Article
Medicine, Research & Experimental
Pei-Shan Yang, Min-Hua Yu, Ya-Chin Hou, Chih-Peng Chang, Shao-Chieh Lin, I-Ying Kuo, Pei-Chia Su, Hung-Chi Cheng, Wu-Chou Su, Yan-Shen Shan, Yi-Ching Wang
Summary: This study provides the first evidence that Rab37 mediates CHI3L1 secretion in immune cells and highlights the dual properties of CHI3L1 nAbs that can target both cancer cells and the tumor microenvironment.
Review
Pharmacology & Pharmacy
Suh-Young Lee, Chang-Min Lee, Bing Ma, Suchitra Kamle, Jack A. Elias, Yang Zhou, Chun Geun Lee
Summary: Chitinase 1 (CHIT1) and chitinase 3-like-1 (CHI3L1) play significant roles in the pathogenesis of pulmonary fibrosis. Their dysregulated expression is associated with clinical outcomes in patients. They mainly act in alveolar macrophages to regulate fibroproliferative responses through various cellular processes. Therefore, CHIT1 and CHI3L1 could be potential therapeutic targets for treating pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ze-Xin Li, Dong-Jing Yang, Zhong-Kun Huo, Pei-Hao Wen, Bo-Wen Hu, Zhi-Hui Wang, Wen-Zhi Guo, Shui-Jun Zhang
Summary: The study found that CHI3L1 plays a crucial role in promoting hepatocyte apoptosis in brain-dead donors, and inhibiting CHI3L1 can reduce liver cell apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Peng-Cheng Li, Mei-Juan Tu, Pui Yan Ho, Neelu Batra, Michelle M. L. Tran, Jing-Xin Qiu, Theodore Wun, Primo N. Lara, Xiang Hu, Ai-Xi Yu, Ai-Ming Yu
Summary: A novel platform for in vivo fermentation production of humanized recombinant ncRNA molecules was developed, demonstrating their important roles in cellular processes and anti-tumor activities. The technology represents a unique addition to conventional technologies for basic research and drug development.
Article
Genetics & Heredity
Andrea D. Kim, Lin Kui, Benedikt Kaufmann, Sung Eun Kim, Aleksandra Leszczynska, Ariel E. Feldstein
Summary: The research found that CHI3L1 protein plays an important role in liver fibrosis diseases and is mainly produced by liver macrophages. The study showed that inhibiting CHI3L1 expression can effectively alleviate the inflammatory response and liver fibrosis. This study revealed a new role of CHI3L1 derived from liver macrophages in the progression of non-alcoholic steatohepatitis (NASH) and identified this protein as a potential anti-fibrotic therapeutic target.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Neurosciences
Hyeon Joo Ham, Yong Sun Lee, Hee Pom Lee, Young Wan Ham, Jaesuk Yun, Sang Bae Han, Jin Tae Hong
Summary: This study investigated the anxiolytic effect of a compound called G721-0282 on mice subjected to chronic stress. The compound was found to relieve anxiety by inhibiting CHI3L1 and reducing the expression of inflammatory proteins and cytokines in the hippocampus. The results suggest that G721-0282 could be a potential treatment for anxiety disorders associated with chronic stress.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Ming Tang, Dongyang Zhou, Junhui He, Hongying Bai, Qianqian Li, Hui Xu
Summary: This study investigated the relationship between serum YKL-40 and MMP-9 levels and positive intracranial arterial remodelling in patients with cerebral small vessel disease (CSVD). The results showed that elevated serum YKL-40 and MMP-9 levels are independent risk factors for positive intracranial arterial remodelling and can predict its presence.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Pan-Woo Ko, Ho-Won Lee, Myunghoon Lee, Young Chul Youn, SangYun Kim, Jong-Heon Kim, Kyunghun Kang, Kyoungho Suk
Summary: The study suggests that plasma CHI3L1 levels may be useful in differentiating iNPH patients from healthy individuals.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hiroko Ishii, Maram H. Zahra, Atushi Takayanagi, Masaharu Seno
Summary: The study developed a novel anti-Cripto-1 artificial antibody by isolating single chain antibody clones, fusing genes, and expressing and purifying the antibody, demonstrating its potential in suppressing the growth of cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Fei Li, An Liu, Minggao Zhao, Lanxin Luo
Summary: CHI3L1 is a secreted glycoprotein that regulates multiple biological processes and serves as a biomarker for neurological disorders. It is associated with brain tumor migration, immune escape, and plays a key role in brain tumor progression.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Dermatology
Alina Jankowska-Konsur, Magdalena Lyko, Klaudia Rubas, Danuta Nowicka-Suszko, Joanna Maj, Jacek C. Szepietowski
Summary: This study evaluated the serum levels of YKL-40 in patients with Pyoderma gangrenosum (PG) and its correlation with clinicopathological data. The results showed that YKL-40 levels were significantly higher in patients with PG and were positively correlated with IL-6 levels.
ACTA DERMATO-VENEREOLOGICA
(2022)
Review
Oncology
Hajime Nakamura, Yohei Arihara, Kohichi Takada
Summary: STEAP1 is overexpressed in multiple types of cancer and associated with poor prognosis. It is a promising therapeutic target due to its tumor specificity and membrane-bound localization. Clinical efficacy of an antibody-drug conjugate targeting STEAP1 has been demonstrated, and STEAP1 is also considered an attractive target for immunotherapies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Dengli Wang, Daiki Ousaka, Handong Qiao, Ziyi Wang, Kun Zhao, Shangze Gao, Keyue Liu, Kiyoshi Teshigawara, Kenzo Takada, Masahiro Nishibori
Summary: This study found that humanized anti-HMGB1 mAb can inhibit the release of HMGB1, reduce the accumulation of 4-HNE and cerebral iron deposition, and decrease brain injury volume in the ICH model. In vitro experiments showed that recombinant HMGB1 delayed hemoglobin clearance, allowing the toxic effects of hemoglobin, heme, and Fe2 + to persist. Additionally, humanized anti-HMGB1 mAb reduced body weight loss and improved behavioral performance after ICH.
Article
Neurosciences
Matteo Lucchini, Valeria De Arcangelis, Geny Piro, Viviana Nociti, Assunta Bianco, Chiara De Fino, Gabriele Di Sante, Francesco Ria, Paolo Calabresi, Massimiliano Mirabella
Summary: This study assessed the concentration of several biomarkers in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients and investigated their diagnostic and prognostic significance. The results showed that higher CSF levels of CHI3L1 and CXCL13 were associated with a higher risk of relapse, MRI activity, and overall disease activity in MS patients. These findings suggest that CSF CHI3L1 and CXCL13 levels can serve as good prognostic biomarkers in MS patients and aid in treatment decisions. The study also found differences in CSF BAFF and APRIL levels between different phases of MS, indicating the modulation of B-cells pathways vary in different disease stages.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Virology
Isabelle Bernard, Doris G. G. Ransy, Jason Brophy, Fatima Kakkar, Ari Bitnun, Lindy Samson, Stanley Read, Hugo Soudeyns, Michael T. T. Hawkes
Summary: This study found that CHI3L1 levels in children perinatally infected with HIV are associated with inflammation, viral load, and microbial translocation, suggesting its potential as a marker for systemic inflammation in CLWH.
Article
Biochemistry & Molecular Biology
Kyung-Ran Park, Joon Yeop Lee, Myounglae Cho, Jin Tae Hong, Hyung-Mun Yun
Summary: PALI from Paeonia suffruticosa promotes early and late osteoblast differentiation without cytotoxicity, mainly through the ERK1/2-RUNX2 signaling pathway, which suggests its potential therapeutic action in bone diseases like osteoporosis and periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Young-Jung Lee, In Jun Yeo, Dong Young Choi, Jaesuk Yun, Dong Ju Son, Sang-Bae Han, Jin Tae Hong
Summary: HIV-1 infection can lead to various HIV-associated neurocognitive disorders, with the gp120 protein playing a role in memory impairment through inducing Aβ accumulation and neuroinflammation.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kyung-Ran Park, Joon Yeop Lee, Myounglae Cho, Jin Tae Hong, Hyung-Mun Yun
Summary: Paeonoside (PASI) isolated from Paeonia suffruticosa roots enhances osteoblast migration, early differentiation, and mineralized nodule formation by regulating RUNX2 expression through the BMP2 and Wnt3a pathways, suggesting a potential therapeutic role in treating bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sun Mi Gu, Sowoon Seo, Daejin Park, Sanghyeon Kim, Santosh Lamichhane, Kyoung-Moon Han, Young-Hoon Kim, Sangmin Lee, Jin Tae Hong, Hye Jin Cha, Jaesuk Yun
Summary: The study suggests that CB1 agonist JWH-210 enhances METH-induced CPP by modulating GABAergic neuronal activity. In mice, CB1 regulates GAD67 expression which in turn affects METH-induced CPP. Human research shows decreased GAD67 mRNA levels in drug users' brains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Public, Environmental & Occupational Health
Jung Hun Ju, Naery Lee, Sun-Hee Kim, Seokkee Chang, Misook Yang, Jihyun Shin, Eunjo Lee, Sunhwa Sung, Jung-Hwan Kim, Jin Tae Hong, Ho Jung Oh
Summary: This paper discusses the considerations for quality control in the manufacturing process of viral vector vaccines, including test items and summary protocol content. With the ongoing COVID-19 pandemic and controversies surrounding the effectiveness of vaccines against new variants, the establishment of standard guidance for accelerated vaccine development is of great importance to the public.
OSONG PUBLIC HEALTH AND RESEARCH PERSPECTIVES
(2022)
Article
Biochemistry & Molecular Biology
Ji-Eun Kim, Yu-Jeong Roh, Yun-Ju Choi, Su-Jin Lee, You-Jeong Jin, Hee-Jin Song, A-Yun Seol, Hong-Joo Son, Jin-Tae Hong, Dae-Youn Hwang
Summary: The neuropathological constipation phenotypes in Tg2576 transgenic mice may be closely linked to dysbiosis of the fecal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Da Eun Hong, Ji Eun Yu, Jin Woo Lee, Dong Ju Son, Hee Pom Lee, Yuri Kim, Ju Young Chang, Dong Won Lee, Won Kyu Lee, Jaesuk Yun, Sang Bae Han, Bang Yeon Hwang, Jin Tae Hong
Summary: In this study, it was found that the natural compound ebractenoid F could inhibit the expression of CHI3L1 and effectively suppress the growth and migration of lung cancer cells while inducing apoptosis. Further investigations revealed that ebractenoid F bound to CHI3L1 and suppressed its associated AKT signaling. Combined treatment with an AKT inhibitor, LY294002, synergistically decreased the expression of CHI3L1 and inhibited the growth and migration of lung cancer cells, as well as inducing apoptosis.
Article
Oncology
Ji Eun Yu, Yuri Kim, Da Eun Hong, Dong Won Lee, Ju Young Chang, Seung Sik Yoo, Min Ji Kim, Dong Ju Son, Jaesuk Yun, Sang-Bae Han, Jin Tae Hong
Summary: Bee venom has been used in oriental medicine to treat inflammatory diseases, and recent studies have shown its potential in treating cancer. It inhibits cell growth and induces apoptotic cell death in lung cancer cells. Additionally, bee venom induces autophagy by inhibiting the mTOR signaling pathway, which further promotes apoptosis. This suggests that bee venom could be a new approach to cancer treatment.
JOURNAL OF ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Seonhwa Kim, Na-Yeon Kim, Jae-Young Park, Hyo-Min Park, Chae-Min Lim, Jinju Kim, Hee Pom Lee, Jin Tae Hong, Do-Young Yoon
Summary: MMPP is a novel synthetic analog that exerts anti-inflammatory and anticancer effects by downregulating the STAT3 pathway and enhancing glucose uptake and insulin sensitivity. It can inhibit the expression of inflammatory cytokines and COX-2 in LPS-stimulated monocytes. MMPP directly binds to CD14 and MD2, inhibits the activation of NF-kappa B and JNK/AP-1 pathways, and shows anti-inflammatory activity.
Article
Neurosciences
Seung Sik Yoo, Dong Won Lee, Hyeon Joo Ham, In Jun Yeo, Ju Young Chang, Jaesuk Yun, Dong Ju Son, Sang-Bae Han, Jin Tae Hong
Summary: Alzheimer's disease (AD) is a common form of dementia, and depression is a critical psychiatric complication of AD. GSK3 beta is associated with AD and depression, and DVL regulates GSK3 beta. PS2 and DVL have cross-talk. Stress leads to cortisol hypersecretion and is associated with depression. DKK-1 regulates depression, and A beta and tau phosphorylation are biomarkers of AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yonghae Son, In-Jun Yeo, Jin-Tae Hong, Seong-Kug Eo, Dongjun Lee, Koanhoi Kim
Summary: The study reveals that elevated levels of IL-1 beta and oxysterols are found in individuals with Alzheimer's disease. Experiments conducted on microglial cells and mice show that side-chain oxysterols can increase the expression of IL-1 beta and activate microglia. These findings suggest that pharmacologic intervention targeting oxysterols could potentially treat neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Seong Hee Jeon, Yong Sun Lee, In Jun Yeo, Hee Pom Lee, Jaesuk Yoon, Dong Ju Son, Sang-Bae Han, Jin Tae Hong
Summary: The study showed that targeting CHI3L1 with K284 can reduce AD-like skin inflammation, suggesting that K284 could be a promising therapeutic agent for AD by inhibiting LTF expression.
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)