Article
Medicine, General & Internal
D. Mevorach, E. Anis, N. Cedar, M. Bromberg, E. J. Haas, E. Nadir, S. Olsha-Castell, D. Arad, T. Hasin, N. Levi, R. Asleh, O. Amir, K. Meir, D. Cohen, R. Dichtiar, D. Novick, Y. Hershkovitz, R. Dagan, I Leitersdorf, R. Ben-Ami, I Miskin, W. Saliba, K. Muhsen, Y. Levi, M. S. Green, L. Keinan-Boker, S. Alroy-Preis
Summary: The incidence of myocarditis increased after receiving the BNT162b2 vaccine in Israel, particularly after the second dose among young male recipients. The clinical presentation of myocarditis after vaccination was usually mild.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Virology
Wongi Woo, Ah Y. Kim, Dong K. Yon, Seung W. Lee, Jimin Hwang, Louis Jacob, Ai Koyanagi, Min S. Kim, Duk H. Moon, Jo W. Jung, Jae Y. Choi, Se Y. Jung, Lucy Y. Eun, Sungsoo Lee, Jae Il Shin, Lee Smith
Summary: Myocarditis after COVID-19 mRNA vaccination mainly affects young males, with milder clinical symptoms and favorable overall prognosis. Patients who received the BNT162b2 vaccine had fewer systemic symptoms and left ventricular dysfunction compared to those who received the mRNA-1273 vaccine.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt, Ishan Kamat, Peter J. Hotez
Summary: Myocarditis is a rare complication of COVID-19 mRNA vaccines, predominantly affecting young adult and adolescent males, with most patients showing improvement in symptoms. Possible mechanisms include molecular mimicry between viral proteins and self-antigens, dysregulated immune pathways, immune response to mRNA, and dysregulated cytokine expression.
Article
Immunology
Saif Abu Mouch, Ariel Roguin, Elias Hellou, Amorina Ishai, Uri Shoshan, Lamis Mahamid, Marwan Zoabi, Marina Aisman, Nimrod Goldschmid, Noa Berar Yanay
Summary: This study reported six cases of myocarditis occurring shortly after BNT162b2 vaccination, all in young males with mild clinical course. All patients responded to the vaccine, and myocarditis post-BNT162b2 vaccination may be considered an adverse reaction.
Article
Cardiac & Cardiovascular Systems
Lael M. Yonker, Zoe Swank, Yannic C. Bartsch, Madeleine D. Burns, Abigail Kane, Brittany P. Boribong, Jameson P. Davis, Maggie Loiselle, Tanya Novak, Yasmeen Senussi, Chi-An Cheng, Eleanor Burgess, Andrea G. Edlow, Janet Chou, Audrey Dionne, Duraisamy Balaguru, Manuella Lahoud-Rahme, Moshe Arditi, Boris Julg, Adrienne G. Randolph, Galit Alter, Alessio Fasano, David R. Walt
Summary: Blood samples from 16 patients who developed myocarditis after SARS-CoV-2 vaccination were analyzed for antibody and T-cell responses. The immune profiles of these patients were similar to those of vaccinated control subjects, except for the presence of free spike antigen in the blood of myocarditis patients.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Chan-Hee Lee, Eun-Jung Kong
Summary: This is a case of acute focal myocarditis after a COVID-19 mRNA vaccination in a 22-year-old male, which has been reported to occur more often after the second dose of the vaccine in young men. The inflammation site was well-visualized using FDG PET/MRI.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Immunology
Devendra Bansal, Jazeel Abdulmajeed, Maha H. M. A. Al-Shamali, Soha S. A. Albayat, Sayed M. Himatt, Farhan S. Cyprian, Tawanda Chivese, Jesha M. A. Mundodan, Hayat S. Khogali, Rekayahouda Baaboura, Anvar H. Kaleeckal, Mujeeb C. Kandy, Ali Nizar Latif, Mohamed Ghaith Al-Kuwari, Hamad Eid Al-Romaihi, Abdullatif Al Khal, Roberto Bertollini, Mohamed Hamad Al-Thani, Elmobashar Farag, Suhail A. R. Doi
Summary: This study conducted a case-control study among individuals with first SARS-CoV-2 infection to evaluate the effectiveness of mRNA vaccines in preventing COVID-19 requiring intensive care. The results showed that the vaccine effectiveness was 59% between the first and second dose, and increased to 89% between the second dose and 4 months post the second dose. There was no waning of vaccine effectiveness from 4 to 12 months after the second dose.
Article
Immunology
Li-Ping Wong, Hai-Yen Lee, Haridah Alias, Sazaly AbuBakar
Summary: This study conducted in Malaysia found that parents' willingness to vaccinate their children against COVID-19 is influenced by their perceived susceptibility to the disease and their concerns about vaccines. A significant number of parents showed a preference for traditional vaccines over mRNA vaccines, citing concerns about mRNA technology and potential side effects. Public education campaigns are needed to address these concerns and increase vaccine acceptance among hesitant parents.
Article
Immunology
Abdallah Alami, Daniel Krewski, Donald Mattison, Kumanan Wilson, Christopher A. Gravel, Paul J. Villeneuve, Patrick J. Farrell, James A. G. Crispo, Santiago Perez-Lloret
Summary: There have been reports of rare complications, such as myocarditis and pericarditis, following mRNA COVID-19 vaccinations among young adults. A higher-than-expected reporting rate of these complications has been observed, particularly after the second dose, in males compared to females, and with decreasing risk with age. Confirmatory epidemiological studies should be conducted due to the limitations of passive surveillance data.
Article
Cardiac & Cardiovascular Systems
Antonio Abbate, Josh Gavin, Nima Madanchi, Christin Kim, Pranav R. Shah, Katherine Klein, Julie Boatman, Charlotte Roberts, Seema Patel, Stamatina Danielides
Summary: Immune-mediated myocardial injury can occur in both adults and children following infection with SARS-CoV2. Recent cases have shown myocarditis following immunization for SARS-CoV2, with most cases being mild and showing spontaneous recovery.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Reem H. Matar, Rania Mansour, Hayato Nakanishi, Karen Smayra, Joe El Haddad, Dilip K. Vankayalapati, Rohan Suresh Daniel, Danijel Tosovic, Christian A. Than, Mohamad H. Yamani
Summary: This systematic review and meta-analysis investigated the clinical characteristics of patients with myocarditis following COVID-19 mRNA vaccination. The study found that myocarditis post vaccination was more common in young male patients. The most common symptoms were chest pain, fever, myalgia, and chills. Imaging findings included ST-related changes on an electrocardiogram and hypokinesia on cardiac magnetic resonance imaging or echocardiography. Laboratory findings showed elevated Troponin I levels and elevated C-reactive protein. Non-steroid anti-inflammatory drugs and colchicine were the most common treatment modalities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Abdallah Alami, Paul J. J. Villeneuve, Patrick J. J. Farrell, Donald Mattison, Nawal Farhat, Nisrine Haddad, Kumanan Wilson, Christopher A. A. Gravel, James A. G. Crispo, Santiago Perez-Lloret, Daniel Krewski
Summary: This study analyzed reports from the Vaccine Adverse Events Reporting System (VAERS) and found safety signals for myocarditis and pericarditis following mRNA COVID-19 vaccination, especially in younger individuals. The study focused on children as young as 6 months old. The results showed a higher reporting rate of myocarditis and pericarditis after the primary vaccine series, particularly in males and mainly after the second dose. However, the reporting cases decreased with booster doses, and no significant signals were detected after the fourth or fifth doses. In children and young adults, there were notable age and sex differences in the reporting of myocarditis and pericarditis cases. Males in the 12-17 and 18-24-year-old age groups had the highest number of cases, with significant signals for both males and females after the second dose. Additionally, an increased reporting of cardiovascular symptoms such as chest pain and dyspnea was identified, which increased with age and were reported more frequently than myocarditis and pericarditis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Andrea Frustaci, Romina Verardo, Nicola Galea, Carlo Lavalle, Giulia Bagnato, Rossella Scialla, Cristina Chimenti
Summary: This study reported the clinical features and treatment of three patients who developed severe myocarditis after receiving the COVID-19 mRNA (BNT162b2) vaccine. The findings showed extensive infiltration of degranulated eosinophils in myocardial tissues, along with increased levels of serum cationic protein. Treatment with oral steroids resulted in complete recovery of cardiac function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Medicine, General & Internal
Lauren H. Zauche, Bailey Wallace, Ashley N. Smoots, Christine K. Olson, Titilope Oduyebo, Shin Y. Kim, Emily E. Petersen, Jun Ju, Jennifer Beauregard, Allen J. Wilcox, Charles E. Rose, Dana M. Meaney-Delman, Sascha R. Ellington
Summary: The risk of spontaneous abortion in early pregnancy after receiving mRNA Covid-19 vaccination is consistent with historical data.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, Research & Experimental
Noemi F. Freise, Milena Kivel, Olaf Grebe, Christian Meyer, Bahram Wafaisade, Matthias Peiper, Tobias Zeus, Jan Schmidt, Judith Neuwahl, Danny Jazmati, Tom Luedde, Edwin Boelke, Torsten Feldt, Bjoern Erik Ole Jensen, Johannes Bode, Verena Keitel, Jan Haussmann, Balint Tamaskovics, Wilfried Budach, Johannes C. Fischer, Wolfram Trudo Knoefel, Marion Schneider, Peter Arne Gerber, Alessia Pedoto, Dieter Haeussinger, Martijn van Griensven, Amir Rezazadeh, Yechan Flaig, Julian Kirchner, Gerald Antoch, Hubert Schelzig, Christiane Matuschek
Summary: This study presents a case series of eight patients who developed cardiac symptoms shortly after receiving SARS-CoV-2 mRNA vaccines. Three patients required hospitalization, but all patients fully recovered within seven days. The results suggest that cardiac adverse events such as myocarditis or pericarditis after mRNA vaccination are rare but possible.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)