Article
Medicine, General & Internal
Zhi-Hong Sun, Chuang Chen, Xin-Wen Kuang, Jun-Long Song, Sheng-Rong Sun, Wei-Xing Wang
Summary: This study found that, compared to mastectomy, breast-conserving therapy (BCT) can provide better breast cancer-specific survival and overall survival benefits in young white patients under 40 with early-stage breast cancer, especially in the 36 to 40 years age group.
Article
Oncology
Fei Wang, Ingrid Meszoely, Tuya Pal, Ingrid A. Mayer, Christina E. Bailey, Wei Zheng, Xiao-Ou Shu
Summary: The study found that elderly patients aged 70 and above who had undergone breast-conserving surgery for early-stage breast cancer had higher mortality rates if they did not receive post-surgery radiotherapy. This suggests that the current recommendations for radiotherapy omission in this patient group may need to be reconsidered.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Dang Van Nguyen, Sang-Won Kim, Young-Taek Oh, O. Kyu Noh, Yongsik Jung, Mison Chun, Dae Sung Yoon
Summary: Young women undergoing breast conserving therapy have a higher risk of local recurrence compared to mastectomy alone. Despite aggressive salvage treatments, those with local recurrence after breast conserving therapy have poor prognosis. Novel systemic treatments are needed to improve outcomes for young women with breast cancer undergoing breast conserving therapy.
Article
Surgery
Quyen D. Chu, Mei-Chin Hsieh, Yong Yi, John M. Lyons, Xiao-Cheng Wu
Summary: A study was conducted to evaluate the outcomes of breast-conserving therapy (BCT) and mastectomy (MST) for women with early-stage breast cancer (ESBC). The results showed that BCT yielded better survival rates than MST for all subtypes of ESBC. The role of mastectomy in the treatment of ESBC should be reassessed in future clinical trials.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Oncology
Song Wang, Yiyuan Zhang, Fangxu Yin, Xiaohong Wang, Zhenlin Yang
Summary: In women with early-stage IMPC, breast-conserving treatment was found to be at least equivalent to mastectomy in terms of survival outcomes. BCT should be recommended as the standard surgical treatment, especially for patients with T2 disease, when both procedures are feasible.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Mohammad Shoaib Abrahimi, Mark Elwood, Ross Lawrenson, Ian Campbell, Sandar Tin Tin
Summary: This study investigated the type of loco-regional treatment and associated factors in New Zealand women with early-stage breast cancer eligible for breast conserving surgery. Results showed variations in the receipt of BCS+RT across demographic and clinical factors, with higher breast cancer-specific mortality risk for women receiving MTX alone compared to BCS+RT. Further research is needed to explore the potential advantages of BCS+RT over alternative treatments.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Jiali Ji, Shushu Yuan, Jiawei He, Hong Liu, Lei Yang, Xuexin He
Summary: This study compared the efficacy of breast-conserving therapy (BCT) and mastectomy in early-stage breast cancer patients using the SEER database. The results showed that BCT was associated with improved overall survival (OS) and breast cancer-specific survival (BCSS) compared to mastectomy. Patients with different subtypes and age groups also showed better survival outcomes with BCT compared to mastectomy.
Article
Oncology
Junsheng Zhang, Ciqiu Yang, Chuqian Lei, Yi Zhang, Fei Ji, Hongfei Gao, Mei Yang, Liulu Zhang, Jieqing Li, Teng Zhu, Weiping Li, Xiaosheng Zhuang, Kun Wang
Summary: This study demonstrated that early-stage MBC patients who underwent BCT had significantly improved overall survival and breast cancer-specific survival compared to those who underwent mastectomy. The improvement was consistent across almost all different T and N stages subgroups.
Article
Oncology
Shengyu Pu, Shaoran Song, Heyan Chen, Can Zhou, Huimin Zhang, Ke Wang, Jianjun He, Jian Zhang
Summary: Breast-conserving surgery (BCS) may bring better overall survival and breast cancer-specific survival for young breast cancer patients. A model was constructed to identify appropriate candidates who benefit from BCS.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Quyen D. Chu, Mei-Chin Hsieh, John M. Lyons, Xiao-Cheng Wu
Summary: Louisiana has a high breast cancer mortality rate despite a lower incidence rate. Research has shown that compared to breast-conserving surgery plus radiation, mastectomy leads to poorer overall survival and breast cancer-specific survival rates.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Oncology
Hakyoung Kim, Sae Byul Lee, Seok-Jin Nam, Eun Sook Lee, Byeong-Woo Park, Ho Yong Park, Hyouk Jin Lee, Jisun Kim, Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn
Summary: This study evaluated the long-term outcomes of Korean women with early breast cancer undergoing breast-conserving surgery plus radiotherapy or total mastectomy. Findings showed that the breast-conserving surgery plus radiotherapy group had better overall survival and breast cancer-specific survival than the total mastectomy group in both the Korean Breast Cancer Registry and Asan Medical Center cohorts. The results suggest that breast-conserving surgery plus radiotherapy is at least equivalent to total mastectomy in terms of overall survival and may influence treatment decisions for early breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Weimin Xie, Min Cao, Zhen Zhong, Zongshuai Huang, Xiaqiu Gao, Zicheng Li
Summary: The study aimed to compare the efficacy of breast conserving surgery (BCS) and mastectomy in elderly breast cancer patients, and found that the two surgical procedures were comparable in overall survival rate after being matched by clinicopathologic features.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Letter
Medicine, General & Internal
Marie Fefferman, Kyra Nicholson, Kristine Kuchta, Catherine Pesce, Katherine Kopkash, Katharine Yao
Summary: This study builds on previous research to assess the ongoing increase in rates of bilateral mastectomy using the National Cancer Database.
Article
Oncology
Maria Paz Galeano Machuca, Wen-Ching Wu, Ben-Long Yu, Chih-Tao Cheng
Summary: This study used nationwide data and found that demographic and clinical factors, such as age, pay-for-performance program participation, number of affected lymph nodes, tumor size, and tumor location, are associated with the use of breast-conserving therapy.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Ivica Ratosa, Gaber Plavc, Nina Pislar, Tina Zagar, Andraz Perhavec, Pierfrancesco Franco
Summary: This study compared survival outcomes in 1360 patients with early-stage breast cancer, showing that patients treated with breast-conserving therapy had lower rates of recurrence and equivalent overall survival compared to those treated with mastectomy alone. The findings emphasize the importance of adjuvant treatments, including radiation therapy, in improving disease-specific outcomes for early-stage breast cancer patients.
