Journal
INFECTION GENETICS AND EVOLUTION
Volume 46, Issue -, Pages 130-137Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2016.10.020
Keywords
Canine distemper virus; Badgers; Whole genome sequencing; Fox; Wildlife; Phylogeny
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Funding
- Italian Ministry of Health (RC)
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Canine distemper virus (CDV) represents an important conservation threat to manywild carnivores. A large distemper epidemic sustained by an Arctic-lineage strain occurred in Italy in 2013, mainly in the Abruzzi region, causing overt disease in domestic and shepherd dogs, Apennine wolves (Canis lupus) and other wild carnivores. Two badgers were collected by the end of September 2015 in a rural area of the Abruzzi region and were demonstrated to be CDV-positive by real time RT-PCR and IHC in several tissues. The genome of CDV isolates from badgers showed Y549H substitution in the mature H protein. By employing all publicly available Arctic-lineage H protein encoding gene sequences, six amino acid changes in recent Italian strainswith respect to Italian strains of dogs from 2000 to 2008, were observed. A CDV strain belonging to the European-wildlife lineage was also identified in a fox found dead in the same region in 2016, proving co-circulation of an additional CDV lineage. (C) 2016 Elsevier B.V. All rights reserved.
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