Review
Biochemistry & Molecular Biology
Han Ah Lee, Hwi Young Kim
Summary: Nonalcoholic fatty liver disease (NAFLD) can lead to liver fibrosis and cirrhosis. Glucagon-like peptide 1 receptor agonists (GLP-1RAs), used for treating type 2 diabetes and obesity, have shown therapeutic effects against NAFLD by improving clinical, biochemical, and histological markers of hepatic steatosis, inflammation, and fibrosis. GLP-1RAs have a good safety profile and show promise as a potential treatment for NAFLD, but further research is needed to determine their long-term safety and efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yuya Seko, Kanji Yamaguchi, Kota Yano, Yusuke Takahashi, Kento Takeuchi, Seita Kataoka, Michihisa Moriguchi, Yoshito Itoh
Summary: Both genetic and metabolic factors have an impact on the pathology of nonalcoholic fatty liver disease (NAFLD). This study found that obesity, diabetes mellitus, and genetic risk factors (alleles of PNPLA3 or HSD17B13) contribute to the risk of nonalcoholic steatohepatitis (NASH) and fibrosis in NAFLD patients. The risk increases with the number of genetic and metabolic risk factors.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Mohammad Shadab Siddiqui, Deven Parmar, Farheen Shaikh, Mikael Forsgren, Samarth Patel, Anh Tuan Bui, Sherry Boyett, Vaishali Patel, Arun J. Sanyal
Summary: This study evaluated the safety and efficacy of saroglitazar in the treatment of post-liver transplantation NAFLD and metabolic burden. Results showed that saroglitazar treatment led to a reduction in liver fat and improvement in metabolic parameters. There was a mild increase in visceral adipose tissue and abdominal subcutaneous adipose tissue, but no effect on muscle fat infiltration or fat-free muscle volume.
LIVER TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Jiarong Xie, Hangkai Huang, Zhening Liu, Youming Li, Chaohui Yu, Lei Xu, Chengfu Xu
Summary: This study systematically explored the relationships between genetically predicted modifiable risk factors and NAFLD. The results showed that genetically predicted alcohol frequency, elevated serum liver enzymes, obesity traits, T2DM, and hypertension were associated with an increased risk of NAFLD, while higher education and HDL-cholesterol were associated with a decreased risk of NAFLD.
Editorial Material
Gastroenterology & Hepatology
Manal F. Abdelmalek
Summary: In 2020, there were significant advances in nonalcoholic fatty liver disease, including new insights into pathophysiology, advancements in non-invasive diagnostics, and the publication of interim results from the first phase III trial showing improvement in hepatic fibrosis.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jiayi Yi, Lili Wang, Jiajun Guo, Xiangpeng Ren
Summary: This study identified three clinically meaningful phenotypes among NAFLD patients, with Cluster 1 patients having the best prognosis and Cluster 2 and 3 patients having higher risks of all-cause and cardiovascular mortality. The study highlights the substantial disease heterogeneity that exists among NAFLD patients and emphasizes the need for precise assessments to define phenotypes and improve clinical practice.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Judith van Dalem, Johanna H. M. Driessen, Andrea M. Burden, Coen D. A. Stehouwer, Olaf H. Klungel, Frank de Vries, Martijn C. G. J. Brouwers
Summary: The study found that patients prescribed TZDs had a lower risk of NAFLD, while there was no significant difference in NAFLD risk between GLP-1 receptor agonist use and insulin use.
Review
Biochemistry & Molecular Biology
Haoyu Tian, Shuairan Zhang, Ying Liu, Yifan Wu, Dianbao Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic condition associated with metabolic dysfunction and obesity, and has become an epidemic worldwide. There is currently no FDA-approved drug for NAFLD, but fibroblast growth factors (FGFs) have shown promising therapeutic benefits in clinical trials. FGF-based therapies, particularly FGF analogs, have been effective in treating NAFLD by alleviating steatosis, liver inflammation, and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Sadatsugu Sakane, Hayato Hikita, Kumiko Shirai, Yuta Myojin, Youichi Sasaki, Shinnosuke Kudo, Kenji Fukumoto, Naoki Mizutani, Yuki Tahata, Yuki Makino, Ryoko Yamada, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Summary: The study showed that autophagy was enhanced in white adipose tissues of mice fed a high-fat diet, and inhibition of autophagy in adipose tissues can ameliorate the liver pathology of NAFLD through adipose-liver crosstalk.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zobair M. Younossi, Maria Stepanova, Sean Felix, Thomas Jeffers, Elena Younossi, Zachary Goodman, Andrei Racila, Brian P. Lam, Linda Henry
Summary: This study determined the cutoff scores of two non-invasive tests (NITs) to assess significant fibrosis in NAFLD patients. The combination of ELF and FIB-4 can assist practitioners in risk stratification of NAFLD patients for referral to specialists or enrollment in clinical trials.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Haifeng Lv, Yanming Jiang, Geli Zhu, Shiyi Liu, Dian Wang, Jie Wang, Ke Zhao, Jing Liu
Summary: This case-control study aimed to identify the clinical characteristics and explore the risk factors for liver fibrosis in MAFLD patients with HBV infection. The study found that patients in the MAFLD + HBV group had lower steatosis scores and ballooning, but higher inflammation scores and liver fibrosis stages compared to the MAFLD group. After adjusting for confounding factors, HBV infection was associated with a higher risk of significant liver fibrosis in MAFLD patients. Further analysis identified hypertension, type 2 diabetes, and elevated glutamyl-transferase levels as risk factors for liver fibrosis in the MAFLD + HBV group.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Te-Jung Chuang, Chung-Wang Ko, Sz-Iuan Shiu
Summary: For patients with NAFLD/NASH, duodenal mucosal resurfacing (DMR) has the trend to improve liver fat at 12 weeks, but the impact on glycemic control in terms of HbA1c level at 24 weeks is not significant.
Article
Gastroenterology & Hepatology
Sanjaya K. Satapathy, Quynh T. Tran, Alexander J. Kovalic, Sai Vineela Bontha, Yu Jiang, Satish Kedia, Saradashri Karri, Vamsee Mupparaju, Pradeep S. B. Podila, Rajanshu Verma, Daniel Maluf, Valeria Mas, Satheesh Nair, James D. Eason, Dave Bridges, David E. Kleiner
Summary: Increase in BMI post-LT is strongly associated with NAFLD recurrence, while post-LT diabetes mellitus is linked to increased severity of NAFLD recurrence. Genetic factors such as ADIPOR1 rs10920533 in the recipient are associated with an increased risk of moderate to severe NAFLD recurrence, while SOD2 rs4880 is associated with a reduced risk.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Review
Multidisciplinary Sciences
George Agyapong, Farzaneh Dashti, Bubu A. A. Banini
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and a leading indication for liver transplantation in the United States. This manuscript provides an overview of NAFLD risk factors, natural history, diagnosis, and current management strategies.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Yu-Guang Chen, Chih-Wei Yang, Chi-Hsiang Chung, Ching-Liang Ho, Wei-Liang Chen, Wu-Chien Chien
Summary: This study emphasizes the significance of metabolic dysfunction in hepatocarcinogenesis of patients with NAFLD. It also suggests that the coexistence of multiple metabolic risk factors increases the risk of developing liver cancer in these patients.
HEPATOLOGY INTERNATIONAL
(2022)
Article
Engineering, Multidisciplinary
Sadia Murawwat, Hafiz M. Asif, Sana Ijaz, Muhammad Imran Malik, Kaamran Raahemifar
Summary: A hybrid technique using MEMD and ANN is proposed for detecting and classifying Arrhythmia, achieving higher accuracy compared to other existing techniques.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Environmental Sciences
Hamza Khurshid, Rafia Mumtaz, Noor Alvi, Ayesha Haque, Sadaf Mumtaz, Faisal Shafait, Sheraz Ahmed, Muhammad Imran Malik, Andreas Dengel
Summary: Water is a vital resource for sustaining life on Earth, and its quality has become increasingly important due to rising water pollution and depletion of freshwater sources. Developing countries with low control over water pollution are likely to have poor public health. The current methods used in most developing countries are ineffective and rely heavily on human intervention rather than technological and automated solutions. There is an urgent need to develop a proper and systematic system for regularly monitoring and managing water quality. Internet of Things (IoT) offers a great alternative to traditional approaches, allowing remote real-time measurements with minimal human involvement. The proposed system consists of water quality measuring nodes with various sensors, transmitting data to a server for analysis and processing. Machine learning algorithms are employed for water quality classification and bacterial prediction. A web portal is developed for data visualization, displaying heat maps and other infographics. The system provides an alternative and convenient solution for bacterial prediction, offering advantages such as remote monitoring, ease of scalability, real-time water quality status, and portable hardware.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2022)
Article
Computer Science, Artificial Intelligence
Muhammad Nabeel Asim, Muhammad Ali Ibrahim, Muhammad Imran Malik, Imran Razzak, Andreas Dengel, Sheraz Ahmed
Summary: The study presents an improved computational framework, Histone-Net, for accurate prediction of histone occupancy and modifications. By generating higher order residue embeddings and incorporating language modeling, Histone-Net demonstrates good performance on multiple histone markers.
COMPLEX & INTELLIGENT SYSTEMS
(2023)
Article
Chemistry, Physical
Daim Asif Raja, Sana Rahim, Muhammad Raza Shah, Muhammad Iqbal Bhanger, Muhammad Imran Malik
Summary: Metal nanoparticles capped with polymers, such as the polypropylene glycol (PPG) capped silver nanoparticles (PPG-AgNPs) synthesized in this study, have been used for analytical and biomedical applications. The PPG-AgNPs were characterized using various techniques and were found to be highly stable. They were employed as a chemosensor for the insecticide Carbaryl, enabling the quantitative, rapid, selective, and efficient detection of Carbaryl in various samples. The PPG-AgNPs based sensor showed great potential for on-spot detection of Carbaryl in ecological, biological, and food samples.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Analytical
Humaira Khan, Muhammad Raza Shah, Jiri Barek, Muhammad Imran Malik
Summary: The article provides a brief history of cancer biomarker discovery and presents statistical data on detection strategies in the past decade. It emphasizes the importance of developing sensitive, cost-effective, and portable monitoring systems for a wide range of biomarkers. The article focuses on the utilization of electrochemical detection methods and discusses the limitations and challenges in this field.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Ho Soonmin, Pronoy Hardani, Pronoy Nandi, Benard Samwel Mwankemwa, Thembinkosi Donald Malevu, Muhammad Imran Malik
Summary: Solar energy, which is free from noise and environmental pollution, can replace limited non-renewable sources such as fossil fuels. The development of solar cells has improved from the first generation (crystalline silicon solar cells) to thin-film, dye-sensitized, perovskite, and organic solar cells. This article discusses the advantages, limitations, challenges, and future trends of these solar cells and highlights the importance of promoting solar energy and improving power conversion efficiency.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Analytical
Aqsa Aijaz, Daim Asif Raja, Farooq-Ahmad Khan, Jiri Barek, Muhammad Imran Malik
Summary: A colorimetric assay based on branched polyethyleneimine-conjugated silver nanoparticles (PEI-AgNPs) has been developed for the on-spot detection of ciprofloxacin (CIP) in the environment. The method exhibits high sensitivity, selectivity, and efficiency for the quantification of CIP in a linear dynamic range of 0.1-200 μM, with a limit of detection (LOD) of 0.038 μM and limit of quantification (LOQ) of 0.12 μM. The proposed method is capable of detecting CIP in complex samples and outperforms UV-Vis spectroscopy and UPLC in terms of performance.
Article
Engineering, Electrical & Electronic
Saqiba Riaz, Muhammad Azhar Ansari, Daim Asif Raja, Hajira Tahir, Muhammad Imran Malik
Summary: Solar cells convert solar energy into electrical energy. Inorganic solar cell production is expensive and poses environmental issues, so there is a need for alternative options. Organic material-based solar cells are a viable alternative due to their low cost and ease of production. However, their low stability and limited lifetime have been obstacles to commercial use. The optoelectronic properties of donor and acceptor materials can be improved, and incorporating different metallic nanoparticles in the donor material opens up possibilities for tuning the materials to match the acceptor material's energy levels.
OPTICAL AND QUANTUM ELECTRONICS
(2023)
Article
Materials Science, Multidisciplinary
Owais Ahmad, Irfan Qasim, Syed M. Hasnain, Zain ul Abdin, Muhammad Farooq Nasir, Muhammad Imran Malik, Asim Rashid
Summary: A study has been conducted to design higher efficiency modules for low-cost, non-toxic Au/Spiro-OmeTAD/CIGS/MASnI3/CdS/ZnO/FTO tandem configuration solar cells using the solar cell capacitance simulator package SCAPS-1D. The selection of appropriate layer materials, such as ZnO, CIGS, MASnI3, Spiro-OmeTAD, and CdS, has been developed to achieve highly efficient device performance. The optimized layer thicknesses for HTL, ETL, buffer layer, and absorber layers are 0.084 μm, 0.051 μm, 0.028 μm, 2.10 μm, and 1.51 μm respectively, resulting in a power conversion efficiency of 36.38%.
ORGANIC ELECTRONICS
(2023)
Article
Multidisciplinary Sciences
Zain ul Abdin, Irfan Qasim, Muhammad Imran Malik, Muhammad Rashid
Summary: Inorganic metal halide perovskite materials have attracted attention for their optoelectronic merits, and Potassium Tin Chloride (KSnCl3) has been synthesized and analyzed for its optical and structural properties. Experimental and theoretical investigations suggest potential applications in optoelectronic devices and photovoltaic technology. Simulation models predict high efficiency solar cell configurations using KSnCl3 and other materials. The thermally stable nature of KSnCl3 makes it a promising candidate for large-scale manufacturing of optoelectronic applications.
Review
Chemistry, Analytical
Zainab Zaman, Saad Bin Ahmed, Muhammad Imran Malik
Summary: "Recent advances in hyperspectral data analysis for document images" is a comprehensive overview of the latest developments in hyperspectral data analysis. It covers fundamental concepts, data acquisition techniques, preprocessing, feature extraction, and classification methods. The paper also explores the potential of hyperspectral imaging in addressing challenges in document analysis and discusses future research directions.
Review
Gastroenterology & Hepatology
Adnan Malik, Mahum Nadeem, Waseem Amjad, Muhammad Imran Malik, Sadia Javaid, Umer Farooq, Khadija Naseem, Ahmad Khan
Summary: This study evaluated the efficacy of Aramchol in patients with NAFLD and found that it did not significantly improve biochemical markers such as ALT, AP, HbA1c, TC, TG, HOMA-IR, and insulin levels.
GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Imran Malik
Summary: This study reports the synthesis of a series of novel epoxy-terminated macromonomers and the subsequent polymerization to form block copolymers with brush-like architectures. The results provide insights into the influence of different network structures on the properties of polymers.
Article
Medicine, General & Internal
Ahmadullah, Sunil Kumar Panjwani, Muhammad Imran Malik, Mahmood Ahmed Memon, Shahzad Ali, Mehran Khan Lashari
Summary: This study aimed to determine the mean SSD for successful disintegration of renal stones in patients undergoing SWL for treatment. The results showed that SSD was associated with complete stone disintegration, and SSD was higher in overweight and obese patients.
RAWAL MEDICAL JOURNAL
(2022)
