Electrostatic influence on IL-1 transport through the GSDMD pore

NINJ1 mediates plasma membrane rupture during lytic cell death

(2021) Nobuhiko Kayagaki et al.   NATURE

Channelling inflammation: gasdermins in physiology and disease

(2021) Xing Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

(2021) Kshiti Phulphagar et al.   Cell Reports

Gasdermin D pore structure reveals preferential release of mature interleukin-1

(2021) Shiyu Xia et al.   NATURE

Migration of ions near charged surface

(2021) Kiwoong Kim   PLoS One

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

(2021) Elisabet Bjanes et al.   PLoS Pathogens

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization

(2019) Zhonghua Liu et al.   IMMUNITY

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Mechanism and Regulation of Gasdermin-Mediated Cell Death

(2019) Shiyu Xia et al.   Cold Spring Harbor Perspectives in Biology

Inflammasome signaling and regulation of interleukin-1 family cytokines

(2019) Amy H. Chan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Cryo-EM structure of the gasdermin A3 membrane pore

(2018) Jianbin Ruan et al.   NATURE

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mean First-Passage Times in Biology

(2016) Nicholas F. Polizzi et al.   ISRAEL JOURNAL OF CHEMISTRY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Refining the treatment of membrane proteins by coarse-grained models

(2015) Igor Vorobyov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A model for membrane potential and intracellular ion distribution

(2014) A.K. Khitrin et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Ionic protein–lipid interaction at the plasma membrane: what can the charge do?

(2014) Lunyi Li et al.   TRENDS IN BIOCHEMICAL SCIENCES