Aryne Three-Component Coupling Involving CS2 for the Synthesis of S-Aryl Dithiocarbamates

A facile synthesis of biologically important S-aryl dithiocarbamates has been demonstrated by the aryne three-component coupling involving CS2 and aliphatic amines. This transition-metal-free and mild reaction is scalable and operates with good functional group compatibility. Preliminary mechanistic experiments, including density functional theory studies, are also provided. Moreover, with 3-triflyloxybenzynes, a unique four-component coupling incorporating tetrahydrofuran was observed.

Automated summary

This study demonstrates a facile synthesis of biologically important S-aryl dithiocarbamates through aryne three-component coupling, and presents preliminary mechanistic experiments. Additionally, a unique four-component coupling reaction was observed.