Danger and distress: Parabrachial-extended amygdala circuits

Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding

(2021) Andrew T. Luskin et al.   Science Advances

Enhanced synaptic transmission in the extended amygdala and altered excitability in an extended amygdala to brainstem circuit in a Dravet syndrome mouse model

(2021) Wen Wei Yan et al.   eNeuro

An Amygdalo-Parabrachial Pathway Regulates Pain Perception and Chronic Pain

(2020) Charles Raver et al.   JOURNAL OF NEUROSCIENCE

Divergent Neural Pathways Emanating from the Lateral Parabrachial Nucleus Mediate Distinct Components of the Pain Response

(2020) Michael C. Chiang et al.   NEURON

Amygdala, neuropeptides, and chronic pain-related affective behaviors

(2020) Volker Neugebauer et al.   NEUROPHARMACOLOGY

Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons

(2020) Anna J Bowen et al.   eLife

Pituitary adenylate cyclase-activating polypeptide (PACAP) modulates dependence-induced alcohol drinking and anxiety-like behavior in male rats

(2020) Antonio Ferragud et al.   NEUROPSYCHOPHARMACOLOGY

Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development

(2020) George F. Koob   PHARMACOLOGICAL REVIEWS

Distinct and Overlapping Patterns of Acute Ethanol-Induced C-Fos Activation in Two Inbred Replicate Lines of Mice Selected for Drinking to High Blood Ethanol Concentrations

(2020) Stacey L. Robinson et al.   Brain Sciences

Cell-type specific parallel circuits in the bed nucleus of the stria terminalis and the central nucleus of the amygdala of the mouse

(2019) Jiahao Ye et al.   Brain Structure & Function

Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis

(2019) Dipanwita Pati et al.   NEUROPSYCHOPHARMACOLOGY

The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea

(2019) William P. Nobis et al.   JOURNAL OF NEUROSURGERY

Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward

(2019) J. Andrew Hardaway et al.   NEURON

Predisposition to Alcohol Drinking and Alcohol Consumption Alter Expression of Calcitonin Gene-Related Peptide, Neuropeptide Y, and Microglia in Bed Nucleus of Stria Terminalis in a Subnucleus-Specific Manner

(2019) Ilaria Rossetti et al.   Frontiers in Cellular Neuroscience

A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding

(2019) Yong Wang et al.   Nature Communications

PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress

(2019) F.P. Varodayan et al.   NEUROPHARMACOLOGY

Spared nerve injury differentially alters parabrachial monosynaptic excitatory inputs to molecularly specific neurons in distinct subregions of the central amygdala

(2019) Jun-Nan Li et al.   PAIN

Cortico-Limbic Interactions Mediate Adaptive and Maladaptive Responses Relevant to Psychopathology

(2019) Rothem Kovner et al.   AMERICAN JOURNAL OF PSYCHIATRY

Manipulations of central amygdala neurotensin neurons alter the consumption of ethanol and sweet fluids in mice

(2019) María Luisa Torruella-Suárez et al.   JOURNAL OF NEUROSCIENCE

Parabrachial Complex: A Hub for Pain and Aversion

(2019) Michael C. Chiang et al.   JOURNAL OF NEUROSCIENCE

Pleiotropic pituitary adenylate cyclase-activating polypeptide (PACAP): Novel insights into the role of PACAP in eating and drug intake

(2019) Andrew T. Gargiulo et al.   BRAIN RESEARCH

Role of the PACAP system of the extended amygdala in the acoustic startle response in rats

(2019) Mariel P. Seiglie et al.   NEUROPHARMACOLOGY

Amygdala-stimulation-induced apnea is attention and nasal-breathing dependent

(2018) William P. Nobis et al.   ANNALS OF NEUROLOGY

Central sensitization of the spino-parabrachial-amygdala pathway that outlasts a brief nociceptive stimulus

(2018) Sarah A Kissiwaa et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm

(2018) Richard D. Palmiter   TRENDS IN NEUROSCIENCES

Pituitary Adenylate Cyclase-Activating Peptide (PACAP) Signaling and the Dark Side of Addiction

(2018) Olivia W. Miles et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Central Amygdala Circuits Mediate Hyperalgesia in Alcohol-Dependent Rats

(2018) Elizabeth M. Avegno et al.   JOURNAL OF NEUROSCIENCE

Collateral Projections from the Lateral Parabrachial Nucleus to the Central Amygdaloid Nucleus and the Ventral Tegmental Area in the Rat

(2018) Yu Qiao et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

α2A-Adrenergic Receptor Activation Decreases Parabrachial Nucleus Excitatory Drive onto BNST CRF Neurons and Reduces Their Activity In Vivo

(2018) Tracy L. Fetterly et al.   JOURNAL OF NEUROSCIENCE

The central amygdala to periaqueductal gray pathway comprises intrinsically distinct neurons differentially affected in a model of inflammatory pain

(2018) Jun‐Nan Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats

(2018) Edward G. Meloni et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Parabrachial CGRP Neurons Establish and Sustain Aversive Taste Memories

(2018) Jane Y. Chen et al.   NEURON

Cell-Type-Specific Afferent Innervation of the Nucleus Accumbens Core and Shell

(2018) Zhao Li et al.   Frontiers in Neuroanatomy

Parabrachial-to-amygdala control of aversive learning

(2018) Masashi Nagase et al.   Current Opinion in Behavioral Sciences

Essential role of endogenous calcitonin gene-related peptide in pain-associated plasticity in the central amygdala

(2017) Kei Shinohara et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Potentiation of NMDA receptor-mediated synaptic transmission at the parabrachial-central amygdala synapses by CGRP in mice

(2017) Yuya Okutsu et al.   Molecular Pain

A competitive inhibitory circuit for selection of active and passive fear responses

(2017) Jonathan P. Fadok et al.   NATURE

A craniofacial-specific monosynaptic circuit enables heightened affective pain

(2017) Erica Rodriguez et al.   NATURE NEUROSCIENCE

Oxytocin-receptor-expressing neurons in the parabrachial nucleus regulate fluid intake

(2017) Philip J. Ryan et al.   NATURE NEUROSCIENCE

A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia

(2017) Satvinder Kaur et al.   NEURON

The Effects of Prior Stress on Anxiety-Like Responding to Intra-BNST Pituitary Adenylate Cyclase Activating Polypeptide in Male and Female Rats

(2017) S Bradley King et al.   NEUROPSYCHOPHARMACOLOGY

Pituitary Adenylate Cyclase-Activating Peptide in the Bed Nucleus of the Stria Terminalis Mediates Stress-Induced Reinstatement of Cocaine Seeking in Rats

(2017) Olivia W Miles et al.   NEUROPSYCHOPHARMACOLOGY

Satiation and re-intake after partial withdrawal of gastric food contents: A dissociation effect in external lateral parabrachial lesioned rats

(2016) María A. Zafra et al.   BRAIN RESEARCH BULLETIN

The House Alarm

(2016) Clifford B. Saper   Cell Metabolism

Parabrachial CGRP Neurons Control Meal Termination

(2016) Carlos A. Campos et al.   Cell Metabolism

Dynamic taste responses of parabrachial pontine neurons in awake rats

(2016) Madelyn A. Baez-Santiago et al.   JOURNAL OF NEUROPHYSIOLOGY

Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala

(2016) Yae K. Sugimura et al.   JOURNAL OF NEUROPHYSIOLOGY

Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat

(2016) Joshua D. Sammons et al.   JOURNAL OF NEUROPHYSIOLOGY

Contributions of the Central Extended Amygdala to Fear and Anxiety

(2016) A. J. Shackman et al.   JOURNAL OF NEUROSCIENCE

Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders

(2016) M A Lebow et al.   MOLECULAR PSYCHIATRY

Elucidating an Affective Pain Circuit that Creates a Threat Memory

(2015) Sung Han et al.   CELL

The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice

(2015) Masaru Sato et al.   Molecular Brain

CGRP Inhibits Neurons of the Bed Nucleus of the Stria Terminalis: Implications for the Regulation of Fear and Anxiety

(2014) N. Z. Gungor et al.   JOURNAL OF NEUROSCIENCE

 2A-Adrenergic Receptors Filter Parabrachial Inputs to the Bed Nucleus of the Stria Terminalis

(2014) S. A. Flavin et al.   JOURNAL OF NEUROSCIENCE

Central amygdala PKC-δ+ neurons mediate the influence of multiple anorexigenic signals

(2014) Haijiang Cai et al.   NATURE NEUROSCIENCE

Parabrachial nucleus (PBn) pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the amygdala: Implication for the sensory and behavioral effects of pain

(2014) Galen Missig et al.   NEUROPHARMACOLOGY

PAC1 receptor antagonism in the bed nucleus of the stria terminalis (BNST) attenuates the endocrine and behavioral consequences of chronic stress

(2014) Carolyn W. Roman et al.   PSYCHONEUROENDOCRINOLOGY

PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors

(2013) Li Wang et al.   JOURNAL OF AFFECTIVE DISORDERS

CGRP antagonist infused into the bed nucleus of the stria terminalis impairs the acquisition and expression of context but not discretely cued fear

(2013) K. S. Sink et al.   LEARNING & MEMORY

Diverging neural pathways assemble a behavioural state from separable features in anxiety

(2013) Sung-Yon Kim et al.   NATURE

Genetic identification of a neural circuit that suppresses appetite

(2013) Matthew E. Carter et al.   NATURE

Experience-dependent modification of a central amygdala fear circuit

(2013) Haohong Li et al.   NATURE NEUROSCIENCE

CRF Mediates the Anxiogenic and Anti-Rewarding, But Not the Anorectic Effects of PACAP

(2013) Riccardo Dore et al.   NEUROPSYCHOPHARMACOLOGY

Synaptic potentiation in the nociceptive amygdala following fear learning in mice

(2013) Ayako M Watabe et al.   Molecular Brain

Disturbances in equilibrium function after major earthquake

(2012) Motoyasu Honma et al.   Scientific Reports

PACAP: a master regulator of neuroendocrine stress circuits and the cellular stress response

(2011) Nikolas Stroth et al.   Annals of the New York Academy of Sciences

Neurologic bases for comorbidity of balance disorders, anxiety disorders and migraine: neurotherapeutic implications

(2011) Carey D Balaban et al.   Expert Review of Neurotherapeutics

Calcitonin Gene-Related Peptide in the Bed Nucleus of the Stria Terminalis Produces an Anxiety-Like Pattern of Behavior and Increases Neural Activation in Anxiety-Related Structures

(2011) K. S. Sink et al.   JOURNAL OF NEUROSCIENCE

Role of Extracellular Signal-Regulated Kinase in Synaptic Transmission and Plasticity of a Nociceptive Input on Capsular Central Amygdaloid Neurons in Normal and Acid-Induced Muscle Pain Mice

(2011) S.-J. Cheng et al.   JOURNAL OF NEUROSCIENCE

Circadian Clock Gene Polymorphisms in Alcohol Use Disorders and Alcohol Consumption

(2010) L. Kovanen et al.   ALCOHOL AND ALCOHOLISM

Roles for Pituitary Adenylate Cyclase-Activating Peptide (PACAP) Expression and Signaling in the Bed Nucleus of the Stria Terminalis (BNST) in Mediating the Behavioral Consequences of Chronic Stress

(2010) Sayamwong E. Hammack et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Facilitation of Synaptic Transmission and Pain Responses by CGRP in the Amygdala of Normal Rats

(2010) Jeong S Han et al.   Molecular Pain

Subnuclear organization of parabrachial efferents to the thalamus, amygdala and lateral hypothalamus in C57BL/6J mice: a quantitative retrograde double labeling study

(2010) K. Tokita et al.   NEUROSCIENCE

Gustatory and Homeostatic Functions of the Rodent Parabrachial Nucleus

(2009) Ivan E. De Araujo   Annals of the New York Academy of Sciences

Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): Roles for PACAP in anxiety-like behavior

(2009) Sayamwong E. Hammack et al.   PSYCHONEUROENDOCRINOLOGY

A naloxonazine sensitive (μ1 receptor) mechanism in the parabrachial nucleus modulates eating

(2008) Nayla N. Chaijale et al.   BRAIN RESEARCH

Role of the extended amygdala in short-duration versus sustained fear: a tribute to Dr. Lennart Heimer

(2008) David L. Walker et al.   Brain Structure & Function