Article
Oncology
Ya-Ya Deng, Xin-Yue Zhang, Peng-Fei Zhu, Hong-Rui Lu, Qian Liu, Shuang-Yue Pan, Zhe-Ling Chen, Liu Yang
Summary: This study analyzed the data of patients with metastatic colorectal cancer who were treated with fruquintinib and regorafenib, and compared the efficacy and safety of the two drugs. The results showed that fruquintinib monotherapy had better disease control rate and objective remission rate in post-line therapy of metastatic colorectal cancer. Additionally, the combination of PD-1 immunotherapy further enhanced the effectiveness. Patients treated with regorafenib and then fruquintinib had significantly longer survival than those with the reverse treatment sequence. The adverse reactions of fruquintinib and regorafenib were similar.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Liying Sun, Shenglan Huang, Dan Li, Ye Mao, Yurou Wang, Jianbing Wu
Summary: The study suggests that fruquintinib combined with PD-1 inhibitor may improve progression-free survival time in patients with advanced MSS or pMMR mCRC compared to regorafenib combined with PD-1 inhibitor.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Arvind Dasari, Alberto Sobrero, James Yao, Takayuki Yoshino, William Schelman, Zhao Yang, Caly Chien, Marek Kania, Josep Tabernero, Cathy Eng
Summary: Fruquintinib, a novel tyrosine kinase inhibitor, is approved in China for metastatic colorectal cancer treatment. The global FRESCO-2 study aims to assess its efficacy and safety in refractory patients.
Article
Oncology
Sirui Tan, Shunyu Zhang, Nan Zhou, Xiaohong Cai, Cheng Yi, Hongfeng Gou
Summary: This study investigates the efficacy and safety of fruquintinib dose-escalation strategy in elderly refractory metastatic colorectal cancer patients.
Article
Multidisciplinary Sciences
Nieves Martinez-Lago, Soledad Cameselle Garcia, Beatriz Alonso de Castro, Martin Gomez-Randulfe Rodriguez, Marta Carmona Campos, Paula Gonzalez Villarroel, Mercedes Salgado Fernandez, Juan C. De la Camara Gomez, Carlos Romero Reinoso, Antia Cousillas Castineiras, Jose Carlos Mendez Mendez, Yolanda Vidal Insua, Ana Fernandez-Montes
Summary: The study demonstrates the efficacy of FA in elderly patients, with a need for careful consideration of side effects and dose adjustments in those over 75 years old. It also highlights the predictive value of hypertension for treatment efficacy.
Article
Oncology
Yefei Shu, Song Zheng
Summary: This case reports a female patient with mCRC who developed severe rashes after taking fruquintinib for 2 weeks. While fruquintinib has shown good safety and manageable toxicity in previous trials, rare cases of severe rash reactions may occur in some patients. This highlights the importance of monitoring for adverse reactions in patients receiving fruquintinib.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yan Song, Tao Qu, Honggang Zhang, Yongkun Sun, Chengxu Cui, Yihebali Chi, Wen Zhang, Xingyuan Wang, Lin Yang
Summary: This study aimed to evaluate the safety and effectiveness of fruquintinib in Chinese mCRC patients, with findings showing a relatively low incidence of TRAEs, and consistent PFS and OS results compared to randomized controlled trials. Patients with hypertension or hypothyroidism may experience a potential survival extension of approximately 6 months.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Weijie Zhang, Zhongyue Zhang, Shitong Lou, Donghui Li, Zhijun Ma, Lei Xue
Summary: Research has shown that combining anti-angiogenesis inhibitors with PD-1 inhibitors can reverse the immunosuppressive tumor microenvironment and enhance the immune response against tumors. This study evaluated the efficacy, safety, and predictors of the combination of fruquintinib and PD-1 inhibitors in patients with MSS/pMMR advanced colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Qi Zhang, Mifen Chen, Zhenghang Wang, Changsong Qi, Yanshuo Cao, Junyan Zhang, Zhi Peng, Xicheng Wang, Ming Lu, Lin Shen, Jian Li
Summary: This ambispective observational cohort study evaluated the differences in efficacy and safety between regorafenib and fruquintinib in patients with refractory metastatic colorectal cancer (mCRC) in China. The study found that regorafenib and fruquintinib had similar efficacy in a real-world setting and their toxicity profiles were also similar but with different frequencies. Additionally, the sequence of regorafenib followed by fruquintinib showed longer overall survival.
CLINICAL COLORECTAL CANCER
(2022)
Review
Oncology
Beatrice Borelli, Carlotta Antoniotti, Martina Carullo, Marco Maria Germani, Veronica Conca, Gianluca Masi
Summary: The manuscript provides a comprehensive overview of the treatment with ICIs in dMMR/MSI-H metastatic colorectal cancer, discussing current challenges, mechanisms of resistance, and potential predictive biomarkers. It highlights the impressive results of ICIs in dMMR/MSI-H mCRC patients, but also addresses the limitations and future perspectives of immunotherapy in this context.
Article
Medicine, General & Internal
Arvind Dasari, Sara Lonardi, Rocio Garcia-Carbonero, Elena Elez, Takayuki Yoshino, Alberto Sobrero, James Yao, Pilar Garcia-Alfonso, Judit Kocsis, Antonio Cubillo Gracian, Andrea Sartore-Bianchi, Taroh Satoh, Violaine Randrian, Jiri Tomasek, Geoff Chong, Andrew Scott Paulson, Toshiki Masuishi, Jeremy Jones, Tibor Csoszi, Chiara Cremolini, Francois Ghiringhelli, Ardaman Shergill, Howard S. Hochster, John Krauss, Ali Bassam, Michel Ducreux, Anneli Elme, Laurence Faugeras, Stefan Kasper, Eric Van Cutsem, Dirk Arnold, Shivani Nanda, Zhao Yang, William R. Schelman, Marek Kania, Josep Tabernero, Cathy Eng
Summary: This study evaluated the efficacy and safety of fruquintinib, a highly selective and potent oral inhibitor of VEGFRs 1, 2, and 3, in patients with advanced, chemotherapy-refractory colorectal cancer. The results showed that fruquintinib significantly prolonged overall survival compared to placebo in patients with refractory metastatic colorectal cancer, with clinical significance. Therefore, fruquintinib could become a global treatment option for patients with refractory metastatic colorectal cancer.
Review
Oncology
Xiaojing Xu, Yiyi Yu, Mengling Liu, Li Liang, Tianshu Liu
Summary: This study extensively examines the efficacy and safety of regorafenib and fruquintinib as third-line treatment options for colorectal cancer, showing both drugs are effective and well-tolerated with similar survival outcomes, but regorafenib has a slightly better toxicity profile.
TRANSLATIONAL CANCER RESEARCH
(2022)
Review
Medicine, General & Internal
Marta Martin-Richard, Maria Tobena
Summary: Many randomized clinical trials evaluating maintenance therapy strategies suffer from incorrect design and methodology flaws, making it challenging to draw conclusions and vague in recommendations. By focusing on design quality and clinical benefit measure with a more objective and accurate methodology, researchers were able to provide a clearer and more exact overview of maintenance treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Martin S. Schulz, Sebastian Wolf, Vera Struck, Niklas Thomas, Gabriele Husman, Stefan Zeuzem, Christine Koch, Joerg Trojan, Andreas Anton Schnitzbauer, Wolf Otto Bechstein, Oliver Waidmann
Summary: This real-world study from a large oncology center in Germany provides evidence that anti-EGFR re-exposure may benefit patients with advanced CRC, regardless of the reason for prior discontinuation.
Article
Pharmacology & Pharmacy
Pu Ge, Ning Wan, Xiao Han, Xinpei Wang, Jinzi Zhang, Xiaoyi Long, Xiaonan Wang, Ying Bian
Summary: This study evaluated the efficacy, safety, and cost-effectiveness of aflibercept for the treatment of mCRC, aiming to provide a decision-making reference for the selection of targeted drugs for second-line treatment of mCRC in the Hong Kong, Macao, and Taiwan regions of China, as well as the selection of new drugs for medical institutions in these regions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jinfeng Liu, Qing LV, Jing Wang, Li Zhang, Mingxing Xie, Yali Yang
Summary: Paracardial cystic lesions are rare, benign lesions that may occur in any part surrounding the heart, with various pathological types such as pericardial cysts, thymic cysts, and bronchogenic cysts. This study aimed to summarize the diagnostic value of echocardiography in different types of PCLs based on the analysis of 43 cases. Echocardiography plays a significant role in the accurate diagnosis of PCLs and intracardiac lesions, mainly through identifying characteristic features in the location and morphology of the lesions.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Biotechnology & Applied Microbiology
Shuai Liu, Pan Pan, Bing Han, Jingnan Wang, Meili Sun, Yuping Sun
Summary: EGISTs are rare malignant tumors that can occur outside the gastrointestinal tract, as seen in a case of a 60-year-old woman with a tumor in the vagina in this report. Surgical excision and histological examination are crucial, and literature reviews provide valuable insights into management and treatment.
ONCOTARGETS AND THERAPY
(2021)
Article
Otorhinolaryngology
Jinfeng Liu, Zhuoming Qian, Zhanfeng Yan, Xuwen Yang, Ningyu Wang
Summary: This study investigated the asymmetry of the inferior turbinate in patients with nasal septum deviation. It was found that the asymmetric width of the inferior turbinate is mainly caused by hypertrophy of the mucosa on the concave side and atrophy of the bone on the convex side. Surgical intervention should protect the inferior turbinate on the convex side and reduce the submucosal tissue on the concave side.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Anatomy & Morphology
J. Liu, Y. Wang, Z. Yan, Y. Yang
Summary: This study investigated the anatomical imaging characteristics of supraseptal posterior ethmoid cells (SPEC). It was found that SPEC is a rare pneumatization that occurs in the posterior superior area of the nasal septum. Care should be taken to protect the skull base, cribriform plate, and posterior ethmoidal artery when dealing with SPEC during endoscopic sinus surgery.
FOLIA MORPHOLOGICA
(2023)
Review
Neurosciences
Mengting Liu, Jinsheng Dai, Mo Zhou, Jinfeng Liu, Xinying Ge, Ningyu Wang, Juan Zhang
Summary: The inferior colliculus (IC) is a crucial hub in the central auditory system (CAS), where most auditory synapses converge. The two sub-regions of the non-lemniscal IC, the dorsal and external cortex, have distinct inputs and outputs, and may serve integration and regulation functions through parallel pathways. Future investigations should study these two sub-regions separately.
NEUROSCIENCE LETTERS
(2022)
Review
Oncology
Jun Peng, Jinfeng Liu, Huining Liu, Yan Huang, Yingchun Ren
Summary: MicroRNAs play an important role in the overall survival of patients with small cell lung cancer, serving as potential prognostic markers and providing valuable information for treatment strategies.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Neurosciences
Xiuxian Gao, Fei Chen, Xinqi Xu, Jinfeng Liu, Fuxing Dong, Yaping Liu
Summary: Oxidative stress is involved in cerebral ischemia-reperfusion injury (CIRI), and the NR2B subunit antagonist Ro25-6981 has been shown to improve this condition through the Nrf2/ARE pathway. This study provides evidence for the potential of Ro25-6981 as a promising treatment or preventive agent for CIRI.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mengqiang Xiao, Meng Zhang, Ming Lei, Fenghuan Lin, Yanxia Chen, Jun Chen, Jinfeng Liu, Jingzhi Ye
Summary: This study aimed to compare the performance of ultra-low-dose computed tomography (ULD-CT) with standard-dose computed tomography (SD-CT) for the diagnosis of non-displaced fractures of the shoulder, knee, ankle, and wrist. The results showed that ULD-CT had similar diagnostic accuracy for non-displaced fractures compared to SD-CT, with a lower radiation dose.
INSIGHTS INTO IMAGING
(2023)
Article
Otorhinolaryngology
Xiaochang Zhao, Zufei Li, Jinfeng Liu
Summary: This study investigated the necessity of subsequent dental treatment for patients with odontogenic sinusitis (OS) after endoscopic sinus surgery (ESS). The results showed that without considering the impact of dental disease on patients' oral health, OS can be completely alleviated by ESS alone, even if no dental treatment is carried out after surgery.
ENT-EAR NOSE & THROAT JOURNAL
(2023)
Review
Geriatrics & Gerontology
Xue Bai, Bing Han, Man Zhang, Jinfeng Liu, Yi Cui, Hong Jiang
Summary: This meta-analysis found that diuretic use increases the risk of falls in older adults.
Article
Medicine, General & Internal
Yuan Zhang, Bing Yan, Shen Shen, Xicheng Song, Yan Jiang, Li Shi, Changqing Zhao, Yi Yang, Luyun Jiang, Jiping Li, Jing Ye, Jinfeng Liu, Lijia Wan, Yucheng Yang, Jianjun Chen, Feng Liu, Lizhong Su, Yu Xu, Guolin Tan, Shaoqing Yu, Yu Zhang, Lin Wang, Shengyang Liu, Hongyue Yan, Wei Liu, Bo Chen, Chengshuo Wang, Luo Zhang
Summary: This study evaluates the efficacy and safety of CM310 in patients with severe eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). The findings suggest that CM310 can reduce nasal polyp size, alleviate nasal congestion, improve sinus CT scores, and significantly relieve daily symptoms and improve quality of life. CM310 also reduces type 2-related biomarkers. Overall, CM310 is an effective additional treatment option for severe ECRSwNP.
Article
Cardiac & Cardiovascular Systems
Jiarong Fu, Jinfeng Liu, Xiaoming Li, Lili Tang, Shan Wu, Huimei Yu, Chun Zhang
Summary: The main objectives of this study were to investigate valvular involvement in patients with cardiac Behcet's disease (BD) and identify the risk factors of valvular involvement in cardiac BD. The study found that aortic regurgitation was the most common valvular abnormality in BD patients, with aortic valve prolapse, echo-free spaces within the aortic annulus, vegetation-like lesions, and aortic root aneurysm being the main manifestations of severe aortic regurgitation. Additionally, echocardiography was found to be valuable in evaluating and diagnosing valvular involvement in BD patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Oncology
Xuqin Fang, Jinfeng Liu, Lili Duan, Rui Xue, Jinghua Zhang, Wei Liu, Yuanying Jiang
Summary: Painless nursing for cesarean delivery parturients due to the failure of natural childbirth via labor analgesia can effectively improve sleep quality and negative moods, reduce pain and stress response during delivery, and result in better satisfaction and compliance.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Zhanfeng Yan, Lili Liu, Jingjing Yuan, Lulu Jiao, Mo Zhou, Jinfeng Liu, Xiaohui Wen, Siming Liu, Pengpeng Hao, Jianhua Liu, Wei Wu
Summary: The study showed that Yiqi Jiemin decoction protected guinea pigs against ovalbumin-induced allergic rhinitis by suppressing inflammation in nasal mucosa, restoring Th1/Th2 balance, and improving cellular metabolism.