Article
Immunology
Bingzhou Bao, Chao Zhu, Jian Shi, Canxing Lu
Summary: This study used the Mendelian randomization (MR) approach to investigate the causal relationship between inflammatory bowel disease (IBD) and hidradenitis suppurativa (HS). The results showed that IBD has a causal effect on HS, while HS does not affect IBD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Wei-Sheng Chung, Sunny Chung, Chung-Y Hsu, Cheng-Li Lin
Summary: The study suggests that regardless of the presence of appendicitis, appendectomy increases the risks of ulcerative colitis and Crohn's disease.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Naim Abu-Freha, Bracha Cohen, Michal Gordon, Sarah Weissmann, Emily H. Kestenbaum, Sergei Vosko, Muhammad Abu-Tailakh, Liza Ben-Shoshan, Daniel L. Cohen, Haim Shirin
Summary: This study investigated the prevalence and risk factors of CRC among a large cohort of IBD patients. The results showed that the rate of CRC was higher in CD and UC patients compared to the general population. Age, primary sclerosing cholangitis, diabetes mellitus, and glucocorticoids treatment were found to be predictors of CRC. Therefore, IBD patients, especially those with risk factors, should be closely monitored for CRC.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Reka Palatka, Eszter Anna Janka, Lilla Soltesz, Imre Lorinc Szabo, Aniko Kapitany, Zsolt Dajnoki, Gabriella Emri, Gabor Nagy, Karoly Palatka, Christos. C. Zouboulis, Andrea Szegedi, Krisztian Gaspar
Summary: In this study, it was found that 28.4% of patients diagnosed with hidradenitis suppurativa (HS) also had chronic inflammatory intestinal disorders (CIID). The use of fecal calprotectin (FC) test or anti-Saccharomyces cerevisiae antibody (ASCA) levels can be effective in assessing colonic inflammation in these patients. The FC test was found to have high sensitivity and specificity in diagnosing CIID.
Article
Gastroenterology & Hepatology
Emily W. Lopes, Paul Lochhead, Kristin E. Burke, James M. Richter, Ashwin N. Ananthakrishnan, Andrew T. Chan, Hamed Khalili
Summary: In this prospective study, it was found that dietary and lifestyle risk factors for inflammatory bowel disease may differ according to disease phenotype.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kristine H. Allin, Rikke K. Jacobsen, Ryan C. Ungaro, Jean-Frederic Colombel, Alexander Egeberg, Marie Villumsen, Tine Jess
Summary: This study found that bariatric surgery is associated with an increased risk of new-onset Crohn's disease, particularly in women, but not ulcerative colitis. The underlying mechanisms remain unclear.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Noreen Singh, Charles N. Bernstein
Summary: This article reviews the impact of environmental risk factors, such as early life exposures, lifestyle and hygiene, vaccinations, surgeries, exposure to drugs and gastrointestinal pathogens, on the risk of developing IBD.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Review
Gastroenterology & Hepatology
Xiaoding Shen, Qianyi Wan, Rui Zhao, Yutao Wu, Yong Wang, Yaping Cui, Xiangnan Su, Xiaoting Wu
Summary: The umbrella review of 25 meta-analyses found that patients with inflammatory bowel diseases had a higher risk of adverse health outcomes in various aspects, but the quality of evidence was generally low. More research is needed to draw firmer conclusions.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Immunology
Wen Cheng, Yang Liao, Ruiyu Mou, Xian Xiao, Yingjie Jia
Summary: Using mendelian randomization (MR) analysis, this study finds no causal association between inflammatory bowel disease (IBD) and prostate cancer (PCa), contradicting most observational studies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biology
Alina Ecaterina Jucan, Otilia Gavrilescu, Mihaela Dranga, Iolanda Valentina Popa, Bogdan Mircea Mihai, Cristina Cijevschi Prelipcean, Catalina Mihai
Summary: New research suggests a possible link between inflammatory bowel disease (IBD) and an increased risk of ischemic heart disease (IHD). The disruption of the intestinal mucosal barrier in IBD may lead to the translocation of endotoxins into the bloodstream, triggering a pro-inflammatory response that can contribute to endothelial dysfunction, atherosclerosis, and acute cardiovascular events. It is crucial to monitor and manage cardiovascular risk factors in IBD patients, and optimize therapy during active flares. Further studies, biomarkers, and scoring systems are needed for optimal management of IHD risk in IBD patients.
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Michelle T. Lee, Dhruv Mahtta, Liang Chen, Aliza Hussain, Mahmoud Al Rifai, Preetika Sinh, Umair Khalid, Khurram Nasir, Christie M. Ballantyne, Laura A. Petersen, Salim S. Virani
Summary: This study found an association between inflammatory bowel disease and extremely premature atherosclerotic cardiovascular disease, especially in patients under 40 years of age. As patients age, this risk is attenuated by traditional cardiometabolic factors such as obesity, hypertension, diabetes, smoking, and dyslipidemia.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Dermatology
Farhat Zaheri, Hendri H. Pas, Jeroen Bremer, Joost M. Meijer, Marieke C. Bolling, Barbara Horvath, Gilles F. H. Diercks
Summary: This study aimed to analyze a cohort of Dutch patients with paraneoplastic pemphigus (PNP) and identify atypical cases that did not meet the diagnostic criteria. The results showed several patients who did not completely meet the set criteria.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Marjolijn S. Haisma, Mathanhy Logendran, Jens Bos, Bert V.d. Vegt, Barbara Horvath, Stijn DE Vos, Geertruida H. D. E. Bock, Eelko Hak, Emoke Racz
Summary: This study investigated the association between hydrochlorothiazide use and skin cancer incidence. It found a clear association between high cumulative hydrochlorothiazide use and the risk of different types of skin cancer.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Urology & Nephrology
Tim J. Knobbe, Daan Kremer, Rianne M. Douwes, Michele F. Eisenga, Antonio W. Gomes-Neto, Coby Annema, J. Casper Swarte, Frank Klont, Gerjan Navis, Stefan P. Berger, Stephan J. L. Bakker
Summary: Prior studies have shown that the use of proton pump inhibitors (PPIs) can negatively impact gut microbiota and the absorption of micronutrients, such as iron and magnesium. This study aims to investigate the association between PPI use and fatigue and health-related quality of life (HRQoL) in kidney transplant recipients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Infectious Diseases
Koos P. J. G. van Dam, Adriaan Volkers, Luuk W. Wieske, Eileen Stalman, Laura Y. L. Kummer, Zoe L. E. van Kempen, Joep W. Killestein, Sander Tas, Laura J. Boekel, Gerrit J. Wolbink, Anneke van der Kooi, Joost Raaphorst, R. Bart Takkenberg, Geert R. A. M. I. D'Haens, Phyllis W. Spuls, Marcel H. Bekkenk, Annelie F. Musters, Nicoline L. Post, Angela L. Bosma, Marc Hilhorst, Yosta J. Vegting, Frederike E. Bemelman, Alexandre Voskuyl, Bo Broens, Agner Parra Sanchez, Cecile A. C. M. van Els, Jelle de Wit, Abraham Rutgers, Karina de Leeuw, Barbara Horvath, Jan J. G. M. M. Verschuuren, Annabel Ruiter, Lotte van Ouwerkerk, Diane van der Woude, Renee C. F. Allaart, Y. K. Onno Teng, Pieter H. van Paassen, Matthias Busch, Papay B. P. Jallah, Esther A. Brusse, Pieter van Doorn, Adaja E. Baars, Dirk Jan Hijnen, Corine R. G. Schreurs, W. Ludo van der Pol, H. Stephan Goedee, Maurice Steenhuis, Sofie Keijzer, Jim B. D. Keijser, Olvi Cristianawati, Anja ten Brinke, Niels J. M. Verstegen, S. Marieke van Ham, Theo W. Rispens, Taco Kuijpers, Mark Lowenberg, Filip Eftimov
Summary: This study investigated the long-term humoral immune responses to SARS-CoV-2 and increased disease activity after a primary infection in unvaccinated patients with immune-mediated inflammatory diseases (IMIDs) using immunosuppressants (ISPs). The results showed that IMID patients using ISPs had reduced long-term humoral immune responses after SARS-CoV-2 infection, especially those using anti-CD20 and anti-tumor necrosis factor (TNF) agents. Increased disease activity after infection was commonly reported, but mostly mild.
BMC INFECTIOUS DISEASES
(2023)
Article
Dermatology
Koen Dudink, Klasiena Bouwman, Yanqing Chen, Samuel E. DePrimo, Ernesto J. Munoz-Elias, Pim Aarts, Renske Schappin, Edwin F. Florencia, Bennie van Heeswijk, Lisette M. Prens, Hessel H. van der Zee, Errol P. Prens, Kelsey R. van Straalen, Barbara Horvath
Summary: 65% of patients with moderate-to-severe hidradenitis suppurativa achieved a clinical response after 16 weeks of guselkumab treatment, which was well tolerated. Transcriptomic data supported the rationale for IL-23 inhibition with guselkumab, but did not consistently correlate with protein expression and clinical responses. Guselkumab seems to be beneficial only in a subgroup of HS patients, suggesting that the IL-23/T helper 17 axis is not central to the pathophysiology of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Eva W. H. Korte, Tobias Welponer, Jan Kottner, Sjoukje van der Werf, Peter C. van den Akker, Barbara Horvath, Dimitra Kiritsi, Martin Laimer, Anna M. G. Pasmooij, Verena Wally, Maria C. Bolling
Summary: This study summarizes the different outcomes and outcome measurement instruments reported in clinical research on epidermolysis bullosa (EB) over the past 30 years and identifies a significant heterogeneity. Adequate evaluation and comparison of EB clinical studies require well-defined and consensus-endorsed outcomes and measurement instruments. This scoping review is the first step towards harmonization of EB outcomes, which is crucial for the clinical translation of novel treatments.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Adrianus. M. van Der Holst, Antonius T. Otten, Elise M. Meima-van Praag, Alexander R. P. K. M. van Renterghem, Arno R. Bourgonje, Ellen S. van Loo, Gerard Dijkstra, Christianne J. Buskens, Laurents P. S. Stassen
Summary: Creation of a diverting stoma in patients with Crohn's disease may counteract luminal inflammation. This study aimed to evaluate the long-term effects of a diverting stoma on the disease course. Findings suggest that a diverting stoma could be an alternative in specific populations of patients with luminal colonic CD, especially in the absence of proctitis.
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Roberta Loveikyte, Arno R. Bourgonje, Johannes J. van der Reijden, Marian L. C. Bulthuis, Lukas J. A. C. Hawinkels, Marijn C. Visschedijk, Eleonora A. M. Festen, Hendrik M. van Dullemen, Rinse K. Weersma, Harry van Goor, Andrea E. van der Meulen-de Jong, Gerard Dijkstra
Summary: Absolute iron deficiency is the main factor determining hepcidin levels, even in an inflammatory state. Induction therapy can decrease hepcidin levels, which may improve the availability of iron. Therefore, hepcidin is a potential diagnostic biomarker for iron deficiency and can assist in therapeutic decision making.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Antonius T. Otten, Hedwig H. van der Meulen, Maurice Steenhuis, Floris C. Loeff, Daan J. Touw, Jos G. W. Kosterink, Henderik W. Frijlink, Theo Rispens, Gerard Dijkstra, Marijn C. Visschedijk, Arno R. Bourgonje
Summary: A finger prick-based capillary blood self-sampling technique was validated for monitoring infliximab, vedolizumab, and C-reactive protein concentrations in patients with inflammatory bowel disease. The technique received substantial support from patients and demonstrated good tolerability and practicality.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Medicine, General & Internal
Antonius Timotheus Otten, V Peters, I Barth, C. L. Stevens, A. R. Bourgonje, H. W. Frijlink, H. J. M. Harmsen, A. Rehman, M. J. E. Campmans-Kuijpers, G. Dijkstra
Summary: This article describes a nutritional intervention trial on patients with Crohn's disease (CD) and their healthy household members, investigating the effects of an evidence-based anti-inflammatory diet and an ileocolonic-targeted capsule containing vitamin B2, B3, and C. The results of the study will provide valuable evidence for dietary recommendations for CD patients and physicians.
Article
Pharmacology & Pharmacy
Aisha A. Ahmed, Antonius T. Otten, Bahez Gareb, Judith E. Huijmans, Anko C. Eissens, Ateequr Rehman, Gerard Dijkstra, Jos G. W. Kosterink, Henderik W. Frijlink, Reinout C. A. Schellekens
Summary: The development of capsules containing riboflavin, nicotinic acid, and ascorbic acid covered with a pH-sensitive coating (ColoVit) was described to achieve site-specific release in the ileocolon. The capsules met the required specifications and had a lag-time in drug release of 277-283 min, which meets the requirements for ileocolonic release. The production process of the ColoVit formulation was validated and reproducible, and the vitamin blend was stable during the production process and in the finished coated product. ColoVit is intended as an innovative treatment approach for beneficial microbiome modulation and optimization of gut health.
Letter
Gastroenterology & Hepatology
Antonius T. Otten, Gerard Dijkstra, Marijn C. Visschedijk, Arno R. Bourgonje
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Sem Geertsema, Arno R. Bourgonje, Raphael R. Fagundes, Ranko Gacesa, Rinse K. Weersma, Harry van Goor, Giovanni E. Mann, Gerard Dijkstra, Klaas N. Faber
Summary: Oxidative stress is an important mechanism in inflammatory bowel disease. The NRF2/Keap1 pathway regulates cellular responses to oxidative stress and has been implicated in the development of inflammatory bowel disease. Activation of the NRF2/Keap1 pathway enhances antioxidant responses and may potentially improve clinical outcomes for inflammatory bowel disease.
TRENDS IN MOLECULAR MEDICINE
(2023)
Review
Immunology
Yuchen Yang, Li Wang, Ivonne Peugnet-Gonzalez, Daniela Parada-Venegas, Gerard Dijkstra, Klaas Nico Faber
Summary: The intestinal mucosa serves as a barrier and is involved in nutrient absorption. Genetic susceptibility and environmental factors play a critical role in the development of intestinal diseases. The innate immune system recognizes potential threats through pattern recognition receptors (PRRs), including the cGAS-STING pathway. However, the role of the cGAS-STING pathway in intestinal diseases is still debated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Angelique Rondags, Laura van Marle, Barbara Horvath, Freke R. Wink, Suzanne Arends, Anneke Spoorenberg
Summary: This study found that psoriasis is often underdiagnosed in patients with axial spondyloarthritis (axSpA), and a patient self-reported questionnaire with prototypical pictures to recognize psoriasis symptoms could be beneficial in tracing undiagnosed psoriasis.
ARTHRITIS RESEARCH & THERAPY
(2023)