Article
Chemistry, Multidisciplinary
Pan Zheng, Binbin Ding, Guoqing Zhu, Chunxia Li, Jun Lin
Summary: Researchers have developed a pyroptosis inducer for cancer immunotherapy by inducing mitochondrial Ca2+ overload. The inducer triggers robust immune responses, effectively suppressing tumor proliferation and lung metastasis, providing new strategies and inspiration for pyroptosis-mediated cancer treatments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Medicine, Research & Experimental
Juanjuan Dai, Mingjie Jiang, Yangyang Hu, Jingbo Xiao, Bin Hu, Jiyao Xu, Xiao Han, Shuangjun Shen, Bin Li, Zengkai Wu, Yan He, Yingchun Ren, Li Wen, Xingpeng Wang, Guoyong Hu
Summary: The study found that hypertriglyceridemia exacerbates acute pancreatitis and hinders pancreatic regeneration by inducing persistent dysregulation of SREBP1c/miR-153 signaling. SREBP1c activators, such as insulin, may be used to treat acute pancreatitis caused by hypertriglyceridemia.
Article
Engineering, Environmental
Shulin Qin, Lichun Ma, Runfeng Li, Pengfei Yuan, Yunfeng Shi, Xin Ji, Wei Xue, Yanli Li, Wen Liu
Summary: This study introduces multifunctional immunomodulatory calcium nanoparticles that reshape the tumor microenvironment to enhance the efficacy of cancer immunotherapy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Zhengke Li, Hui Wang-Heaton, Brian M. Cartwright, Yetunde Makinwa, Benjamin A. Hilton, Phillip R. Musich, Nikolozi Shkriabai, Mamuka Kvaratskhelia, Shengheng Guan, Qian Chen, Xiaochun Yu, Yue Zou
Summary: ATR kinase suppresses necrotic cell death induced by ionophores by phosphorylating PARP1 at a specific site, inhibiting necrosis. This anti-necrotic mechanism occurs without detectable DNA damage signaling and supports the cellular stress response to calcium influx in neuronal cells.
Article
Chemistry, Multidisciplinary
Xuan Tan, Jingzhao Huang, Yiqian Wang, Shasha He, Le Jia, Yanhong Zhu, Kanyi Pu, Yan Zhang, Xiangliang Yang
Summary: The study introduces a smart nanosonosensitizer TiO2@CaP which enhances the generation of reactive oxygen species (ROS) under ultrasound activation, inducing mitochondrial dysfunction in the tumor microenvironment and promoting immunogenic cell death, resulting in T-cell infiltration and systemic antitumor immunity. This approach holds promise for developing TME-activatable sonosensitizers with temporospatial control over antitumor responses.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo, Tie-Shan Tang
Summary: This study reveals that excessive ER Ca2+ can directly activate the IRE1a-XBP1 pathway, and inhibition of over-activated IRE1a-XBP1 signaling in TMCO1-deficient cells can lead to significant cell death.
CELL AND BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yansong Xu, Yuansong Sun, Ran Yin, Tao Dong, Kai Song, Yang Fang, Guodong Liu, Bing Shen, He Li
Summary: The incidence rate of acute pancreatitis is increasing, and understanding its pathogenesis is crucial for reducing the high mortality rate associated with severe acute pancreatitis (SAP). This study aimed to identify potential biomarkers for early detection and monitoring of acute pancreatitis and shed light on the underlying mechanisms of SAP. The expression levels of plasma exosomal microRNA (miRNA) were compared between patients with SAP and healthy participants, revealing three differentially expressed novel miRNAs. Further analysis predicted a target gene, complement component 3 (C3), which was found to be consistently expressed in both patients and a mouse model of acute pancreatitis. These findings suggest that C3 may serve as an early biomarker and therapeutic target for SAP.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Cheng Peng, Guangping Tu, Jiale Wang, Yilin Wang, Peng Wu, Li Yu, Zhiqiang Li, Xiao Yu
Summary: Acute pancreatitis (AP) is a disease characterized by inflammation and has an increasing incidence worldwide. The proteins RIPK3, MLKL, and macrophages play a role in the pathogenesis of AP. This study found that MLKL and its phosphorylated form p-MLKL were upregulated in AP mouse models and treated pancreatic acinar cells, independent of Ripk3, and appeared to function in a cell death-independent manner. Knockout of Mlkl attenuated AP in mice by reducing the polarization of pancreatic macrophages, while knockout of Ripk3 did not. Neutralization of CXCL10 reduced the severity of AP in mice. Targeting the MLKL-CXCL10-macrophage axis may be a promising strategy for AP treatment.
CELL DEATH & DISEASE
(2023)
Article
Food Science & Technology
Shasha Chen, Tong Xu, Anqi Xu, Jiahong Chu, Dongliu Luo, Guangliang Shi, Shu Li
Summary: Zearalenone (ZEA) is a highly contaminated mycotoxin in feed that can cause severe toxic effects on the kidneys and other organs of animals. Quercetin (QUE) is a plant-derived flavonoid with detoxification properties, but its mechanism in detoxifying ZEA-induced toxicity has not been fully elucidated. This study demonstrated the mechanism by which ZEA induces apoptosis and necroptosis in PK15 cells and the protective role of QUE in this process.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Qi Yang, Yalan Luo, Peng Ge, Bowen Lan, Jin Liu, Haiyun Wen, Yinan Cao, Zhenxuan Sun, Guixin Zhang, Huiming Yuan, Lihua Zhang, Hailong Chen
Summary: This study found that emodin improves organ damage in SAP rats by modulating the miRNA expression profile of exosomes derived from plasma and BALF. The novel miRNA NOVEL-rno-miR-29a-3p, specific to BALF-derived exosomes, may play a crucial role in the therapeutic efficacy of emodin.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Immunology
Deyi Wu, Yi Wu, Meng Zhang, Hainan Lan
Summary: Exposure to AFB1 has been found to cause premature skin aging, primarily through the ERMCS/Ca2+/ROS signaling pathway. Prolonged exposure to AFB1 makes the skin more vulnerable to damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Wen Jing Yang, Ruixiang Ma, Shibing Wei, Wenping Sun, Wenya Xu, Lianhui Wang
Summary: An injectable nanocomposite hydrogel with melittin and polyaniline nanofibers was developed for Ca2+-overload and photothermal combination cancer therapy. Melittin enhances Ca2+ influx, while polyaniline nanofibers provide glutathione depletion and photothermal ability to the hydrogel.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Caihong Dong, Xinyue Dai, Xi Wang, Qing Lu, Liang Chen, Xinran Song, Li Ding, Hui Huang, Wei Feng, Yu Chen, Meiqi Chang
Summary: This study introduces a calcium fluoride nanozyme with ultrasound-enhanced peroxidase-like activity, which can efficiently promote tumor catalytic nanotherapy induced by calcium overload. The discovery of enzyme-like activity of valence-invariable metal compounds expands the understanding of nanozymes and has significant application prospects in the field of catalytic and chemoreactive nanomedicine.
ADVANCED MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Fatimat Kipkeeva, Tatyana Muzaffarova, Alexandra Korotaeva, Danzan Mansorunov, Pavel Apanovich, Maxim Nikulin, Olga Malikhova, Ivan Stilidi, Alexander Karpukhin
Summary: MiRNAs, which influence IC gene expression in tumor and T-cells, show potential as agents for cancer immunotherapy with tumor specificity. Further research on miRNA-gene interaction features and optimal miRNA mimic structure is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Pan Zheng, Binbin Ding, Run Shi, Zhongyu Jiang, Weiguo Xu, Gao Li, Jianxun Ding, Xuesi Chen
Summary: This study presents a multichannel calcium ion nanomodulator that enhances mitochondrial dysfunction in cancer therapy, resulting in effective tumor inhibition. After systemic administration, the nanomodulator selectively accumulates in tumor tissues, providing targeted treatment.
ADVANCED MATERIALS
(2021)
Article
Gastroenterology & Hepatology
Xinmin Yang, Ruwen Zhang, Tao Jin, Ping Zhu, Linbo Yao, Lan Li, Wenhao Cai, Rajarshi Mukherjee, Dan Du, Xianghui Fu, Jing Xue, Reynaldo Martina, Tingting Liu, Sayali Pendharkar, Anthony R. Phillips, Vikesh K. Singh, Robert Sutton, John A. Windsor, Lihui Deng, Qing Xia, Wei Huang
Summary: This study identified optimal blood glucose levels to define stress hyperglycemia in non-diabetic and diabetic acute pancreatitis patients and found a significant relationship between stress hyperglycemia and adverse clinical outcomes.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Endocrinology & Metabolism
Yupu Liu, Juan Li, Yuchao Wu, Han Zhang, Qingguo Lv, Yuwei Zhang, Xiaofeng Zheng, Nanwei Tong
Summary: This meta-analysis suggests that the established WHO diagnostic criteria for IGT should be revised to separately identify individuals with IGT+NFG or IGT+IFG.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Wei Li, Chengshi Wang, Zhenghao Wang, Liping Gou, Ye Zhou, Ge Peng, Min Zhu, Jiayi Zhang, Ruoqing Li, Hengfan Ni, Lei Wu, Wanli Zhang, Jiaye Liu, Yali Tian, Zhong Chen, Yuan-Ping Han, Nanwei Tong, Xianghui Fu, Xiaofeng Zheng, Per-Olof Berggren
Summary: A novel bioscaffold ILGel was developed to accelerate diabetic alveolar bone injury healing, promoting M2 macrophage polarization and osteogenesis through sustained release of IL-10 cytokine. The findings suggest the potential application of DNA hydrogel bioscaffold for cytokine-based immunotherapy in diabetic alveolar bone injury and other periodontal diseases.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Gastroenterology & Hepatology
Tianci Zhang, Ruofei Zhang, Guangfu Zhao, Wei Liu, Liwei Pan, Ying Tong, Mingshan Jiang, Hu Zhang, Zhixiong Xiao, Stephen J. Pandol, Xiansheng Fu, Yuan-Ping Han, Xiaofeng Zheng
Summary: Inflammatory bowel disease (IBD) is a chronic and recurrent gastrointestinal disease, and its etiology is still poorly understood. This study found that autophagy in the intestinal tissue of IBD mice was persistently activated. Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, can attenuate colitis by regulating autophagy and inflammation. Therefore, consumption of green vegetables and chlorophyllin may be beneficial for IBD recovery.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaofeng Zheng, Qing Wei Calvin Ho, Minni Chua, Olga Stelmashenko, Xin Yi Yeo, Sneha Muralidharan, Federico Torta, Elaine Guo Yan Chew, Michelle Mulan Lian, Jia Nee Foo, Sangyong Jung, Sunny Hei Wong, Nguan Soon Tan, Nanwei Tong, Guy A. Rutter, Markus R. Wenk, David L. Silver, Per-Olof Berggren, Yusuf Ali
Summary: Western-type diets, high in saturated fatty acids (SFAs), are associated with obesity and diabetes. This study reveals that SFAs, but not unsaturated fatty acids (USFAs), reduce lipid droplets (LDs) in pancreatic beta cells. SFAs induce the degradation of fat storage-inducing transmembrane protein 2 (FIT2), inhibiting LD formation. Reduction of FIT2 in beta cells impairs cellular functions and exacerbates diet-induced diabetes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Gastroenterology & Hepatology
Wenhua He, Wenhao Cai, Xinmin Yang, Georgette Camilleri, Xi Zheng, Qiqi Wang, Yuying Li, Rajarshi Mukherjee, Wei Huang, Robert Sutton
Summary: This study compared the effectiveness of insulin-based treatment (IT) and blood purification treatment (BPT) for hypertriglyceridemia-induced acute pancreatitis (HTG-AP) through systematic review and meta-analysis. The results showed that IT was less effective than BPT in reducing serum triglyceride levels, but was associated with fewer adverse events and lower cost. The study suggested the routine use of IT for inpatient management of HTG-AP, with BPT reserved for patients predicted or found to respond poorly to IT.
Review
Pharmacology & Pharmacy
Peter Szatmary, Tassos Grammatikopoulos, Wenhao Cai, Wei Huang, Rajarshi Mukherjee, Chris Halloran, Georg Beyer, Robert Sutton
Summary: Acute pancreatitis is a common disease that requires comprehensive management and may lead to severe complications and death. Patients with local complications should receive specialist management.
Review
Biochemistry & Molecular Biology
Qing Wei Calvin Ho, Xiaofeng Zheng, Yusuf Ali
Summary: Ceramides, a class of sphingolipids, play a role in various skin disorders and metabolic diseases. Recent research has focused on identifying specific ceramide species and their effects on different diseases, and has found ceramides linked to metabolic dysfunction and cardiac decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Agnieszka A. Kusiak, Monika A. Jakubowska, Kinga B. Stopa, Xiaoying Zhang, Wei Huang, Julia Gerasimenko, Oleg Gerasimenko, Robert Sutton, Ole H. Petersen, Pawel E. Ferdek
Summary: Alcohol abuse is a growing problem in developed societies and a leading cause of acute and chronic pancreatitis. Research has shown that quiescent pancreatic stellate cells are more sensitive to ethanol metabolites, while activated stellate cells can withstand noxious signals and deposit extracellular matrix components despite ongoing inflammation.
CELL DEATH & DISEASE
(2022)
Article
Evolutionary Biology
Chuang Zhou, Xiaofeng Zheng, Kaize Feng, Kexin Peng, Yanni Zhang, Guangqing Zhao, Yang Meng, Li Zhang, Bisong Yue, Yongjie Wu
Summary: In this study, the whole genome of the Tibetan partridge was sequenced to explore its genetic adaptation mechanisms to high-altitude environments and determine its phylogenetic relationship with typical pheasants. Additionally, genes related to hypoxia and changes in gene families associated with energy metabolism and immune system were identified. These findings provide important genomic data for understanding the evolutionary history and adaptation strategies of the Tibetan partridge.
JOURNAL OF HEREDITY
(2023)
Editorial Material
Surgery
Rajarshi Mukherjee
Article
Cell Biology
Kinga B. Stopa, Filip Lozinski, Agnieszka A. Kusiak, Jacek Litewka, Daria Krzysztofik, Sylwester Mosiolek, Jan Morys, Pawel E. Ferdek, Monika A. Jakubowska
Summary: The glandular pancreatic epithelia of the acinar or ductal phenotype show remarkable cell plasticity but are implicated in the mechanisms of carcinogenesis. Pancreatic ductal adenocarcinoma is linked with the onco-transformation of ductal epithelia and with the trans-differentiation of pancreatic acini. The driver mutations Kras(G12D) and Trp53(R172H) in acinar cells affect cytosolic Ca2+ signals and can potentially impact the physiology of the pancreas.