Previews The developmental roots of neurodegeneration

Neurodegenerative disorders can alter neural circuitry long before symptoms appear, but the path from early changes to later pathologies is obscure. In this issue of Neuron, Capizzi et al. (2021) show how early axonal growth defects in Huntington's disease create vulnerability to later degeneration.

Automated summary

This article explores the relationship between early axonal growth defects and later degeneration in Huntington's disease.