Article
Biochemistry & Molecular Biology
Michitaka Fujiwara, Farhana Ferdousi, Hiroko Isoda
Summary: With the progression of an aging society, cognitive aging has become an urgent concern. This study uses the senescence-accelerated mouse-prone 8 (SAMP8) model to investigate molecular changes in the brain cortex, identifying key functional alterations and candidate genes associated with brain aging, as well as pivotal hub genes involved in these functional domains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Avital Sternin, Lucy M. McGarry, Bobby Stojanoski, Jessica A. Grahn, Adrian M. Owen
Summary: Our study explored the impact of repeated exposure on intersubject synchrony in the brains of young and older adults. Using fMRI, we measured brain responses to familiar and novel stimuli. Surprisingly, synchrony was not influenced by the amount of exposure, as both young and older adults showed more synchrony to novel stimuli. Synchrony differences were found in various brain regions, emphasizing the importance of considering exposure effects in future studies.
Article
Biochemistry & Molecular Biology
Candida Dias, Eliana Fernandes, Rui M. Barbosa, Joao Laranjinha, Ana Ledo
Summary: This study demonstrates that lactate, produced by astrocytes through aerobic glycolysis, is used as an oxidative fuel by neurons in hippocampal tissue. The presence of excess glucose does not hinder the utilization of lactate for oxidative metabolism. Neurons take up lactate from the extracellular space via a neuronal lactate transporter, supporting the concept of an inward flux of lactate for neuronal oxidative metabolism.
Article
Plant Sciences
Qiang-Song Wang, Kuo Yan, Kuang-Dai Li, Li-Na Gao, Xu Wang, Haibo Liu, Zuoguang Zhang, Kefeng Li, Yuan-Lu Cui
Summary: Albiflorin demonstrates rapid antidepressant effects in animal models of depression by restoring common metabolic abnormalities in the hippocampus, particularly in phospholipid and tryptophan metabolism, through mechanisms involving the suppression of hippocampal cytosolic phospholipases A2 and normalization of the kynurenine pathway of tryptophan metabolism. This study provides insights into the homogeneous metabolic mechanisms of depression and suggests a potential rapid treatment approach targeting dysregulated neurometabolic pathways.
Review
Biochemistry & Molecular Biology
Konrad Kaminiow, Izabella Rygula, Justyna Paprocka
Summary: There are over 150 inherited metabolic disorders that can present as ataxia in children. Neuroimaging studies and genetic studies are essential for diagnosis. Prompt treatment can positively influence neurodevelopment.
Article
Psychology, Biological
Yuguang Zhao, Peiying Liu, Monroe P. Turner, Dema Abdelkarim, Hanzhang Lu, Bart Rypma
Summary: Studies indicate a close relationship between neural-vascular coupling and cognition, challenging the hemodynamic equivalence assumption. Through research elucidating the relationships between cognition, cerebrovascular dynamics, and aging, a theory about the decline in processing speed in aging and its relation to age-related neural-vascular coupling changes has been proposed.
Article
Neurosciences
Celine Maes, Koen Cuypers, Ronald Peeters, Stefan Sunaert, Richard A. E. Edden, Jolien Gooijers, Stephan P. Swinnen
Summary: Recent studies emphasize the important role of the principal inhibitory neurotransmitter GABA in motor performance during aging. Behavioral results indicate poorer motor performance in older adults compared to young adults. Moreover, a transient task-related decrease in GABA+ levels was observed during task execution, which was linked to task-related brain activity patterns.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Didac Vidal-Pineiro, Markus H. Sneve, Inge K. Amlien, Hakon Grydeland, Athanasia M. Mowinckel, James M. Roe, Oystein Sorensen, Lars H. Nyberg, Kristine B. Walhovd, Anders M. Fjell
Summary: It is suggested that specific forms of cognition in older age rely largely on late-life specific mechanisms. However, using task-fMRI, researchers found that the functional foundations of successful episodic memory encoding adhere to a principle of lifespan continuity, with no evidence of age-specific mechanisms. The study provides novel support for a broader perspective on memory aging that considers maintenance and decay of episodic memory throughout life rather than just in old age.
Article
Psychology, Multidisciplinary
Tian Lin, Didem Pehlivanoglu, Maryam Ziaei, Peiwei Liu, Adam J. Woods, David Feifel, Hakan Fischer, Natalie C. Ebner
Summary: The study found that older adults show dampened response to faces with lower trustworthiness compared to young adults, supporting the idea of reduced sensitivity to cues of untrustworthiness in aging. Additionally, the results extend evidence of an age-related positivity effect to the evaluation of face trustworthiness.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Biochemical Research Methods
Jesus Cabrera-Alvarez, Nina Doorn, Fernando Maestu, Gianluca Susi
Summary: In this study, computational models were used to investigate the role of the thalamus in generating brain synchrony at rest. The findings suggest that the structural connectivity of the thalamus is not its primary contribution to brain synchrony. Instead, the thalamus plays a critical role in driving cortical activity.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Immunology
Natalia C. Guimaraes, Debora S. Alves, Wembley R. Vilela, Eduardo de-Souza-Ferreira, Bruna R. B. Gomes, Daniela Ott, Jolanta Murgott, Paulo E. N. de Souza, Marcelo de Sousa, Antonio Galina, Joachim Roth, Andreza Fabro de Bem, Fabiane H. Veiga-Souza
Summary: The study suggests that using MPC inhibitor UK 5099 in rats can alleviate LPS-induced fever, reduce hypothalamic mitochondrial function, and neuroinflammation. Pre-treatment with UK 5099 can affect LPS-induced oxygen consumption, ATP synthesis, and spare capacity, decreasing mitochondrial H2O2 production. Additionally, UK 5099 treatment can decrease the secretion of proinflammatory cytokines and the immunoreactivity of inflammatory transcription factors in rat POA microcultures after LPS stimulation.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Chris B. Martin, Bryan Hong, Rachel N. Newsome, Katarina Savel, Melissa E. Meade, Andrew Xia, Christopher J. Honey, Morgan D. Barense
Summary: The act of remembering everyday experiences affects our perception of the world, future thinking, and self-perception. However, the ability to recall specific details and relive the past tends to decline with age. To address this, a smartphone application called HippoCamera was developed to help older adults enhance their episodic memory. By repeatedly reactivating memories of real-world events, participants experienced improved recollection and more positive emotions. These benefits were observed shortly after the intervention and even after a 3-month delay.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Roni Setton, Laetitia Mwilambwe-Tshilobo, Signy Sheldon, Gary R. Turner, R. Nathan Spreng
Summary: Recollection of personal past, or autobiographical memory (AM), varies across individuals and the life span, and is associated with functional brain networks. Older adults showed lower connectivity within certain brain regions but greater connectivity with the default network compared to younger adults. The connectivity patterns were related to specific types of memories.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Masaya Misaki, Kara L. Kerr, Erin L. Ratliff, Kelly T. Cosgrove, W. Kyle Simmons, Amanda Sheffield Morris, Jerzy Bodurka
Summary: This article focuses on the application and analysis methods of fMRI hyperscanning in social interaction research, highlighting the potential of studying fundamental aspects of social cognition with this technique.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Lisa Byrge, Dorit Kliemann, Ye He, Hu Cheng, J. Michael Tyszka, Ralph Adolphs, Daniel P. Kennedy
Summary: This study examines the consistency of brain responses to videos across different data acquisition sites in functional magnetic resonance imaging (fMRI). The results show that video-evoked brain responses have high consistency across different sites, which has implications for studying individual differences in healthy and clinical populations.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Jiook Cha, Daniel DeDora, Sanja Nedic, Jaime Ide, Tsafrir Greenberg, Greg Hajcak, Lilianne Rivka Mujica-Parodi
JOURNAL OF NEUROSCIENCE
(2016)
Article
Clinical Neurology
Joshua M. Carlson, Denis Rubin, Lilianne R. Mujica-Parodi
PSYCHIATRY RESEARCH-NEUROIMAGING
(2017)
Article
Neurosciences
Jaime S. Ide, Sanja Nedic, Kin F. Wong, Shmuel L. Strey, Elizabeth A. Lawson, Bradford C. Dickerson, Lawrence L. Wald, Giancarlo La Camera, Lilianne R. Mujica-Parodi
Article
Multidisciplinary Sciences
Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, Kieran Clarke
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Clinical Neurology
Lilianne R. Mujica-Parodi, Helmut H. Strey
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2020)
Review
Neurosciences
Andre Zugman, Anita Harrewijn, Elise M. Cardinale, Hannah Zwiebel, Gabrielle F. Freitag, Katy E. Werwath, Janna M. Bas-Hoogendam, Nynke A. Groenewold, Moji Aghajani, Kevin Hilbert, Narcis Cardoner, Daniel Porta-Casteras, Savannah Gosnell, Ramiro Salas, Karina S. Blair, James R. Blair, Mira Z. Hammoud, Mohammed Milad, Katie Burkhouse, K. Luan Phan, Heidi K. Schroeder, Jeffrey R. Strawn, Katja Beesdo-Baum, Sophia I. Thomopoulos, Hans J. Grabe, Sandra van der Auwera, Katharina Wittfeld, Jared A. Nielsen, Randy Buckner, Jordan W. Smoller, Benson Mwangi, Jair C. Soares, Mon-Ju Wu, Giovana B. Zunta-Soares, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, Michal Assaf, Gretchen J. Diefenbach, Paolo Brambilla, Eleonora Maggioni, David Hofmann, Thomas Straube, Carmen Andreescu, Rachel Berta, Erica Tamburo, Rebecca Price, Gisele G. Manfro, Hugo D. Critchley, Elena Makovac, Matteo Mancini, Frances Meeten, Cristina Ottaviani, Federica Agosta, Elisa Canu, Camilla Cividini, Massimo Filippi, Milutin Kostic, Ana Munjiza, Courtney A. Filippi, Ellen Leibenluft, Bianca A. V. Alberton, Nicholas L. Balderston, Monique Ernst, Christian Grillon, Lilianne R. Mujica-Parodi, Helena van Nieuwenhuizen, Gregory A. Fonzo, Martin P. Paulus, Murray B. Stein, Raquel E. Gur, Ruben C. Gur, Antonia N. Kaczkurkin, Bart Larsen, Theodore D. Satterthwaite, Jennifer Harper, Michael Myers, Michael T. Perino, Qiongru Yu, Chad M. Sylvester, Dick J. Veltman, Ulrike Lueken, Nic J. A. van der Wee, Dan J. Stein, Neda Jahanshad, Paul M. Thompson, Daniel S. Pine, Anderson M. Winkler
Summary: The ENIGMA-Anxiety/GAD group is conducting a mega-analysis of brain structural scans for generalized anxiety disorder. This report summarizes the challenges faced and the approach taken to overcome them, aiming to guide other research groups working with large brain imaging data sets.
HUMAN BRAIN MAPPING
(2022)
Review
Neurosciences
Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Moji Aghajani, Gabrielle F. Freitag, Anita Harrewijn, Kevin Hilbert, Neda Jahanshad, Sophia I. Thomopoulos, Paul M. Thompson, Dick J. Veltman, Anderson M. Winkler, Ulrike Lueken, Daniel S. Pine, Nic J. A. van der Wee, Dan J. Stein
Summary: Anxiety disorders are prevalent and disabling, but can be effectively studied using translational neuroscience methodologies. The ENIGMA-Anxiety Working Group aims to address the limitations of small sample sizes and heterogenous imaging methodology in anxiety disorders research, and generate more reliable and reproducible findings. The group has created a harmonized and coordinated effort to study different subtypes of anxiety disorders using neuroimaging data.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemical Research Methods
Corey Weistuch, Luca Agozzino, Lilianne R. Mujica-Parodi, Ken A. Dill
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Neurosciences
Rajat Kumar, Liang Tan, Alan Kriegstein, Andrew Lithen, Jonathan R. Polimeni, Lilianne R. Mujica-Parodi, Helmut H. Strey
Summary: This study addresses the issue of noise in fMRI scans by introducing a dynamic phantom, comparing ground-truth time-series with fMRI data, and introducing new data-quality metrics. By training a convolutional neural network, researchers were able to effectively remove scanner-induced noise, improving the sensitivity of resting-state networks.
Article
Pharmacology & Pharmacy
Rajat Kumar, Lilianne R. Mujica-Parodi, Michael Wenke, Anar Amgalan, Andrew Lithen, Sindhuja T. Govindarajan, Rany Makaryus, Helene Benveniste, Helmut H. Strey
Summary: This study presents an MRI-compatible nicotine delivery system to model nicotine addiction as a control system. They establish the viability of this delivery method for studying the brain's response to nicotine addiction and demonstrate its potential application in reliably identifying neuromodulatory targets for pharmacotherapy or brain stimulation. The method enables the measurement of neural circuit responses to drug doses on a single-subject level, aiding the development of data-driven predictive models for addiction research.
Article
Biology
Botond Antal, Liam P. McMahon, Syed Fahad Sultan, Andrew Lithen, Deborah J. Wexler, Bradford Dickerson, Eva-Maria Ratai, Lilianne R. Mujica-Parodi
Summary: This study analyzed neuroimaging and cognitive data from a large cohort of individuals with type 2 diabetes mellitus (T2DM) and healthy controls. The findings show that T2DM is associated with significant cognitive deficits and structural and functional brain changes, with overlap with aging effects. The duration of the disease is linked to more severe neurodegeneration. Treatment with metformin does not improve neurocognitive outcomes.
Article
Neurosciences
Antoine Hone-Blanchet, Botond Antal, Liam McMahon, Andrew Lithen, Nathan A. Smith, Steven Stufflebeam, Yi-Fen Yen, Alexander Lin, Bruce G. Jenkins, Lilianne R. Mujica-Parodi, Eva-Maria Ratai
Summary: This study found that administration of the ketone d-beta-hydroxybutyrate significantly reduced levels of GABA and Glu in the anterior and posterior cortices of fasting healthy participants. The effect was specific to the ketone and not observed with glucose administration. Furthermore, the magnitude of the effect was greater in older age and correlated with blood levels of the ketone. This suggests an increased sensitivity to ketones in the aging brain.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Rostam M. Razban, Jonathan Asher Pachter, Ken A. Dill, Lilianne R. Mujica-Parodi
Summary: Through targeted attacks on the brain network, we found that increasing white matter tract lengths and densities had consistent effects on global communication, regardless of aging and disease. By reversing the attack computation, we derived an analytical equation that explains the brain development mechanism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Neurosciences
Lilianne R. Mujica-Parodi, Jiook Cha, Jonathan Gao
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2017)
