Review
Plant Sciences
Haoyu Xue, Mengjuan Wei, Lili Ji
Summary: This review analyzes the hepatoprotective effect of chlorogenic acids (CGAs) and their mechanisms. CGAs have been found to improve various liver diseases, including drug-induced liver injury, alcoholic liver disease, metabolic-associated fatty liver disease, cholestatic liver disease, liver fibrosis, and liver cancer. They exhibit remarkable antioxidant and anti-inflammatory effects by activating Nrf2 and inhibiting TLR4/NF-kappa B signaling pathways, and also involve key molecules such as AMPK and ERK1/2, as well as physiological processes like intestinal barrier and gut microbiota.
Article
Agriculture, Multidisciplinary
Xiangyang Zhu, Fan Si, Rili Hao, Jingjie Zheng, Chen Zhang
Summary: This study investigated the protective effects of nuciferine on kidney damage caused by high-fat diets and its underlying mechanisms. The results showed that nuciferine could alleviate chronic renal dysfunction, delay renal fibrosis progression, and prevent podocyte apoptosis. It achieved these effects by reducing renal lipid accumulation, suppressing inflammation and oxidative stress, and regulating key protein factors.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Xiaoya Li, Changxin Sun, Jingyi Zhang, Lanqing Hu, Zongliang Yu, Xiaonan Zhang, Zeping Wang, Jiye Chen, Min Wu, Longtao Liu
Summary: This review evaluates the pharmacological effects and potential mechanisms of paeoniflorin in the treatment of cardiovascular diseases, aiming to advance its further development and application. Paeoniflorin can protect the cardiovascular system by regulating glucose and lipid metabolism, exerting anti-inflammatory, anti-oxidative stress, and anti-arteriosclerotic activities, improving cardiac function, and inhibiting cardiac remodeling. However, further studies on its bioavailability, toxicology, safety, and clinical efficacy are needed.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agricultural Engineering
Xiaobo Huang, Nan Hao, Genqiang Chen, Shengming Liu, Zhiping Che
Summary: This overview comprehensively summarizes the widespread knowledge regarding the chemistry and biology of nuciferine, including isolation techniques, synthesis, structural modification, bioactivities, metabolism, and biosynthesis. Furthermore, it provides a prospective outlook on future research in this field.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Medicine, Research & Experimental
Naoual El Menyiy, Sara Aboulaghras, Saad Bakrim, Rania Moubachir, Doaue Taha, Asaad Khalid, Ashraf N. Abdalla, Alanood S. Algarni, Andi Hermansyah, Long Chiau Ming, Marius Emil Rusu, Abdelhakim Bouyahya
Summary: Plant bioactive molecules, particularly genkwanin, have potential preventive and therapeutic roles in aging and chronic diseases due to their antioxidant and anti-inflammatory properties. The present review provides a comprehensive analysis of genkwanin, including its natural sources, pharmacokinetics, and various biological and pharmacological activities. Genkwanin exhibits antioxidant, anti-inflammatory, antihyperglycemic, cardioprotective, neuroprotective, antitumor, antibacterial, antiviral, and dermatoprotective effects. Further research is needed to fully understand its therapeutic potential, including pharmacodynamics, pharmacokinetics, and toxicological and clinical investigations, to unlock the complete range of its therapeutic applications.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Yingying Lu, Zhijia Li, Shuangqian Zhang, Tongtong Zhang, Yanjun Liu, Lan Zhang
Summary: Cellular mitophagy refers to the process in which cells selectively wrap and degrade damaged mitochondria through autophagy, thus maintaining mitochondrial and intracellular homeostasis. In recent years, mitophagy has gained attention as a research hotspot in the pathogenesis of various clinical diseases. It has been discovered that regulating mitophagy may open up new directions for disease treatment. Additionally, there have been reports of small molecule modulators of mitophagy, providing opportunities to understand the process and potential for therapeutic development.
Review
Immunology
Mohammad Ghanbari, Salar Momen Maragheh, Aida Aghazadeh, Seyed Reza Mehrjuyan, Bashdar Mahmud Hussen, Mahdi Abdoli Shadbad, Narges Dastmalchi, Reza Safaralizadeh
Summary: Obesity leads to chronic low-grade inflammation by upregulating pro-inflammatory interleukins (ILs), particularly IL-1 alpha and IL-1 beta, which promote insulin resistance and dysfunction of adipocytes. The study aims to review the molecular mechanisms and roles of IL-1 in obesity-related complications like type II diabetes, non-alcoholic steatohepatitis, atherosclerosis, and cognitive disorders, as well as discuss advances in treating these complications through IL-1 suppression with natural drugs, synthetic agents, and gene therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Mengzhen Xue, Fangqi Xia, Yaqi Wang, Leiqi Zhu, Yuanyang Li, Dengke Jia, Yan Gao, Yue Shi, Changcheng Zhang, Yumin He, Chaoqi Liu, Ding Yuan, Chengfu Yuan
Summary: As people's living standards improve, obesity has become a focus. TUG1 is related to the occurrence and development of obesity-related diseases, while exosomes play a role in regulating disease molecular mechanisms.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Xi-Tao Li, Jie-Chun Zhou, Yu Zhou, Ying-Shan Ren, Yu-Hong Huang, Shu-Mei Wang, Long Tan, Zhi-You Yang, Yue-Wei Ge
Summary: This review summarizes the traditional uses and therapeutic effects of Eleutherococcus senticosus in the treatment of fatigue, depression, Alzheimer's disease, Parkinson's disease, and cerebral ischemia, and discusses the underlying mechanisms involved.
PHYTOTHERAPY RESEARCH
(2022)
Review
Food Science & Technology
Xiao-Yu Xu, Cai-Ning Zhao, Bang-Yan Li, Guo-Yi Tang, Ao Shang, Ren-You Gan, Yi-Bin Feng, Hua-Bin Li
Summary: Obesity is a global health concern and tea and its components have the potential to combat obesity by increasing energy expenditure and lipid catabolism, decreasing nutrient digestion and absorption, and regulating adipocytes, neuroendocrine system, and gut microbiota.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Plant Sciences
Sabrin R. M. Ibrahim, Alaa Sirwi, Basma G. Eid, Shaimaa G. A. Mohamed, Gamal A. Mohamed
Summary: Liver diseases are a significant threat to human health, with autoimmune hepatitis being a chronic condition that can lead to severe complications. Natural products are promising therapies for treating liver disorders, and there is a need for discovering new drug candidates to treat immune-mediated liver injury.
Review
Nutrition & Dietetics
Carmen M. Claro-Cala, Francesc Jimenez-Altayo, Sebastian Zagmutt, Rosalia Rodriguez-Rodriguez
Summary: Dietary components, specifically olive oil triterpenes, have potential protective effects against obesity and related metabolic and cardiovascular disorders. This review focuses on understanding the molecular mechanisms and targets of these triterpenic compounds in improving glucose and insulin homeostasis, lipid metabolism, adiposity, and cardiovascular dysfunction in obesity. The study highlights the potential of olive oil as a dietary component for long-term management of obesity and metabolic syndrome in humans.
Review
Medicine, Research & Experimental
Zehui Xu, Houle Zhou, Yihan Zhang, Ziji Cheng, Melisandre Wan, Wanting Qin, Peiyu Li, Jiaming Feng, Shuijin Shao, Wenlong Xue, Haidong Guo, Baonian Liu
Summary: Cardiovascular disease (CVD) is the leading cause of death and disability globally, and traditional Chinese medicine (TCM) has advantages in CVD treatment. Astragaloside IV (AS-IV), a major active ingredient in Astragalus membranaceus, has shown promising results in CVD treatment and has attracted significant attention.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Food Science & Technology
Fengzhang Wang, Yong Xue, Lin Fu, Yongtao Wang, Minxia He, Liang Zhao, Xiaojun Liao
Summary: Capsaicin, a well-known vanilloid found in chili peppers, exhibits diverse biological activities including antimicrobial, anti-obesity, anticancer properties, and pain relief effects. Its potential applications range from food flavorings to therapeutics, with promising roles in biofilms, antifouling coatings, metabolic disorders, and cancer prevention. Further research is needed to explore its interaction with gut microbiota and its mechanisms of action for future applications in human health and manufacturing.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Raz Alfahel, Tomasz Sawicki, Monika Jablonska, Katarzyna E. Przybylowicz
Summary: This article explores the potential anti-hyperglycemic effects of bioactive compounds in functional foods, specifically flavonoids and phenolic acids, and their roles in mitigating chronic diseases and promoting human health. The study investigates how these compounds modulate glucose transporters, with the aim of identifying effective strategies for the prevention and treatment of diet-related diseases.
Review
Chemistry, Applied
Zhong-Hui Pu, Min Dai, Liang Xiong, Cheng Peng
Summary: Rhizome Chuanxiong (RCX), a geoauthentic traditional Chinese medicine herb, has been found to have efficacy in promoting blood circulation, removing blood stasis, and alleviating pain. Rhizome Chuanxiong total alkaloids (RCXTAs) are the major characteristic constituents of RCX and have been shown to have various biological activities, such as antimigraine and neuroprotective effects. Recent advances in the chemical analysis and biological activities of RCXTAs are reviewed in this article.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Dan Li, Chao Yang, Jian-zhong Zhu, Eduardo Lopez, Tian Zhang, Qiang Tong, Cheng Peng, Li-gen Lin
Summary: The study demonstrated that BBR improved adipose tissue remodelling by activating SIRT3, which reduced the secretion of microRNA-155-5p by macrophages, thereby alleviating obesity, insulin resistance, and liver injury.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Integrative & Complementary Medicine
Guan-ru Chen, Xiao-fang Xie, Cheng Peng
Summary: Irritable bowel syndrome (IBS) is a common and difficult-to-treat disease, and Chinese medicine has shown remarkable efficacy and advantages in its treatment. This review summarizes the literature on the treatment of IBS with Chinese medicine, highlighting the latest treatment methods and underlying mechanisms. The primary methods of Chinese medicine treatment for IBS are herbal prescriptions, acupuncture, and moxibustion, with potential mechanisms involving the regulation of the enteric nervous system, alleviation of visceral hypersensitivity, stability of intestinal flora, and regulation of the immune system.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Plant Sciences
Guanru Chen, Xiaofang Xie, Fu Peng, Tianzhixin Wang, Junren Chen, Gangmin Li, Juan Liu, Cheng Peng
Summary: The combination of essential oils from patchouli and tangerine peel can repair gastric mucosal damage in GU rats, prevent ulcer occurrence by inhibiting gastric acid secretion, enhancing gastric mucosal defensive ability, and suppressing gastric epithelial cell apoptosis. The optimal compatible ratio of patchouli and tangerine peel is 1:2.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Wu-wen Feng, Juan Liu, Hao Cheng, Cheng Peng
Summary: Chinese medicines are attracting more attention worldwide, and understanding the interactions between Chinese medicines and the human body is crucial. Emerging fields such as gut microbiota and metabolomics provide new avenues for deciphering these mechanisms.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Shengnan Shen, Qiwen Liao, Xiuping Chen, Cheng Peng, Ligen Lin
Summary: This review summarizes the roles of irisin in regulating glucose metabolism, neuroplasticity, satiety, cell function, bone remodeling, and adipose tissue function. Irisin acts as a key communicator between skeletal muscle and other organs, and manipulating its levels could be a promising therapeutic strategy for treating obesity and related metabolic disorders.
DRUG DISCOVERY TODAY
(2022)
Article
Chemistry, Organic
Yan-Qing Liu, Qing-Zhu Li, Xin-Xin Kou, Rong Zeng, Ting Qi, Xiang Zhang, Cheng Peng, Bo Han, Jun-Long Li
Summary: An N-heterocyclic carbene organocatalytic 1,4-difunctionalization of 1,3-enynes has been developed, allowing efficient synthesis of allenic ketones bearing diverse substituents. Preliminary mechanistic studies suggest a radical reaction pathway for this organocatalytic acylalkylation process.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Chemistry, Analytical
Zhentao Tang, Fei Liu, Fang Fang, Xuelu Ding, Qingrong Han, Yuzhu Tan, Cheng Peng
Summary: This paper summarizes the use of solid-phase extraction techniques as methodological solutions for mycotoxin analysis, with a focus on the application of nanomaterials in this technology, discussing the advantages, limitations, and potential prospects.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Chemistry, Analytical
Dongbin Zheng, Tingrui Zhang, Ying Huang, Hanlin Chen, Yuzhi Li, Zhixing Cao, Yun Deng, Yuyu Fang, Cheng Peng
Summary: In this study, a new turn-on fluorescent probe PhB was designed and synthesized to detect SO2 and its derivatives with high sensitivity and selectivity. The probe showed excellent fluorescence recognition ability under physiological conditions and had low cytotoxicity.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Fei Zhou, Rui Feng, Ou Dai, Lian Yang, Yu Liu, Yun-Cai Tian, Cheng Peng, Liang Xiong
Summary: In this study, phenanthrene derivatives were isolated from the tubers of B. striata and one compound showed cytotoxicity against non-small cell lung cancer cells. It inhibited cell proliferation and migration and promoted cell apoptosis, possibly by regulating Akt, MEK/ERK, and Bcl-2/Bax signaling pathways.
Article
Engineering, Biomedical
Yang He, Chenyan Hu, Zhijia Li, Chuan Wu, Yuanyuan Zeng, Cheng Peng
Summary: Early diagnosis of infectious diseases and tumors is crucial for global public health. Carbon nanomaterials have been widely studied and proven to improve the accuracy of diagnosis in various scientific fields. This review focuses on their applications in diagnosing infectious diseases and tumors over the past five years. Recent advances in biosensing, bioimaging, and nucleic acid amplification technologies using carbon nanomaterials are discussed, highlighting their unique properties and the challenges and opportunities for future clinical applications.
MATERIALS TODAY BIO
(2022)
Review
Medicine, Research & Experimental
Jiao-Jiao Wu, Yu Yang, Yan Wan, Jia Xia, Jin-Feng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao, Cheng Peng
Summary: Alzheimer's disease is a common neurodegenerative disorder in the elderly, characterized by memory loss and cognitive dysfunction. Ginsenoside Rg1, the main component of ginseng roots, has shown therapeutic effects in the treatment of Alzheimer's disease. This review summarizes the therapeutic effects and mechanisms of ginsenoside Rg1 and its derivatives in Alzheimer's disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Integrative & Complementary Medicine
Xu Xin, Xie Xiao-fang, Dong Yan-hong, Zhang Hui-qiong, Peng Cheng
Summary: This study found that ginsenoside Rg(1) can inhibit the cardiotoxic effect of aconitine (AC) and enhance its cardiotonic effect. This synergistic mechanism is mediated through the regulation of ion channels pathway ([Na+],[K+], and [Ca2+]). In addition, Rg(1) also has a protective effect on damaged cardiomyocytes.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Review
Integrative & Complementary Medicine
Yan Chen, Meifeng Li, Jiayu Wen, Xiaoqi Pan, Zixin Deng, Junren Chen, Guanru Chen, Lei Yu, Yunli Tang, Gangmin Li, Xiaofang Xie, Cheng Peng
Summary: This paper reviews the main chemical constituents, pharmacological properties, and clinical applications of safflower yellow (SY), a natural pigment extracted from safflower petals. The results show that SY has a wide range of pharmacological activities, especially in improving cardiovascular and cerebrovascular diseases.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Zhentao Tang, Zhiguo Gong, Wei Jia, Wenxuan Shen, Qingrong Han, Fang Fang, Cheng Peng
Summary: This study investigated the occurrence and risk assessment of phthalate esters (PAEs) in imported plant oils in western China. The results showed that PAEs were ubiquitous contaminants in these oils, with potential health risks.
