon, Pedro J. J. Alvarez
Summary: Combining UV and free chlorine is an efficient method for degrading recalcitrant organic compounds in water. This study found that chlorine monoxide was the main radical species responsible for the degradation of the neonicotinoid insecticide clothianidin, and the reaction rate constants indicated a faster degradation rate compared to other radical species. The presence of humic acid was found to inhibit the degradation process.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Chemical
Ke Zhang, Yajing Wei, Hongyang Cao, Yue Xin, Chuanyi Wang
Summary: Tuning the reactive species in peroxymonosulfate (PMS) activation has been extensively studied in catalysis, but the photothermal effect on reactive species alteration has been neglected. In this study, a ZnFe2O4/C photocatalyst with oxygen vacancy was synthesized. The experimental results revealed that the photocatalytic activity of the catalyst without temperature control was higher than that under temperature control, and the primary reactive species were 1O2 and h+ without temperature control, while only 1O2 under temperature control. The possible activation site was speculated through in-situ Raman spectroscopy, XPS spectra, and cycling experiments. This research provides insight into enhancing the degradation rate of pollutants in photocatalysis by utilizing the photothermal effect on PMS activation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Shokraneh K. Moghaddam, Kazuhiro Saitou
Summary: In this paper, a new predictive-reactive rescheduling method based on the dynamic pegging concept is presented. It allows scheduling adjustments in a multi-level, mixed-model production system in response to un-planned events. The results indicate that implementing the predictive-reactive approach can significantly improve cost-efficiency in certain scenarios.
COMPUTERS & INDUSTRIAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Xuechun Wang, Jiana Jing, Minghua Zhou, Raf Dewil
Summary: This review critically discusses the application of H2O2-based advanced oxidation processes (AOPs) for the removal of antibiotics from wastewater. The article presents recent research progress in the combination of H2O2 with AOPs through different reaction mechanisms, recent advances in AOPs that can generate and activate H2O2 in situ, and the use of H2O2-based AOPs in combination with other techniques for the degradation and mineralization of antibiotics. Future research trends in H2O2-based AOPs are also discussed.
CHINESE CHEMICAL LETTERS
(2023)
Article
Electrochemistry
Brent Verhoeven, Maarten Nagels, Pieter Van Aken, Roberto Gaggiano, Barbara Rossi, Walter Bogaerts, Raf Dewil
Summary: A new 3D-printed sample holder was designed and validated for studying pitting corrosion of metals, which significantly improved the reliability and efficiency of the testing method by avoiding unrealistic crevice corrosion. The results showed that the designed sample holder enables more realistic and representative pitting results in corrosion research.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2023)
Article
Environmental Sciences
Izba Ali, Allisson Barros de Souza, Steven De Laet, Kwinten Van Eyck, Raf Dewil
Summary: A double chamber electrochemical system was developed, consisting of a boron-doped diamond anode and a graphite cathode, which efficiently degrades sulfamethoxazole (SMX) and generates hydrogen peroxide (H2O2) simultaneously. The system showed excellent performance at optimized conditions, achieving SMX degradation of 95% and COD reduction of 90% after 180 minutes of electrolysis, while accumulating around 535 μM H2O2. A degradation pathway for SMX was proposed based on the identification of five intermediates.
Review
Environmental Sciences
Yongtao Xue, Mohammadreza Kamali, Xi Zhang, Najmeh Askari, Clem De Preter, Lise Appels, Raf Dewil
Summary: Photocatalysis is a promising technology for water pollution removal. Recent advancements in various types of photocatalysts have addressed the limitations of conventional photocatalysts. However, challenges still exist in the design of photocatalytic reactors, particularly in their recovery and reuse from treated water. 3D printing technologies have emerged as a solution for immobilizing photocatalytic materials in novel reactor designs.
ENVIRONMENTAL POLLUTION
(2023)
Article
Green & Sustainable Science & Technology
Xi Zhang, Mohammadreza Kamali, Yongtao Xue, Shaoxian Li, Maria Elisabete V. Costa, Deirdre Cabooter, Raf Dewil
Summary: CuO was synthesized and characterized for the activation of periodate (PI) and exhibited improved degradation performance for ciprofloxacin (CIP). Both radical and nonradical degradation pathways were identified, with the nonradical pathway playing the most important role. The system showed improved efficiency under acidic or near-neutral conditions and demonstrated excellent removal efficiency for other organic contaminants in various water matrices.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Engineering, Environmental
Sven Poelmans, Maarten Nagels, Melanie Mignot, Raf Dewil, Deirdre Cabooter, Jan Dries
Summary: This study investigates the influence of pilot scale ozone treatment on reverse osmosis concentrate (ROC), showing that ozone oxidation has a beneficial effect on COD removal and enhances biodegradation potential, but also leads to the formation of ecotoxic by-products.
WATER SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Environmental
Xi Zhang, Matthias Verbist, Mohammadreza Kamali, Yongtao Xue, Yong Liu, Pengrui Jin, Maria Elisabete V. Costa, Lise Appels, Deirdre Cabooter, Raf Dewil
Summary: This study investigated the degradation kinetics and mechanisms of different types of recalcitrant organic pollutants (ROPs) using a biochar-CuO/periodate (PI) system. The study found that the pH had significant effects on the formation of oxidative species, with the system being most efficient at pH 7. The system was able to efficiently remove methylene blue (MB) at pH 7, while under highly alkaline pH values, the degradation kinetics of the pollutant were lower. The system maintained its efficiency for other types of ROPs and could detoxify MB.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Green & Sustainable Science & Technology
Mohammadreza Kamali, Yutong Guo, Tejraj M. Aminabhavi, Rouzbeh Abbassi, Raf Dewil, Lise Appels
Summary: Microbial fuel cells (MFCs) have the potential to simultaneously remove contaminants from wastewater and generate bioelectricity as a green and renewable source of energy. However, large-scale applications of these technologies face technical and economic issues related to the fabrication and performance of MFC components. Innovative approaches such as using waste-driven carbonaceous structures and novel fabrication techniques like 3-D printing are discussed to enhance the efficiency and reduce costs of MFCs. Integrations with other technologies and novel applications are reviewed for practical implementation of MFCs in sustainable wastewater treatment.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Green & Sustainable Science & Technology
Yimin Deng, Shuo Li, Lise Appels, Huili Zhang, Nick Sweygers, Jan Baeyens, Raf Dewil
Summary: Catalytic steam reforming of ethanol (CSRE) is a promising method for hydrogen production. Ethanol can be derived from low-cost carbohydrates or biomass through fermentation. This study explores the use of novel non-noble catalysts, impregnated in alpha-Al2O3, for CSRE. The catalytic experiments demonstrate high hydrogen yields and negligible catalyst deactivation. Pilot-scale investigations have been initiated.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Review
Biotechnology & Applied Microbiology
Sara Feijoo, Xiaobin Yu, Mohammadreza Kamali, Lise Appels, Raf Dewil
Summary: In response to the increasing presence of emerging contaminants in water streams, advanced oxidation processes have gained significant research interest due to their ability to effectively degrade recalcitrant compounds through the generation of oxidative radicals. This review paper provides insights into the generation methods of various oxidative species, with a focus on hydroxyl, sulfate, chlorine, and iodine radicals. Understanding the strengths and limitations of each generation route is crucial for future industrial applications. The review presents a comprehensive summary of different techniques that result in distinct radical types, and discusses the environmental and economic aspects of these methods.
REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY
(2023)
Review
Engineering, Environmental
Yong Liu, Xiaobin Yu, Mohammadreza Kamali, Xi Zhang, Sara Feijoo, S. M. Al-Salem, Raf Dewil, Lise Appels
Summary: This review summarizes the desirable physicochemical properties of biochar for its application as a catalyst or electrode material in electrochemical advanced oxidation processes. It also presents the mechanisms for electrocatalytic in-situ generation and activation of H2O2 by biochar in these processes, providing deeper insights into the degradation of organic pollutants. Additionally, modification strategies to improve the performance of biochar in these processes are addressed, along with the remaining challenges and future perspectives.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Allisson Barros de Souza, Joerg Mielcke, Izba Ali, Raf Dewil, Tom van de Goor, Deirdre Cabooter
Summary: This study examined the degradation of miconazole (MCZ) in water using ozone, photodegradation, and electrochemical processes. The results showed that MCZ can be efficiently removed by ozonation (98%) and electrochemical processes (94%). Matrix effects were observed in simulated wastewater, and the formation mechanism and ecological toxicity of degradation by-products were studied. Moreover, the automated online sampling technology provided a diagnostic tool for real-time process monitoring during water treatment.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Engineering, Environmental
Xi Zhang, Mohammadreza Kamali, Regory Van Beeck, Ward Hens, Jelto Truyen, Deirdre Cabooter, Raf Dewil
Summary: This study investigated the activation mechanisms of periodate by magnetite and found that the combined system exhibited superior degradation efficiency for ciprofloxacin. The study identified the key reactive species at different pH levels and confirmed the high thermal stability of periodate. The Fe3O4/IO4 system offers an efficient alternative for treating effluents containing ciprofloxacin.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Engineering, Environmental
Boyang Chen, Samet Azman, Raf Dewil, Lise Appels
Summary: This study provides a comprehensive examination and evaluation of the alkaline anaerobic digestion of livestock manure. It reveals that alkaline anaerobic digestion is a successful method for treating livestock manure, but there are still knowledge gaps and challenges in terms of economic analysis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)