Corneal lymphangiogenesis in dry eye disease is regulated by substance P/neurokinin-1 receptor system through controlling expression of vascular endothelial growth factor receptor 3

Restoration of regulatory T cell function in dry eye disease by antagonizing substance P/neurokinin-1 receptor

(2020) Yukako Taketani et al.   AMERICAN JOURNAL OF PATHOLOGY

Sensory neurons directly promote angiogenesis in response to inflammation via substance P signaling

(2020) Lingjia Liu et al.   FASEB JOURNAL

Substance P accelerates the progression of human esophageal squamous cell carcinoma via MMP-2, MMP-9, VEGF-A, and VEGFR1 overexpression

(2020) Fariba Mohammadi et al.   MOLECULAR BIOLOGY REPORTS

Aqueous humor induces lymphatic regression on the ocular surface

(2020) Meng Shi et al.   Ocular Surface

High resolution three-dimensional imaging of the ocular surface and intact eyeball using tissue clearing and light sheet microscopy

(2020) Yujia Yang et al.   Ocular Surface

Epithelium-derived IL-33 activates mast cells to initiate neutrophil recruitment following corneal injury

(2020) Elsayed Elbasiony et al.   Ocular Surface

Activation of ocular surface mast cells promotes corneal neovascularization

(2020) WonKyung Cho et al.   Ocular Surface

A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain

(2019) Dustin P. Green et al.   NEURON

Tear film substance P: A potential biomarker for diabetic peripheral neuropathy

(2019) Shyam Sunder Tummanapalli et al.   Ocular Surface

Neurotrophic keratopathy: Pros and cons of current treatments

(2019) Antonio Di Zazzo et al.   Ocular Surface

Neurokinin-1 Receptor Antagonism Ameliorates Dry Eye Disease by Inhibiting Antigen-Presenting Cell Maturation and T Helper 17 Cell Activation

(2019) Man Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

Corneal lymphangiogenesis facilitates ocular surface inflammation and cell trafficking in dry eye disease

(2018) Yong Woo Ji et al.   Ocular Surface

Corneal pain and experimental model development

(2018) Tina B. McKay et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis

(2017) Susmit Suvas   JOURNAL OF IMMUNOLOGY

The Intriguing Role of Neuropeptides at the Ocular Surface

(2017) Francesco Sabatino et al.   Ocular Surface

The Pathophysiology of Dry Eye Disease

(2017) Stephen C. Pflugfelder et al.   OPHTHALMOLOGY

Neuropeptide substance P and the immune response

(2016) Alireza Mashaghi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Understanding lymphangiogenesis in knockout models, the cornea, and ocular diseases for the development of therapeutic interventions

(2016) Jessica F. Yang et al.   SURVEY OF OPHTHALMOLOGY

Inflammation-induced lymphangiogenesis and lymphatic dysfunction

(2014) Shan Liao et al.   ANGIOGENESIS

NK1 Receptor Antagonists as a New Treatment for Corneal Neovascularization

(2014) F. Bignami et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Dry Eye Disease

(2012) William Stevenson   ARCHIVES OF OPHTHALMOLOGY

Ocular surface immunity: Homeostatic mechanisms and their disruption in dry eye disease

(2012) Stefano Barabino et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation

(2010) Steven D. Douglas et al.   Annals of the New York Academy of Sciences

Evidence of Corneal Lymphangiogenesis in Dry Eye Disease

(2010) Sunali Goyal   ARCHIVES OF OPHTHALMOLOGY

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Tumor-Associated Lymphangiogenesis in the Development of Conjunctival Squamous Cell Carcinoma

(2010) Ludwig M. Heindl et al.   OPHTHALMOLOGY

Novel aspects of corneal angiogenic and lymphangiogenic privilege

(2010) David Ellenberg et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Architecture and distribution of human corneal nerves

(2009) M. A. Al-Aqaba et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Identification of lymphatics in the ciliary body of the human eye: A novel “uveolymphatic” outflow pathway

(2009) Yeni H. Yücel et al.   EXPERIMENTAL EYE RESEARCH

VEGF-A expression by HSV-1–infected cells drives corneal lymphangiogenesis

(2009) Todd R. Wuest et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth

(2009) Romulo J C Albuquerque et al.   NATURE MEDICINE

The Lymphatic System in Health and Disease

(2008) Leah N. Cueni et al.   Lymphatic Research and Biology