Journal
MOLECULES
Volume 26, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/molecules26195982
Keywords
andrographolide; RGR; RCR; ECI; ECD; molecular docking
Funding
- King Saud University, Riyadh, Saudi Arabia [RSP- 2021/186]
- Chiang Mai University, Chiang Mai, Thailand
- Early Career Research Award - Science and Engineering Research Board [DST-SERB], Government of India [ECR/2018/000552]
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Andrographolide, a plant-derived compound, exhibits pronounced mortality of S. litura by inhibiting enzyme secretion and food intake, showing potential as a biocontrol agent against this pest.
Spodoptera litura Fab. is a polyphagous pest causing damage to many agriculture crops leading to yield loss. Recurrent usage of synthetic pesticides to control this pest has resulted in resistance development. Plant-derived diterpenoid compound andrographolide was isolated from the leaves of Andrographis paniculata. It was analysed by gas chromatography-mass spectroscopy and quantified by HPLC. Nutritional indices and digestive enzymatic profile were evaluated. Third, fourth and fifth instar larvae were treated with different concentrations of andrographolide. At 3, 6 and 9 ppm-treated concentrations the larvae showed decreased RGR, RCR, ECI, ECD values with adverse increase in AD. The digestive enzymes were significantly inhibited when compared with control. Conspicuously, andrographolide showed pronounced mortality of S. litura by inhibition of enzyme secretion and intake of food. The binding ability of andrographolide with CYTP450 showed high affinity with low binding energy. Andrographolide has the potential to be exploited as a biocontrol agent against S. litura as an eco-friendly pesticide.
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