Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis

Regulation of blood pressure and renal function by NCC and ENaC: lessons from genetically engineered mice

(2015) Sophia N Verouti et al.   CURRENT OPINION IN PHARMACOLOGY

Current and Emerging Biologics for Ulcerative Colitis

(2015) Sung Chul Park et al.   Gut and Liver

Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel  -Subunit

(2015) R. Perrier et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments

(2015) Bruno Rafael Ramos de Mattos et al.   MEDIATORS OF INFLAMMATION

Claudin-related intestinal diseases

(2015) Christian Barmeyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Current stage in inflammatory bowel disease: What is next?

(2015) Gonzalo Jesús Gómez-Gómez   WORLD JOURNAL OF GASTROENTEROLOGY

A Novel Tumor Necrosis Factor–mediated Mechanism of Direct Epithelial Sodium Channel Activation

(2014) István Czikora et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

New Drugs on the Horizon for IBD

(2014) Bruce E. Sands   DIGESTIVE DISEASES

MMP3 and CXCL1 are potent stromal protein markers of dysplasia–carcinoma transition in sporadic colorectal cancer

(2014) Ferenc Sipos et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition

(2014) Giovanna Crisante et al.   FASEB JOURNAL

Colon-Specific Deletion of Epithelial Sodium Channel Causes Sodium Loss and Aldosterone Resistance

(2014) S. Malsure et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Functional Analysis of a Missense Mutation in the Serine Protease Inhibitor SPINT2 Associated with Congenital Sodium Diarrhea

(2014) Nicolas Faller et al.   PLoS One

Intestinal barrier homeostasis in inflammatory bowel disease

(2014) Rasmus Goll et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

TGF-Beta Signaling Manipulation as Potential Therapy for IBD

(2013) Irene Marafini et al.   CURRENT DRUG TARGETS

Short Communication Transient increase in IL-1β, IL-6 and TNF-α gene expression in rat liver exposed to gold nanoparticles

(2013) H.A. Khan et al.   GENETICS AND MOLECULAR RESEARCH

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome

(2013) Dan Knights et al.   GUT

Genetic characterization of congenital tufting enteropathy: epcam associated phenotype and involvement of SPINT2 in the syndromic form

(2013) Julie Salomon et al.   HUMAN GENETICS

The Channel-Activating Protease CAP1/Prss8 Is Required for Placental Labyrinth Maturation

(2013) Edith Hummler et al.   PLoS One

TGF-  directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury

(2013) D. M. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations of the Serine Protease CAP1/Prss8 Lead to Reduced Embryonic Viability, Skin Defects, and Decreased ENaC Activity

(2012) Simona Frateschi et al.   AMERICAN JOURNAL OF PATHOLOGY

Dynamic activation of the key pathways: linking colitis to colorectal cancer in a mouse model

(2012) Anliu Tang et al.   CARCINOGENESIS

Dysplasia-Carcinoma Transition Specific Transcripts in Colonic Biopsy Samples

(2012) Orsolya Galamb et al.   PLoS One

Membrane-Bound Serine Protease Inhibitor HAI-1 Is Required for Maintenance of Intestinal Epithelial Integrity

(2011) Makiko Kawaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Infective and inflammatory diarrhoea: mechanisms and opportunities for novel therapies

(2011) Geoffrey I Sandle   CURRENT OPINION IN PHARMACOLOGY

TGF- 1 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6

(2011) A. Saito et al.   HUMAN REPRODUCTION

Matriptase Protects Against Experimental Colitis and Promotes Intestinal Barrier Recovery

(2011) Sarah Netzel-Arnett et al.   INFLAMMATORY BOWEL DISEASES

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin

(2011) Simona Frateschi et al.   Nature Communications

The mouse frizzy (fr) and rat ‘hairless’ (frCR) mutations are natural variants of protease serine S1 family member 8 (Prss8)

(2010) Damek V. Spacek et al.   EXPERIMENTAL DERMATOLOGY

Mutations in SPINT2 Cause a Syndromic Form of Congenital Sodium Diarrhea

(2009) Peter Heinz-Erian et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

(2009) Karin List et al.   AMERICAN JOURNAL OF PATHOLOGY

ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1

(2009) Carole Planès et al.   EMBO Molecular Medicine

Changes in Mucosal Homeostasis Predispose NHE3 Knockout Mice to Increased Susceptibility to DSS-Induced Epithelial Injury

(2009) Pawel R. Kiela et al.   GASTROENTEROLOGY

Increased expression of protease-activated receptor-2 in mucosal mast cells in Crohn's ileitis

(2009) Ulrika Christerson et al.   Journal of Crohns & Colitis

Altered ENaC Expression Leads to Impaired Sodium Absorption in the Noninflamed Intestine in Crohn's Disease

(2008) Sebastian Zeissig et al.   GASTROENTEROLOGY

Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: Potential contributors to IBD-associated diarrhea

(2008) Sean Sullivan et al.   INFLAMMATORY BOWEL DISEASES

Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease

(2008) Silvia Melgar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice

(2008) Milena Traykova-Brauch et al.   NATURE MEDICINE

Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome

(2007) Marko Bertog et al.   JOURNAL OF PHYSIOLOGY-LONDON