Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson’s disease

Light-activated genetic therapy to treat blindness enters clinic

(2021) Mark Ratner   NATURE BIOTECHNOLOGY

Thalamic projections to the subthalamic nucleus contribute to movement initiation and rescue of parkinsonian symptoms

(2021) Glenn D. R. Watson et al.   Science Advances

Deep brain stimulation of midbrain locomotor circuits in the freely moving pig

(2021) Stephano J. Chang et al.   Brain Stimulation

Freely Behaving Mice Can Brake and Turn During Optogenetic Stimulation of the Mesencephalic Locomotor Region

(2021) Cornelis Immanuel van der Zouwen et al.   Frontiers in Neural Circuits

MR Tractography-Based Targeting and Physiological Identification of the Cuneiform Nucleus for Directional DBS in a Parkinson’s Disease Patient With Levodopa-Resistant Freezing of Gait

(2021) Stephano J. Chang et al.   Frontiers in Human Neuroscience

Modulation of motor behavior by the mesencephalic locomotor region

(2021) Daniel Dautan et al.   Cell Reports

Measuring and modeling the motor system with machine learning

(2021) Sebastien B. Hausmann et al.   CURRENT OPINION IN NEUROBIOLOGY

Brainstem neurons that command mammalian locomotor asymmetries

(2020) Jared M. Cregg et al.   NATURE NEUROSCIENCE

Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms

(2020) Sébastien Valverde et al.   Nature Communications

Control of Orienting Movements and Locomotion by Projection-Defined Subsets of Brainstem V2a Neurons

(2020) Giovanni Usseglio et al.   CURRENT BIOLOGY

Heterogeneous expression of dopaminergic markers and Vglut2 in mouse mesodiencephalic dopaminergic nuclei A8–A13

(2020) Maxime Fougère et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Calcium imaging in freely-moving mice during electrical stimulation of deep brain structures

(2020) James K Trevathan et al.   Journal of Neural Engineering

A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex

(2020) Miguel M. Carvalho et al.   Cell Reports

Dissecting Brainstem Locomotor Circuits: Converging Evidence for Cuneiform Nucleus Stimulation

(2020) Stephano J. Chang et al.   Frontiers in Systems Neuroscience

Glutamatergic neurons of the gigantocellular reticular nucleus shape locomotor pattern and rhythm in the freely behaving mouse

(2019) Maxime Lemieux et al.   PLOS BIOLOGY

Using DeepLabCut for 3D markerless pose estimation across species and behaviors

(2019) Tanmay Nath et al.   Nature Protocols

Multiple stimulation parameters influence efficacy of deep brain stimulation in parkinsonian mice

(2019) Jonathan S. Schor et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential effects of HDAC inhibitors on PPN oscillatory activity in vivo

(2019) Veronica Bisagno et al.   NEUROPHARMACOLOGY

Distinct Contributions of Mesencephalic Locomotor Region Nuclei to Locomotor Control in the Freely Behaving Mouse

(2018) Nicolas Josset et al.   CURRENT BIOLOGY

Deep Brain Stimulation of the Pedunculopontine Nucleus Area in Parkinson Disease: MRI-Based Anatomoclinical Correlations and Optimal Target

(2018) Laurent Goetz et al.   NEUROSURGERY

Parallel descending dopaminergic connectivity of A13 cells to the brainstem locomotor centers

(2018) Sandeep Sharma et al.   Scientific Reports

Midbrain circuits that set locomotor speed and gait selection

(2018) V. Caggiano et al.   NATURE

DeepLabCut: markerless pose estimation of user-defined body parts with deep learning

(2018) Alexander Mathis et al.   NATURE NEUROSCIENCE

Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson’s disease evaluated with multimodal MRI

(2018) Vincent Perlbarg et al.   PLoS One

Class II histone deacetylases require P/Q-type Ca2+ channels and CaMKII to maintain gamma oscillations in the pedunculopontine nucleus

(2018) Francisco J. Urbano et al.   Scientific Reports

Frequency-dependent effects of subthalamic deep brain stimulation on motor symptoms in Parkinson’s disease: a meta-analysis of controlled trials

(2018) Dongning Su et al.   Scientific Reports

Normal and pathological neuronal distribution of the human mesencephalic locomotor region

(2018) Sophie B. Sébille et al.   MOVEMENT DISORDERS

Nigral Glutamatergic Neurons Control the Speed of Locomotion

(2017) Dimitri Ryczko et al.   JOURNAL OF NEUROSCIENCE

Pedunculopontine nucleus deep brain stimulation in Parkinson's disease: A clinical review

(2017) Wesley Thevathasan et al.   MOVEMENT DISORDERS

Locomotor speed control circuits in the caudal brainstem

(2017) Paolo Capelli et al.   NATURE

Dopamine and the Brainstem Locomotor Networks: From Lamprey to Human

(2017) Dimitri Ryczko et al.   Frontiers in Neuroscience

Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia

(2016) Thomas K. Roseberry et al.   CELL

A descending dopamine pathway conserved from basal vertebrates to mammals

(2016) Dimitri Ryczko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Anatomy and Terminology

(2016) Clement Hamani et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Techniques, Side Effects, and Postoperative Imaging

(2016) Clement Hamani et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

The mesencephalic locomotor region sends a bilateral glutamatergic drive to hindbrain reticulospinal neurons in a tetrapod

(2015) Dimitri Ryczko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Freezing of gait: a practical approach to management

(2015) Jorik Nonnekes et al.   LANCET NEUROLOGY

Motor and Nonmotor Circuitry Activation Induced by Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease

(2015) Emily J. Knight et al.   MAYO CLINIC PROCEEDINGS

Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers

(2015) Peter H. Weiss et al.   MOVEMENT DISORDERS

Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson's disease: Indications of a principal role of the brainstem

(2015) Štefan Holiga et al.   NeuroImage-Clinical

Evolutionarily conserved organization of the dopaminergic system in lamprey: SNc/VTA afferent and efferent connectivity and D2 receptor expression

(2014) Juan Pérez-Fernández et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Identification of a Brainstem Circuit Regulating Visual Cortical State in Parallel with Locomotion

(2014) A. Moses Lee et al.   NEURON

Exploring the cortical and subcortical functional magnetic resonance imaging changes associated with freezing in Parkinson's disease

(2013) James M. Shine et al.   BRAIN

The Multifunctional Mesencephalic Locomotor Region

(2013) Dimitri Ryczko et al.   CURRENT PHARMACEUTICAL DESIGN

Pedunculopontine nucleus evoked potentials from subthalamic nucleus stimulation in Parkinson's disease

(2013) Bogdan Neagu et al.   EXPERIMENTAL NEUROLOGY

High-level gait and balance disorders in the elderly: a midbrain disease?

(2013) Adèle Demain et al.   JOURNAL OF NEUROLOGY

Lhx3-Chx10 Reticulospinal Neurons in Locomotor Circuits

(2013) F. Bretzner et al.   JOURNAL OF NEUROSCIENCE

Lack of Evidence for Vesicular Glutamate Transporter Expression in Mouse Astrocytes

(2013) D. Li et al.   JOURNAL OF NEUROSCIENCE

Pedunculopontine Nucleus Area Oscillations during Stance, Stepping and Freezing in Parkinson’s Disease

(2013) Valerie Fraix et al.   PLoS One

Forebrain dopamine neurons project down to a brainstem region controlling locomotion

(2013) Dimitri Ryczko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep Brain Stimulation of the Midbrain Locomotor Region Improves Paretic Hindlimb Function After Spinal Cord Injury in Rats

(2013) L. C. Bachmann et al.   Science Translational Medicine

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evolutionary Conservation of the Basal Ganglia as a Common Vertebrate Mechanism for Action Selection

(2011) Marcus Stephenson-Jones et al.   CURRENT BIOLOGY

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease

(2010) Carine Karachi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Transformation of a Unilateral Locomotor Command into a Symmetrical Bilateral Activation in the Brainstem

(2010) F. Brocard et al.   JOURNAL OF NEUROSCIENCE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Evidence for a dopaminergic innervation of the pedunculopontine nucleus in monkeys, and its drastic reduction after MPTP intoxication

(2009) Anne-Sophie Rolland et al.   JOURNAL OF NEUROCHEMISTRY

Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson's disease is related to disability of the patients

(2008) Juha O. Rinne et al.   PARKINSONISM & RELATED DISORDERS