Article
Plant Sciences
Irvine Niyonizigiye, Daniel Ngabire, David Nkurunziza, Maheshkumar Prakash Patil, Alka Ashok Singh, Jeremie Ngezahayo, Gun-Do Kim
Summary: This study explored the potential anti-inflammatory effects of Aspilia africana in lipopolysaccharide-stimulated macrophages, revealing that A. africana inhibited the production of nitric oxide and suppressed the expression of inflammatory enzymes and cytokines. Furthermore, A. africana was found to prevent the activation of NF-kB and PI3K/Akt pathways, ultimately influencing gene expression related to inflammation at the transcriptional level.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Nutrition & Dietetics
Gabriele Serreli, Micaela Rita Naitza, Sonia Zodio, Vera Piera Leoni, Martina Spada, Maria Paola Melis, Anna Boronat, Monica Deiana
Summary: Ferulic acid and its metabolites show efficacy in combating inflammation by limiting the expression and activity of proinflammatory enzymes, reducing NF-κB translocation, and promoting Nrf2 expression.
Article
Biochemistry & Molecular Biology
Raissa Volpatto Marques, Stefania Enza Sestito, Frederic Bourgaud, Sissi Miguel, Frederic Cailotto, Pascal Reboul, Jean-Yves Jouzeau, Sophie Rahuel-Clermont, Sandrine Boschi-Muller, Henrik Toft Simonsen, David Moulin
Summary: The study found that the biologically active extracts of Dicranum majus and Thuidium delicatulum exhibited significant anti-inflammatory effects, potentially serving as a perspective for developing innovative therapeutic agents.
Article
Biochemistry & Molecular Biology
Sang Min Lee, Kyung-No Son, Dhara Shah, Marwan Ali, Arun Balasubramaniam, Deepak Shukla, Vinay Kumar Aakalu
Summary: This study investigated the effects of histatin-1 (Hst1) on LPS-induced inflammatory responses and the underlying molecular mechanisms in RAW264.7 (RAW) macrophages. The results demonstrated that Hst1 can inhibit LPS-induced inflammatory mediator production and MAPK signaling pathways in macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Di Li, Jinlin He, Caihong Fang, Yiwen Zhang, Mingli He, Zhanqi Zhang, Jinsong Hou, Qiong Xu
Summary: Excessive differentiation of osteoclasts contributes to the disruption of bone homeostasis in inflammatory bone diseases. METTL3 deficiency leads to decreased osteoclast differentiation and increased apoptosis in inflammatory conditions, possibly due to the exacerbation of iNOS/NO-mediated mitochondrial dysfunction by promoting Nos2 mRNA stability in a YTHDF1-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Pablo Rayff da Silva, Nadjaele de Melo Apolinario, Simone Angela Soares da Silva, Maria Elaine Cristina Araruna, Thassia Borges Costa, Yvnni M. S. de Medeiros e Silva, Teresinha Goncalves da Silva, Ricardo Olimpio de Moura, Vanda Lucia dos Santos
Summary: This study evaluated the anti-inflammatory potential of the compound JR19 and found that it can exert its anti-inflammatory effects through the nitric oxide pathway and cytokine signaling.
Article
Immunology
Kuluvar Gouthannchandra, Heggar Venkataramana Sudeep, Siddappa Chandrappa, Amrith Raj, Puttaswamy Naveen, Kodimule Shyamaprasad
Summary: In this study, bisdemethoxycurcumin (BDMC) was enriched to 70% and named as REVERC3 for the first time, showing significant anti-inflammatory activity in comparison to regular turmeric extract. The results demonstrated that REVERC3 effectively inhibited inflammation processes in both in vitro and in vivo models.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
M. E. Inda-Webb, M. Jimenez, Q. Liu, N. V. Phan, J. Ahn, C. Steiger, A. Wentworth, A. Riaz, T. Zirtiloglu, K. Wong, K. Ishida, N. Fabian, J. Jenkins, J. Kuosmanen, W. Madani, R. McNally, Y. Lai, A. Hayward, M. Mimee, P. Nadeau, A. P. Chandrakasan, G. Traverso, R. T. Yazicigil, T. K. Lu
Summary: A miniaturized device has been developed that combines genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip to track short-lived molecules in the gastrointestinal tract. This device can help diagnose diseases like inflammatory bowel disease earlier and track disease progression more accurately.
Article
Cell Biology
Chunchun Zhang, Dandan Ning, Jieli Pan, Cheng Chen, Chengxian Gao, Zhishan Ding, Fusheng Jiang, Meiya Li
Summary: Bletilla striata is a traditional Chinese herb with anti-inflammatory properties, especially in treating lung conditions like silicosis and tuberculosis. The study found that the enriched fraction EFBS from Bletilla striata contains coelonin, batatasin III, 3'-O-methylbatatasin III, and 3-hydroxy-5-methoxy bibenzyl as main anti-inflammatory components. EFBS demonstrated significant anti-inflammatory activities by reducing lung injury, inflammatory cell infiltration, and cytokine levels.
MEDIATORS OF INFLAMMATION
(2021)
Article
Chemistry, Medicinal
Barbara Terroni, Luis Henrique Oliveira de Moraes, Aline Renata Pavan, Gerson Jhonatan Rodrigues, Jean Leandro Dos Santos
Summary: The study found that Lapdesf-4c can induce vasodilation and counteract endothelial dysfunction, showing great potential as a new drug candidate.
Article
Medicine, Research & Experimental
Mei-Hua Jin, Dong-Qin Chen, Ying-Hua Jin, Ying-Hao Han, Hu-Nan Sun, Taeho Kwon
Summary: Neuroinflammation is linked to various neurodegenerative diseases, with abnormal activation of microglial cells and overproduction of NO playing a crucial role. Hispidin, a polyphenol from Phellinus linteus, has been shown to significantly inhibit NO production in macrophages. This study demonstrated that Hispidin can effectively reduce NO production and iNOS expression in microglial cells, suggesting its potential as a therapeutic agent for NO-induced neuroinflammation and as a novel iNOS inhibitor.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sigal Fleisher-Berkovich, Veronica Battaglia, Francesca Baratta, Paola Brusa, Yvonne Ventura, Nitzan Sharon, Arik Dahan, Massimo Collino, Shimon Ben-Shabat
Summary: This study investigates the combined role of CBD and ARBs in the modulation of glial inflammation, finding that the combination can significantly inhibit the release of nitric oxide and has anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Integrative & Complementary Medicine
Jiha Byun, Su Kang Kim, Ju Yeon Ban
Summary: The study evaluated the protective effects of Korean ginseng berry extract (KGB) on LPS-induced inflammation and found that KGB can inhibit cytokine production, reduce expression of inflammation-related genes, and decrease oxidative stress through multiple pathways. These results suggest that KGB may have the potential to be a therapeutic agent for inflammatory and oxidative stress-related diseases.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Minghan Zhao, Yuting Han, Qi Yang, Qiulin Yue, Song Zhang, Chen Zhao, Xin Sun, Jing Xu, Xingtao Jiang, Kunlun Li, Baojun Li, Lin Zhao, Le Su
Summary: With the progression of society, e-cigarettes have become popular among many people. While some studies suggest that e-cigarettes are a safer alternative to traditional cigarettes, there are conflicting findings. This in vitro study compared the effects of e-cigarettes and tobacco cigarettes on RAW264.7 cells. The results showed that low nicotine concentration and certain flavors in e-cigarettes promoted cell viability, while high nicotine concentration and certain flavors decreased cell viability. Additionally, tobacco cigarettes reduced the phagocytic capability of cells and increased inflammation and oxidative stress compared to e-cigarettes.
Article
Cell Biology
Hyo-Jin An, Ji-Young Lee, Wansu Park
Summary: This study found that baicalin can inhibit the inflammatory response of macrophages activated by LPS, reduce the production of various inflammatory mediators, suppress oxidative stress, decrease the levels of phosphorylated p38 MAPK and Fas protein, and inhibit the expression of inflammatory genes.
Article
Chemistry, Applied
Caiyun Gao, Ruijun Li, Miaomiao Zhou, Yanwei Yang, Lingyi Kong, Jun Luo
NATURAL PRODUCT RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Ruolan Yao, Yucheng Zhao, Tingting Liu, Chuanlong Huang, Sheng Xu, Ziwei Sui, Jun Luo, Lingyi Kong
PLANT MOLECULAR BIOLOGY
(2017)
Article
Chemistry, Organic
Lin Wu, Ya-Long Zhang, Xiao-Bing Wang, Yang-Mei Zhang, Ming-Hua Yang, Jun Luo, Ling-Yi Kong
Article
Plant Sciences
Tingting Liu, Ruolan Yao, Yucheng Zhao, Sheng Xu, Chuanlong Huang, Jun Luo, Lingyi Kong
FRONTIERS IN PLANT SCIENCE
(2017)
Article
Chemistry, Medicinal
Fa-Liang An, Dong-Mei Sun, Xiao-Bing Wang, Lei Yang, Yong Yin, Jun Luo, Ling-Yi Kong
Article
Chemistry, Medicinal
Ya-lin Hu, Yi Li, Lu Qiu, Jun-he Li, Li Heng, Shan-shan Wei, Hong-liang Gao, Xiao-bing Wang, Jun Luo, Ling-yi Kong
Article
Agricultural Engineering
Shu-jun Shan, Jun Luo, De-ran Xu, Xing-liang Niu, Ding-qiao Xu, Pan-pan Zhang, Ling-yi Kong
INDUSTRIAL CROPS AND PRODUCTS
(2018)
Article
Plant Sciences
Tian-Xiao Li, Rui-Huan Liu, Xiao-Bing Wang, Jun Luo, Jian-Guang Luo, Ling-Yi Kong, Ming-Hua Yang
JOURNAL OF NATURAL PRODUCTS
(2018)
Article
Plant Sciences
Wen-Yan Zhang, Lu Qiu, Qin-Pei Lu, Miao-Miao Zhou, Jun Luo, Yi Li
PHYTOCHEMISTRY LETTERS
(2018)
Article
Plant Sciences
Miao-Miao Zhou, Wen-Yan Zhang, Rui-Jun Li, Chao Guo, Shan-Shan Wei, Xiao-Meng Tian, Jun Luo, Ling-Yi Kong
Article
Chemistry, Multidisciplinary
Dong-Mei Sun, Fa-Liang An, Shan-Shan Wei, Yan-Qiu Zhang, Xiao-Bing Wang, Jun Luo, Ling-Yi Kong
Article
Biochemistry & Molecular Biology
Fa-Liang An, Dong-Mei Sun, Rui-Zhi Wang, Ming-Hua Yang, Jun Luo, Ling-Yi Kong
Article
Oncology
Jie Luo, Yuanzheng Xia, Jun Luo, Junhe Li, Chao Zhang, Hao Zhang, Ting Ma, Lei Yang, Lingyi Kong
Article
Chemistry, Analytical
Wenda Zhang, Feiyan Liu, Chao Zhang, Jian-Guang Luo, Jun Luo, Wenying Yu, Lingyi Kong
ANALYTICAL CHEMISTRY
(2017)