Article
Biochemistry & Molecular Biology
Ruchika Ojha, Peter C. Junk, Alan M. Bond, Glen B. Deacon
Summary: Pt-IV coordination complexes were synthesized by oxidizing the antitumor agent [Pt-II(p-BrC6F4)NCH2CH2NEt2}Cl(py)]. Experimental data showed that excess H2O2 and elevated temperature favored the oxidation of the ligand, while a smaller amount of H2O2 at room temperature favored the oxidation of the metal, resulting in the formation of platinum(IV) complexes.
Article
Biochemistry & Molecular Biology
Eleonora Colombo, Davide Andrea Coppini, Laura Polito, Umberto Ciriello, Giuseppe Paladino, Mariafrancesca Hyeraci, Maria Luisa Di Paolo, Giulia Nordio, Lisa Dalla Via, Daniele Passarella
Summary: Cannabidiol (CBD), a compound found in Cannabis plants, is shown to be an effective inducer in the formation of nanoparticles. These nanoparticles, formed through solvent displacement, exhibit monodisperse and stable structures. They show low micromolar range cytotoxicity on human tumor cell lines, with the involvement of paclitaxel confirmed in the most effective nanoparticle (NP 8B) through further biological assays.
Article
Automation & Control Systems
Zheng Ning, Ge Chen
Summary: Chemical self-assembly is considered one of the most important scientific problems in the 21st century, but currently lacks a comprehensive mathematical theory. This paper presents a novel multi-agent system for chemical self-assembly, formulated as a group of stochastic differential equations. It proposes an optimal control scheme using temperature as input and Hamiltonian as the optimal objective to greatly improve the product of self-assembly.
Article
Chemistry, Multidisciplinary
Jiakun Tang, Ye Liu, Dongmei Qi, Lan Yang, Hui Chen, Chenhui Wang, Xuli Feng
Summary: The study introduces an efficient intranuclear protein delivery nanoplatform based on protein co-assembly, utilizing modified RNase A and WLC to enhance the delivery of multiple proteins into the nucleus, leading to significantly improved antitumor efficacy in vitro and in vivo.
Review
Pharmacology & Pharmacy
Yijia Zhao, Huafeng Pan, Wei Liu, E. Liu, Yaobin Pang, Hongjin Gao, Qingying He, Wenhao Liao, Yejing Yao, Jinhao Zeng, Jing Guo
Summary: This study reviewed the anticancer activity and underlying mechanism of menthol, highlighting its safety profile and multiple pathways of action. Due to its excellent anticancer activity, further research is needed to develop menthol as a novel anticancer agent.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Baoning Li, Yaping Wang, Michael Ho-Yeung Chan, Mei Pan, Yonguang Li, Vivian Wing-Wah Yam
Summary: By utilizing cationic organoplatinum(II) complexes with switchable luminescence properties, precise imaging of subcellular distribution within cells can be achieved, offering a new way to differentiate live and dead cells. This research lays the groundwork for potential subcellular detection assays.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Masaya Yoshida, Takehiro Hirao, Takeharu Haino
Summary: The synthesized platinum complexes formed helically twisted stacked assemblies in chloroform and toluene, while emitting micellar aggregates in a THF/water mixed solvent. Dynamic light scattering experiments showed that micellar aggregates with a diameter of approximately 100 nm emitted strong light, and the nanostructure could be modulated by changing the solvent polarity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Juan Sanchez-Camacho, Sonia Infante-Tadeo, Ana C. Carrasco, Stefano Scoditti, A'lvaro Martinez, Fabienne Barroso-Bujans, Emilia Sicilia, Ana M. Pizarro, Luca Salassa
Summary: In this study, two new asymmetric Pt(IV) derivatives were designed and synthesized, which could be effectively activated into toxic Pt(II) species by incubation with nicotinamide adenine dinucleotide, sodium ascorbate, and glutathione in the dark and under light irradiation. One of the derivatives displayed enhanced toxicity in MDA-MB-231 breast cancer cells preincubated with ascorbate, suggesting selective triggering of oxaliplatin generation through redox activation. Covalent binding of the flavin to the Pt complex was shown to be pivotal for this effect.
INORGANIC CHEMISTRY
(2023)
Article
Engineering, Biomedical
Xiaohui Xiao, Yupeng Wang, Jieyao Chen, Peng Qin, Peiyao Chen, Dongfang Zhou, Yue Pan
Summary: This study presents a self-targeting nano-assembly strategy based on platinum(IV)-lactose amphiphilic prodrug for synergistic and safe chemoradiotherapy of hepatocellular carcinoma (HCC). The nano-assembly targets HCC cells and releases cisplatin to induce DNA damage and cell apoptosis. Under X-ray irradiation, the assembly enhances the cell-killing effect of radiotherapy.
Article
Chemistry, Multidisciplinary
Shuoxin Li, Xiaosa Yan, Junqing Zhang, Xia Guo, Yongkang Zhang, Meihui Su, Chun Yang, Hao Zhang, Changhua Li
Summary: This study utilizes the J-stacking of dyes to drive the assembly of amphiphilic polymers, using a molecular glue strategy to restore dye J-stacking and create novel nano-assemblies with excellent optical and thermal properties, demonstrating potential for photothermal treatment of tumors in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Oncology
Madilyn Mason, Marcelline R. Harris, Joseph A. Greer, Yun Jiang
Summary: The concept of oral anticancer agent self-management (OAA-SM) and its components, factors, and consequences were clarified in this study. A conceptual model of OAA-SM was proposed. Effective OAA-SM is associated with better patient and healthcare outcomes.
Review
Engineering, Biomedical
Tianyuan Zhong, Jie Yu, Yong Pan, Ning Zhang, Yanxin Qi, Yubin Huang
Summary: Platinum drugs are widely used in cancer treatment, but their toxicity and drug resistance pose challenges. Combination therapy with platinum drugs can effectively inhibit tumor growth and metastasis, reducing toxicity and overcoming resistance. This review summarizes the current progress and challenges in platinum-based combination therapy, including gene editing, ROS-based therapy, thermal therapy, immunotherapy, and imaging modality. It hopes to inspire researchers for the development of more effective platinum-based anti-cancer complexes in the future.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Li Zhang, Qian Dong, Yumin Hao, Zihan Wang, Wenjuan Dong, Yang Liu, Yueping Dong, Hongpeng Wu, Shaomin Shuang, Chuan Dong, Zhuo Chen, Xiaojuan Gong
Summary: This study constructs a novel nano-assembly (CDs@Pt SAs/NCs@DOX) using drug-primed platinum single-atom or nanocluster nanozymes, which exhibit dual enzymatic activities to mimic peroxidase and glutathione oxidase. The nano-assembly also enables low-temperature photothermal therapy and controlled disassembly and drug release, effectively regulating cellular redox homeostasis and inhibiting tumor growth.
Article
Chemistry, Physical
Dong-Hui Zhao, Chao-Qing Li, Xiao-Lin Hou, Gui-Ying Wu, Xiao-Ting Xie, Dan Zhu, Fang Jin, Yuan-Di Zhao, Bo Liu
Summary: This study demonstrates the assembly of CCD nanoparticles to respond to the tumor microenvironment, achieving enhanced chemodynamic therapy effects. The CCD NPs show excellent biocompatibility and synergistic anti-tumor ability, effectively inhibiting tumor growth.
Article
Chemistry, Multidisciplinary
Zhong-Liang Gong, Yu-Wu Zhong
Summary: This research demonstrates the preparation of polymorphic helical architectures with highly efficient CPL and inverted handedness by controlling the assembly pathway of chiral emitters.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Masoume Malmir, Majid M. Heravi, Zahra Yekke-Ghasemi, Masoud Mirzaei
Summary: In this study, a tri-component composite consisting of Fe3O4 nanoparticles, Keggin-type polyoxometalate, and graphene oxide was prepared and investigated as a catalyst for the oxidation of sulfides to sulfoxides. The catalyst showed excellent stability, high yields, and recyclability, making it a promising choice for organic-inorganic hybrid catalytic reactions conducted under mild conditions.
Article
Chemistry, Inorganic & Nuclear
Samuel D. Juarez-Escamilla, Sriloy Dey, Bruno Donnadieu, T. Keith Hollis
Summary: In this study, a bidentate Mo complex was synthesized using metalation and transmetalation methodology. The synthesis was optimized to achieve a high yield. The crystal structure of the bidentate complex was determined. Additionally, alternative forms of ligands were discovered in the reaction.
Article
Chemistry, Inorganic & Nuclear
Mohamed H. Abdel-Rhman, Ghada Samir, Mostafa A. Hussien, Nasser M. Hosny
Summary: This study investigated the dissolution performance of hydrazine carbonate solution on zirconium dibutyl phosphate (Zr-DBP), and found that hydrazine carbonate solution could promote the dissolution of Zr-DBP. The effects of dissolution temperature and hydrogen peroxide concentration on the dissolution efficiency were also explored, and the corrosion effect on stainless steel by hydrazine carbonate solution was studied.
Article
Chemistry, Inorganic & Nuclear
Qiaofang Fu, Fangyu Tan, Wu Ying
Summary: This study successfully prepared vermiculite/g-C3N4/TiO2 composites and found that under specific conditions, the composites exhibited excellent degradation effects, with a high degradation rate for methylene blue. Additionally, the composites were able to enhance surface area, reduce carrier loading rate, improve light energy utilization, and enhance durability.
Article
Chemistry, Inorganic & Nuclear
Annabelle G. W. Hodson, Robert T. Mason
Summary: Functionalised polystyrene resins have been found to be efficient catalysts in the synthesis of specific complexes, with the conversion rate controlled by the polymer structure. The addition of amines or amino acids can further yield substituted 13-butadienyl complexes, which have been analyzed by NMR.
Article
Chemistry, Inorganic & Nuclear
C. Kavitha, S. Anbarasan, P. Subramaniam
Summary: The sulfoxidation of PMAAs by the oxo(salen)chromium(V) complex in aqueous acetonitrile medium was studied. The rate of the reaction is influenced by the polarity of the medium and the substituents on PMAA, with electron donating substituents accelerating the reaction and electron withdrawing substituents retarding the reaction.
Article
Chemistry, Inorganic & Nuclear
Qiang-Qiang Liu, Mithun Kumar Ghosh, Shu-Lan Cai, Xiao-Hong Liu, Lu Lu, Mohd. Muddassir, Tanmay Kumar Ghorai, Jun Wang
Summary: Three newly developed coordination polymers (CPs) with semiconducting properties were synthesized using hydrothermal methods. These CPs exhibit superior photocatalytic activity and can degrade organic pollutants effectively.
Article
Chemistry, Inorganic & Nuclear
Mehrnaz Aliahmadi, Ali Nemati Kharat, Jan Janczak
Summary: This study proposes a method for synthesizing allyl alcohol using cost-effective and renewable bio-resource glycerol. By utilizing catalysts, alcohol as a solvent, and a reducing agent, allyl alcohol with an efficiency of 100% was obtained. The structures of the newly synthesized complexes were determined using X-ray single crystallography.
Article
Chemistry, Inorganic & Nuclear
Ji-Yan Gao, Nan Zhang, Dong-Sheng Huang, Xiang-Rong Liu, Zai-Wen Yang, Shun-Sheng Zhao
Summary: Two new transition metal complexes I and II were synthesized and characterized. The complexes exhibited strong thermal stabilities and showed effective binding to CT-DNA and BSA. Complex II exhibited stronger inhibition activity against P. aeruginosa than gentamicin sulfate. These complexes have potential applications in drug research.
Article
Chemistry, Inorganic & Nuclear
Rishabh Ujjval, Hilal Ahmad Khan, Chinnappan Sivasankar, Natesan Thirupathi
Summary: In this study, a rigid 2-aminobenzimidazole type guanidine and its platinum complexes were synthesized through a series of reactions and characterized by various physical and chemical methods. The reaction mechanism was also explained through DFT calculations.
Article
Chemistry, Inorganic & Nuclear
Marcelo Carpes Nunes, Thais Zaboenco, Vinicius Kemper Melara, Gabriel Barros Baptistella, Andre Luiz Barboza Formiga, Andersson Barison, Fabio Souza Nunes
Summary: A new luminescent molecular thermometer has been developed, which uses the spin-crossover equilibrium of a nickelcyclen derivative to measure temperature. The sensor shows high sensitivity and accuracy.
Article
Chemistry, Inorganic & Nuclear
Yuyu Shan, Zhenqin Zhao, Xia Zhang, Zhan Wu, Xiu-Ling Li
Summary: In this study, a new bridging ligand was synthesized through refluxing, and two mononuclear Cu(I) complexes and two trinuclear Cu(I)-Eu(III) complexes were obtained through self-assembly. The Cu(I) antenna chromophores successfully transferred energy to the Eu(III) centers, achieving sensitized Eu(III) luminescence.
Article
Chemistry, Inorganic & Nuclear
Gabriela Sanchez-Lecuona, Mayra C. Vazquez-Nunez, Bruno Donnadieu, Miguel A. Munoz-Hernandez, Virginia Montiel-Palma
Summary: The reaction of RuHCl(PPh3)3 with GaMe3 has been studied and the obtained complexes were analyzed in detail. The results indicate the formation of a Ru-Ga bond, suggesting the generation of an in situ formed ambiphilic phosphinogallyl ligand. This is of significance for understanding the interaction between metal-halogen bonds and metal-small molecule bonds.
Article
Chemistry, Inorganic & Nuclear
Sevil Sener, Nursel Acar, Fatih Dumludag
Summary: The synthesis, characterization, spectroscopic and bonding features of a new Co (II) phthalocyanine compound containing two thiocarbohydrazone groups were explained. The compound showed semiconductor properties and potential as a temperature sensor.
Article
Chemistry, Inorganic & Nuclear
Ledja B. O. Davi, Aryanna S. P. N. Costa, Mariana S. Silva, Adriana S. Ribeiro, Cintya D. A. E. S. Barbosa, Julio C. S. Da Silva, Dimas J. P. Lima, Daniela S. Anunciacao
Summary: In this study, a dansyl derivative sensor called o-PDDS was prepared and used for the detection of Al3+ ions in water. The o-PDDS sensor exhibited high sensitivity and linear response towards Al3+ ions. Experimental and computational studies confirmed a 1:1 stoichiometry ratio between o-PDDS and Al3+ ions. Real sample analysis demonstrated the selectivity and detection performance of the sensor, indicating its potential for field use.