Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 8, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2117221119
Keywords
biomimicry; dynamic biomaterial design; natural receptor-ligand interaction; cell regulation; tissue repair
Categories
Funding
- National Key Research and Development Program of China [2019YFA0112000, 2016YFC1100203]
- National Natural Science Foundation of China [21875092, 81925027, 32130059]
- Innovation and Entrepreneurship Program of Jiangsu Province
- Six Talent Peaks Program of Jiangsu Province [2018-XCL-013]
- Research Grants Council of Hong Kong [15202119, 25208218]
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This study reports a nature-derived strategy for the fabrication of a dynamic biointerface and a 3D hydrogel structure. The reversible receptor-ligand interaction allows for the reversible regulation of multiple cell types, and the dynamic hydrogel serves as a functional antibacterial scaffold.
Dynamic biomaterials excel at recapitulating the reversible interlocking and remoldable structure of the extracellular matrix (ECM), particularly in manipulating cell behaviors and adapting to tissue morphogenesis. While strategies based on dynamic chemistries have been extensively studied for ECM-mimicking dynamic biomaterials, biocompatible molecular means with biogenicity are still rare. Here, we report a nature-derived strategy for fabrication of dynamic biointerface as well as a three-dimensional (3D) hydrogel structure based on reversible receptor-ligand interaction between the glycopeptide antibiotic vancomycin and dipeptide D-Ala-D-Ala. We demonstrate the reversible regulation of multiple cell types with the dynamic biointerface and successfully implement the dynamic hydrogel as a functional antibacterial 3D scaffold to treat tissue repair. In view of the biogenicity and high applicability, this nature-derived reversible molecular strategy will bring opportunities for malleable biomaterial design with great potential in biomedicine.
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