Article
Pharmacology & Pharmacy
Sergio E. Rodriguez, David W. Hawman, Teresa E. Sorvillo, T. Justin O'Neal, Brian H. Bird, Luis L. Rodriguez, Eric Bergeron, Stuart T. Nichol, Joel M. Montgomery, Christina F. Spiropoulou, Jessica R. Spengler
Summary: This article reviews the progress in immunobiology research of Crimean-Congo hemorrhagic fever virus (CCHFV), including the relationship between different outcomes and disease severity, and provides recommendations for future research.
ANTIVIRAL RESEARCH
(2022)
Article
Microbiology
Ayman Ahmed, Yousif Ali, Bashir Salim, Isabelle Dietrich, Jakob Zinsstag
Summary: This study reviewed the epidemiological reports of Crimean-Congo hemorrhagic fever (CCHF) in Sudan between 2010 and 2020. It identified 88 cases of CCHF, including 13 fatalities, with the majority concentrated in the Kordofan region. The study calls for the establishment of a genomic-based integrated One Health surveillance and response system.
Article
Infectious Diseases
Angela Fanelli, Domenico Buonavoglia, Gianvito Lanave, Federica Monaco, Vincenzo Quaranta, Roberta Catanzariti, Francisco Ruiz-Fons, Canio Buonavoglia
Summary: This study reports the first detection of anti-Crimean-Congo haemorrhagic fever virus (CCHFV) antibodies in transhumant bovines in Italy. The detection of antibodies in indigenous cattle indicates the occurrence of infection in the study area. Further studies are needed to identify areas at higher risk of zoonotic infection.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Letter
Immunology
Mohammad M. Obaidat, James C. Graziano, Maria Morales-Betoulle, Shelley M. Brown, Cheng-Feng Chiang, John D. Klena
Summary: The epidemiology of Rift Valley fever virus (RVFV) and Crimean-Congo hemorrhagic fever virus (CCHFV) in Jordan is unknown. A study found 3% of tested dairy cattle, sheep, and goats were RVFV seropositive and 14% were CCHFV seropositive. Ongoing surveillance is necessary to evaluate the risk to humans and protect public health.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Aykut Ozdarendeli
Summary: Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly infectious virus transmitted to humans through tick bites or contact with infected animal blood, causing severe symptoms and a high mortality rate. The lack of effective medical countermeasures and its potential for global spread have made CCHFV a high-priority pathogen. Recent advances in biotechnology and suitable animal models have accelerated the development of CCHFV vaccines.
Article
Public, Environmental & Occupational Health
Vincent Obanda, Bernard Agwanda, Isabel Blanco-Penedo, Irene Ann Mwangi, Edward King'ori, George P. Omondi, Clas Ahlm, Magnus Evander, Olivia Wesula Lwande
Summary: The study in Kenya found that the seroprevalence of CCHFV in buffalo is significantly higher than in cattle, with the highest prevalence in closed wildlife habitats. The overlap of habitats between cattle and buffalo makes cattle a bridge species for CCHFV transmission, increasing the risk to humans.
VECTOR-BORNE AND ZOONOTIC DISEASES
(2021)
Article
Virology
Serdal Arslan, Burcu Bayyurt, Aynur Engin, Mehmet Bakir
Summary: The study identified significant changes in miRNA expression in patients with Crimean Congo hemorrhagic fever, with some miRNAs showing differential expression in acute and severe cases. These miRNAs are associated with antiviral and proinflammatory pathways, suggesting potential therapeutic targets for the acute phase of the disease.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Virology
Mohammad Fereidouni, Dmitry A. Apanaskevich, David B. Pecor, Natalia Yu. Pshenichnaya, Gulzhan N. Abuova, Farida H. Tishkova, Yekaterina Bumburidi, Xiankun Zeng, Jens H. Kuhn, Maryam Keshtkar-Jahromi
Summary: This study summarizes the status of Crimean-Congo hemorrhagic fever (CCHF) in Central, Eastern, and South-eastern Asia. The risk and burden of CCHF were assessed based on case reports, antibody prevalence, and vector ticks isolation. The majority of cases were reported in Central Asia, while only China reported cases in Eastern Asia. No cases were reported in South-eastern Asia. Countries were classified into different levels based on evidence of CCHF, guiding the strengthening or establishment of CCHF surveillance systems.
Article
Immunology
Johan Espunyes, Oscar Cabezon, Lola Pailler-Garcia, Andrea Dias-Alves, Lourdes Lobato-Bailon, Ignasi Marco, Maria P. Ribas, Pedro E. Encinosa-Guzman, Marta Valldeperes, Sebastian Napp
Summary: A serosurvey in Catalonia, northeastern Spain, found high seroprevalence of Crimean-Congo hemorrhagic fever virus antibodies in southern Catalonia, indicating potential presence of competent virus vectors in the region.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Virology
Kubra Dogan, Serkan Bolat, Caner Oksuz, Seyit Ali Buyuktuna
Summary: Crimean-Congo hemorrhagic fever (CCHF) is a viral infection disease with unknown pathophysiology. This study investigated the levels of lipid mediators and cytokines in CCHF patients. The results showed lower 5-LO levels and higher ferritin and IL-6 levels in patients compared to healthy controls. No significant differences were found in CYSLT levels between patients and controls. The study suggests that changes in 5-LO enzyme and increased inflammation play a role in CCHF.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Anoop T. Ambikan, Nazif Elaldi, Sara Svensson- Akusjaervi, Binnur Bagci, Ayse Nur Pektas, Roger Hewson, Gokhan Bagci, Mehmet Arasli, Sofia Appelberg, Adil Mardinoglu, Vikas Sood, Akos Vegvari, Rui Benfeitas, Soham Gupta, Ilhan Cetin, Ali Mirazimi, Ujjwal Neogi
Summary: This study analyzed the trajectory of host response and metabolic changes following CCHFV infection, revealing that antiviral immune responses are regulated by genes and signaling pathways. The reorganization of metabolism during the acute phase contributes to pathogenicity, while downregulated metabolic processes during the convalescent phase may lead to metabolic rewiring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Virology
Feyza Izci, Zeynep Ture, Pinar Sagiroglu, Sahin Temel, Orhan Yildiz
Summary: This study reports a case of severe CCHF with Clostridium perfringens bacteremia in a female patient, who presented with symptoms such as fever, nausea, vomiting, and abdominal pain. The diagnosis was confirmed using real-time polymerase chain reaction, and successful treatment was achieved through a multidisciplinary approach.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Zeynep Ture, Gamze Kalin-Unuvar
Summary: Crimean-Congo hemorrhagic fever (CCHF) is a common tick-borne hemorrhagic infection. Apart from fever and hemorrhage, CCHF can present with different clinical manifestations. This study reports a rare case of a female patient with pulmonary embolism associated with severe CCHF, who was successfully treated with supportive and anticoagulation therapy.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Shohra Qaderi, Masoud Mardani, Asghar Shah, Jaffer Shah, Narges Bazgir, Jalal Sayad, Ehsan Ghandchi, Majid Samsami, Javad Zebarjadi Bagherpour
Summary: The prevalence of CCHF is increasing in Afghanistan, with a majority of cases seeking medical care during the late phase of infection, which could negatively impact treatment efficacy. Impaired Alanine aminotransferase (ALT), hemorrhagic manifestations (including epistaxis), and impaired consciousness were factors associated with a higher mortality rate, potentially providing clues for early effective interventions.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Anabel Negredo, Rafael Sanchez-Arroyo, Francisco Diez-Fuertes, Fernando de Ory, Marco Antonio Budino, Ana Vazquez, Angeles Garcinuno, Lourdes Hernandez, Cesar de la Hoz Gonzalez, Almudena Gutierrez-Arroyo, Carmen Grande, Paz Sanchez-Seco
Summary: In August 2018, a fatal autochthonous case of Crimean-Congo hemorrhagic fever was confirmed in western Spain, with a new virus circulating as the genotype differs from a previous case in 2016. Practitioners must remain alert to the possibility of new cases.
EMERGING INFECTIOUS DISEASES
(2021)