Journal
POLISH JOURNAL OF MICROBIOLOGY
Volume 70, Issue 4, Pages 421-429Publisher
POLSKIE TOWARZYSTWO MIKROBIOLOGOW-POLISH SOCIETY OF MICROBIOLOGISTS
DOI: 10.33073/pjm-2021-040
Keywords
silent genes; antimicrobial resistance; Salmonella spp; Escherichia coli; mutations
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Silent genes are DNA sequences that are not expressed or expressed at a very low level, and can become active through mutation, recombination, or insertion. Studying silent genes helps to understand the mechanism behind the spreading of antibiotic resistance.
Silent genes are DNA sequences that are generally not expressed or expressed at a very low level. These genes become active as a result of mutation, recombination, or insertion. Silent genes can also be activated in laboratory conditions using pleiotropic, targeted genome-wide, or biosynthetic gene cluster approaches. Like every other gene, silent genes can spread through horizontal gene transfer. Most studies have focused on strains with phenotypic resistance, which is the most common subject. However, to fully understand the mechanism behind the spreading of antibiotic resistance, it is reasonable to study the whole resistome, including silent genes. [GRAPHICS] .
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