Journal
ADDICTION BIOLOGY
Volume 21, Issue 2, Pages 422-437Publisher
WILEY
DOI: 10.1111/adb.12295
Keywords
Addictive behaviours; dependence; reward
Categories
Funding
- Swedish Research Council [2009-2782, 2011-4646]
- Swedish Society for Medical Research
- Swedish Brain Foundation
- LUA/ALF from the Sahlgrenska University Hospital
- Ragnar Soderberg
- Alcohol Research Council of the Swedish Alcohol Retailing Monopoly
- Foundation of Adlerbertska
- Foundation of Fredrik and Ingrid Thuring
- Foundation of Tore Nilsson
- Foundation of Langmanska
- Foundation of Wilhelm and Martina Lundgren
- Foundation of Knut and Alice Wallenberg
- Foundation of Magnus Bergvall
- Foundation of Aners
- Foundation of Jeansons and Ake Wiberg
- Swedish Society of Medicine
- Novo Nordisk Fonden [NNF15OC0016020] Funding Source: researchfish
Ask authors/readers for more resources
The incretin hormone, glucagon-like peptide 1 (GLP-1), regulates gastric emptying, glucose-dependent stimulation of insulin secretion and glucagon release, and GLP-1 analogs are therefore approved for treatment of type II diabetes. GLP-1 receptors are expressed in reward-related areas such as the ventral tegmental area and nucleus accumbens, and GLP-1 was recently shown to regulate several alcohol-mediated behaviors as well as amphetamine-induced, cocaine-induced and nicotine-induced reward. The present series of experiments were undertaken to investigate the effect of the GLP-1 receptor agonist, liraglutide, on several alcohol-related behaviors in rats that model different aspects of alcohol use disorder in humans. Acute liraglutide treatment suppressed the well-documented effects of alcohol on the mesolimbic dopamine system, namely alcohol-induced accumbal dopamine release and conditioned place preference in mice. In addition, acute administration of liraglutide prevented the alcohol deprivation effect and reduced alcohol intake in outbred rats, while repeated treatment of liraglutide decreased alcohol intake in outbred rats as well as reduced operant self-administration of alcohol in selectively bred Sardinian alcohol-preferring rats. Collectively, these data suggest that GLP-1 receptor agonists could be tested for treatment of alcohol dependence in humans.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available