Article
Pharmacology & Pharmacy
Sirinart Kumfu, Jirapas Sripetchwandee, Chanisa Thonusin, Natticha Sumneang, Chayodom Maneechote, Busarin Arunsak, Titikorn Chunchai, Thura Tun Oo, Aphisek Kongkaew, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Iron overload cardiomyopathy (IOC) is the leading cause of death in patients with iron overload. This study indicates that ferroptosis may play a dominant role in IOC, and inhibiting ferroptosis could be a potential novel treatment for improving cardiac function in iron-overloaded rats.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Cell Biology
Guojing Li, Yu Lin, Yili Zhang, Nihao Gu, Bingxin Yang, Shan Shan, Na Liu, Jing Ouyang, Yisai Yang, Feng Sun, Hong Xu
Summary: Endometriosis, a chronic disorder characterized by abnormal distribution of tissue, can cause iron overload and oxidative stress. The study found that ferroptosis of endometrial stromal cells can trigger the secretion of cytokines, promoting angiogenesis in adjacent lesions. VEGFA and IL8, important angiogenic factors, are upregulated in ectopic lesions. These findings provide a rationale for clinical practice and drug development for endometriosis.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Ameer Alakkal, Faisal Thayyullathil, Siraj Pallichankandy, Karthikeyan Subburayan, Anees Rahman Cheratta, Sehamuddin Galadari
Summary: Sanguinarine induces cell death in human cervical cancer cells through activation of both apoptosis and ferroptosis pathways. Apoptosis is characterized by caspase activation and PARP cleavage, while ferroptosis involves SLC7A11 down-regulation, GSH depletion, iron accumulation, and lipid peroxidation. These findings suggest that apoptosis and ferroptosis act as partners in Sanguinarine-mediated tumor suppression. Additionally, Sanguinarine increases the generation of reactive oxygen species (ROS), and inhibiting ROS blocks the induction of both apoptosis and ferroptosis.
Review
Cell Biology
Lai-Hua Xie, Nadezhda Fefelova, Sri Harika Pamarthi, Judith K. Gwathmey
Summary: Ferroptosis is a regulated non-apoptotic cell death characterized by iron-dependence and the accumulation of lipid peroxidation. Excessive iron promotes the generation of soluble and lipid ROS through an iron-dependent Fenton reaction and lipoxygenase (LOX) enzyme activity, inducing ferroptosis. Cytosolic glutathione peroxidase 4 (cGPX4) and mitochondrial glutathione peroxidase 4 (mGPX4) serve as defense systems to detoxify lipid peroxidation in the cytoplasmic and mitochondrial membrane, respectively, defending against ferroptosis under normal conditions.
Review
Cell Biology
Yangshuo Li, Yalun He, Wen Cheng, Zhihao Zhou, Zhexin Ni, Chaoqin Yu
Summary: Endometriosis is strongly associated with infertility, and the mechanisms by which it affects fertility have not been fully elucidated. Iron overload may be one of the mechanisms that lead to endometriosis-related infertility, causing damage to ovarian granulosa cells, oocytes, and embryos. This article summarizes the possible mechanisms of iron overload and explores its impact on endometriosis-related infertility.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Shuzheng Tan, Ying Kong, Yongtong Xian, Pengbo Gao, Yue Xu, Chuzhong Wei, Peixu Lin, Weilong Ye, Zesong Li, Xiao Zhu
Summary: Ferroptosis is a newly discovered non-apoptotic cell death mode that is distinct from classical cell death modes. It is characterized by the accumulation of iron dependence and lipid peroxides. Identifying key sites of ferroptosis in diseases is crucial, and it is also linked to tumor development, providing personalized plans for cancer patients. Despite the need for further study on its mechanisms and side effects, ferroptosis remains a promising method for cancer treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guanpeng Xu, Xi Li, Zhiyong Zhu, Huisheng Wang, Xizhuang Bai
Summary: Iron overload can lead to apoptosis and autophagy in osteoblast cells, as well as increased production of reactive oxygen species (ROS), which may serve as a novel approach for treating iron overload-induced osteoporosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jiedong Ma, Hongqi Zhang, Yufei Chen, Xiaojin Liu, Jiamin Tian, Wei Shen
Summary: This article summarizes the role of iron overload and ferroptosis in macrophages in the development of AS from the perspective of iron metabolism, highlighting their significant contribution to AS progression.
Review
Pharmacology & Pharmacy
Meng Zhang, Qian Lei, Xiaobo Huang, Yi Wang
Summary: This study reviews the role and mechanism of ferroptosis in glioblastoma, as well as the research status and progress on ferroptosis as a potential therapeutic target. The mechanism of ferroptosis is related to intracellular iron metabolism level, lipid peroxide content, and glutathione peroxidase 4 activity. While ferroptosis holds promise as a therapeutic target for glioblastoma, its relation to other apoptosis methods is poorly understood and methods of applying ferroptosis to drug-resistant tumors are insufficiently explored.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Wan Ma, Li Jia, Qingqing Xiong, Huahua Du
Summary: Iron overload protects mice from obesity, especially under high-fat diet conditions, by triggering imbalanced glycolipid metabolism in the liver and reducing lipid accumulation through decreased PLIN2 protein levels and induction of ferroptosis.
Article
Cell Biology
Yanchun Li, Xin Wang, Zhihui Huang, Yi Zhou, Jun Xia, Wanye Hu, Xu Wang, Jing Du, Xiangmin Tong, Ying Wang
Summary: CISD3 plays a crucial regulatory role in cancer progression and ferroptosis, with its overexpression associated with poorer survival rates, while its depletion accelerates ferroptotic cell death. Depletion of CISD3 leads to metabolic reprogramming towards glutaminolysis, which is essential for mitochondrial oxidative phosphorylation.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Jingmin Che, Huanhuan Lv, Jiancheng Yang, Bin Zhao, Sibo Zhou, Tongyao Yu, Peng Shang
Summary: In this study, iron overload induced apoptosis in osteoblasts through activating ER stress, resulting in mitochondrial dysfunction. Pretreatment with NAC or TUDC attenuated cell apoptosis and restored protein expression related to iron metabolism.
CELLULAR SIGNALLING
(2021)
Article
Environmental Sciences
Lu Yu, Zhanjun Lv, Siyu Li, Huijie Jiang, Biqi Han, Xiaoyan Zheng, Yunfeng Liu, Zhigang Zhang
Summary: This study found that long-term exposure to arsenic in the environment can cause liver injury in chickens, which is induced by activating autophagy to degrade ferritin and promote iron-dependent lipid peroxidation, leading to cell death. Blocking this process may provide insights for preventing and treating liver injury induced by environmental arsenic exposure in livestock and poultry.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Ke Gu, Aimin Wu, Bing Yu, Tingting Zhang, Xin Lai, Junzhou Chen, Hui Yan, Ping Zheng, Yuheng Luo, Junqiu Luo, Junning Pu, Quyuan Wang, Huifen Wang, Daiwen Chen
Summary: Iron plays a pivotal role in intestinal inflammation, ferroptosis, and the modulation of the gut microbiome. This study found that iron overload exacerbated colitis in mice by modulating ferroptosis and perturbing the gut microbiota. Specific microbial taxa and their associated metabolites were closely intertwined with both colitis and ferroptosis markers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Clinical Neurology
Xiao-Ling Fang, Shao-Yun Ding, Xiao-Zheng Du, Jin-Hai Wang, Xing-Lan Li
Summary: Stroke is a neurological disease with complex mechanisms involving neuroinflammation, oxidative stress, apoptosis, autophagy, and excitotoxicity. Ferroptosis, a form of iron-dependent regulated cell death, has been found to be closely related to the onset and development of stroke. Understanding the relationship between ferroptosis and stroke may lead to more effective treatment strategies.
FRONTIERS IN NEUROLOGY
(2022)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)