4.4 Editorial Material

Enhancing the impact of Artificial Intelligence in Medicine: A joint AIFM-INFN Italian initiative for a dedicated cloud-based computing infrastructure

Journal

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.ejmp.2021.10.005

Keywords

Artificial intelligence; Decision support systems; Computing infrastructure; Distributed learning

Ask authors/readers for more resources

AI techniques have been utilized in Medical Imaging for over forty years, with recent advancements in Radiomics, Machine Learning, and Deep Learning. Despite progress, barriers remain in fully integrating AI tools into clinical workflows. As Medical Imaging enters the Big Data era, innovative solutions are needed to efficiently handle data and computing resources.
Artificial Intelligence (AI) techniques have been implemented in the field of Medical Imaging for more than forty years. Medical Physicists, Clinicians and Computer Scientists have been collaborating since the beginning to realize software solutions to enhance the informative content of medical images, including AI-based support systems for image interpretation. Despite the recent massive progress in this field due to the current emphasis on Radiomics, Machine Learning and Deep Learning, there are still some barriers to overcome before these tools are fully integrated into the clinical workflows to finally enable a precision medicine approach to patients' care. Nowadays, as Medical Imaging has entered the Big Data era, innovative solutions to efficiently deal with huge amounts of data and to exploit large and distributed computing resources are urgently needed. In the framework of a collaboration agreement between the Italian Association of Medical Physicists (AIFM) and the National Institute for Nuclear Physics (INFN), we propose a model of an intensive computing infrastructure, especially suited for training AI models, equipped with secure storage systems, compliant with data protection regulation, which will accelerate the development and extensive validation of AI-based solutions in the Medical Imaging field of research. This solution can be developed and made operational by Physicists and Computer Scientists working on complementary fields of research in Physics, such as High Energy Physics and Medical Physics, who have all the necessary skills to tailor the AI-technology to the needs of the Medical Imaging community and to shorten the pathway towards the clinical applicability of AI-based decision support systems.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Materials Science, Multidisciplinary

A 3D diamond dosimeter with graphitic surface connections

A. Porter, K. Kanxheri, I. Lopez, A. Oh, L. Servoli, C. Talamonti

Summary: A new prototype 3D diamond dosimeter, featuring laser-written graphitic surface connections and bonding pads, was tested on medical dosimetry. The device was made with a polycrystalline chemical vapour deposition diamond substrate and showed potential advantages over single crystal diamond in terms of size and cost. The 3D design of the device allowed for more efficient charge collection and reduced distortion of the electric field close to the surface of the diamond. By removing metal-diamond contacts, the operating voltage was lowered without affecting dose-rate independence.

DIAMOND AND RELATED MATERIALS (2023)

Article Radiology, Nuclear Medicine & Medical Imaging

Impact of patient?s habitus on image quality and quantitative metrics in 18F-FDG PET/CT images

Alessandra Zorz, Andrea D'Alessio, Federica Guida, Rehema Masaka Ramadan, Elisa Richetta, Lea Cuppari, Riccardo Pellerito, Gian Mauro Sacchetti, Marco Brambilla, Marta Paiusco, Michele Stasi, Roberta Matheoud

Summary: This study aims to investigate the changes in quantitative parameters of 18F-FDG PET imaging with respect to emission scan duration (ESD) and body-mass-index (BMI) in phantom and patients. Results show that a reduction in ESD may significantly impact the variations of SUVmax and SULmax in 18F-FDG PET/CT imaging. The use of SUL is recommended for lesion uptake quantification, as it is unaffected by BMI variation.

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS (2023)

Article Radiology, Nuclear Medicine & Medical Imaging

Quality assessment, variability and reproducibility of anatomical measurements derived from T1-weighted brain imaging: The RIN-Neuroimaging Network case study

Paolo Bosco, Marta Lancione, Alessandra Retico, Anna Nigri, Domenico Aquino, Francesca Baglio, Irene Carne, Stefania Ferraro, Giovanni Giulietti, Antonio Napolitano, Fulvia Palesi, Luigi Pavone, Giovanni Savini, Fabrizio Tagliavini, Gandini Wheeler-Kingshott, Michela Tosetti, Laura Biagi

Summary: This study assessed the brain anatomical variability of MRI-derived measurements obtained from T1-weighted images according to standardized procedures. The results indicated some variability in the measurements obtained from multi-site and multi-vendor datasets, but no systematic biases were detected.

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS (2023)

Article Radiology, Nuclear Medicine & Medical Imaging

Deriving quantitative information from multiparametric MRI via Radiomics: Evaluation of the robustness and predictive value of radiomic features in the discrimination of low-grade versus high-grade gliomas with machine learning

Leonardo Ubaldi, Sara Saponaro, Alessia Giuliano, Cinzia Talamonti, Alessandra Retico

Summary: This study aims to discriminate between high-grade (HGG) and low-grade (LGG) gliomas using a robust processing pipeline based on Radiomics and Machine Learning (ML) with multiparametric Magnetic Resonance Imaging (MRI) data. The results show that using MRI-reliable features improves the performance in glioma grade classification.

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS (2023)

Article Engineering, Biomedical

Hydrogenated amorphous silicon high flux x-ray detectors for synchrotron microbeam radiation therapy

Matthew J. Large, Marco Bizzarri, Lucio Calcagnile, Mirco Caprai, Anna Paola Caricato, Roberto Catalano, Giuseppe A. P. Cirrone, Tommaso Croci, Giacomo Cuttone, Sylvain Dunand, Michele Fabi, Luca Frontini, Benedetta Gianfelici, Catia Grimani, Maria Ionica, Keida Kanxheri, Michael L. F. Lerch, Valentino Liberali, Maurizio Martino, Giuseppe Maruccio, Giovanni Mazza, Mauro Menichelli, Anna Grazia Monteduro, Francesco Moscatelli, Arianna Morozzi, Stefania Pallotta, Andrea Papi, Daniele Passeri, Maddalena Pedio, Giada Petringa, Francesca Peverini, Lorenzo Piccolo, Pisana Placidi, Gianluca Quarta, Silvia Rizzato, Alessandro Rossi, Giulia Rossi, Vincent de Rover, Federico Sabbatini, Leonello Servoli, Alberto Stabile, Cinzia Talamonti, Luca Tosti, Mattia Villani, Richard J. Wheadon, Nicolas Wyrsch, Nicola Zema, Marco Petasecca

Summary: Microbeam radiation therapy (MRT) is a promising alternative radiotherapy treatment method that effectively controls radioresistant tumors while sparing healthy tissue. In this study, radiation-hardened a-Si:H diodes were characterized for x-ray dosimetry and real-time beam monitoring in high-flux beamlines for MRT. The devices showed excellent radiation hardness and accurate dosimetric performance, making them suitable for high dose-rate environments like FLASH and MRT.

PHYSICS IN MEDICINE AND BIOLOGY (2023)

Article Physics, Multidisciplinary

Quantification of pulmonary involvement in COVID-19 pneumonia: an upgrade of the LungQuant software for lung CT segmentation

Francesca Lizzi, Ian Postuma, Francesca Brero, Raffaella Fiamma Cabini, Maria Evelina Fantacci, Alessandro Lascialfari, Piernicola Oliva, Lisa Rinaldi, Alessandra Retico

Summary: This study presents an improved version of the LungQuant automatic segmentation software, which uses three deep neural networks to evaluate lung involvement in COVID-19 pneumonia patients through CT scans. The new version introduces BB-net for defining lung boundaries, adds a new term in the U-net loss function for lesion segmentation, and includes a post-processing procedure to separate the right and left lungs. The results show that LungQuant v2 achieves high accuracy in lung and lesion segmentation with vDSC and sDSC scores of 0.96/0.97 and 0.69/0.83 respectively.

EUROPEAN PHYSICAL JOURNAL PLUS (2023)

Article Chemistry, Multidisciplinary

Artificial Intelligence-Based Patient Selection for Deep Inspiration Breath-Hold Breast Radiotherapy from Respiratory Signals

Alessandra Vendrame, Cristina Cappelletto, Paola Chiovati, Lorenzo Vinante, Masud Parvej, Angela Caroli, Giovanni Pirrone, Loredana Barresi, Annalisa Drigo, Michele Avanzo

Summary: Deep Bidirectional Long Short-Term Memory (BLSTM) recurrent neural networks were used to predict eligibility for deep inspiration breath-hold (DIBH) radiotherapy treatment in patients with left breast cancer based on analysis of respiratory signals. The BLSTM-RNN accurately classified patients eligible for DIBH, achieving high accuracy, specificity, sensitivity, F1 score, and AUC in the test dataset. This provides promising results for the development of an accurate and robust decision system to assist the radiotherapy team in assigning patients to DIBH.

APPLIED SCIENCES-BASEL (2023)

Article Chemistry, Multidisciplinary

Multi-Site MRI Data Harmonization with an Adversarial Learning Approach: Implementation to the Study of Brain Connectivity in Autism Spectrum Disorders

Federico Campo, Alessandra Retico, Sara Calderoni, Piernicola Oliva

Summary: Magnetic resonance imaging (MRI) is important in identifying brain underpinnings in neuropsychiatric disorders, including Autism Spectrum Disorders (ASD). Two approaches, DNN and ComBat-GAM, are comparable in dealing with multicenter MRI data harmonization.

APPLIED SCIENCES-BASEL (2023)

Article Computer Science, Information Systems

Double-Tuned Birdcage Radio Frequency Coil for 7 T MRI: Optimization, Construction and Workbench Validation

Alessandra Retico, Francesca Maggiorelli, Giulio Giovannetti, Eddy Boskamp, Fraser Robb, Marco Fantasia, Angelo Galante, Marcello Alecci, Gianluigi Tiberi, Michela Tosetti

Summary: The present study aims to optimize, construct, and validate a double-tuned H-1-Na-23 volume RF coil suitable for human head imaging at 7 T, based on the birdcage geometry. A four-ring model has been selected and evaluated through simulations based on Maxwell's equations to ensure RF magnetic field homogeneity and efficiency. The best-performing four-ring model has been built and tested on a workbench using a cylindrical phantom filled with a 0.05 M saline solution, demonstrating its potential for H-1-Na-23 human head imaging at 7 T.

ELECTRONICS (2023)

Article Radiology, Nuclear Medicine & Medical Imaging

A multicenter evaluation of a deep learning software (LungQuant) for lung parenchyma characterization in COVID-19 pneumonia

Camilla Scapicchio, Andrea Chincarini, Elena Ballante, Luca Berta, Eleonora Bicci, Chandra Bortolotto, Francesca Brero, Raffaella Fiamma Cabini, Giuseppe Cristofalo, Salvatore Claudio Fanni, Maria Evelina Fantacci, Silvia Figini, Massimo Galia, Pietro Gemma, Emanuele Grassedonio, Alessandro Lascialfari, Cristina Lenardi, Alice Lionetti, Francesca Lizzi, Maurizio Marrale, Massimo Midiri, Cosimo Nardi, Piernicola Oliva, Noemi Perillo, Ian Postuma, Lorenzo Preda, Vieri Rastrelli, Francesco Rizzetto, Nicola Spina, Cinzia Talamonti, Alberto Torresin, Angelo Vanzulli, Federica Volpi, Emanuele Neri, Alessandra Retico

Summary: This study evaluated the performance of the LungQuant system, a software for quantitative analysis of chest CT, by comparing its results with independent visual evaluations by clinical experts. The aim was to assess the ability of the automated tool to extract quantitative information from lung CT relevant to the clinical assessment of COVID-19 pneumonia.

EUROPEAN RADIOLOGY EXPERIMENTAL (2023)

Article Instruments & Instrumentation

Neutron irradiation of Hydrogenated Amorphous Silicon p-i-n diodes and charge selective contacts detectors

M. Menichelli, M. Bizzarri, M. Boscardin, L. Calcagnile, M. Caprai, A. P. Caricato, G. A. P. Cirrone, M. Crivellari, I. Cupparo, G. Cuttone, S. Dunand, L. Fano, B. Gianfelici, O. Hammad, M. Ionica, K. Kanxheri, M. Large, G. Maruccio, A. G. Monteduro, F. Moscatelli, A. Morozzi, A. Papi, D. Passeri, M. Pedio, M. Petasecca, G. Petringa, F. Peverini, G. Quarta, S. Rizzato, A. Rossi, G. Rossi, A. Scorzoni, L. Servoli, C. Talamonti, G. Verzellesi, N. Wyrsch

Summary: Hydrogenated amorphous silicon is commonly used in radiation-resistant detectors for particle beam flux measurements and space solar panels. This study focuses on p-i-n and charge selective contacts planar diode detectors with a thickness of 10 μm, which were irradiated with neutrons at two fluence values. The radiation resistance of the detectors was evaluated by measuring leakage current and response to x-ray photons. The results show that the leakage current increased by a factor of 2 after irradiation at 1016 neq/cm2, but was completely recovered after annealing for p-i-n devices. X-ray dosimetric sensitivity degraded after irradiation, but partially recovered for charge selective contact devices and increased for p-i-n devices after annealing. For the irradiation test at 5 x 1016 neq/cm2, noticeable degradation in leakage current and x-ray sensitivity was observed after storage, with a small recovery after annealing.

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT (2023)

Article Medicine, General & Internal

Artificial Intelligence-Assisted Processing of Anterior Segment OCT Images in the Diagnosis of Vitreoretinal Lymphoma

Fabrizio Gozzi, Marco Bertolini, Pietro Gentile, Laura Verzellesi, Valeria Trojani, Luca De Simone, Elena Bolletta, Valentina Mastrofilippo, Enrico Farnetti, Davide Nicoli, Stefania Croci, Lucia Belloni, Alessandro Zerbini, Chantal Adani, Michele De Maria, Areti Kosmarikou, Marco Vecchi, Alessandro Invernizzi, Fiorella Ilariucci, Magda Zanelli, Mauro Iori, Luca Cimino

Summary: This cross-sectional single-center study investigated the ability of anterior segment optical coherence tomography (AS-OCT) to distinguish vitreous involvement due to vitreoretinal lymphoma (VRL) from vitritis in uveitis. AS-OCT images from 28 patients were analyzed using radiomics software, and a classification model was built using xgboost python function. The model achieved an 87% accuracy in diagnosing VRL or uveitis.

DIAGNOSTICS (2023)

Proceedings Paper Engineering, Electrical & Electronic

X-ray qualification of hydrogenated amorphous silicon sensors on flexible substrate

M. Menichelli, L. Antognini, A. Bashiri, M. Bizzarri, L. Calcagnile, M. Caprai, A. P. Caricato, R. Catalano, G. A. P. Cirrone, T. Croci, G. Cuttone, S. Dunand, M. Fabi, L. Frontini, C. Grimani, M. Ionica, K. Kanxheri, M. Large, V. Liberali, M. Martino, G. Maruccio, G. Mazza, A. G. Monteduro, A. Morozzi, F. Moscatelli, S. Pallotta, A. Papi, D. Passeri, M. Pedio, M. Petasecca, G. Petringa, F. Peverini, L. Piccolo, P. Placidi, G. Quarta, S. Rizzato, G. Rossi, F. Sabbatini, A. Stabile, L. Servoli, C. Talamonti, L. Tosti, M. Villani, R. J. Wheadon, N. Wyrsch, N. Zema

Summary: This paper examines the dosimetric X-ray response of p-i-n diodes deposited on Polyimide. The linearity of the photocurrent response to X-rays versus dose-rate is studied, and the dosimetric sensitivity at various bias voltages is extracted. This study is repeated for devices with two different areas (2 mm x 2 mm and 5 mm x 5 mm), and the stability of X-ray response over time is also demonstrated.

2023 9TH INTERNATIONAL WORKSHOP ON ADVANCES IN SENSORS AND INTERFACES, IWASI (2023)

No Data Available