Article
Infectious Diseases
Sebastian Wurster, Timotheos Paraskevopoulos, Mitsuru Toda, Ying Jiang, Jeffrey J. Tarrand, Samantha Williams, Tom M. Chiller, Brendan R. Jackson, Dimitrios P. Kontoyiannis
Summary: This study investigated the incidence of invasive mould infections (IMIs) in immunocompromised cancer patients before and after Hurricane Harvey. The results showed that the number of patients with mould-positive cultures almost doubled after the hurricane, but there were no significant changes in the incidence of IMIs or the etiological mould genera. However, patients with IMIs from flood-affected areas had significantly higher in-hospital mortality.
JOURNAL OF INFECTION
(2022)
Article
Immunology
Catherine E. Foster, Paula A. Revell, Judith R. Campbell, Lucila Marquez
Summary: Cutaneous mucormycosis in children is an opportunistic fungal infection with significant morbidity and mortality. This study identified 12 cases of healthcare-associated cutaneous mucormycosis without a definitive source, suggesting that skin lesions near medical device securement sites should raise concern for mucormycosis in patients with underlying medical conditions.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Dermatology
Duarte Flor, Joana Xara, Sofia Pereira, Sara Brandao, Maria M. Brites, Jose C. Cardoso
Summary: We present a case of a 74-year-old immunosuppressed man with multiple skin lesions on his right upper limb. Histological examination revealed pseudocarcinomatous hyperplasia of the epidermis and a dermal granulomatous suppurative infiltrate with aggregates of Gram-positive microorganisms compatible with a grain-forming infection.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Pediatrics
Laura Olivier-Gougenheim, Nicolas Rama, Damien Dupont, Paul Saultier, Guy Leverger, Wadih AbouChahla, Catherine Paillard, Virginie Gandemer, Alexandre Theron, Claire Freycon, Claire Pluchart, Pascale Blouin, Isabelle Pellier, Sandrine Thouvenin-Doulet, Claire Desplantes, Stephane Ducassou, Caroline Oudot, Jeremie Rouger-Gaudichon, Nathalie Cheikh, Maryline Poiree, Pascale Schneider, Genevieve Plat, Audrey Contet, Fanny Rialland, Elodie Gouache, Benoit Brethon, Yves Bertrand, Carine Domenech
Summary: The study provides a national overview of epidemiology and management of invasive fungal infections in severely immunocompromised children treated for acute leukemia or allogeneic hematopoietic stem cell transplantation in France. Emergent fungi and antifungal resistance are important factors to consider in IFI management in this population.
JOURNAL OF PEDIATRICS
(2021)
Article
Microbiology
Patrick Schwarz, Ilya Nikolskiy, Anne-Laure Bidaud, Frank Sommer, Gert Bange, Eric Dannaoui
Summary: The study evaluated the interaction between two antifungal drugs against different strains, and found that the combination of amphotericin B and colistin showed synergistic effects against most Candida species, with some discrepancies for Candida auris. The interaction between the drugs was indifferent for Aspergillus and Rhizopus species.
Review
Infectious Diseases
Zoe Freeman Weiss, Jessica Little, Sarah Hammond
Summary: The current armamentarium of antifungal agents has significantly improved over the last 50 years. However, existing therapies still have their limitations and novel antifungals are needed to address the increasing prevalence of invasive mold infections and antifungal resistance.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Critical Care Medicine
Guillaume Dumas, Virginie Lemiale, Nisha Rathi, Andrea Cortegiani, Frederic Pene, Vincent Bonny, Jorge Salluh, Guillermo M. Albaiceta, Marcio Soares, Ayman O. Soubani, Emmanuel Canet, Tarik Hanane, Achille Kouatchet, Djamel Mokart, Pia Lebiedz, Melda Turkoglu, Remi Coudroy, Kyeongman Jeon, Alexandre Demoule, Sangeeta Mehta, Pedro Caruso, Jean-Pierre Frat, Kuang-Yao Yang, Oriol Roca, John Laffey, Jean-Francois Timsit, Elie Azoulay, Michael Darmon
Summary: This study examined survival trends in immunocompromised patients receiving invasive mechanical ventilation, showing improved survival rates over time. Delayed intubation after ICU admission was found to be significantly associated with higher mortality rates.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Ilse Yolanda Osorio-Aragon, Sonia Toussaint-Caire, Simon Guzman-Bucio, Bibiana Monserrat Barbosa-Ramirez, Victor A. Vazquez-Aceituno, Juan Xicohtencatl-Cortes, Rigoberto Hernandez-Castro
Summary: We report a case of primary cutaneous mucormycosis in a patient with bone marrow failure due to paroxysmal nocturnal haemoglobinuria (PNH). The patient presented with papules on the lower limbs that rapidly progressed to necrotic plaques within 2 months. Histopathological examination showed granulomatous and suppurative dermatitis with tissue necrosis, and molecular identification confirmed Rhizopus arrhizus. Despite treatment with liposomal amphotericin B and surgical debridement, the patient developed severe anemia, thrombocytopenia, and septic shock, ultimately resulting in death after 6 days of hospitalization.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2023)
Editorial Material
Public, Environmental & Occupational Health
Pooja Gandhi, Kaitlin Benedict, Mitsuru Toda, Karlyn D. Beer, Tom M. Chiller, Brendan R. Jackson
Summary: Investigating hospital-associated clusters of invasive mold infections (IMIs) poses challenges for public health and hospital personnel due to difficulty confirming outbreaks and determining sources. Early, nuanced communication about IMI clusters is crucial in reducing patient health risks and building trust between patients and hospitals.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Infectious Diseases
Ghefar Furaijat, Lucas Bettac, Martin Kaechele, Beate Gruener, Christian Skrabal, Thomas F. E. Barth, Melih Parlak, Juergen Benjamin Hagemann, Lynn Peters, Grit Walther, Johannes Kersten
Summary: We report a case of a 54-year-old immunocompromised patient who presented with Fusarium keratitis, chorioretinitis, and a new endovascular aortic mass. This case highlights the importance of an interdisciplinary approach for treating invasive mycoses.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Microbiology
Alice J. Hsu, Pranita D. Tamma, Sean X. Zhang
Summary: Establishing the diagnosis of invasive mold infections in immunocompromised children is challenging, with 1,3-beta-D-glucan showing limited accuracy in this population. However, serum and bronchoalveolar lavage galactomannan can be used as diagnostic tools with comparable performance to adults.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Infectious Diseases
Min Zhang, Hui Huang, Haichao Yang, Ge Yang, Wenwen Wang, Juying He, Guiyu Wang, Xichuan Yang, Zhifang Zhai
Summary: This case report describes a rare occurrence of recurrent skin and soft tissue infections caused by U. urealyticum in an immunocompromised adult patient. The diagnosis and treatment of this case were limited by traditional culture methods, suggesting the use of metagenomic next-generation sequencing to identify atypical pathogens and improve antimicrobial treatment of complicated infections.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Medicine, General & Internal
Stephanie R. Cohen, Carolina Espinoza, Kathia Valverde Munoz
Summary: Leishmaniasis is a disease caused by the parasite Leishmania, with clinical presentation varying depending on factors such as patient immunity. Cutaneous leishmaniasis, a main type known to mimic other conditions, can be more aggressive and challenging to diagnose in immunodeficient populations. Diagnostic methods for cutaneous leishmaniasis are not standardized and limitations such as interpreter expertise and patient immunity may delay diagnosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Mycology
Cornelia Geisler Crone, Jannik Helweg-Larsen, Morten Steensen, Maiken Cavling Arendrup, Marie Helleberg
Summary: Mucormycosis has recently been recognized as a severe complication of COVID-19 with high fatality rates. It is important to distinguish COVID-19 associated mucormycosis (CAM) from COVID-19 associated aspergillosis (CAPA) as they have different clinical courses and treatment approaches. Early diagnosis is crucial for timely treatment of CAM with surgical debridement and targeted antifungal therapy.
JOURNAL DE MYCOLOGIE MEDICALE
(2022)
Article
Virology
Martina Brandolini, Silvia Zannoli, Giulia Gatti, Valentina Arfilli, Monica Cricca, Giorgio Dirani, Agnese Denicolo, Simona Semprini, Laura Grumiro, Manuela Imola, Damiano Larne, Maria Michela Marino, Martina Manera, Andrea Mancini, Francesca Taddei, Manuel Zagarrigo, Carlo Biagetti, Vittorio Sambri
Summary: This study aims to provide further insight into the evolutionary dynamics of SARS-CoV-2 by analyzing a patient with follicular lymphoma who developed a persistent infection for over 7 months. The analysis revealed the evolution of genetically similar subpopulations within the host, indicating that prolonged replication is associated with intra-host virus evolution. These findings support the hypothesis that SARS-CoV-2 can undergo adaptive evolution in immunocompromised patients.
