Review
Immunology
Virginia Camacho, Valeriya Kuznetsova, Robert S. Welner
Summary: The immune microenvironment plays a crucial role in regulating hematopoiesis and immune cell dysfunction significantly contributes to neoplastic disease. Leukemic inflammatory cytokines can alter immune cells, and targeting the immune landscape may have therapeutic value in limiting leukemia growth. Further research is needed to understand how leukemic cytokines impact immune cells and potential immunotherapeutic approaches for patients with hematological myeloid malignancies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Defne Bayik, Cynthia F. Bartels, Katreya Lovrenert, Dionysios C. Watson, Duo Zhang, Kristen Kay, Juyeun Lee, Adam Lauko, Sadie Johnson, Alice Lo, Daniel J. Silver, Mary McGraw, Matthew Grabowski, Alireza M. Mohammadi, Filippo Veglia, Yi Fan, Michael A. Vogelbaum, Peter Scacheri, Justin D. Lathia
Summary: The study revealed that the enhanced cell adhesion ability of mMDSC in the GBM microenvironment is linked to tumor promotion, and targeting Integrin (31) and DPP-4 to interfere with mMDSC may be an effective way to alleviate immune suppression driven by myeloid cells in GBM.
Article
Immunology
Patrick P. G. Mulder, Marcel Vlig, Bouke K. H. L. Boekema, Matthea M. Stoop, Anouk Pijpe, Paul P. M. van Zuijlen, Evelien de Jong, Bram van Cranenbroek, Irma Joosten, Hans J. P. M. Koenen, Magda M. W. Ulrich
Summary: Severe burn injury induces persistent systemic inflammation marked by continuous release of immature neutrophils and shifts in T cell composition toward a more pro-inflammatory phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Anik Pramanik, Sankar Bhattacharyya
Summary: The MDSC population in the tumor microenvironment plays a crucial role in tumor immune evasion and cancer progression by disrupting antitumor T cell activity and potentially affecting other immune cell functions.
Article
Immunology
Stefanie Kroeze, Theresa M. Rossouw, Helen C. Steel, Ferdinand W. Wit, Cissy M. Kityo, Margaret Siwale, Sulaimon Akanmu, Kishor Mandaliya, Marleen De Jager, Pascale Ondoa, Peter Reiss, Tobias F. Rinke De Wit, Neeltje A. Kootstra, Raph L. Hamers
Summary: Persistent systemic inflammation, as indicated by plasma biomarkers, during suppressive antiretroviral therapy in HIV-1-infected individuals, may impact CD4(+) T-cell recovery and viral rebound during long-term treatment. Changes in biomarker concentrations could affect viral replication and immune recovery in patients. Further research is needed to understand these potential mechanisms in order to improve clinical outcomes.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Aleksandra M. Mazitova, Ana Cristina Marquez-Sanchez, Ekaterina K. Koltsova
Summary: Adipose tissue inflammation is connected to chronic inflammatory diseases and cancer. Perivascular adipose tissue plays a role in atherosclerosis development and stores various immune cells. Recent studies show that adipocytes can directly respond to inflammatory stimuli.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Kenia Ubieta, Matthew James Thomas, Lutz Wollin
Summary: The study revealed that nintedanib blocks T-cell activation by inhibiting Lck-Y394 phosphorylation, reduces cluster formation as a marker of activation, and inhibits the release of various cytokines. These immunomodulatory effects further explain how nintedanib slows the progression of pulmonary fibrosis in different ILDs.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Immunology
Claudia Giannotta, Federica Autino, Massimo Massaia
Summary: Myeloid derived suppressor cells (MDSC) have significant roles in regulating immune homeostasis and immune responses, especially in cancer. MDSC interact with cancer cells in the tumor microenvironment through various mechanisms such as producing soluble factors, expressing inhibitory molecules, rewiring metabolism, and releasing exosomes. The relationship between MDSC and tumor cells leads to immune evasion and cancer growth. In multiple myeloma (MM), MDSC play a major role in creating a tumor-promoting microenvironment. This minireview discusses the interplay between MDSC and MM microenvironment, as well as potential strategies to target MDSC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Tony J. F. Guo, Gurpreet K. Singhera, Janice M. Leung, Delbert R. Dorscheid
Summary: The airway epithelium plays a crucial role in the defense and immune response of the lungs against COVID-19. Severe COVID-19 is characterized by an excessive inflammatory response, which can lead to lung injury and organ failure. The immune response of the airway epithelium to SARS-CoV-2 infection may contribute to the pathogenesis of severe COVID-19. This article reviews the barrier and immune functions of the airway epithelium, the interaction between SARS-CoV-2 and the epithelium, and the role of epithelial-derived cytokines and chemokines in COVID-19 as well as their potential as biomarkers and therapeutic targets.
Article
Immunology
Graeme P. Sullivan, Pavel Davidovich, Natalia Munoz-Wolf, Ross W. Ward, Yasmina E. Hernandez Santana, Danielle M. Clancy, Aoife Gorman, Zaneta Najda, Boris Turk, Patrick T. Walsh, Ed C. Lavelle, Seamus J. Martin
Summary: IL-37, a member of the IL-1 family, can be activated and exhibit proinflammatory effects upon processing by specific proteases. This finding is consistent with other IL-1 family members.
SCIENCE IMMUNOLOGY
(2022)
Article
Immunology
Giuseppe Bronte, Alberto Verlicchi, Serena De Matteis, Alice Rossi, Alessandra Affatato, Francesco Giulio Sullo, Caterina Gianni, Matteo Canale, Marco Angelo Burgio, Angelo Delmonte, Michele Milella, Lucio Crino
Summary: Immune checkpoint inhibition has shown significant progress in treating non-small cell lung cancer patients, though resistance mechanisms like myeloid-derived suppressor cells and exhausted immune cells may limit effectiveness. Analyzing changes in immune cell subsets and disease progression during treatment could offer insights for developing new targets or biomarkers for cancer immunotherapy resistance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Pin-yi Liu, Hui-qin Li, Meng-qi Dong, Xin-ya Gu, Si-yi Xu, Sheng-nan Xia, Xin-yu Bao, Yun Xu, Xiang Cao
Summary: Properdin activates Mincle receptors on microglia to drive inflammatory responses, exacerbating brain injury in ischemic stroke patients. The interaction between properdin and Mincle on microglia may be a potential therapeutic target for improving ischemic stroke prognosis.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Suzanne H. Bongers, Na Chen, Erinke van Grinsven, Selma van Staveren, Marwan Hassani, Roy Spijkerman, Lilian Hesselink, Adele T. Lo Tam Loi, Corneli van Aalst, Guus P. Leijte, Matthijs Kox, Peter Pickkers, Falco Hietbrink, Luke P. H. Leenen, Leo Koenderman, Nienke Vrisekoop
Summary: Neutrophil phenotypes exhibit changes in disease states, with acute inflammation showing more heterogeneity and chronic inflammation not leading to increases in specific neutrophil subsets. The dynamics of neutrophil subsets in various inflammatory conditions contribute to our understanding of the role of neutrophils in health and disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Vineet Agrawal, Jonathan A. Kropski, Jason J. Gokey, Elizabeth Kobeck, Matthew B. Murphy, Katherine T. Murray, Niki L. Fortune, Christy S. Moore, David F. Meoli, Ken Monahan, Yan Ru Su, Thomas Blackwell, Deepak K. Gupta, Megha H. Talati, Santhi Gladson, Erica J. Carrier, James D. West, Anna R. Hemnes
Summary: This study investigates whether a well-accepted murine model of HFpEF displays features of PH, and identifies potential pathways driving early remodeling of the pulmonary vasculature in HFpEF.
CIRCULATION RESEARCH
(2023)