Article
Dermatology
Ariel Knowles, Donald A. Glass II
Summary: Keloids remain a painful condition, especially for patients with skin of color. Recent research has revealed associations with other medical conditions and an inflammatory component to the disease, shedding light on its complexity. Future studies aim to identify causal genes and systemic diseases linked to keloids, and explore therapeutic options targeting the upregulated inflammatory and fibroproliferative genes. The ultimate goal is to prevent or reverse the irreversible scarring process in keloids.
DERMATOLOGIC CLINICS
(2023)
Article
Health Care Sciences & Services
Faris Yahya Asiri, Estie Kruger, Marc Tennant
Summary: This bibliometric review analyzed the top 100 most-cited publications in dentistry and found that the USA was the major contributing country with most articles being narrative reviews and evidence level mostly being V.
Article
Endocrinology & Metabolism
Hao Zhang, Yongqian Bian, Congying Zhao, Yan Wang, Rong Huang, Bin Lin, Danying Qin, Wei Xiong, Jing Li, Xueyong Li
Summary: This study found bacterial colonization in keloids and hypertrophic scars, and the differences in the species and number of colonizing bacteria may cause the heterogeneity of clinical manifestations. The pathogenicity and athletic ability of colonizing bacteria were positively correlated with the degree of hyperplasia and invasions of scars.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Dermatology
Grace C. Limandjaja, Frank B. Niessen, Rik J. Scheper, Susan Gibbs
Summary: Hypertrophic scars and keloids, although similar in many aspects, differ mainly in the extent of growth beyond the original wound for keloids. The distinction between the two is mostly qualitative, with histopathological differences not being as straightforward. Many similarities exist between the two, but there are also fundamental differences that suggest they should still be treated as separate entities until new findings convincingly prove otherwise.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
G. V. Oliveira, L. D. Metsavaht, B. Kadunc, S. K. K. Jedwab, M. S. Bressan, H. O. Stolf, R. G. Castro, S. M. F. M. C. Bezerra, D. A. Calil, F. A. Z. Addor, J. C. S. Fraga, C. M. S. Reis, E. Reis-Filho, M. R. Silva, M. Ramos-e-Silva, D. M. Hexsel
Summary: Keloids and hypertrophic scars are abnormal responses to wound healing caused by dermal inflammation. The lack of objective data, large genetic variability among patients and difficulties in conducting multicentre studies limit the progress of their treatment. A group of senior Brazilian dermatologists has contributed to the Brazilian Guidelines for the treatment of keloids and hypertrophic scars in order to facilitate multicentre studies.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Dermatology
Fabio Stefano Frech, Loren Hernandez, Rebecca Urbonas, Ghufran Abo Zaken, Isabella Dreyfuss, Keyvan Nouri
Summary: Hypertrophic scars and keloids can have significant negative impacts on patients, and it is important to identify patient risk factors and create a comprehensive management plan. Prevention is the best approach, but when it fails, a variety of therapies including corticosteroids, 5-fluorouracil, radiotherapy, lasers, and surgical excision can be used. Treatment should be tailored to the individual patient's risk factors with the use of combination therapies to reduce recurrence rates.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Review
Dermatology
Emily Y. Kim, Aamir Hussain, Amor Khachemoune
Summary: This paper reviews the evidence-based management of scars, including currently widely used treatment options and promising newly emerging therapies. Hypertrophic scars and keloids result from an abnormal wound-healing process, and can be prevented or treated by reducing inflammation and tension. Treatment options range from non-invasive modalities like pressure therapy and topicals to invasive methods such as injections, lasers, and surgery.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Dermatology
Hamideh Moravej, Ali Forghanian, Sahar Dadkhahfar, Nikoo Mozafari
Summary: Comparing the safety and efficacy of intralesional triamcinolone and bleomycin in the treatment of hypertrophic scars and keloids, the study found no significant difference in clinical improvement and level of lesion flattening between the two treatments, but bleomycin had more adverse events.
DERMATOLOGIC THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Chenyu Huang, Rei Ogawa
Summary: Studies suggest that inflammasomes may participate in the formation of pathological scars. Keloids predominantly consist of anti-inflammatory macrophages, while inflammasome activation is observed in diabetic wound healing and fibrotic conditions. Mechanical stimuli can activate inflammasomes via the cytoskeleton and contribute to fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Bruno Bordoni, Allan R. Escher, Gregory T. Girgenti, Filippo Tobbi, Roberto Bonanzinga
Summary: The skin is a complex organ that is influenced and influences the body system. Lesions in the dermis can lead to sensory, morphological, and functional changes in the skin, followed by the formation of scar tissue. Some healing processes result in pathological scars with symptoms such as pain, itching, and functional limitations. Manual medicine, which involves direct manual approaches to the site of injury, is one potential treatment option. However, there is still a lack of a gold standard treatment for different scars. Gentle manual approaches may be more beneficial for pathological scar adaptations.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Dermatology
Quan-Feng Luo
Summary: Through the combined treatment of bleomycin and triamcinolone in 86 patients with keloids and hypertrophic scars, it was observed that the pain and itching symptoms of scars were relieved, some keloids disappeared, and small keloids did not recur after treatment. Large keloids had local recurrence but it disappeared after further treatment. The combined application of bleomycin and triamcinolone is effective in the treatment of keloids and hypertrophic scars.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Review
Dermatology
Brandon Worley, Kathyrn Kim, Ketan Jain-Poster, Kelly A. Reynolds, Emily A. Merkel, Bianca Y. Kang, McKenzie A. Dirr, Noor Anvery, Rachel E. Christensen, Farhana Ikmal Hisham, Sarah A. Ibrahim, Sepideh Nikki Asadbeigi, Emily Poon, Murad Alam
Summary: Excessive healing after skin injury can lead to hypertrophic and keloidal scars, which negatively affect the quality of life. This review compares the effectiveness of different treatments for these scars. Intralesional injection may be more effective than physical or topical treatments. The combination of 5-fluorouracil and triamcinolone showed superior results for keloid treatment. Laser treatments, especially ablative laser and pulsed-dye laser, were found to be useful. Overall, appropriate treatment can greatly improve the quality of life for individuals with pathological scars.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Cell Biology
Ilias G. Petrou, Sofia Nikou, Srinivas Madduri, Martha Nifora, Vasiliki Bravou, Daniel F. Kalbermatten
Summary: This study found that the deregulation of Hippo signaling and Integrin-linked kinase (ILK) are closely associated with the formation of hypertrophic scars and keloids.
Article
Dermatology
Basma H. M. Khatery, Heba A. Hussein, Talal A. Abd-el-Raheem, Hala M. El Hanbuli, Noha N. Yassen
Summary: This study evaluated the clinical and histopathological effects of Botulinum toxin type A (BTX-A) injection on keloids and hypertrophic scars. The results showed significant improvement in both clinical and histological evaluations after the treatment.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Yuting Yang, Lan Liu, Ruxi Yang, Xiaobing Ding, Ying Li, Hongjun Liu, Hong Yan
Summary: The study used laser speckle contrast imaging (LSCI) to evaluate differences in blood perfusion between hypertrophic scars and keloids. The results suggest that differences in perfusion distribution between keloids and hypertrophic scars may provide insights for their identification, with LSCI being a potentially useful method for differentiation.
SKIN RESEARCH AND TECHNOLOGY
(2021)