Article
Geriatrics & Gerontology
Diana Younan, Xinhui Wang, Tara Gruenewald, Margaret Gatz, Marc L. Serre, William Vizuete, Meredith N. Braskie, Nancy F. Woods, Ka Kahe, Lorena Garcia, Fred Lurmann, JoAnn E. Manson, Helena C. Chui, Robert B. Wallace, Mark A. Espeland, Jiu-Chiuan Chen
Summary: This study found that ambient fine particles (PM2.5) may contribute to racial/ethnic disparities in Alzheimer's disease (AD) risk, with a stronger association observed among Black women.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Editorial Material
Neurosciences
Daniel Oudin Astrom, Rolf Adolfsson, David Segersson, Bertil Forsberg, Anna Oudin
Summary: The study examines the association between fine particulate air pollution (PM2.5) and dementia, finding a correlation between local PM2.5 concentrations and the incidence of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Public, Environmental & Occupational Health
Jinyoung Shin, Hyuk Jung Kweon, Kyoung Ja Kwon, Seol-Heui Han
Summary: Long-term exposure to PM10 was associated with newly diagnosed osteoporosis in Korean adults aged 40 years and older, especially in females, individuals under 65 years old, and residents in low urbanization areas. However, exposure to NO2, CO, SO2, or PM2.5 did not lead to an increase in osteoporosis.
Article
Multidisciplinary Sciences
Liuhua Shi, Qiao Zhu, Yifan Wang, Hua Hao, Haisu Zhang, Joel Schwartz, Heresh Amini, Aaron van Donkelaar, Randall V. Martin, Kyle Steenland, Jeremy A. Sarnat, W. Michael Caudle, Tszshan Ma, Haomin Li, Howard H. Chang, Jeremiah Z. Liu, Thomas Wingo, Xiaobo Mao, Armistead G. Russell, Rodney J. Weber, Pengfei Liu
Summary: Growing evidence suggests that long-term exposure to fine particulate matter (PM2.5) and its major constituents is significantly associated with higher rates of incident dementia and Alzheimer's disease (AD). Specific constituents related to traffic and fossil fuel combustion, such as BC, OM, and SO42-, showed the strongest associations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Public, Environmental & Occupational Health
Giovanni Veronesi, Sara De Matteis, Giuseppe Calori, Nicola Pepe, Marco M. Ferrario
Summary: In a prospective study of residents in Varese city, long-term exposure to airborne pollutants, especially PM2.5, increased the incidence of COVID-19. The findings highlight the importance of reducing air pollution.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Kevin J. Sullivan, Xinhui Ran, Fan Wu, Chung-Chou H. Chang, Ravi Sharma, Erin Jacobsen, Sarah Berman, Beth E. Snitz, Akira Sekikawa, Evelyn O. Talbott, Mary Ganguli
Summary: This study examined the association between ambient PM2.5 levels and the risk of incident MCI and dementia in an older population, finding that higher estimated PM2.5 levels were associated with increased risk of both conditions, particularly with longer-term exposure.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Environmental Sciences
Hedi Katre Kriit, Bertil Forsberg, Daniel Oudin Astrom, Anna Oudin
Summary: This study estimated that approximately 5% of annual dementia cases in Sweden could be attributed to PM2.5 exposure, leading to a substantial monetary burden. These findings highlight the importance of considering airborne toxic pollutants associated with dementia incidence in public health policy decisions.
ENVIRONMENTAL HEALTH
(2021)
Article
Public, Environmental & Occupational Health
R. Wilkinson, T. Afework, A. Mortimore, D. I. W. Phillips, M. Willcox, D. Levene, M. Kaba
Summary: The study found that the use of purposely produced smoke (PPS) is widespread in the Ethiopian community, with many perceived benefits, making it a significant part of local culture. Public health interventions aimed at reducing household air pollution in this setting should take into consideration PPS.
JOURNAL OF PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Sarah E. Chambliss, Carlos P. R. Pinon, Kyle P. Messier, Brian LaFranchi, Crystal Romeo Upperman, Melissa M. Lunden, Allen L. Robinson, Julian D. Marshall, Joshua S. Apte
Summary: This study reveals that Hispanic and Black populations in urban areas are exposed to higher levels of ultrafine particles, nitrogen dioxide, and nitric oxide (8-30% above average) compared to White populations (9-14% below average). These racial/ethnic disparities in air pollution exposure are influenced by regional concentration gradients and demographic differences among cities and urban districts, as well as localized pollution peaks.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Vikas Dhiman, Tanwi Trushna, Dharma Raj, Rajnarayan R. Tiwari
Summary: This study utilized meta-analysis to assess the association between air pollution exposure and the risk of developing dementia. The results revealed that exposure to PM2.5 and O-3 may be risk factors for all-cause dementia, AD, and VaD. These findings have implications for policy measures and further research.
Article
Environmental Sciences
Steve Hung Lam Yim, Tao Huang
Summary: Past studies have focused on ground-level air quality, but this study utilized the 3DREAMS system to provide vertical profiles of aerosols in the upper atmospheric boundary layer (ABL) of a high-density city in Asia. The results show opposite diurnal profiles of aerosols between ground-level and upper ABL, and significant spatial variations in aerosol distribution at different locations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Massimo Stafoggia, Paola Michelozzi, Alexandra Schneider, Ben Armstrong, Matteo Scortichini, Masna Rai, Souzana Achilleos, Barrak Alahmad, Antonis Analitis, Christofer Astrom, Michelle L. Bell, Neville Calleja, Hanne Krage Carlsen, Gabriel Carrasco, John Paul Cauchi, Micheline D. S. Z. S. Coelho, Patricia M. Correa, Magali H. Diaz, Alireza Entezari, Bertil Forsberg, Rebecca M. Garland, Yue Leon Guo, Yuming Guo, Masahiro Hashizume, Iulian H. Holobaca, Carmen Iniguez, Jouni J. K. Jaakkola, Haidong Kan, Klea Katsouyanni, Ho Kim, Jan Kysely, Eric Lavigne, Whanhee Lee, Shanshan Li, Marek Maasikmets, Joana Madureira, Fatemeh Mayvaneh, Chris Fook Sheng Ng, Baltazar Nunes, Hans Orru, Nicolas Ortega, Samuel Osorio, Alfonso D. L. Palomares, Shih-Chun Pan, Mathilde Pascal, Martina S. Ragettli, Shilpa Rao, Raanan Raz, Dominic Roye, Niilo Ryti, Paulo H. N. Saldiva, Evangelia Samoli, Joel Schwartz, Noah Scovronick, Francesco Sera, Aurelio Tobias, Shilu Tong, Cesar D. L. C. Valencia, Ana Maria Vicedo-Cabrera, Ales Urban, Antonio Gasparrini, Susanne Breitner, Francesca K. de Donato
Summary: Suggestive evidence of effect modification between air temperature and air pollutants on mortality during the warm period was found in a global dataset of 620 cities.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Geriatrics & Gerontology
Ying Xu, Louise Lavrencic, Kylie Radford, Andrew Booth, Sohei Yoshimura, Kaarin J. Anstey, Craig S. Anderson, Ruth Peters
Summary: Seizures are common in individuals with AD, with higher risk among younger adults. Monitoring for seizures may be particularly important for those with ADAD.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Environmental Sciences
Jorn Rittweger, Lorenza Gilardi, Maxana Baltruweit, Simon Dally, Thilo Erbertseder, Uwe Mittag, Muhammad Naeem, Matthias Schmid, Marie-Therese Schmitz, Sabine Wuest, Stefan Dech, Jens Jordan, Tobias Antoni, Michael Bittner
Summary: This study investigated the medium-term residential exposure to meteorological and pollutant factors in rural and urban areas in a temperate climate, and found that fine particulate matter, air temperature, precipitation, and NO2 significantly influenced the incidence of influenza.
ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Marine Savoure, Emeline Lequy, Jean Bousquet, Jie Chen, Kees de Hoogh, Marcel Goldberg, Danielle Vienneau, Marie Zins, Rachel Nadif, Benedicte Jacquemin
Summary: The study found that long-term residential exposure to PM2.5, BC, and NO2 was significantly associated with an increase in the prevalence of current rhinitis in French adults. Among air pollutants, BC may be of particular interest in relation to rhinitis.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Clinical Neurology
Erin O. Semmens, Cindy S. Leary, Annette L. Fitzpatrick, Sindana D. Ilango, Christina Park, Claire E. Adam, Steven T. DeKosky, Oscar Lopez, Anjum Hajat, Joel D. Kaufman
Summary: This study found that long-term exposure to fine particulate matter (PM2.5) air pollution may increase the risk of dementia, particularly mixed vascular and Alzheimer's disease dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Margaret Gatz, Stefan Schneider, Erik Meijer, Jill E. Darling, Bart Orriens, Ying Liu, Arie Kapteyn
Summary: This study aimed to develop a classification for web-based self-administered assessments of cognitive status. The results showed that the web-administered HRS TICS score and the phone-based score had modest correlations. Using latent variable modeling, a probability of cognitive impairment score for the web-based battery was successfully created, achieving good correspondence to the phone-based Langa-Weir classification.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Ophthalmology
Catherine Wang, Sasha Kravets, Abhishek Sethi, Mark A. Espeland, Louis R. Pasquale, Stephen R. Rapp, Barbara E. Klein, Stacy M. Meuer, Mary N. Haan, Pauline M. Maki, Joelle A. Hallak, Thasarat Sutabutr Vajaranant
Summary: This study investigates the relationship between optic nerve cupping and total and regional brain volumes. The results suggest that in women aged 65 years or more, large cup-to-disc ratio (CDR) is associated with smaller absolute regional volumes in the frontal and occipital lobes, as well as lower relative total brain volume.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Eun-Young Kang, Ashley Weir, Nicola S. Meagher, Kyo Farrington, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Adelyn Bolithon, Gordana Popovic, Betty Leung, Katrina Tang, Neil Lambie, Joshua Millstein, Jennifer Alsop, Michael S. Anglesio, Beyhan Ataseven, Ellen Barlow, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Hans Boesmueller, Jessica Boros, Alison H. Brand, Angela Brooks-Wilson, Sara Y. Brucker, Michael E. Carney, Yovanni Casablanca, Alicia Cazorla-Jimenez, Paul A. Cohen, Thomas P. Conrads, Linda S. Cook, Penny Coulson, Madeleine Courtney-Brooks, Daniel W. Cramer, Philip Crowe, Julie M. Cunningham, Cezary Cybulski, Kathleen M. Darcy, Mona A. El-Bahrawy, Esther Elishaev, Ramona Erber, Rhonda Farrell, Sian Fereday, Anna Fischer, Maria J. Garcia, Simon A. Gayther, Aleksandra Gentry-Maharaj, C. Blake Gilks, Marcel Grube, Paul R. Harnett, Shariska Petersen Harrington, Philipp Harter, Arndt Hartmann, Jonathan L. Hecht, Sebastian Heikaus, Alexander Hein, Florian Heitz, Joy Hendley, Brenda Y. Hernandez, Susanna Hernando Polo, Sabine Heublein, Akira Hirasawa, Estrid Hogdall, Claus K. Hogdall, Hugo M. Horlings, David G. Huntsman, Tomasz Huzarski, Andrea Jewell, Mercedes Jimenez-Linan, Michael E. Jones, Scott H. Kaufmann, Catherine J. Kennedy, Dineo Khabele, Felix K. F. Kommoss, Roy F. P. M. Kruitwagen, Diether Lambrechts, Nhu D. Le, Marcin Lener, Jenny Lester, Yee Leung, Anna Linder, Liselore Loverix, Jan Lubinski, Rashna Madan, G. Larry Maxwell, Francesmary Modugno, Susan L. Neuhausen, Alexander Olawaiye, Siel Olbrecht, Sandra Orsulic, Jose Palacios, Celeste Leigh Pearce, Malcolm C. Pike, Carmel M. Quinn, Ganendra Raj Mohan, Cristina Rodriguez-Antona, Matthias Ruebner, Andy Ryan, Stuart G. Salfinger, Naoko Sasamoto, Joellen M. Schildkraut, Minouk J. Schoemaker, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Naveena Singh, Gabe S. Sonke, Linda Steele, Colin J. R. Stewart, Karin Sundfeldt, Anthony J. Swerdlow, Aline Talhouk, Adeline Tan, Sarah E. Taylor, Kathryn L. Terry, Aleksandra Toloczko, Nadia Traficante, Koen K. Van de Vijver, Maaike A. van der Aa, Toon Van Gorp, Els Van Nieuwenhuysen, Lilian Van-Wagensveld, Ignace Vergote, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Anna H. Wu, Javier Benitez, Andrew Berchuck, Francisco J. Candido Dos Reis, Anna DeFazio, Peter A. Fasching, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, Beth Y. Karlan, Stefan Kommoss, Usha Menon, Hans-Peter Sinn, Annette Staebler, James D. Brenton, David D. Bowtell, Paul D. P. Pharoah, Susan J. Ramus, Martin Kobel
Summary: This study validates that high-level amplification of CCNE1 is associated with shorter survival in tubo-ovarian high-grade serous carcinoma (HGSC), supporting its use as a prognostic biomarker in this disease.
Article
Endocrinology & Metabolism
Felicia R. Simpson, Jamie N. Justice, Scott J. Pilla, Stephen B. Kritchevsky, Edward J. Boyko, Medha N. Munshi, Chloe K. Ferris, Mark A. Espeland
Summary: This study aimed to explore the relationship between glycated hemoglobin (HbA(1c)) levels and strategies to control type 2 diabetes with biological aging as measured by a deficit accumulation frailty index (FI). The study found that lower HbA(1c) levels were associated with slower biological aging, while higher levels were associated with faster aging. Additionally, the use of metformin and weight loss greater than 5% were independently associated with slower increases in frailty.
Article
Oncology
Jingyuan Wang, Joanne Xiu, Alex Farrell, Yasmine Baca, Hiroyuki Arai, Francesca Battaglin, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Joshua Millstein, Anthony F. Shields, Axel Grothey, Benjamin A. Weinberg, John L. Marshall, Emil Lou, Moh'd Khushman, Davendra P. S. Sohal, Michael J. Hall, Tianshu Liu, Matthew Oberley, David Spetzler, W. Michael Korn, Lin Shen, Heinz-Josef Lenz
Summary: This study aimed to characterize the genomic features of microsatellite stable (MSS) tumors with high tumor mutational burden (TMB-H) that are independent of mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H) status. The results showed that mutations in certain genes might impair the antitumor immune response despite TMB-H, while mutations in other genes were related to TMB-H with enhanced antitumor immune response. These findings are important for tailoring treatment with immune checkpoint inhibitors.
Review
Biochemistry & Molecular Biology
Priya Jayachandran, Francesca Battaglin, Carly Strelez, Annika Lenz, Sandra Algaze, Shivani Soni, Jae Ho Lo, Yan Yang, Joshua Millstein, Wu Zhang, Jean C. Shih, Janice Lu, Shannon M. Mumenthaler, Darcy Spicer, Josh Neman, Evanthia T. Roussos Torres, Heinz-Josef Lenz
Summary: Exploring the relationship between neurotransmitters and breast cancer cell growth has revealed their importance in improving breast cancer treatment. Neurotransmitters affect various pathways in breast cancer biology and play a vital role in cancer initiation, progression, and drug resistance. Understanding neurotransmitters may lead to lower-cost and lower-risk antitumor therapeutic strategies. This review discusses multiple neurotransmitters, risk factors, pharmaceuticals impacting neurotransmitter pathways, and integration with non-pharmacologic considerations.
Review
Clinical Neurology
Erin R. Kulick, Joel D. Kaufman, Coralynn Sack
Summary: Despite recent advances in treatment and prevention, stroke remains a leading cause of morbidity and mortality. A body of evidence suggests that elevated levels of ambient air pollutants may trigger cerebrovascular events in susceptible people and increase the risk of future events. This review assesses the evidence for both short and long-term exposure to ambient air pollution as a risk factor for stroke incidence and outcomes, and makes recommendations for mitigating exposure.
Letter
Peripheral Vascular Disease
Lyndia C. Brumback, Leah I. B. Andrews, David R. Jacobs, Daniel Duprez, Elizabeth K. Hom Thepaksorn, Joel D. Kaufman, Julie Denenberg, Matthew Allison
Article
Respiratory System
Mudiaga O. Sowho, Abigail L. Koch, Nirupama Putcha, Han Woo, Amanda Gassett, Laura M. Paulin, Kirsten Koehler, R. Graham Barr, Alejandro P. Comellas, Christopher B. Cooper, Igor Barjaktarevic, Michelle R. Zeidler, Martha E. Billings, Russell P. Bowler, MeiLan K. Han, Victor Kim, Robert Paine III, Trisha M. Parekh, Jerry A. Krishnan, Stephen P. Peters, Prescott G. Woodruff, Aaron M. Baugh, Joel D. Kaufman, David Couper, Nadia N. Hansel
Summary: This study examined the association between air pollution exposure, obesity, and sleep disturbances in individuals with chronic obstructive pulmonary disease (COPD). The results showed that overweight and obese COPD patients were more susceptible to the effects of ambient PM2.5 on sleep quality, while no association was found in lean/normal weight patients. This suggests that obesity and ambient PM2.5 may be modifiable risk factors for improving sleep quality in COPD.
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2023)
Article
Biochemical Research Methods
Nand Sharma, Joshua Millstein
Summary: This article introduces a dynamic programming based algorithm with built-in dimensionality reduction and parent set identification for finding globally optimal Bayesian Networks. The algorithm outperforms three state-of-art algorithms in both synthetic and real data. It is also successfully applied to an Ovarian Cancer gene expression dataset, where it finds an optimal network with only 6 genes in just 3.4 minutes on a personal computer. This algorithm is efficient and scalable for finding optimal Bayesian Networks in high-dimensional data situations.
BMC BIOINFORMATICS
(2023)
Article
Engineering, Biomedical
Ty D. Holcomb, Madison E. Marks, N. Stewart Pritchard, Logan Miller, Mark A. Espeland, Christopher M. Miles, Justin B. Moore, Kristie L. Foley, Joel D. Stitzel, Jillian E. Urban
Summary: This study evaluated head acceleration events (HAEs) in youth football practice drills using a mouthpiece-based sensor, differentiating between inertial and direct HAEs. A total of 3237 HAEs were verified and evaluated from 29 football athletes enrolled in this study, and head kinematics varied significantly between drill categorizations. Higher intensity drills resulted in significantly greater head kinematics than lower-intensity drills.
JOURNAL OF APPLIED BIOMECHANICS
(2023)
Article
Geriatrics & Gerontology
Joni K. Evans, Chinenye O. Usoh, Felicia R. Simpson, Sara Espinoza, Helen Hazuda, Ambarish Pandey, Tara Beckner, Mark A. Espeland
Summary: Multidomain lifestyle interventions may slow down aging and reduce the accumulation of deficits. This study found that a multidomain lifestyle intervention focused on caloric restriction, increased physical activity, and diet can continue to provide benefits for 8 years after the intervention ends, reducing the rate of aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hillard Kaplan, Paul L. Hooper, Margaret Gatz, Wendy J. Mack, E. Meng Law, Helena C. Chui, M. Linda Sutherland, James D. Sutherland, Christopher J. Rowan, L. Samuel Wann, Adel H. Allam, Randall C. Thompson, David E. Michalik, Guido Lombardi, Michael I. Miyamoto, Daniel Eid Rodriguez, Juan Copajira Adrian, Raul Quispe Gutierrez, Bret A. Beheim, Daniel K. Cummings, Edmond Seabright, Sarah Alami, Angela R. Garcia, Kenneth Buetow, Gregory S. Thomas, Caleb E. Finch, Jonathan Stieglitz, Benjamin C. Trumble, Michael D. Gurven, Andrel Irimia
Summary: This study examines brain volume in two indigenous South American populations and finds that the decline in brain volume with age is slower compared to high-income nations. The results are consistent with the evolutionary model of brain health and have implications for interventions to improve brain health.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Geriatrics & Gerontology
Xiao Zhang, Jason L. Sanders, Robert M. Boudreau, Alice M. Arnold, Jamie N. Justice, Mark A. Espeland, George A. Kuchel, Nir Barzilai, Lewis H. Kuller, Oscar L. Lopez, Stephen B. Kritchevsky, Anne B. Newman
Summary: By analyzing the relationships between multiple biomarkers and mortality, a biomarker index (BI) was found to be significantly associated with the composite outcome of death and chronic disease. It may serve as a practical intermediate phenotype for interventions aiming to modify the course of aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)