Journal
ORGANIC LETTERS
Volume 23, Issue 22, Pages 8921-8925Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c03413
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Funding
- NNSFC [21971026]
- Jiangsu Key Laboratory of Advanced Catalytic Materials Technology [BM2012110]
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The catalyst-free reaction described in this study allows for the straightforward synthesis of 1,5-dihydro-2H-benzo[b]azepin-2-ones under mild reaction conditions, with a broad substrate scope and good functional group tolerance. Additionally, a series of pyridoazepinones have been prepared using N-pyridinyl sulfilimine as the substrate.
A catalyst-free [4+3]-cycloaddition reaction of N-aryl sulfilimines with cyclobutenones is described, which provides a straightforward protocol for synthesizing 1,5-dihydro-2H-benzo[b]azepin-2-ones under mild reaction conditions. This reaction features a broad substrate scope and good functional group tolerance and does not require catalysts or additives. Moreover, using N-pyridinyl sulfilimine as the substrate, a series of pyridoazepinones have also been prepared.
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