Article
Chemistry, Multidisciplinary
Zhen Xu, Tianhui Shi, Fengye Mo, Wenqian Yu, Yu Shen, Qunying Jiang, Fuan Wang, Xiaoqing Liu
Summary: In this study, programmable DNA-protein superstructures were successfully assembled through biomimetic assembly, by combining programmable polymer DNA wire with alkaline protein protamine to form densely packed DNA nanospheres. These DNA-protein superstructures exhibited specifically high affinity and stability, enabling high cancer cell selectivity and reduced side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yuxiang Dong, Jiliang Liu, Xuanzhao Lu, Jialin Duan, Liqi Zhou, Lizhi Dai, Min Ji, Ningning Ma, Yong Wang, Peng Wang, Jun-Jie Zhu, Qianhao Min, Oleg Gang, Ye Tian
Summary: Self-assembly processes are important for fabricating complexly organized nanomaterials, but often limited in creating structures with multiscale order. In this study, a two-stage assembly strategy is introduced to successfully form complexly organized nanoparticle crystals.
Article
Chemistry, Multidisciplinary
Yong Wang, Xuehui Yan, Zhaoyu Zhou, Ningning Ma, Ye Tian
Summary: DNA nanotechnology allows for the assembly of 3D lattices with complex patterns, but altering their symmetries through non-thermal treatments is challenging. This study demonstrates the synthesis of DNA lattices with switchable shapes upon pH change, using octahedral DNA origami frames. The results show the feasibility of obtaining 3D lattices that respond to external stimuli.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Luyang Zhao, Zhiguang Suo, Yong Liu, Min Wei, Huali Jin
Summary: A ratiometric fluorescent aptasensor based on dendrimer-like DNA nanostructures and catalytic hairpin self-assembly was constructed for the specific detection of aflatoxin B1 (AFB1) in food. The ratio-signal mode using FCy3/FCy5 showed a wider linear range and higher R2 compared to the single-signal mode for AFB1 detection. The aptasensor with ratio-signal mode also demonstrated higher accuracy than the single-signal-based aptasensor in spiking experiments of peanut, soybean, and wine samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Arlin Rodriguez, Dhanush Gandavadi, Johnsi Mathivanan, Tingjie Song, Bharath Raj Madhanagopal, Hannah Talbot, Jia Sheng, Xing Wang, Arun Richard Chandrasekaran
Summary: The programmable nature of DNA allows the construction of custom-designed static and dynamic nanostructures. However, the high concentrations of magnesium ions required for assembly restrict their applications. In this study, we investigate the assembly of DNA nanostructures in various ions and successfully assemble a majority of these structures in Ca2+, Ba2+, Na+, K+ and Li+. We also find that structures assembled in monovalent ions exhibit significantly higher nuclease resistance compared to those assembled in divalent ions.
Article
Optics
Zhanghang Zhu, Di Zhang, Fei Xie, Junjun Ma, Jiaxin Chen, Shengchao Gong, Wei Wu, Wei Cai, Xinzheng Zhang, Mengxin Ren, Jingjun Xu
Summary: This paper presents a nonlinear polarization imaging technique based on parametric upconversion, which can decode the polarization information of near-infrared light from the upconverted visible light. By utilizing the parametric upconversion process in a nanometers thin lithium niobate film, the polarization states of near-infrared fundamental frequency light are encoded into the generated visible wave, and then the polarization information is successfully retrieved using the nonlinear Stokes-Mueller formalism. The technique demonstrates high-precision polarization imaging over various targets and provides a fresh perspective on manufacturing novel polarimeters for various near-infrared polarization imaging and metrological applications.
Review
Chemistry, Multidisciplinary
Hui Jin, Meng Yang, Rijun Gui
Summary: This review provides an overview of the recent advances in ratiometric upconversion luminescence (UCL) nanoprobes, particularly in the areas of sensing, imaging, and phototherapy. It discusses the construction strategies, sensing applications, and phototherapeutic applications of these nanoprobes. The review also presents the current state, challenges, and future perspectives in this field. Overall, it highlights the potential of these luminescent nanoprobes for various applications in significant fields.
Article
Chemistry, Multidisciplinary
Yihao Zhou, Jinyi Dong, Chao Zhou, Qiangbin Wang
Summary: Using three-dimensional DNA origami as the building block, it is practical to construct finite hierarchical nanostructures with complicated conformations through orthogonal and directional bonding.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Joshua A. Johnson, Vasiliki Kolliopoulos, Carlos E. Castro
Summary: Simultaneous self-assembly of two distinct DNA origami nanostructures folded with the same scaffold strand was achieved in a single pot by adjusting concentrations of competing strands. The relative yields were correlated well with folding kinetics of individual structures, facilitating efficient fabrication of multi-structure systems and materials.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Sandra Kroell, Kersten S. Rabe, Christof M. Niemeyer
Summary: This study reports a rational re-engineering of the genetically fusible SNAP-tag linker, resulting in increased coupling efficiency with benzylguanine-modified oligonucleotides and DNA origami nanostructures. The novel linker, combined with another efficient oligonucleotide binding tag, allowed orthogonal assembly of an enzyme cascade on DON, showing higher activity than free solubilized enzymes. This connector system and the validation methods used represent important tools for further developing multienzyme systems based on DNA origami nanostructures.
Article
Engineering, Biomedical
Jinpeng Han, Yuchen Cui, Zi Gu, Dayong Yang
Summary: The study developed a nanocarrier system that can efficiently release drugs in cells while minimizing side effects, utilizing polyphenol-DNA nanocomplexes. Through programmable assembly and disassembly processes, this method achieves precise release of multiple genes and drugs in cells.
Article
Chemistry, Multidisciplinary
Ruixin Li, Haorong Chen, Jong Hyun Choi
Summary: Deployable geometries are finite auxetic structures that can maintain their overall shape while expanding and contracting. A deployable flight ring made from DNA origami has been demonstrated in this study, showing the feasibility of deployable nanostructures. The flight ring consists of six triangles in two layers that can switch between open and closed states, with a trefoil knot topology and negative Poisson's ratios. This work provides a versatile platform for topological studies and opens up new opportunities for bioengineering.
Article
Chemistry, Analytical
Chenchen Yang, Yueyue Li, Na Wu, Yinchan Zhang, Wei Feng, Mingming Yu, Zhanxian Li
Summary: In this study, core-shell rare earth upconversion nanoparticles were synthesized and utilized for the fabrication of mercury ion colorimetric nanoprobes with rapid response and low detection limits. These nanoprobes could also be applied for Hg2+ imaging and localization in living cells and lysosomes.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Jacob M. Majikes, Paul N. Patrone, Anthony J. Kearsley, Michael Zwolak, J. Alexander Liddle
Summary: Understanding the folding process of DNA origami is crucial for the broader application of nucleic acid nanofabrication technology. By real-time probing the unit operation of origami assembly, a previously unobserved blocked state was elucidated, which acts as a limit on yield for single folds and may pose a barrier in whole origami assembly.
Article
Multidisciplinary Sciences
Yong Wang, Lizhi Dai, Zhiyuan Ding, Min Ji, Jiliang Liu, Hang Xing, Xiaoguo Liu, Yonggang Ke, Chunhai Fan, Peng Wang, Ye Tian
Summary: DNA origami technology is a valuable tool for precise manipulation of molecules in a three-dimensional manner, but the design and assembly of origami units into single crystals is challenging. Here, the authors report successful fabrication of DNA origami single crystals with Wulff shapes, and regulation of their shapes by changing the symmetry and binding modes of DNA origami building blocks.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Hedong Qi, Yuwei Xu, Pin Hu, Chi Yao, Dayong Yang
Summary: This review introduces the construction, characteristics, functions, and applications of DNA-based nanomaterials, as well as their future development and challenges. DNA-based nanomaterials have multiple functions such as targeting, stimulus responsiveness, and regulation of biological activities, making them highly promising in the treatment of major human diseases.
CHINESE CHEMICAL LETTERS
(2022)
Review
Chemistry, Multidisciplinary
Xiaolei Sun, Yuhang Dong, Yujie Liu, Nachuan Song, Feng Li, Dayong Yang
Summary: Self-assembly is widely present in natural living systems and artificial synthetic material systems. The recent progress in artificial self-assembly in living cells focuses on constructing dynamic assemblies that respond to intracellular stimuli in order to regulate morphology, behavior, and fate of living cells. This advancement in artificial self-assembly is believed to elaborate the molecular mechanisms in cells and further promote biological and medical-related applications in the future.
SCIENCE CHINA-CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Xiaohui Ding, Zhaoyue Lv, Nuo Xu, Feng Li, Dayong Yang
Summary: DNA nanostructures that respond to intracellular signals have potential applications as artificial functional structures in living cells. This review summarizes and discusses the development and dynamic transformation properties of these DNA nanostructures. Challenges and prospects in instructing dynamic DNA nanostructures in living cells are also discussed.
Editorial Material
Chemistry, Physical
Dayong Yang
CHEMISTRY OF MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Pin Hu, Yuhang Dong, Chi Yao, Dayong Yang
Summary: This review focuses on the construction of branched DNA-based nanostructures for biological and biomedical applications. It discusses the molecular design, synthesis methods, and construction strategies. The review provides guidance for the further development of branched DNA-based nanomaterials in the field of biomedicine.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Feng Li, Yujie Liu, Yuhang Dong, Yiwen Chu, Nachuan Song, Dayong Yang
Summary: This study develops a dynamic assembly of DNA tetrahedrons inside cells which mediate K+ and efficiently interfere with mitochondria, leading to a regulation of cell energy metabolism. The developed method significantly inhibits cell migration and holds great potential for biomedical applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Multidisciplinary
Yang Sen, Pan XiaoRui, Tang JianPu, Yao Chi, Yang DaYong
Summary: A luminescent supramolecular hydrogel containing Ln(3+) ions was successfully synthesized by employing coordination and electrostatic interactions with linear single-stranded DNA. The luminescent intensity and color of the hydrogel were finely tuned, and it exhibited reversible luminescent stimulation response. This study enriches the strategies of constructing DNA hydrogels and promotes the development of stimuli-responsive supramolecular materials.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Qingyi Han, Dingding Zhang, Rui Zhang, Jianpu Tang, Keying Xu, Mingzheng Shao, Yuyan Li, Peiyao Du, Ruizhong Zhang, Dayong Yang, Libing Zhang, Xiaoquan Lu
Summary: A DNA-functionalized metal-organic framework (MOF)-based ratiometric fluorescent probe was developed for sensitive detection and imaging of miRNA-21 in living cells. The probe achieved picomolar limit detection without signal amplification and allowed imaging of intracellular miRNA-21 through strand-displacement reaction, enabling discrimination between cancer cells and normal cells. This work presents a new approach for intracellular molecular analysis and has significant implications for early disease diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Shuai Li, Feng Li, Yuhang Dong, Nachuan Song, Li Pan, Dayong Yang
Summary: Carbon dots synthesized from ribonucleosides can mimic artificial enzymes and regulate the structure and oxidative cleavage of DNA.
Review
Chemistry, Multidisciplinary
Chi Yao, Junhan Ou, Jianpu Tang, Dayong Yang
Summary: Facing the increasing demand for precision medicine, materials chemistry systems with accurate molecular design, controllable structure, and adjustable biological activity are required for bioanalysis. In recent years, DNA has been considered a potential biomaterial for analysis and has been applied in various fields. DNA supramolecular assembly on micro/nanointerfaces is an effective strategy to concentrate functional DNA modules and enhance their functions in bioanalysis. This research direction is expected to guide the construction of more bioanalytical materials and promote the development of precision medicine.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Fengqin Li, Junru Li, Weiqiang Yang, Shuai Yang, Congshuo Chen, Ling Du, Junyang Mei, Qianyun Tang, Xiaojing Chen, Chi Yao, Dayong Yang, Xiaolei Zuo, Peifeng Liu
Summary: The trans-cleavage property of CRISPR-Cas12a system is utilized for disease diagnosis. The effect of different local densities of Framework-Hotspot reporters (FHRs) on the cleavage activity of Cas12a is investigated. A modular sensing platform is constructed with target recognition by CRISPR-Cas12a and signal transduction by FHR. This platform enables sensitive and rapid detection of pathogen nucleic acids and tumor protein markers without pre-amplification.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Jianpu Tang, Xuemei Jia, Qian Li, Zhen Cui, Aiqi Liang, Bin Ke, Dayong Yang, Chi Yao
Summary: In this study, a DNA-based hydrogel was developed for the specific and nondestructive separation of exosomes from complex biological media. The separated exosomes were used for breast cancer detection and the therapeutics of myocardial infarction. The DNA hydrogel showed promising potential in the classification of breast cancer patients and the repair of infarcted myocardium in rat models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Materials Science, Biomaterials
Yuwei Xu, Zhaoyue Lv, Chi Yao, Dayong Yang
Summary: DNA-based materials have great potential in biomedical applications due to their programmability and designability. Rolling circle amplification (RCA) is a highly efficient enzymatic amplification strategy that produces long single-stranded DNA with customized functional groups. The rational design of templates and introduction of other functional components enable the production of RCA-based DNA materials with dynamic responsiveness and diverse biological functions, facilitating their use in biomedical applications.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Chi Yao, Yuwei Xu, Pin Hu, Junhan Ou, Dayong Yang
Summary: Developing a new system of material chemistry is crucial for the design and preparation of functional materials, with DNA molecules serving as bioactive macromolecules that can encode genetic information and act as building blocks. The precise control of DNA assembly behaviors and topological structures is essential for constructing a wider variety of functional DNA materials following a gene-like paradigm. This work aims to promote the development of materials genome by exemplifying the gene-like precise construction of functional materials.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xintong Zhang, Yanhong Liu, Wei Liu, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang
Summary: This study developed a macrophage-hitchhiking gene delivery system for the treatment of rheumatoid arthritis. The system demonstrated excellent targeting ability and nuclear entry ability, leading to efficient transfection of interleukin-10 in macrophages and alleviation of inflammation symptoms. This research provides a novel strategy for gene therapy and gene delivery system design for rheumatoid arthritis and other similar inflammatory diseases.
Article
Chemistry, Multidisciplinary
Richard K. Cross, Dave Spurgeon, Claus Svendsen, Elma Lahive, Simon Little, Frank von der Kammer, Frederic Loosli, Marianne Matzke, Teresa F. Fernandes, Vicki Stone, Willie J. G. M. Peijnenburg, Eric A. J. Bleeker
Summary: Even small changes in physicochemical properties of nanoforms (NFs) can influence their environmental fate and hazard. Testing and characterizing each individual NF will not be feasible due to the large number of new materials being developed. Targeting the most relevant form of the NF for a given exposure is important for efficient risk assessment. In aquatic systems, functional fate processes play a key role in determining the exposure relevant form of NFs. Grouping of NFs and read-across based on functional fate pathways can be justified by considering the shared fate and hazard profile. A new Integrated Approaches to Testing and Assessment (IATA) is presented, focusing on dissolution, dispersion stability, chemical transformations, and the contribution to toxicity from particles and dissolved components. This IATA can be used as a template for future in vivo kinetic assessments.
Article
Chemistry, Multidisciplinary
Minhui Lu, Xiaoxuan Zhang, Lijun Cai, Jingjing Gan, Jinglin Wang, Yu Wang, Yuanjin Zhao
Summary: Researchers have proposed a novel black phosphorus-loaded hydrogel inverse opal microneedle patch that exhibits photothermal responsive capacity and vivid structural color screening for psoriasis treatment. With improved materials, structures, and functions, the microneedle patch enables intelligent drug delivery and enhances drug loading and controllable release.
Article
Chemistry, Multidisciplinary
Qianyun Tang, Dandan Wang, Jinhui Cui, Yiheng Zhang, Junyang Mei, Jing Du, Anyue Xia, Qian Sun, Dan Luo, Baosan Han, Mingzhe Gan, Peifeng Liu
Summary: This study presents a novel microfluidic platform for precise and flexible control of oxygen concentrations in microbial suspension culture. The platform demonstrates unique capabilities for spatiotemporal gas control and detection, allowing for applications in screening, studying, and culturing industrial or niche-specific environmental microbiomes.
Review
Chemistry, Multidisciplinary
Jiaen Wu, Hao Chen, Jiawei Xu, Muhammad Saif Ur Rahman, Shengmei Li, Jie Wang, Shifen Huang, Charles C. Han, Shanshan Xu, Ying Liu
Summary: This review categorizes the potential health risks of microplastic pollution by focusing on the three primary pollution sources. It provides an in-depth analysis of the pharmacokinetics, toxicity potential, and biological mechanism of microplastics in the human body. The review aims to fill knowledge gaps about the toxicity of microplastics on human health and provide ideas for repairing the damage caused by microplastics.
Article
Chemistry, Multidisciplinary
Fanshu Ma, Yi Cao, Jincong Yan, Zhongzhong Lu, Lina Sun, Zahid Hussain, Zheng Wang, Li Wang, Renjun Pei
Summary: This study proposes a simple yet powerful method to create multifunctional hybrid nanovesicles that combine the characteristics of oncolytic viruses and pyroptosis, leading to enhanced tumor targeting and improved immune response. The results demonstrate excellent tumor inhibition efficacy against melanoma and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Fangmian Wei, Johannes Karges, Siyuan Gao, Lili Wang, Xiting Zhang, Xing-Can Shen, Liangnian Ji, Hui Chao
Summary: This study presents the coordination of Ru(II) polypyridine complexes to graphitic carbon nitride nanosheets for oxygen-self-sufficient two-photon photodynamic immunotherapy. The conjugates were found with strong two-photon absorption and could generate reactive oxygen species (ROS) to induce cell death and inhibit tumor growth through immune system activation.
Article
Chemistry, Multidisciplinary
Weiwei Zheng, Shun-Yu Yao, Haijun Hu, Xiping Chen, Zhefeng Qian, Wenxing Liu, Yang Zhu, Zhengwei Mao, Dong-Sheng Guo, Changyou Gao
Summary: In this study, a hypoxia-responsive self-assembled peptide hydrogel was prepared for ischemic stroke treatment. The hydrogel showed the ability to release drugs and effectively improve motor function, reduce infarct volume, and alleviate inflammation.
Article
Chemistry, Multidisciplinary
Qianqian Qiao, Jinyu Wang, Kai Long, Linwei Li, Jiahao Chen, Yuhao Guo, Ziqiang Xu, Ying Kuang, Tianjiao Ji, Cao Li
Summary: This study developed a catalytic system using titanium-based MXene nanosheets to load enzymes and anticancer drugs. The nanosheets demonstrated catalase-like activity and photothermal capability, enabling enhanced cancer treatment through starvation therapy and alleviation of hypoxia. In vitro and in vivo studies confirmed the effective anticancer capability of this enzyme cascade system.
Article
Chemistry, Multidisciplinary
Shiyang Wu, Yan He, Ruiqi Zhou, Chunlin Chen, Dawei Chen, Haiyang Hu
Summary: In this research, LDHA@MIP-DSD nanoparticles were designed to enhance the effectiveness of immunogenic cell death (ICD) in cancer immunotherapy. LDHA@MIP-DSD improved the accessibility of nanodrugs to cancer cells by surface imprinting LDHA and induced autophagy with SLN. The combination of these two effects resulted in optimal immune stimulation and antitumor efficiency.
Article
Chemistry, Multidisciplinary
Xu Zhang, Kejian Shi, Jiahui Mao, Kerou Mao, Yangrui Jia, Jiakun Zhang, Qingzhen Wang, Ru Bai, Fene Gao, Shihui Liu, Mengyu Guo, Fenglan Qin, Shengmin Li, Chunying Chen, Huige Zhou, Jing Liu, Fulin Chen
Summary: Compared with vein injection, oral administration is a preferred non-invasive and self-help treatment option for cancer therapy. However, the harsh gastrointestinal tract and biological barriers limit the stability and efficiency of oral drug delivery systems. To overcome these challenges, researchers have developed Cyssome, a drug delivery platform that can maintain stability in harsh environments, penetrate biological barriers, and improve drug release and bioavailability.
