Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

(2021) Kristen R. Maynard et al.   NATURE NEUROSCIENCE

Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells

(2021) Xitiz Chamling et al.   Nature Communications

Decoding the development of the human hippocampus

(2020) Suijuan Zhong et al.   NATURE

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Microglia Heterogeneity in the Single-Cell Era

(2020) Takahiro Masuda et al.   Cell Reports

Construction of a human cell landscape at single-cell level

(2020) Xiaoping Han et al.   NATURE

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

(2020) Julien Bryois et al.   NATURE GENETICS

Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk

(2020) Andrew E. Jaffe et al.   NATURE NEUROSCIENCE

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

(2020) Corina Nagy et al.   NATURE NEUROSCIENCE

dotdotdot: an automated approach to quantify multiplex single molecule fluorescent in situ hybridization (smFISH) images in complex tissues

(2020) Kristen R Maynard et al.   NUCLEIC ACIDS RESEARCH

A dopamine-induced gene expression signature regulates neuronal function and cocaine response

(2020) Katherine E. Savell et al.   Science Advances

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans

(2020) Nicola Thrupp et al.   Cell Reports

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

(2019) Lindsay F. Rizzardi et al.   NATURE NEUROSCIENCE

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Identification of common genetic risk variants for autism spectrum disorder

(2019) Jakob Grove et al.   NATURE GENETICS

Sexually Dimorphic Control of Parenting Behavior by the Medial Amygdala

(2019) Patrick B. Chen et al.   CELL

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Genome-wide association study identifies 30 loci associated with bipolar disorder

(2019) Eli A. Stahl et al.   NATURE GENETICS

Single-cell genomics identifies cell type–specific molecular changes in autism

(2019) Dmitry Velmeshev et al.   SCIENCE

Neuronal vulnerability and multilineage diversity in multiple sclerosis

(2019) Lucas Schirmer et al.   NATURE

Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia

(2019) Leonardo Collado-Torres et al.   NEURON

Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons

(2019) Hope Kronman et al.   Scientific Reports

Conserved cell types with divergent features in human versus mouse cortex

(2019) Rebecca D. Hodge et al.   NATURE

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

(2019) Caroline M. Nievergelt et al.   Nature Communications

Orchestrating single-cell analysis with Bioconductor

(2019) Robert A. Amezquita et al.   NATURE METHODS

Continuous and Discrete Neuron Types of the Adult Murine Striatum

(2019) Geoffrey Stanley et al.   NEURON

Functions and the related signaling pathways of the neurotrophic factor neuritin

(2018) Jin-jing Yao et al.   ACTA PHARMACOLOGICA SINICA

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice

(2018) Joakim S. Dahlin et al.   BLOOD

A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex

(2018) Suijuan Zhong et al.   NATURE

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

(2018) Laleh Haghverdi et al.   NATURE BIOTECHNOLOGY

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Detection and removal of barcode swapping in single-cell RNA-seq data

(2018) Jonathan A. Griffiths et al.   Nature Communications

Individualized Functional Parcellation of the Human Amygdala Using a Semi-supervised Clustering Method: A 7T Resting State fMRI Study

(2018) Xianchang Zhang et al.   Frontiers in Neuroscience

Sex Differences in Medium Spiny Neuron Excitability and Glutamatergic Synaptic Input: Heterogeneity Across Striatal Regions and Evidence for Estradiol-Dependent Sexual Differentiation

(2018) Jinyan Cao et al.   Frontiers in Endocrinology

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man

(2018) Robert J. Fenster et al.   NATURE REVIEWS NEUROSCIENCE

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

(2018) Mingfeng Li et al.   SCIENCE

Cell-Type-Specific Afferent Innervation of the Nucleus Accumbens Core and Shell

(2018) Zhao Li et al.   Frontiers in Neuroanatomy

NPFFR2 Activates the HPA Axis and Induces Anxiogenic Effects in Rodents

(2017) Ya-Tin Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq

(2017) Peng Hu et al.   MOLECULAR CELL

Multiplexed droplet single-cell RNA-sequencing using natural genetic variation

(2017) Hyun Min Kang et al.   NATURE BIOTECHNOLOGY

Massively parallel single-nucleus RNA-seq with DroNc-seq

(2017) Naomi Habib et al.   NATURE METHODS

Detecting Activated Cell Populations Using Single-Cell RNA-Seq

(2017) Ye Emily Wu et al.   NEURON

Corticotropin-releasing hormone and dopamine release in healthy individuals

(2017) Doris Payer et al.   PSYCHONEUROENDOCRINOLOGY

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

In vivo delineation of subdivisions of the human amygdaloid complex in a high-resolution group template

(2016) J. Michael Tyszka et al.   HUMAN BRAIN MAPPING

Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation

(2016) Ya-Tin Lin et al.   PSYCHONEUROENDOCRINOLOGY

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

(2016) B. B. Lake et al.   SCIENCE

Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons

(2016) Naomi Habib et al.   SCIENCE

Nuclear RNA-seq of single neurons reveals molecular signatures of activation

(2016) Benjamin Lacar et al.   Nature Communications

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

Neuronal Pentraxin 1 Negatively Regulates Excitatory Synapse Density and Synaptic Plasticity

(2015) J. Figueiro-Silva et al.   JOURNAL OF NEUROSCIENCE

From circuits to behaviour in the amygdala

(2015) Patricia H. Janak et al.   NATURE

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

The basolateral amygdala in reward learning and addiction

(2015) Kate M. Wassum et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A survey of human brain transcriptome diversity at the single cell level

(2015) Spyros Darmanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nucleus Accumbens: A Comprehensive Review

(2015) Sanjay Salgado et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

Alcohol-Preferring Rats Show Decreased Corticotropin-Releasing Hormone-2 Receptor Expression and Differences in HPA Activation Compared to Alcohol-Nonpreferring Rats

(2014) Weidong Yong et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

The brain reward circuitry in mood disorders

(2013) Scott J. Russo et al.   NATURE REVIEWS NEUROSCIENCE

Neuronal populations in the basolateral nuclei of the amygdala are differentially increased in humans compared with apes: A stereological study

(2012) Nicole Barger et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Stereological analysis of the rat and monkey amygdala

(2011) Loïc J. Chareyron et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Corticotropin-Releasing Hormone Network and the Hypothalamic-Pituitary-Adrenal Axis: Molecular and Cellular Mechanisms Involved

(2011) Juan José Bonfiglio et al.   NEUROENDOCRINOLOGY

Modulation of Neuronal Signal Transduction and Memory Formation by Synaptic Zinc

(2011) Carlos Sindreu et al.   Frontiers in Behavioral Neuroscience

Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala

(2010) Elisabeth A. Murray et al.   BIOLOGICAL PSYCHIATRY

The Reward Circuit: Linking Primate Anatomy and Human Imaging

(2009) Suzanne N Haber et al.   NEUROPSYCHOPHARMACOLOGY

Localization of chondroitin sulfate proteoglycan versican in adult brain with special reference to large projection neurons

(2008) Noriko Horii-Hayashi et al.   CELL AND TISSUE RESEARCH