Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides

N,N & PRIME;-Bis(pyridin-2-ylmethyl)oxalamide (BPMO) was found to be an apposite promoter for the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with (hetero)aryl iodides at room temperature. Excellent chemoselectivity reached between aryl iodides and aryl bromides, and a wide range of functional groups tolerated the reaction conditions, which led to the formation of greatly diverse N-arylation products.

Automated summary

BPMO is an appropriate promoter for the Cu-catalyzed N-arylation reaction at room temperature, showing excellent chemoselectivity between aryl iodides and aryl bromides, and good tolerance towards diverse functional groups.