TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures
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Title
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures
Authors
Keywords
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Journal
NATURE IMMUNOLOGY
Volume 23, Issue 1, Pages 99-108
Publisher
Springer Science and Business Media LLC
Online
2021-12-23
DOI
10.1038/s41590-021-01087-w
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Note: Only part of the references are listed.- Best practices for the visualization, mapping, and manipulation of R‐loops
- (2021) Frédéric Chédin et al. EMBO JOURNAL
- Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA–DNA hybrid imaging
- (2021) Magdalena P. Crossley et al. JOURNAL OF CELL BIOLOGY
- TET methylcytosine oxidases: new insights from a decade of research
- (2020) Chan-Wang J. Lio et al. JOURNAL OF BIOSCIENCES
- Regulatory R-loops as facilitators of gene expression and genome stability
- (2020) Christof Niehrs et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity
- (2020) Shinya Tanaka et al. NATURE IMMUNOLOGY
- TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis
- (2020) Wojciech Rosikiewicz et al. Science Advances
- A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization
- (2020) William T. Yewdell et al. IMMUNITY
- Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability
- (2020) Suhas S. Kharat et al. Science Signaling
- R-Loops as Cellular Regulators and Genomic Threats
- (2019) Madzia P. Crossley et al. MOLECULAR CELL
- Paradoxical association of TET loss of function with genome-wide DNA hypomethylation
- (2019) Isaac F. López-Moyado et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TET enzymes augment activation-induced deaminase (AID) expression via 5-hydroxymethylcytosine modifications at the Aicda superenhancer
- (2019) Chan-Wang J. Lio et al. Science Immunology
- Mapping Native R-Loops Genome-wide Using a Targeted Nuclease Approach
- (2019) Qingqing Yan et al. Cell Reports
- Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
- (2018) Bjoern Chapuy et al. NATURE MEDICINE
- Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma
- (2018) Roland Schmitz et al. NEW ENGLAND JOURNAL OF MEDICINE
- DNA G-quadruplex structures mold the DNA methylome
- (2018) Shi-Qing Mao et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
- (2018) Alessio De Magis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AID Recognizes Structured DNA for Class Switch Recombination
- (2017) Qi Qiao et al. MOLECULAR CELL
- R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters
- (2017) Liang Chen et al. MOLECULAR CELL
- Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation
- (2017) Kyong-Rim Kieffer-Kwon et al. MOLECULAR CELL
- Antigen receptor repertoire profiling from RNA-seq data
- (2017) Dmitriy A Bolotin et al. NATURE BIOTECHNOLOGY
- DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
- (2017) Robert Hänsel-Hertsch et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The monoclonal S9.6 antibody exhibits highly variable binding affinities towards different R-loop sequences
- (2017) Fabian König et al. PLoS One
- Role of TET enzymes in DNA methylation, development, and cancer
- (2016) Kasper Dindler Rasmussen et al. GENES & DEVELOPMENT
- Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals
- (2016) Lionel A. Sanz et al. MOLECULAR CELL
- G-quadruplex structures mark human regulatory chromatin
- (2016) Robert Hänsel-Hertsch et al. NATURE GENETICS
- TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells
- (2016) Ageliki Tsagaratou et al. NATURE IMMUNOLOGY
- Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing
- (2016) Jiazhi Hu et al. Nature Protocols
- deepTools2: a next generation web server for deep-sequencing data analysis
- (2016) Fidel Ramírez et al. NUCLEIC ACIDS RESEARCH
- Tissue-specific DNA demethylation is required for proper B-cell differentiation and function
- (2016) Shari Orlanski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nascent Connections: R-Loops and Chromatin Patterning
- (2016) Frédéric Chédin TRENDS IN GENETICS
- 5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability
- (2016) Georgia Rose Kafer et al. Cell Reports
- Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility
- (2016) Chan-Wang Lio et al. eLife
- DNA methylation and hydroxymethylation in hematologic differentiation and transformation
- (2015) Myunggon Ko et al. CURRENT OPINION IN CELL BIOLOGY
- TET1 is a tumor suppressor of hematopoietic malignancy
- (2015) Luisa Cimmino et al. NATURE IMMUNOLOGY
- G-quadruplexes and their regulatory roles in biology
- (2015) Daniela Rhodes et al. NUCLEIC ACIDS RESEARCH
- Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis
- (2015) Jinsuk Kang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens
- (2015) Ryan M. Young et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
- (2014) Hao Wu et al. CELL
- N-methylmesoporphyrin IX fluorescence as a reporter of strand orientation in guanine quadruplexes
- (2014) Navin C. Sabharwal et al. FEBS Journal
- A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression
- (2014) K. Skourti-Stathaki et al. GENES & DEVELOPMENT
- G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD
- (2014) Lucas T Gray et al. Nature Chemical Biology
- Connections between TET proteins and aberrant DNA modification in cancer
- (2014) Yun Huang et al. TRENDS IN GENETICS
- Quantitative visualization of DNA G-quadruplex structures in human cells
- (2013) Giulia Biffi et al. Nature Chemistry
- TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
- (2013) William A. Pastor et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Optimized End-Stacking Provides Specificity of N-Methyl Mesoporphyrin IX for Human Telomeric G-Quadruplex DNA
- (2012) John M. Nicoludis et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
- (2012) Sebastian Müller et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation
- (2011) R. Shaknovich et al. BLOOD
- TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation
- (2011) Luisa Cimmino et al. Cell Stem Cell
- Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
- (2011) M. Ko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine
- (2011) S. Ito et al. SCIENCE
- In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo
- (2011) Takuya Nojima et al. Nature Communications
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
- (2010) Sven Heinz et al. MOLECULAR CELL
- Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
- (2010) Myunggon Ko et al. NATURE
- Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
- (2010) Chun-Xiao Song et al. NATURE BIOTECHNOLOGY
- Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma
- (2010) Mridula Nambiar et al. NUCLEIC ACIDS RESEARCH
- BSMAP: whole genome bisulfite sequence MAPping program
- (2009) Yuanxin Xi et al. BMC BIOINFORMATICS
- Circos: An information aesthetic for comparative genomics
- (2009) M. Krzywinski et al. GENOME RESEARCH
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
- (2009) M. Tahiliani et al. SCIENCE
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